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Progress in Natural Science:Materials International 2020年第5期30卷 707-710页

作者： Yunmei Mu Yusuke Kinashi Akihiro Kishimura takeshi mori Koji Hase Yoshiki Katayama Graduate School of Systems Life Sciences Kyushu University Division of Biochemistry Faculty of Pharmacy Keio University Department of Applied Chemistry Faculty of Engineering Kyushu University Center for Future Chemistry Kyushu University International Research Center for Molecular System Kyushu University Division of Mucosal Barrierology International Research and Development Center for Mucosal Vaccines The Institute of Medical Science the University of Tokyo Department of Biomedical Engineering Chung Yuan Christian University

The nanoparticles(NPs) from polyvinyl butyrate(PVBu) which can work as an orally applicable donor of butyrate for intestine were prepared. Immunotolerance inducing molecules such as vitamin D3and all-trans retinoic acid(ATRA) were incorporated into PVBu NPs. The alteration in populations and numbers of DC103+dendritic cells(DC) and regulatory T(Treg) cells in intestinal immune tissues were examined after oral administration of NPs. It was found that NPs reduced the population of CD103+DC and Treg cells in Peyer’s patched in lower part of the intestine and inversely increased the population of CD103+DC in mesenteric lymph node(MLN), while the population of Treg cells in MLN was unchanged. These observations indicate that NPs may enhance the immunotolerance at MLN and lamina propria toward luminal antigens, indicating the promising features of PVBu NPs as therapeutics of allergy and autoimmune diseases.

关键词： Butyrate Polyvinyl butyrate Retinoic acid Vitamin D 3 Tolerogenic dendritic cells Regulatory T cells

Targeting therapy for hepatocellular carcinoma by delivering microRNAs as exosomal cargo

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World Journal of Gastroenterology 2024年第17期30卷 2369-2370页

作者： takeshi Suda Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami Uonuma 949-7302NiigataJapan

Exosomes,the smallest extracellular vesicles,have gained significant attention as key mediators in intercellular communication,influencing both physiological and pathological processes,particularly in cancer progression.A recent review article by Wang et al was published in a timely manner to stimulate future research and facilitate practical developments for targeted treatment of hepatocellular carcinoma using exosomes,with a focus on the origin from which exosomes *** information about the mechanisms for delivering exosomes to specific cells is incorporated,the concept of targeted therapy for hepatocellular carcinoma using exosomes could be more comprehensively understood.

关键词： Exosomal delivery Therapeutic targets MicroRNAs Hepatocellular carcinoma

Safety and efficacy of self-expandable metallic stents in malignant small bowel obstructions

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World Journal of Gastroenterology 2016年第40期22卷 9022-9027页

作者： Akiyoshi Tsuboi Toshio Kuwai Tomoyuki Nishimura Sumio Iio takeshi mori Hiroki Imagawa Toshiki Yamaguchi Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer Center

In this report, we present 3 cases of malignant small bowel obstruction, treated with palliative care using endoscopic self-expandable metallic stent(SEMS) placement, with the aim to identify the safety and efficacy of this procedure. Baseline patient characteristics, procedure methods, procedure time, technical and clinical success rates, complications, and patient outcomes were obtained. All 3 patients had pancreatic cancer with small bowel strictures. One patient received the SEMS using colonoscopy, while the other 2 patients received SEMS placement via double balloon endoscopy using the through-the-overtube technique. The median procedure time was 104 min. The technical and clinical success rates were 100%. Post-treatment, obstructive symptoms in all patients improved, and a low-residue diet could be tolerated. All stents remained within the patients until their deaths. The median overall survival time(stent patency time) was 76 d. SEMS placement is safe and effective as a palliative treatment for malignant small bowel obstruction.

关键词：自我可扩充的金属性的 stents 恶意的小肠阻塞内视镜检查法案例报告胰腺的癌症

Status and challenges of global antimicrobial resistance control: A dialogue between Professors Yonghong Xiao and takeshi Nishijima

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hLife 2024年第2期2卷 47-49页

作者： Yonghong Xiao takeshi Nishijima State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalZhejiang University School of MedicineZhejiangChina Antimicrobial Resistance Essential Medicines and Health TechnologiesDivision of Health Systems and ServicesWHO Regional Office for the Western PacificManilaPhilippines

Antimicrobial resistance(AMR)is one of the top 10 public health threats,which is not only related to human health,but also closely related to animal health and environmental *** health concept and framework are the core strategy to contain *** World Health Organization(WHO)has already issued the Global Action Plan to contain AMR,which includes surveillance,education,stewardship,and innovation of new diagnostics and *** Asia–Pacific region is the most populous area of WHO,and also a region with severe ***,***,a professional officer of AMR control from WHO Regional Office for the Western Pacific discussed with Professor Yonghong Xiao(Zhejiang University)about the epidemiology,socioeconomic impact of AMR globally and in Western Asia–Pacific region(WPRO),and they talked the actions and strategies,achievements and shortcomings in the control of AMR during the past years,introduced the initiative of quadripartite One *** outstanding results of China in AMR containment were recognized.

