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A NOTE ON MULTILINEAR FRACTIONAL INTEGRALS

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Analysis in Theory and Applications 2010年第4期26卷 301-307页

作者： takeshi iida Yasuo Komori-Furuya Enji Sato Yamagata University Tokai University

Shi and Wao[6] studied the boundedness of multilinear fractional integrals introduced by Kenig and Stein[3] on product of weighted LP-spaces, and got some results. We give some remarks with respect to their results an... 详细信息

关键词： multilinear fractional integral Ap,q weight Aαp,q weight

Postsurgical radiation therapy for gastric carcinosarcoma with c-kit expression: A case report

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World Journal of Gastroenterology 2015年第9期21卷 2830-2835页

作者： takeshi Gohongi Hiroyuki iida Naoto Gunji Kazuo Orii Takesaburo Ogat Department of Surgery and Pathology Tsukuba-Gakuen HospitalIbaraki 305-0857Japan

Gastric carcinosarcomas are rare morphologically biphasic tumors, consisting of carcinoma and sarcoma components, with a poor clinical *** we report the case of a 70-year-old man with advanced Borrmann type Ⅲ carcinosarcoma arising from the upper body of the stomach with extensive lymph node metastasis who underwent a total, but palliative, *** showed the tumor consisted of a biphasic structure of tubular adenocarcinoma and spindle *** revealed sarcoma cells expressing c-kit(CD117) and CD34, which are criteria for gastrointestinal stromal *** months after the surgical operation, tumor metastases had extended to the hepatohilar, retroperitoneal and mediastinal lymph *** therapy of 50 Gy markedly decreased the size of each of these nodes and reduced the risk of respiratory complications and ***, the patient died of respiratory failure due to bronchopneumonia with multiple lung metastases 22 mo after *** revealed severe necrosis in most of the lymph nodes with tumor *** therapy combined with gastrectomy should be considered to improve survival in patients with gastric carcinosarcomas that express c-kit.

关键词： CD34 C-kit Gastric carcinosarcoma Radiation therap

Implantable Venous Access Ports for Chemotherapy in Lung Cancer Patients: Comparison of the Femoral and Subclavian Vein Approaches without Guidance

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Open Journal of Radiology 2012年第2期2卷 39-45页

作者： takeshi Fujita Masahiro Tanabe Masatoshi Kato Taiga Kobayashi Etsushi iida Naofumi Matsunaga Department of Radiology Graduate School of Medicine Yamaguchi University Yamaguchi Japan

Background: The goal of this study was to retrospectively compare the initial success rate and rate of intraoperative and late complications between the femoral and subclavian vein approaches used to implant venous access ports without guidance in lung cancer patients. Methods: We conducted a retrospective review of total 163 lung cancer patients who underwent implantations of a central venous access port for chemotherapy. 95 patients received the ports by the femoral vein blind-puncture technique and 68patients had the port implanted via the subclavian vein blind-puncture technique. The initial success rate of port implantation and the frequency of occurrence of complications were calculated. Results: The primary success rate of venous port implantation was 93.7% for femoral approach and 88.2% for the subclavian approach respectively (p < 0.05). Intraoperative complications developed in two patients (2.1%) in the femoral approach group and in five patients (7.4%) in the subclavian approach group. Although a higher intraoperative complication ratio for the subclavian approach was encountered compared to that for the femoral vein approach, there was no statistically significant difference (p = 0.103). Nor was there any statistically significant difference in terms of the occurrence of late complications. Conclusions: Venous access port implantation via the femoral vein approach is safe, and its success rate is very high, with the equal complication rates comparable to the subclavian approach. This approach avoids many of the intraoperative complications. Thus, the femoral vein approach for implanting a venous access port in lung cancer patients should be considered a valid, and safe technique.

关键词： Central Venous Access Implantable Port Femoral Vein Subclavian Vein Lung Cancer Patients

Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis

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World Journal of Gastroenterology 2010年第4期16卷 484-489页

作者： Tomoyuki Akiyama Masahiko Inamori Hiroshi iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima Gastroenterology Division Yokohama City University School of Medicine3-9 FukuuraKanazawa-kuYokohama 236-0004Japan

AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive ***:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our *** presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M *** originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 *** of shape and length of Barrett's epithelium with erosive esophagitis was ***:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's *** prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 ***:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis.

