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Number and distribution of eosinophils and lymphocytes in the Japanese pediatric gastrointestinal tract:in search of a definition for"abnormally increased eosinophils"

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World Journal of Pediatrics 2023年第3期19卷 251-260页

作者： Mai Iwaya Shota Kobayashi Yoshiko Nakayama Sawako Kato Shingo Kurasawa Tomomitsu Sado Yugo lwaya takeshi uehara Hiroyoshi Ota Department of Laboratory Medicine Shinshu University Hospital3-1-1 AsahiMatsumotoNaganoJapan Department of Pediatrics Shinshu University School of MedicineMatsumotoJapan Division of Gastroenterology and Hepatology Department of MedicineShinshu University School of MedicineMatsumotoJapan Department of Laboratory Medicine Shinshu University School of MedicineMatsumotoJapan Department of Clinical Laboratory Sciences School of Health SciencesShinshu UniversityMatsumotoJapan

Background Primary eosinophilic gastrointestinal disorders(EGIDs)constitute chronic allergic *** number of eosinophils is one of the diagnostic criteria;more than 20 eosinophils per high-power field(HPF)in the gastrointestinal(GI)tract are considered abnormal in ***,the quantity of eosinophils considered normal varies according to anatomical location and geographical region;such values have not been reported in Japanese pediatric patients,nor have the numbers of lymphocytes in the normal pediatric *** establish a reference for defining diagnostic criteria for EGIDs,we evaluated the number of eosinophils in the normal Japanese pediatric GI *** We examined 131 biopsy cases without significant clinical history,endoscopic abnormality,or histological *** analysis of CD3 and CD20 was *** The mean eosinophil density was highest in the cecum(49.5±22.4 per HPF).Counts of more than 20 eosinophils per HPF were observed in the duodenum[bulb(20.0±9.6)and second portion(30.0±15.8)],terminal ileum(38.3±22.7),cecum(49.5±22.4),ascending colon(42.3±25.3),transverse colon(29.4±17.0),and descending colon(32.2±17.9).Counts of fewer than 10 eosinophils per HPF were observed in the stomach and rectum;a count of fewer than one eosinophil per HPF was observed in the *** than 100 CD3-positive T cells per HPF were observed in the *** The mean numbers of eosinophils in the bowel were greater than 20 per *** Japanese pediatrics,the cur-rent threshold eosinophil count should be revised.

关键词： Eosinophil Gastrointestinal tract Japanese Lymphocyte Normal Pediatrics

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Gallbladder Burkitt's lymphoma mimicking gallbladder cancer:A case report

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World Journal of Gastroenterology 2022年第6期28卷 675-682页

作者： Kiyotaka Hosoda Akira Shimizu Koji Kubota Tsuyoshi Notake Hikaru Hayashi Koya Yasukawa Kentaro Umemura Atsushi Kamachi Takamune Goto Hidenori Tomida Shiori Yamazaki Yuri Narusawa Naoko Asano takeshi uehara Yuji Soejima Division of Gastroenterological Hepato-Biliary-PancreaticTransplantation and Pediatric SurgeryDepartment of SurgeryShinshu University School of MedicineMatsumoto 390-8621Japan Department of Laboratory Medicine Shinshu University School of MedicineMatsumoto 390-8621Japan

BACKGROUND Malignant lymphoma is a rare form of gallbladder *** of these malignancies are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas;however,Burkitt’s lymphoma of the gallbladder is extremely rare,and only two previous reports are available in the ***,we report a rare case of Burkitt’s lymphoma of the gallbladder mimicking gallbladder *** SUMMARY An 83-year-old man with no abdominal complaints was found to have a gallbladder tumor and periportal lymph node enlargement on computed tomography(CT)performed for hypertension *** laboratory data revealed slightly elevated serum levels of carcinoembryonic antigen and soluble interleukin 2 *** examinations revealed two irregular and contrastenhanced masses extending into the gallbladder lumen,but these did not infiltrate the ***,a periportal lymph node had enlarged to 30 *** on these findings,we diagnosed the patient as having gallbladder adenocarcinoma with lymph node metastasis,which was treated using bile duct resection with gallbladder bed resection and periportal lymph node ***,the patient was finally diagnosed as having Burkitt’s *** the surgical margin was pathologically negative,recurrence was noted at the hepatic radical margin and superior pancreaticoduodenal lymph nodes on positron emission tomography/CT soon after ***,he was referred to a hematologist and started receiving treatment with reduced-dose cyclophosphamide,doxorubicin,vincristine,and *** Burkitt’s lymphoma can occur in the *** can be useful in cases with findings suggestive of gallbladder malignant lymphoma.