关键词： resistance globally shortcomings

Method to measure tree-ring width,density,elemental composition,and stable carbon and oxygen isotopes using one sample

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Journal of Forestry Research 2024年第3期35卷 167-174页

作者： Chenxi Xu Yaru Zhao Wenling An Qingyu Zhao Yucheng Liu Masaki Sano takeshi Nakatsuka Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029People's Republic of China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044People's Republic of China College of Earth Sciences University of Chinese Academy of SciencesBeijing 100049People's Republic of China Graduate School of Environment Studies Nagoya UniversityNagoya 4648601Japan

Tree-ring width(RW),density,elemental com-position,and stable carbon and oxygen isotope(δ^(13)C,δ^(18)O)are widely used as proxies to assess climate change,ecology,and environmental pollution;however,a specific pretreat-ment has been needed for each ***,we developed a method by which each proxy can be measured in the same ***,the sample is polished for ring width *** obtaining the ring width data,the sample is cut to form a 1-mm-thick wood *** sample is then mounted in a vertical sample holder,and gradually scanned by an X-ray ***,the count rates of the fluorescent photons of elements(for chemical characteriza-tion)and a radiographic grayscale image(for wood density)are obtained,*** density and the element content are ***,cellulose is isolated from the 1-mm wood plate by removal of lignin,and *** producing this cellulose plate,cellulose subsamples are separated by knife under the microscope for inter-annual and intra-annual stable carbon and oxygen isotope(δ^(13)C,δ^(18)O)*** on this method,RW,density,elemental composition,δ^(13)C,and δ^(18)O can be measured from the same sample,which reduces sample amount and treatment time,and is helpful for multi-proxy comparison and combination research.

关键词： Tree-ring width Tree-ring density Tree-ring elemental composition Tree-ring stable carbon and oxygenisotopes

A plant growth chamber system equipped with aerosol generators for studying aerosol-vegetation interactions

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Particuology 2024年第2期85卷 122-132页

作者： Masao Gen Seiji Ikawa Masahiro Yamaguchi Fong Zyin Lim takeshi Izuta I.Wuled Lenggoro Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai980-8577Japan Faculty of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasaki852-8521Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509 Japan Department of Applied Physics and Chemical Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan

Understanding aerosol-vegetation interactions is vital in ***,the interactions remain elusive partly due to the lack of suitable plant growth chamber ***,deposition of submicron particles on leaf surfaces is challenging due to its low deposition velocities compared to larger *** this work,we present a plant-growth chamber that was used to study the effect of sub-micron black carbon(BC)particles on the growth and photosynthesis of *** chamber system simultaneously enables the growth of multiple plants in pots and the deposition of submicron particles onto *** spraying methods assisted by ultrasonic and electrostatic forces were employed as aerosol generators to realize the particle *** flow regime inside the chamber was numeri-cally calculated to predict the transportation of aerosol particles,suggesting the optimal operating conditions of the *** gas-phase particle size distribution measurements showed that gener-ated BC particles were suspended in submicron diameter *** aerosol generators were examined in the chamber using three conductor and insulator substrates as a model of plant *** observations and spectroscopic analysis ascertained that submicron BC particles generated from our generators were deposited on all substrate *** the developed chamber system,systematic studies can be performed to advance the fundamental understanding of aerosol-vegetation interactions.

关键词： Aerosol Exposure chamber Spray drying Black carbon

Endoscopic hemostasis using self-expandable metal stent combinedwith PuraStat® for patient with high risk of post-endoscopicsphincterotomy bleeding (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 94-96页

作者： takeshi Ogura Yuki Uba Masahiro Yamamura Nobu Nishioka Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan

To the Editor:Endoscopic sphincterotomy(EST)is an established technique for removal of bile duct stones and self-expandable metal stent(SEMS)***,bleeding can be considered an adverse event after EST,particularly for patients with high risk of bleeding such as those on *** the various techniques reported for obtaining endoscopic hemostasis[1-3].

