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Neuroscience Bulletin 2018年第5期34卷 849-853页

作者： Yasuhide Mitsumoto Atsushi mori Laboratory of Alternative Medicine and Experimental Ther- apeutics Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University Ho-3 Kana- gawa-machi Kanazawa Ishikawa 920-1181 Japan Department of Perioperative Management System Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya Aichi 466-8550 Japan

As an environmental risk factor, psychological stress may trigger the onset or accelerate the progression of Parkinson＇s disease （PD）. Here, we evaluated the effects of acute restraint stress on striatal dopaminergic terminals and the brain metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahy- dropyridine （MPTP）, which has been widely used for creating a mouse model of PD. Exposure to 2 h of restraint stress immediately after injection of a low dose of MPTP caused a severe loss of striatal dopaminergic terminals as indicated by decreases in the dopamine transporter protein and dopamine levels compared with MPTP administration alone. Both striatal 1-methyl-4-phenylpyridinium ion （MPP＋） and MPTP concentrations were significantly increased by the application of restraint stress. Striatal monoamine oxidase-B, which catalyzes the oxidation of MPTP to MPP＋, was not changed by the restraint stress. Our results indicate that the enhanced striatal dopaminergic terminal loss in the stressed mice is associated with an increase in the transport of neurotoxin into the brain.

关键词： MPTP MPP+ Mouse model Restraint stress Dopaminergic neuron Degeneration Dopamine transporter Dopamine

Duodenal-type follicular lymphoma more than 10 years after treatment intervention:A retrospective single-center analysis

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1552-1561页

作者： Makoto Saito Akio mori Shihori Tsukamoto Takashi Ishio Emi Yokoyama Koh Izumiyama Masanobu morioka Takeshi Kondo Hirokazu Sugino Blood Disorders Center Aiiku HospitalSapporo 064-0804Japan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 060-8638Japan

BACKGROUND Duodenal-type follicular lymphoma(D-FL)has been recognized as a rare entity that accounts for approximately 4%of primary gastrointestinal lymphomas.D-FL follows an indolent clinical course compared with common nodal FL and is generally considered to have a better ***,the“watch and wait”approach is frequently adopted as the treatment ***,there is an option to actively intervene in ***,the long-term outcomes of such cases are poorly *** To clarify the clinical outcomes after long-term follow-up in cases of D-FL with treatment *** We retrospectively analyzed patients who met the following criteria:the lesion was confirmed by endoscopy,the diagnosis of D-FL was confirmed histopathologically,and the patient was followed-up for more than 10 years after the intervention at our *** We identified 5 cases of *** patients showed a small amount of bone marrow involvement(Stage IV).Rituximab was used as a treatment for remission in all 5 *** was also used in combination with chemotherapy in 2 Stage IV patients as well as for maintenance *** therapy was performed in 2 cases,which was followed by complete remission(CR).Eventually,all 5 patients achieved CR and survived for more than 10 ***,3 patients experienced *** patient achieved a second CR by retreatment,and in another case,the lesion showed spontaneous *** remaining patient had systemic widespread recurrence 13 years after the first *** results suggested that the FL lesions were transformed into diffuse large B-cell *** patient died 4 years later despite receiving various *** In this study,the treatment for patients of D-FL in Stage IV was *** the future,criteria for how to treat“advanced”D-FL should be established based on additional *** study of patients with D-FL indicates that whole-body follow-up examinations shou

关键词： Duodenal-type follicular lymphoma Treatment Long-term follow-up Radiation Rituximab Chemotherapy

Differences between diffuse and focal autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第17期18卷 2099-2104页

作者： Taku Tabata Terumi Kamisawa Kensuke takuma Seiichi Hara Sawako Kuruma Yoshihiko Inaba Department of Internal Medicine Tokyo Metropolitan Komagome Hospital3-18-22 HonkomagomeBunkyo-kuTokyo 113-8677Japan