关键词： Gallbladder Malignant lymphoma Burkitt’s lymphoma Gallbladder cancer Lymphadenopathy Case report

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Histological Findings of Bone Marrow Lesions on Magnetic Resonance Images in Patients with Varus Knee Osteoarthritis

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Open Journal of Orthopedics 2014年第12期4卷 327-334页

作者： Takehiko Sugita Tomomaro Kawamata Toshimi Aizawa Akira Sasaki Naohisa Miyatake takeshi uehara Department of Orthopaedic Surgery Tohoku Orthopaedic Clinic Sendai Japan Department of Orthopaedic Surgery Sendai Orthopaedic Hospital Sendai Japan Department of Orthopaedic Surgery Tohoku University Graduate School of Medicine Sendai Japan

Bone marrow lesions (BMLs) on magnetic resonance (MR) images in knee osteoarthritis patients are considered to predict the severity and progression of the disease. We evaluated the histological findings of BMLs on MR images of the subchondral area of the medial femoral condyle in varus osteoarthritic knees. In 24 patients with varus knee osteoarthritis who underwent total knee arthroplasty (TKA), sagittal T1- and T2-weighted MR images of the affected knee were acquired before TKA. During TKA, resected bone pieces from the distal medial femoral condyle were obtained. Sagittal specimens obtained from the center of the bone pieces were histologically examined. Twenty patients had BMLs. Histological findings of BMLs in the subchondral area showed various features, such as fibrovascular tissue, cyst formation, active bone remodeling with bone formation and bone resorption, and hyaline cartilage. BMLs were not found in four patients;histological findings of these patients showed normal bone marrow tissue with normal-thickness trabeculae. Subchondral bony end plate in knees with BMLs was usually thin or destroyed, while that without BMLs was thick or normal. The condition of the subchondral bony end plate would explain the differences in the severity and progression between patients with or without BMLs.

关键词： Knee Osteoarthritis Magnetic Resonance Images Histology Bone Marrow Lesion

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Unexpected Occurrence of Fetal Hemophagocytic Syndrome in a Patient with Hereditary Diffuse Leukoencephalopathy with Spheroids

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Case Reports in Clinical Medicine 2016年第3期5卷 77-84页

作者： Yasufumi Kondo Michiaki Kinoshita Takuhiro Yoshida Hisanori Matoba takeshi uehara Meguru Ikeyama Jun Nakayama Kunihiro Yoshida Shu-Ichi Ikeda Department of Medicine (Neurology & Rheumatology) Shinshu University School of Medicine Matsumoto Japan Department of Neurology Komoro Kosei General Hospital Komoro Japan Department of Neurology Suwa Red Cross Hospital Suwa Japan Department of Neurology Ina Central Hospital Ina Japan Department of Laboratory Medicine Shinshu University School of Medicine Matsumoto Japan Department of Molecular Pathology Shinshu University Graduate School of Medicine Matsumoto Japan Department of Brain Disease Research Shinshu University School of Medicine Matsumoto Japan

