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World Journal of Gastroenterology 2012年第45期18卷 6674-6676页

作者： Koichiro tsutsumi Hironari Kato Takeshi Tomoda Kazuyuki Matsumoto Ichiro Sakakihara Naoki Yamamoto Yasuhiro Noma Takayuki Sonoyama Hiroyuki Okada Kazuhide Yamamoto Department of Gastroenterology and Hepatology Dentistry and Pharmaceutical SciencesOkayama University Graduate School of MedicineOkayama 700-8558Japan

Endoscopic intervention is less invasive than percutaneous or surgical approaches and should be considered the primary drainage procedure in most cases with obstructive ***,therapeutic endoscopic retrograde cholangiopancreatography(ERCP) using double-balloon enteroscopy(DBE) has been shown to be feasible and effective,even in patients with surgically altered *** the other hand,endoscopic partial stent-in-stent(PSIS) placement of selfexpandable metallic stents(SEMSs) for malignant hilar biliary obstruction in conventional ERCP has also been shown to be feasible,safe and *** performed PSIS placement of SEMSs for malignant hilar biliary obstruction due to liver metastasis using a short DBE in a patient with Roux-en-Y anastomosis and achieved technical and clinical *** procedure can result in quick relief from obstructive jaundice in a single session and with short-term hospitalization,even in patients with surgically altered anatomies.

关键词： Double-balloon enteroscopy Malignant hi-lar biliary obstruction Self-expandable metallic stent Partial stent in stent Roux-en-Y anastomosis

“变化”的力量——iSpace北京来福士店

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设计家 2013年第5期 116-117页

作者： Yoshimasa tsutsumi Misae Hiromatsu tsutsumi & Associates

项目位于北京来福士广场．是美国苹果公司授权的产品零售店。建筑本身是极具动态效果的现代建筑．店铺空间被复杂的混凝土结构所包围．包括倾斜的混凝土柱子、三角形玻璃窗等。在这样的环境下．如何凸显苹果品牌“简单的抽象性”的特征... 详细信息

项目位于北京来福士广场．是美国苹果公司授权的产品零售店。建筑本身是极具动态效果的现代建筑．店铺空间被复杂的混凝土结构所包围．包括倾斜的混凝土柱子、三角形玻璃窗等。在这样的环境下．如何凸显苹果品牌“简单的抽象性”的特征成为设计的核心问题。

关键词：北京混凝土结构苹果公司现代建筑动态效果玻璃窗三角形抽象性

NO-1886降低脂负荷新西兰兔血清甘油三酯和游离脂肪酸

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中国药理学通报 2005年第3期21卷 280-283页

作者：张弛肖俊霞席守民张秋菊王宗保 Kusunoki M tsutsumi K 尹卫东南华大学生物化学与分子生物学教研室湖南衡阳421001 南华大学肿瘤研究所湖南衡阳421001 南华大学实验动物学部湖南衡阳421001 Dept of Internal Medicine Faculty of MedicineAichi Medical UniversityNagakute-choAichigunteAichi480-11Japan Research and Development Otsuka Pharmaceutical Factory IncTokushimaJapan

目的观察NO1886(ibrolipim)对脂肪餐后血脂水平的影响。方法将25只♂新西兰兔随机分为5组正常对照组、脂负荷组、脂负荷+NO1886(05g·kg-1)组、脂负荷+NO1886(10g·kg-1)组、脂负荷+NO1886(15g·kg-1)组;分别在给予20%脂肪乳和相应剂量N... 详细信息

目的观察NO1886(ibrolipim)对脂肪餐后血脂水平的影响。方法将25只♂新西兰兔随机分为5组正常对照组、脂负荷组、脂负荷+NO1886(05g·kg-1)组、脂负荷+NO1886(10g·kg-1)组、脂负荷+NO1886(15g·kg-1)组;分别在给予20%脂肪乳和相应剂量NO1886前后第1、2、4、6、8、24h从兔耳缘静脉采血,离心收集血清,测定血清甘油三酯和游离脂肪酸。结果NO1886能有效地降低脂负荷后新西兰兔血清甘油三酯和游离脂肪酸水平,呈剂量依赖性,并能使游离脂肪酸恢复到正常。结论NO1886具有调节脂肪餐后血脂水平的作用。