AIM:To investigate differences in clinical features between diffuse-and focal-type autoimmune pancreatitis(AIP).METHODS:Based on radiological findings by computed tomography and/or magnetic resonance imaging,we divided 67 AIP patients into diffuse type(D type) and focal type(F type).We further divided F type into head type(H type) and body and/or tail type(B/T type) according to the location of ***,we classified the 67 AIP patients into three groups:D type,H type and B/T *** compared the three types of AIP in terms of clinical,laboratory,radiological,functional and histological findings and clinical ***:There were 34 patients with D-type,19 with H-type and 14 with B/T-type *** obstructive jaundice was frequently detected in D-typepatients(88%) and H-type patients(68%),no B/T-type patients showed jaundice as an initial symptom(P < 0.001).There were no differences in frequency of abdominal pain,but acute pancreatitis was associated more frequently in B/T-type patients(36%) than in D-type patients(3%)(P = 0.017).Serum immunoglobulin G(IgG)4 levels were significantly higher in D-type patients(median 309 mg/dL) than in B/T-type patients(133.5 mg/dL)(P = 0.042).Serum amylase levels in B/T-type patients(median:114 IU/L) were significantly greater than in H-type patients(72 IU/L)(P = 0.049).Lymphoplasmacytic sclerosing pancreatitis(LPSP) was histologically confirmed in 6 D-type,7 H-type and 4 B/T-type patients;idiopathic duct-centric pancreatitis was observed in no *** fibrosis and abundant infiltration of CD20-positive B lymphocytes with few IgG4-positive plasma cells were detected in 2 B/T-type *** therapy was effective in all 50 patients(31 D type,13 H type and 6 B/T type).Although AIP relapsed during tapering or after stopping steroids in 3 D-type and 3 H-type patients,no patients relapsed in B/T *** follow-up,radiological features of 6 B/T-type patients were not changed and 1 B/T-type patient impr

关键词：急性胰腺炎自身免疫性弥漫性计算机断层扫描血清免疫球蛋白临床特点检查结果 AIP

Amount of TNF-αreleased from macrophagesreacting with polyethylene particles showeddose-dependent relationship to the totalsurface area of added particles

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Biosurface and Biotribology 2018年第4期4卷 122-127页

作者： Weiqi Shen Naohide Tomita Miho Niikura takuma Sugino Department of MechanicalEngineering and Science Kyoto UniversityKyotoJapan

The immune response to ultra-high molecular weight polyethylene wear debris is thought to beone of the majorcauses of osteolysis and aseptic *** in-vitro methodfor the measurement of the response is necessary in orderto priori estimate the lifespan of the *** is of importance to distinguish the bioactivity of various *** current research focused on the inverse culturing process,which was shown to be effective toevaluate the biological reaction of mouse macrophages and wear particles by estimating the amount of *** this study,several improvements were carried out through trial *** sheet wasintroduced instead of PVC seal to remove air bubbles and to eliminate the influence of potentially-attached *** along with experiments according to Stokes'law were also performed to determine the reaction time andthe minimum particle size that can be phagocytosed by macrophages in the improved *** authorsco-incubated mouse macrophages and polyethylene particles in different sizes,densities and molecular weights usingthe new *** result suggests that the amount of tumour necrosis factor-α(TNF-α)generated is dosagedependent on the total surface area of particles added regardless of particle size,density and molecular weight ofpolyethylene.

关键词： wear surface dosage

Reevaluation of the Taxonomic Status of a Poorly Known Gecko, Gekko liboensis(Reptilia: Squamata)

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Asian Herpetological Research 2015年第3期6卷 229-236页

作者： Teppei JONO Li DING takuma KAITO Yezhong TANG Mamoru TODA Chengdu Institute of Biology Chinese Academy of Sciences Department of Chemistry Biology and Marine ScienceGraduate School of Engineering and ScienceUniversity of the Ryukyus Tropical Biosphere Research Center University of the Ryukyus

Gekko liboensis Zhou and Li, 1982 is a poorly known gecko originating from Libo, Guizhou, southern China. Since the original description based on a single female from Libo, only three specimens（two females and one juvenile） have been reported from the type locality. Because of its close morphological resemblance to G. hokouensis Pope, 1927, G. liboensis is required to be reevaluated for its taxonomic status by studies based on additional specimens. Here we report for the first time the morphological features of 31 newly obtained specimens of G. liboensis from type locality and others, including males, and compare them with those of related species, chiefly on the basis of information from the literature. In addition, specimen-based comparisons were also made with G. hokouensis and an undescribed cryptic species known from the Ryukyus Islands, Japan. Results showed that the species is distinguished from its congeners in having a larger body size（60–91 mm）, 0–2 small internasals, 10–13 supralabials, 10–13 infralabials, smooth enlarged tubercles present on the dorsum forming 4–10 irregular rows at the midbody but absent on the four limbs and tail, both fingers and toes without developed interdigital webs, a single cloacal spur on each side, and 10–12 precloacal pores in males. It most resembles G. hokouensis and its cryptic species but is clearly differentiated by having a larger body size, a predominantly absent internasal, fewer number of dorsal tubercle rows, larger number of precloacal pores, and conspicuous white marks on the dorsum and head. Judging from these results, we confirmed the taxonomic validity of G. liboensis. In addition, the geographic distribution of this gecko on the basis of obtained data was briefly discussed.