Colony stimulating factor-1 receptor (CSF1R) plays important roles in the differentiation and proliferation of macrophage and microglia in systemic organs and the brain. A genetic defect in CSF1R causes hereditary diffuse leukoencephalopathy with spheroids (HDLS). HDLS mainly affects the cerebral white matter and shows pre-senile cognitive decline, motor disturbance, and epilepsy. However, systemic manifestations outside the brain have not yet been described in patients with HDLS. Here, we report the case of a 41-year-old man with HDLS carrying the p. K793T mutation in CSF1R, who unexpectedly died of sepsis and hemophagocytic syndrome shortly after the onset of HDLS. The fetal sequence of sepsis and hemophagocytic syndrome was triggered by enterocolitis. An autopsy revealed that focal inflammation in the intestine had almost resolved. Most strikingly, massive infiltration of cluster of differentiation (CD) 68- and CD163-immunopositive macrophages with hemophagocytosis was observed in the bone marrow, spleen, and liver. Less abundant infiltration of CD68- and CD204-immunopositive macrophages without hemophagocytosis was also seen in the lung and intestine. At present, the pathogenetic link between CSF1R mutation and hemophagocytic syndrome in this patient is unclear. Our case, however, clearly shows that even in patients with HDLS, aberrant activation of functional macrophages can be induced under certain conditions in visceral organs.

关键词： HDLS (Hereditary Diffuse Leukoencephalopathy with Spheroids) CSF1R (Colony Stimulating Factor-1 Receptor) Enterocolitis Macrophage Hemophagocytic Syndrome

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Quality Assurance for Respiratory-Gated Radiotherapy Using the Real-Time Tumor-Tracking Radiotherapy System

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第3期3卷 125-132页

作者： Takehiro Shiinoki Shinji Kawamura Takuya uehara Yuki Yuasa takeshi Kamomae Takaya Kotakebayashi Masahiro Koike Ryuji Kanzaki Sung Chul Park Hideki Hanazawa Shotaro Takahashi Keiko Shibuya Department of Radiological Technology Yamaguchi University Hospital Yamaguchi Japan Department of Therapeutic Radiology Graduate School of Medicine Nagoya University Aichi Japan Department of Therapeutic Radiology Graduate School of Medicine Yamaguchi University Yamaguchi Japan

Purpose: Respiratory-gated radiation therapy (RT) using the real-time tumor-tracking radiotherapy (RTRT) system is an effective technique for managing tumor motion. High dosimetric and geometric accuracy is needed;however, quality assurance (QA) for respiratory-gated RT using the RTRT system has not been reported. The purpose of this study was to perform QA for respiratorygated RT using the RTRT system. Materials and Methods: The RTRT system detected the position of the fiducial marker and radiation delivery gated to the motion of the marker was performed. The dynamic anthropomorphic thorax phantom was positioned at the isocenter using the fiducial marker in the phantom. The phantom was irradiated only when the fiducial marker was within a three-dimensional gating window of ±2 mm from the planned position. First, the absolute doses were measured using anionization chamber inserted in the phantom under the stationary, gating and non-gating state for sinusoidal (nadir-to-peak amplitude [A]: 20 - 40 mm, breathing period [T]: 2 - 4 s) and the basic respiratory patterns. Second, the dose profiles were measured using Gafchromic films in the phantom under the same conditions. Differences between dose profiles were calculated to evaluate the dosimetric and geometric accuracy. Finally, differences between the actual and measured position of the fiducial marker were calculated to evaluate the tracking accuracy for sinusoidal and basic respiratory patterns. Results: For the sinusoidal patterns, the relative doses were 0.93 for non-gating and 0.99 for gating (A = 20 mm, T = 2 s), 0.94 for non-gating and 1.00 for gating (A = 20 mm, T = 4 s), 0.55 for non-gating and 1.00 for gating (A = 40 mm, T = 4 s), respectively. For the basic respiratory pattern, the relative doses were 1.00 for non-gating and 1.00 for gating, respectively. Compared to the stationary conditions, the differences in lateral distance between the 90% dose of dose profiles were 6.23 mm for non-gating and 0.36 mm

关键词： Quality Assurance Respiratory Gating Real-Time Tumor-Tracking Radiotherapy System

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Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis

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World Journal of Gastroenterology 2015年第44期21卷 12667-12675页

作者： Saifun Nahar Atsushi Iraha Akira Hokama Ayako uehara Gretchen Parrott Tetsuya Ohira Masatoshi Kaida Tetsu Kinjo takeshi Kinjo Tetsuo Hirata Nagisa Kinjo Jiro Fujita Department of Infectious Respiratory and Digestive Medicine University of the Ryukyus Department of Endoscopy University of the Ryukyus

