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Hypoxia-inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis

World Journal of Gastroenterology 2005年第10期11卷 1535-1539页

作者： Tomoyuki Okuda takeshi Azuma Masahiro Ohtani Ryuho Masaki Yoshiyuki Ito Yukinao yamazaki Shigeji Ito Masaru Kuriyama Second Department of Internal Medicine Department of Endoscopic Medicine Department of Internal Medicine

AIM: To examine the etiology and pathophysiology in human ischemic colitis from the viewpoint of ischemic favors such as hypoxia-inducible factor 1 alpha (HIF-1alpha and vascular endothelial growth factor (VEGF).METHODS: Thirteen patients with ischemic colitis and 21 normal controls underwent colonoscopy. The follow-up colonoscopy was performed in 8 patients at 7 to 10 d after theoccurrence of ischemic colitis. Biopsy samples were subjected to real-time RT-PCR and immunohistochemistry to detect the expression of HIF-1 alpha and ***: HIF-1 alpha and VEGF expression were found in the normal colon tissues by RT-PCR and ***-1 alpha and VEGF were overexpressed in the lesions of ischemic colitis. Overexpressed HIF-1 alpha and VEGF RNA quickly decreased to the normal level in the scar regions at 7 to 10 d after the occurrence of ischemic ***: Constant expression of HIF-1 alpha and VEGF in normal human colon tissue suggested that HIF-1alpha and VEGF play an important role in maintaining tissue integrity. We confirmed the ischemic crisis in ischemic colitis at the molecular level, demonstrating overexpression of HIF-1 alpha and VEGF in ischemic lesions. These ischemic factors may play an important role in the pathophysiology of ischemic colitis.

关键词：缺氧诱导因子-1α 血管生长因子大肠炎病理学

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SD3, an Arabidopsis thaliana Homolog of TIM21, Affects Intracellular ATP Levels and Seedling Development

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Molecular Plant 2012年第2期5卷 461-471页

作者： Hidefumi Hamasaki takeshi Yoshizumi Naoki Takahashi Mieko Higuchi Takashi Kuromori Yuko Imura Hiroaki Shimada Minami Matsui Plant Functional Genomics Research Group Plant Science Center RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa 230-0045 Japan Department of Biological Science and Technology Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan Gene Discovery Research Group RIKEN Plant Science Center RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa 230-0045 Japan

It is poorly understood how plants control their growth by cell division, elongation, and differentiation. We have characterized a seedling-lethal mutant segregation distortion 3 （sd3） that showed a very dwarf phenotype when grown in the light and, in the dark, had short hypocotyls with reduced ploidy levels. The corresponding gene of SD3 encodes a protein with high similarity to yeast translocase on the inner mitochondrial membrane 21 （TIM21）, which is a component of the TIM23 complex. Indeed, SD3 protein fused to GFP localized in the mitochondria. SD3 overexpression increased cotyledon size in the light and hypocotyl thickness in the dark. The expression of genes for several subunits of the respiratory-chain complexes III and IV was up-regulated in SD3-overexpressing plants. Furthermore, these plants showed high levels of ATP whereas those of sd3 were low. These results suggested that SD3 induced an increase in cell size by raising the expression of the respiratory-chain subunit genes and hence increased the intracellular ATP levels, We propose that intracellular ATP levels regulated by mitochondria control plant organ size.

关键词： hypocotyl elongation endoreduplication mitochondria ATR

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The Relationship between Neck and Shoulder Pain and the Sagittal Alignment of the Spine in Standing in Younger Generation

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Open Journal of Orthopedics 2015年第11期5卷 337-344页

作者： Tomonori Kenmoku Takane Suzuki Nobuyasu Ochiai Tatsuki Ebata Genyo Miyajima Naoshige Nagura Mitsufumi Nakawaki Ryo Tazawa Sho Hiramatsu Hironori yamazaki Yu Sasaki takeshi Yamaguchi Eiko Hashimoto Kenji Onuma Naonobu Takahira Kazuhisa Takahashi Masashi Takaso Department of Orthopedic Surgery Kitasato University School of Medicine Sagamihara Japan Sakura Orthopaedic Hospital Sakura Japan Department of Bioenvironmental Medicine Graduate School of Medicine Chiba Japan Department of Orthopaedic Surgery Chiba University Graduate School of Medicine Chiba Japan Department of Orthopedic Surgery Kitasato Medical Center Kitamoto Japan School of Allied Health Science Kitasato University Sagamihara Japan

Background: The relationship between chronic neck and shoulder pain and posture remains controversial. The purpose of this study was to investigate the relationship between chronic neck and shoulder pain and spinal sagittal alignment in standing posture in younger generation. Methods: Subjects included 57 females and 32 males (average age, 29.9 ± 5.7 years). All subjects were 20s or 30s. Spinal curvature was assessed using SpinalMouse. The subjects were also divided into a normal group (VAS zero group) and a pain group by VAS results. Statistical analysis was performed by Student’s t-test. Significance was defined as p < 0.05. Results: The normal group and pain group included 29 and 60 subjects, respectively. In terms of location of pain, thirty-one subjects felt neck pain, 50 felt pain above the scapula, and 17 felt pain between the thoracic spine and scapula. Thoracic kyphosis and lumbar lordosis in the pain group were significantly higher than those in the normal group (p = 0.013 and p = 0.020, respectively). Thoracic kyphosis in subjects with neck pain or pain above scapula was significantly higher than that in subjects without pain (p = 0.0075 and p = 0.025, respectively). Lumbar lordosis in subjects with pain above the scapula or interscapula was significantly higher than that in subjects without pain (p = 0.016).

关键词： Choronic Neck and Shoulder Pain Sagittal Alignment of the Spine Thoracic Kyphosis Lumber Lordosis

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