关键词： China East Asia Gekkonidae Gekko japonicus group taxonomy morphology

Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly:A case report

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世界临床病例杂志 2023年第26期11卷 6262-6267页

作者： Mari mori Satoru Takeshita Nami Nakamura Yuki Mizuno Akiko Tomita Mineyoshi Aoyama Hiroki Kakita Yasumasa Yamada Department of Perinatal and Neonatal Medicine Aichi Medical UniversityNagakute 480-1195Japan Department of Pathobiology Nagoya City University Graduate School of Pharmaceutical SciencesNagoya 467-8603Japan Department of Pediatrics Aichi Medical UniversityNagakute 480-1195Japan Department of Pharmacy Aichi Medical UniversityNagakute 480-1195Japan

BACKGROUND Holoprosencephaly(HPE)is a congenital malformation with various degrees of incomplete separation of the cerebral hemispheres due to differentiation disorders of the *** HPE with diabetes insipidus due to associated pituitary dysfunction has been reported,HPE with the syndrome of inappropriate antidiuretic hormone secretion(SIADH)is very ***,a vasopressin V2 receptor antagonist,is effective in adults with ***,there is no report of its efficacy in infants with *** purpose of this report is to demonstrate that tolvaptan is effective for SIADH in infants and that administration of tolvaptan eliminates the need for restriction of water intake and sodium *** SUMMARY A 2414-g female infant was born at 38 wk by normal vaginal *** anomalies and head magnetic resonance imaging indicated semilobar *** birth,she had hyponatremia due to SIADH and was treated using water and sodium ***,she developed an exaggerated response to the fluid restrictions,resulting in large fluctuations in serum sodium *** administration of tolvaptan improved the fluctuations in serum sodium levels without the need for adjustment of water or sodium *** sodium was maintained within the normal range after discontinuation of tolvaptan at 80 d of *** were no side effects,such as hypernatremia or liver dysfunction,during the administration of *** This is the first report on the safety and efficacy of tolvaptan in an infant with SIADH associated with HPE.

关键词： Tolvaptan Holoprosencephaly Antidiuretic hormone Syndrome of inappropriate secretion of antidiuretic hormone Hyponatremia Case report

Catalytic Conversion of Methanol by Oxidative Dehydrogenation

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Journal of Natural Gas Chemistry 2007年第1期16卷 1-5页

作者： Toshihito Ohtake Tohru mori Yutaka morikawa Department of Electronic Chemistry Interdisciplinary Graduate School of Science and EngineeringTokyo Institute of Technology4259 NagatsutaMidori-kuYokohama 226-8502 Japan

This study investigates the effects of addition of oxygen on the oxidative dehydrogenation （ODH） of methanol when a fluorotetrasilicic mica ion-exchanged with palladium （Pd2^＋-TSM） was used as the catalyst. The reaction proceeded at a very low temperature in the presence of oxygen, and HCOOCH3 was obtained at high selectivity. By calculating the equilibrium conversion, it has been shown that substantial ODH took place for HCOOCH3 production. Consequently, this reaction would make dehydrogenation the dominant reaction at equilibrium. Not all the H dissociated from CH3OH was converted to H20 by oxidation. It has been shown that the H2O was not produced from oxidative dehydrogenation by the direct reaction of CH3OH and O2 when an attempt was made to carry out oxidative dehydrogenation using an isotope oxygen trace method in the gas phase. Therefore, when CHaOH was converted to CO2 and dehydrogenated to HCOOCH3, the C-O bonds were not dissociated.

