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HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer

World Journal of Clinical Cases 2019年第15期7卷 1964-1977页

作者： Akio Kaito takeshi kuwata Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita Department of Gastric Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Gastrointestinal Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research&Clinical Trial Center(EPOC) National Cancer Center Hospital EastKashiwa 277-8577Japan Juntendo University Graduate School of Medicine Tokyo 163-8001Japan Department of Radiation Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan

BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based *** To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based *** Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were *** patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were *** A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based ***,HER2 heterogeneity should be considered during the assessment of HER2 expression.

关键词： Human epidermal growth factor receptor 2 Heterogeneity Trastuzumab Gastric cancer Chemotherapy

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Erratum: Author’s Affiliation Correction. Type Ⅱ human epidermal growth factor receptor heterogeneity is a poor prognosticator for type Ⅱ human epidermal growth factor receptor positive gastric cancer (World J Clin Cases 2019;Aug 6;7 (15): 1964-1977)

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World Journal of Clinical Cases 2020年第21期8卷 5494-5495页

作者： Akio Kaito takeshi kuwata Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita Gastric Surgery Division National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Gastrointestinal Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of MedicineTokyo 163-8001Japan Exploratory Oncology Research and Clinical Trial Center(EPOC) National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Radiation Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan

Correction to"Type II human epidermal growth factor receptor heterogeneity is a poor prognosticator for type II human epidermal growth factor receptor-positive gastric cancer"World J Clin Cases 2019;7(15):*** this article,one of the affiliation of the first author was *** Kaito,the first author,belonged to Course of Advanced Clinical Research of Cancer,Juntendo University Graduate School of Medicine,Tokyo 163-8001,Japan.

关键词： Correction

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