关键词： Barrett’s epithelium Esophagitis Endoscopy

Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis

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World Journal of Gastroenterology 2021年第18期27卷 2160-2176页

作者： Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito Department of Molecular Gastroenterology and Hepatology Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Medical Innovation and Translational Medical Science Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Food Science Ishikawa Prefectural UniversityNonoichi 921-8836Japan Department of Health Care Nutrition Showa Gakuin Junior CollegeIchikawa 272-0823Japan Division of Gastroenterology Department of Internal MedicineKawasaki Medical SchoolKurashiki 701-0192Japan Department of Nutrition Taiyo Kagaku Co.LtdYokkaichi 510-0844Japan

BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease *** such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut *** hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic ***,its effects on NAFLD remain to be fully *** determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver *** Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%*** intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate *** weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were *** Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG ***,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluatin

关键词： Non-alcoholic fatty liver disease Partially hydrolyzed guar gum Gut-liver axis Intestinal barrier integrity Microbiota Short-chain fatty acids

Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival

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World Journal of Gastroenterology 2021年第41期27卷 7190-7206页

作者： Kentaro Yamada Tsunaki Sawada Masanao Nakamura takeshi Yamamura Keiko Maeda Eri Ishikawa Tadashi iida Yasuyuki Mizutani Naomi Kakushima Takuya Ishikawa Kazuhiro Furukawa Eizaburo Ohno Takashi Honda Hiroki Kawashima Masatoshi Ishigami Satoshi Furune Tetsunari Hase Kenji Yokota Osamu Maeda Naozumi Hashimoto Masashi Akiyama Yuichi Ando Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Endoscopy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Clinical Oncology and Chemotherapy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Respiratory Medicine Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Dermatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Gastroenterology and Hepatology Graduate School of MedicineThe University of TokyoTokyo 1138655Japan

BACKGROUND Despite the popularity of immune checkpoint inhibitors(ICIs)in the treatment of advanced cancer,patients often develop gastrointestinal(GI)and non-GI immune-related adverse events(irAEs).The clinical characteristics and survival outcomes of GI-irAEs have not been fully elucidated in previous *** necessitates the evaluation of the impact of GI-irAEs on patients receiving ICI *** To evaluate the clinical characteristics of GI-irAEs and their impact on survival in patients treated with *** In this single-center,retrospective,observational study,we reviewed the records of 661 patients who received ICIs for various cancers at Nagoya University Hospital from September 2014 to August *** analyzed the clinical characteristics of patients who received ICI *** also evaluated the correlation between GI-irAE development and prognosis in non-small cell lung cancer(LC)and malignant melanoma(MM).Kaplan-Meier analysis was used to compare the median overall survival(OS).Multivariate Cox proportional hazards models were used to identify prognostic factors.A P value<0.05 was considered statistically *** GI-irAEs occurred in 34 of 605 patients(5.6%)treated with an anti-programmed cell death-1/programmed death-ligand 1(anti-PD-1/PD-L1)antibody alone and in nine of 56 patients(16.1%)treated with an anti-cytotoxic T-lymphocyte antigen 4(CTLA-4)antibody alone or a combination of anti-PD-1 and anti-CTLA-4 *** cumulative incidence and median daily diarrhea frequency were significantly higher in patients receiving anti-CTLA-4 antibodies(P<0.05).In 130 patients with MM,OS was significantly prolonged in the group that continued ICI treatment despite the development of GI-irAEs compared to the group that did not experience GI-irAEs(P=0.035).In contrast,in 209 patients with non-small cell LC,there was no significant difference in OS between the *** multivariate analyses showed that a performance status of 2-3(ha

关键词： Colitis Cytotoxic T-lymphocyte antigen 4 Diarrhea Drug-related side effects and adverse reactions Immune checkpoint inhibitors Prognosis