关键词：甘油三脂游离脂肪酸脂肪耐量实验新西兰兔 NO-1886

Gentian extract induces caspase-independent and mitochondria-modulated cell death

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Advances in Biological Chemistry 2011年第3期1卷 49-57页

作者： Mika Ogata Kazushige Matsukawa Kiyomi Kogusuri Tetsuro Yamashita Takashi Hikage Kikukatsu Ito Yasushi Saitoh Ken-ichi tsutsumi 不详

Extracts from the dried roots of gentian plant, Gentiana triflora, exhibit an antiproliferative activity against cultured and implanted tumor cells. However, the underlying mechanism has been unclear. In the present study, we show that the cell death induced by the extract occurs caspase-independently and depends on metabolic status of mitochondrial respiration. We observed that sensitivity to the extract was considerably lower in HeLa cells, which have a low rate of mitochondrial respiration, in comparison to Y3-Ag1.2.3 cells, which have a higher rate of respiration. Furthermore, sensitivity of HeLa cells to the extract increased significantly when they were forced to switch their energy dependency from glycolysis to mitochondrial respiration. These results indicate that the gentian extract targets on mitochondrial respira-tion. Consequently, different respiratory activities in mitochondria confer cells to have different suscepti-bilities to the extract-induced cell death.

关键词： Antiproliferative Activity Cell Death Mitochondria Respiration Gentiana Triflora

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高速、高精度数控伺服工作台摩擦误差的研究

机械工程学报 2001年第6期37卷 76-81页

作者：梅雪松陶涛堤正臣孙挪刚西安交通大学机械工程学院西安710049 日本东京农工大学西安交通大学

建立了一种考虑摩擦影响的PID控制下的高速、高精度进给伺服工作台的数学模型。伺服机构中的摩擦力是采用一种“两维混合摩擦模型”来描述的。该模型可以根据滑动速度、表面接触物体的油膜厚度等计算摩擦力。通过数值仿真与实际测量 ,... 详细信息

建立了一种考虑摩擦影响的PID控制下的高速、高精度进给伺服工作台的数学模型。伺服机构中的摩擦力是采用一种“两维混合摩擦模型”来描述的。该模型可以根据滑动速度、表面接触物体的油膜厚度等计算摩擦力。通过数值仿真与实际测量 ,在大范围的工况下 ,研究了圆运动过象限时出现凸起的误差现象。通过计算与试验结果的比较 ,证明了提出的考虑摩擦影响的数学模型能够精确地模拟PID控制下的高速、高精度进给伺服工作台的动力学过程 ,能够正确地预测进给运动过程中摩擦误差大小及特征。

关键词：摩擦误差数学模型 PID控制动力学数控机床工作台

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加酶浴剂的功效

日用化学品科学 1988年第4期 53-55页

作者： Iwdo tsutsumi 郭俊旺

浴剂用酶为了开发酶的实际用途,应确定对使用目的最适合的酶,酶对其作用物具有高度的专一性,在非常苛刻的温度和pH条件下,它能加速特定的化学反应,而对于消费品,这种特性并不受欢迎。因此,在开发加酶浴剂时,酶对其作用物质的专一性不应... 详细信息

浴剂用酶为了开发酶的实际用途,应确定对使用目的最适合的酶,酶对其作用物具有高度的专一性,在非常苛刻的温度和pH条件下,它能加速特定的化学反应,而对于消费品,这种特性并不受欢迎。因此,在开发加酶浴剂时,酶对其作用物质的专一性不应太强,它的催化能力应在一定宽的反应条件有效,而且应具有足够的稳定性。在大多数情况下,浴剂中使用的酶都是蛋白酶。从增强浴剂效果的观点来看,它是一种非常理想的物质。浴用产品种类繁多,如浴晶、浴盐、浴油、浴胶囊、奶浴液、浴洗液、泡沫浴剂、