AIM: To evaluate a multiplex PCR assay for the detection of bacterial and viral enteropathogens in stool samples from patients with ulcerative colitis(UC). METHODS: We prospectively analyzed 300 individuals, including immunocompetent patients, immunocompromised patients, and patients with UC. Stool samples were collected from the recto-sigmoid region of the colon by endoscopy. The samples were qualitatively analyzed for bacterial and viral enteropathogens with a multiplex PCR assay using a Seeplex® Kit. Additional clinical and laboratory data were collected from the medical records. RESULTS: A multiplex PCR assay detected 397 pathogens(191 bacteria and 206 viruses) in 215 samples(71.7%). The most frequently detected bacteria were Escherichia coli H7, 85(28.3%); followed by Aeromonas spp., 43(14.3%); and Clostridium perfringens, 36(12.0%) samples. The most prevalent viruses were Epstein-Barr virus(EBV), 90(30.0%); followed by human herpes virus-6(HHV-6), 53(17.7%); and cytomegalovirus(CMV), 37(12.3%) samples. The prevalence rate of CMV infection was significantly higher in the immunocompromised group than in the immunocompetent group(P < 0.01). CMV infection was more common in patients with UC(26/71; 36.6%)than in the immunocompetent patients excluding UC(6/188; 3.2%)(P < 0.01). CMV infection was more prevalent in UC active patients(25/58; 43.1%) than in UC inactive patients(1/13; 7.7%)(P < 0.05). Among 4 groups which defined by the UC activity and immunosuppressive drugs, the prevalence rate of CMV infection was highest in the UC active patients with immunosuppressive drugs(19/34; 55.8%). EpsteinBarr virus(EBV) infection was more common in the immunocompromised patients excluding UC(18/41; 43.9%) than in the immunocompetent patients excluding UC(47/188; 25.0%)(P < 0.05). The simultaneous presence of CMV and EBV and/or HHV6 in UC active patients(14/58; 24.1%) was greater than in immunocompromised patients excluding UC(5/41; 12.2%)(P < 0.05). CONCLUSION: The mult

关键词： Polymerase chain reaction Ulcerativecolitis Cytome

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Memory consolidation during sleep and adult hippocampal neurogenesis

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Neural Regeneration Research 2019年第1期14卷 20-23页

作者： Iyo Koyanagi Katherine G.Akers Pablo Vergara Sakthivel Srinivasan takeshi Sakurai Masanori Sakaguchi International Institute for Integrative Sleep Medicine University of Tsukuba Shiffman Medical Library Wayne State University

In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.

关键词： rapid eye movement sleep sleep deprivation optogenetics real-time sleep analysis hippocampus fear memory synaptic plasticity memory processing

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多元羧酸与木材酯化反应特征和交联反应参数

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林业科学 1998年第6期34卷 93-98页

作者：方桂珍李坚孔漫上源澈古野毅东北林业大学中国医学科学院药物研究所岛根大学

本研究采用以多元羧酸类化合物为酯化剂，以无机盐为催化剂的交联体系。这一体系是新型的、水溶的、无毒害、无污染、木材交联反应未采用过的非甲醛系试剂交联体系。本文采用ＦＴＩＲ和ＣＰ／ＭＡＳ１３ＣＮＭＲ的光谱法确定了多元羧酸... 详细信息

本研究采用以多元羧酸类化合物为酯化剂，以无机盐为催化剂的交联体系。这一体系是新型的、水溶的、无毒害、无污染、木材交联反应未采用过的非甲醛系试剂交联体系。本文采用ＦＴＩＲ和ＣＰ／ＭＡＳ１３ＣＮＭＲ的光谱法确定了多元羧酸类化合物与木材交联反应产物的形成特征和交联反应参数。

关键词：多元羧酸类交联反应酯化度羰基比木材

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多元羧酸与木材酯化反应的固体核磁共振谱CPMAS^(13)CNMR的表征