关键词： C1 chemistry conversion methanol oxidative dehydrogenation catalysis

Deformation behaviors of magnesium alloy AZ31 sheet in cold deep drawing

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中国有色金属学会会刊：英文版 2008年第1期18卷 86-91页

作者：杨连发 mori Ken-ichiro TSUJI Hirokazu School of Electromechnical Engineering Guilin University of Electronic Technology Department of Production Systems Engineering Toyohashi University of Technology

To investigate how the popular magnesium alloy AZ31 sheet(aluminum 3%,zinc 1%)behaves in cold working,deep drawing experiments at room temperature,along with finite element(FE)simulation,were performed on the cold forming sheet of the AZ31 alloy after being annealed under various *** activities were focused on the fracture pattern,limit drawing ratio(LDR),deformation load,thickness distribution,anisotropic effect,as well as the influences of the annealing conditions and tool configuration on *** results display that punch shoulder radius instead of die clearance,has much influence on the thickness *** anisotropy is remarkable in cold working,which adversely impacts the *** fracture often happens on the side wall at an angle to axis of the deformed *** results also imply that the LDR for the material under present experimental conditions is 1.72,and annealing the material at 450 ℃ for 1 h may be preferable for the cold deep drawing.

关键词： AZ31镁合金冷压制各向异性有限元素模拟

Discovery of a strongly r-process enhanced extremely metal-poor star LAMOST J110901.22+075441.8

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Research in Astronomy and Astrophysics 2015年第8期15卷 1264-1274页

作者： Hai-Ning Li Wako Aoki Satoshi Honda Gang Zhao Norbert Christlieb takuma Suda Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences National Astronomical Observatory of Japan 2-21-1 OsawaMitakaTokyo181-8588Japan Department of Astronomical Science School of Physical SciencesThe Graduate University of Advanced Studies (SOKENDAI)2-21-1 OsawaMitakaTokyo 181-8588Japan University of Hyogo Center for AstronomyNishigaichiSayo-choSayoHyogo679-5313Japan Zentrum für Astronomie der Universitt Heidelberg LandessternwarteKnigstuhl 12D-69117 HeidelbergGermany Research Center for the Early Universe The University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan

We report the discovery of an extremely metal-poor（EMP） giant,LAMOST J110901.22＋075441.8, which exhibits a large excess of r-process elements with [Eu/Fe] ～＋1.16. The star is one of the newly discovered EMP stars identified from the LAMOST low-resolution spectroscopic survey and a highresolution follow-up observation with the Subaru Telescope. Stellar parameters and elemental abundances have been determined from the Subaru spectrum. Accurate abundances for a total of 23 elements including 11 neutron-capture elements from Sr through Dy have been derived for LAMOST J110901.22＋075441.8. The abundance pattern of LAMOST J110901.22＋075441.8 in the range of C through Zn is in line with the ＂normal＂ population of EMP halo stars, except that it shows a notable underabundance in carbon. The heavy element abundance pattern of LAMOST J110901.22＋075441.8 is in agreement with other well studied cool r-II metal-poor giants such as CS 22892-052 and CS 31082-001. The abundances of elements in the range from Ba through Dy match the scaled solar r-process pattern *** J110901.22＋075441.8 provides the first detailed measurements of neutroncapture elements among r-II stars at such low metallicity with [Fe/H]-3.4, and exhibits similar behavior as other r-II stars in the abundance ratio of Zr/Eu as well as Sr/Eu and Ba/Eu.

关键词： star: abundances—stars: PopulationⅡ— nucleosynthesis

Update on quinolone-containing rescue therapies for Helicobacter pylori infection

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World Journal of Gastroenterology 2020年第15期26卷 1733-1744页

作者： Hideki mori Hidekazu Suzuki Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersUniversity of LeuvenLeuven 3000Belgium Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of MedicineIsehara 259-1193Japan

Third generation of quinolones,such as levofloxacin and moxifloxacin,-containing regimens are often used in second-line or rescue treatment of Helicobacter pylori ***,the increasing antibiotic resistance to quinolones affects the efficacies of quinolones-containing therapies in recent ***,there is a need to enhance the effectiveness of quinolonescontaining ***,a fourth-generation quinolone,and vonoprazan,a novel potassium-competitive acid blocker,are now available as more effective treatment *** aim of this paper is to summarize the current evidence of quinolone-containing therapies in rescue treatments,and to discuss the importance of drug sensitivity tests or analysis of gyrA mutation before treatments.

关键词： Helicobacter pylori Levofloxacin Sitafloxacin Moxifloxacin gyrA Vonoprazan