关键词：污垢森林浴胃蛋白酶脑血流量伤口

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锡联溶聚丁苯橡胶的结构及动态性能

橡胶译丛 1992年第1期26卷 15-22页

作者： F.tsutsumi 江畹兰

引言轮胎要求具有低的滚动阻力及高抗湿滑性能。胎面胶的滚动阻力主要是由滞后现象引起的。大多数胎面胶配方中含有丁苯橡胶(SBR)、天然橡胶(NR)和顺丁橡胶(1,4-BR)。标准低温乳液聚合丁苯橡胶(苯乙烯含量23％)具有良好的抗湿滑性能,但... 详细信息

引言轮胎要求具有低的滚动阻力及高抗湿滑性能。胎面胶的滚动阻力主要是由滞后现象引起的。大多数胎面胶配方中含有丁苯橡胶(SBR)、天然橡胶(NR)和顺丁橡胶(1,4-BR)。标准低温乳液聚合丁苯橡胶(苯乙烯含量23％)具有良好的抗湿滑性能,但滚动阻力较大。

关键词：轮胎丁苯橡胶锡联溶聚胎面胶

Crystal Structures and Thin-Film Electronic Properties of a Series of Zwitterionic Molecules

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Russell body gastritis with Dutcher bodies evaluated using magnification endoscopy

The 9th China-Japan Joint Symposium on Conduction and Photoconduction in Organic Solids and Related Phenomena

作者： Jun’ya tsutsumi Hiroyuki Yoshida Naoki Sato Shigeki Kato Inta Muzikante Ojars Neilands Institute for Chemical Research Kyoto University Uji Kyoto 611-0011 Japan Department of Chemistry Graduate School of Science Sakyo-ku Kyoto 606-8502 Institute of Solid State Physics University of Latvia Kengaraga Str.8 Riga LV 1063 Latvia Riga Technical University Riga LV-1048 Latvia

The research group of the Institute of Chemical Research,Kyoto University among the authors above is aiming at exploring novel organic electronic systems that could show notable electronic properties,by selecting unique molecules and controlling their arrangements to realize peculiar aggregation structures in the solid *** line with such a strategy,we have investigated several molecular systems in terms of correlation among crystallographic structure,electronic structure and electronic *** results on a series of compounds studied with particular interests in molecular polarity which is often neglected in the field of conducting molecular solids will be described below.

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 417-424页

作者： Kenji Yorita Takehiro Iwasaki Kunihisa Uchita Naoto Kuroda Koji Kojima Shinichi Iwamura Yutaka tsutsumi Akinobu Ohno Hiroaki Kataoka Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital Department of Internal Medicine Japanese Red Cross Kochi Hospital Department of Pathology Fujita Health University School of Medicine Pathology Section University of Miyazaki Hospital Section of Oncopathology and Regenerative Biology Department of PathologyFaculty of MedicineUniversity of Miyazaki

Russell body gastritis(RBG) is an unusual type of chronic gastritis characterized by marked infiltration of Mott cells,which are plasma cells filled with spherical eosinophilic bodies referred to as Russell *** was initially thought that Helicobacter pylori(***) infection was a major cause of RBG and that the infiltrating Mott cells were polyphenotypic;however,a number of cases of RBG without *** infection or with monoclonal Mott cells have been ***,diagnostic difficulty exists in distinguishing RBG with monoclonal Mott cells from malignant ***,we report an unusual case of an 86-year-old-Japanese man with ***-positive *** the examination of melena,endoscopic evaluation confirmed a 13-mm whitish,flat lesion in the gastric *** endoscopy with narrowband imaging suggested that the lesion was most likely a poorly differentiated *** findings were consistent with chronic gastritis with many Mott cells with intranuclear inclusions referred to as Dutcher *** submucosal dissection confirmed the diagnosis of RBG with kappa-restricted monoclonal Mott *** lymphoma was unlikely given the paucity of cytological atypia and Ki-67 immunoreactivity of monoclonal Mott *** is the first reported case of RBG with endoscopic diagnosis of malignant tumor and the presence of Dutcher bodies.

关键词： Russell body gastritis Mott cell Dutcher body Mucosa-associated lymphoid tissue lymphoma Plasmacytoma Magnification endoscopy with narrow-band imaging