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林业科学 2001年第2期37卷 108-111页

作者：方桂珍李坚孔漫上原徹古野毅东北林业大学哈尔滨150040 中国医学科学院药物研究所北京100001 岛根大学

本研究要用以多元羧酸为酯化剂 ,以无机盐为催化剂的交联体系。这一体系是新型的、水溶的、无毒害、无污染的非甲醛系试剂并联体系。本文采用固体核磁共振谱CP MAS1 3 CNMR ,测定木材主要组分酯化反应的CP MAS1 3 CNMR波谱 ,归属主要谱... 详细信息

本研究要用以多元羧酸为酯化剂 ,以无机盐为催化剂的交联体系。这一体系是新型的、水溶的、无毒害、无污染的非甲醛系试剂并联体系。本文采用固体核磁共振谱CP MAS1 3 CNMR ,测定木材主要组分酯化反应的CP MAS1 3 CNMR波谱 ,归属主要谱线 ,分析了多元羧酸与木材交联反应过程中主要组分的化学结构变化。结果表明 :酯化反应后 ,羧基碳的比率增加 ;芳香族碳和羟基碳的比率减少 ;烷基碳的变化随着羧基碳的变化而改变。

关键词：多元羧酸木材酯化反应固体核磁共振谱化学成分科学结构

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Nature:科学家鉴别出调节机体睡眠的两个关键基因

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现代生物医学进展 2017年第6期17卷 I0002-I0002页

作者： Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Shinichi Miyazaki, Linzi Connor, Yu Hayashi, Qinghua Liu, Joseph S. Takahashi Masashi Yanagisawa Hiromasa Funato Makito Sato Masashi Yanagisawa Shin Nakane, Jun Tomita Kazuhiko Kume Seiya Mizuno, Fumihiro Sugiyama Satoru Takahashi Vivek Kumar Joseph S. Takahashi Vivek Kumar Ikuo Miura, Tomohiro Suzuki Shigeharu Wakana Atsushi Watanabe Manabu Abe Kenji Sakimura Yu Hayashi Qinghua Liu Joseph S. Takahashi Masashi Yanagisawa Masashi Yanagisawa International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Anatomy Faculty of Medicine Toho University Ota-ku Tokyo 143-8540 Japan Department of Molecular Genetics University of Texas Southwestern Medical Center Dallas Texas 75390 USA Department of Neuropharmacology Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Aichi 467-8603 Japan Laboratory Animal Resource Center University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Neuroscience University of Texas Southwestern Medical Center Dallas Texas 75390 USA The Jackson Laboratory Bar Harbor Maine 04609 USA Technology and Development Team for Mouse Phenotype Analysis RIKEN Bioresource Center Tsukuba Ibaraki 305-0074 Japan Laboratory of Research Advancement National Center for Geriatrics and Gerontology Obu Aichi 474-8511 Japan Department of Cellular Neurobiology Brain Research Institute Niigata University Niigata 951-8585 Japan PRESTO Japan Science and Technology Agency Kawaguchi Saitama 332-0012 Japan Department of Biochemistry University of Texas Southwestern Medical Center Dallas Texas 75390 USA Howard Hughes Medical Institute University of Texas Southwestern Medical Center Dallas Texas 75390 USA Life Science Center Tsukuba Advanced Research Alliance University of Tsukuba Tsukuba Ibaraki 305-8575 Japan

近日，刊登在国际杂志Nature上的一项研究报告中，来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因，这两个基因能够帮助调节机体深度睡眠和做梦的水平，相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。... 详细信息

近日，刊登在国际杂志Nature上的一项研究报告中，来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因，这两个基因能够帮助调节机体深度睡眠和做梦的水平，相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。此前研究者通过对小鼠进行研究发现了能够控制机体快速眼动睡眠的基因，同时该基因还能够诱导深度睡眠。而第二个基因能够控制机体对快速眼动睡眠的需求量，相关研究为科学家们提供了一个关键的切入点来帮助解释睡眠工作的机制，同时研究者还鉴别出了治疗睡眠障碍的潜在靶点。

关键词：睡眠障碍核心基因科学家机体鉴别基因控制研究人员需求量

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