关键词： bleeding stasis endoscopic

Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation

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Neural Regeneration Research 2025年第1期20卷 188-190页

作者： Shiho Ito takeshi Kawauchi Department of Adaptive and Maladaptive Responses in Health and Disease Graduate School of MedicineKyoto UniversityKyotoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Cell adhesion plays pivotal roles in the morphogenesis of multicellular *** cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically observed only in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily consists of more than 100 members,but classic cadherins.

关键词： cerebral skeletal cooperation

Propensity score matching analysis for clinical impact of braided-type versus laser-cut-type covered self-expandable metal stents for endoscopic ultrasound-guided hepaticogastrostomy

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 181-185页

作者： Mitsuki Tomita takeshi Ogura Akitoshi Hakoda Saori Ueno Atsushi Okuda Nobu Nishioka Yoshitaro Yamamoto Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan Endoscopy Center Osaka Medical and Pharmaceutical UniversityOsakaJapan

Background:To prevent stent migration during endoscopic ultrasound-guided hepaticogastrostomy(EUS-HGS),intra-scope channel release technique is important,but is unfamiliar to non-expert *** self-expandable metal stent(SEMS)is an additional factor to prevent stent ***,no compara-tive studies of laser-cut-type and braided-type during EUS-HGS have been *** aim of this study was to compare the distance between the intrahepatic bile duct and stomach wall after EUS-HGS among laser-cut-type and braided-type ***:To evaluate stent anchoring function,we measured the distance between the hepatic parenchyma and stomach wall before EUS-HGS,one day after EUS-HGS,and 7 days after ***,propensity score matching was performed to create a propensity score for using laser-cut-type group and braided-type ***:A total of 142 patients were enrolled in this *** them,24 patients underwent EUS-HGS using a laser-cut-type SEMS,and 118 patients underwent EUS-HGS using a braided-type ***-HGS using the laser-cut-type SEMS was mainly performed by non-expert endoscopists(n=21);EUS-HGS using braided-type SEMS was mainly performed by expert endoscopists(n=98).The distance after 1 day was significantly shorter in the laser-cut-type group than that in the braided-type group[2.00(1.70-3.75)vs.6.90(3.72-11.70)mm,P<0.001].In addition,this distance remained significantly shorter in the laser-cut-type group after 7 *** these results were similar after propensity score matching analysis,the distance between hepatic parenchyma and stomach after 7 days was increased by 4 mm compared with the distance after 1 day in the braided-type *** the other hand,in the laser-cut-type group,the distance after 1 day and 7 days was almost the ***:EUS-HGS using a laser-cut-type SEMS may be safe to prevent stent migration,even in non-expert hands.

关键词： Endoscopic ultrasound-guided hepaticogastrostomy Endoscopic ultrasound-guided biliary drainage Endoscopic retrograde cholangiopancreatography

An Evans Syndrome Case Expressing Anti-Jk<sup>a</sup>Autoantibody under Condition of Primary IgA Immunodeficiency

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International Journal of Clinical Medicine 2015年第7期6卷 496-499页

作者： takeshi Sugimoto Ayumi Tani Ikuyo Hayakawa Makoto Hashimoto Tomoko Yanai Ikuko Kubokawa takeshi mori takeshi Kato Satoshi Hirase Nobuyuki Yamamoto Hironobu Minami Akira Hayakawa Department of Hematology and Oncology Kita-Harima Medical Center Ono Japan Department of Blood Transfusion Kobe University Hospital Kobe Japan Institute of Biomedical Research and Innovation Kobe Japan Department of Pediatric Medicine Kobe University Hospital Kobe Japan

Autoimmune haemolytic anaemia is a haemolytic disease resulting from an autoimmune reaction to the surface of red blood cells. A part of autoantibody is known to react with the blood type antigen. This is the case of a 14 years old female with Evans syndrome in which autoimmune haemolysis may cause from anti-Jka autoantibody reaction. As this case is complicated with primary IgA immunodeficiency syndrome, anti-Jka autoantibody may occur under the condition of primary immunodeficiency status, in which autoantibody production is accelerated. Considering the co-occurrence of autoimmune haemolytic anaemia and primary IgA immunodeficiency syndrome, analysis focusing on specificity for red blood cells antigens will be required in IgA immunodefi-ciency syndrome patients.

关键词： Anti-Jka Autoantibody Evans Syndrome IgA Immunodeficiency