检索结果-南通市图书馆

Spreading pattern and CT findings of very early-stage peripheral small-cell lung cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Lung Cancer 2013年第4期2卷 73-78页

作者： takeshi terashima Tatsu Matsuzaki Shotaro Chubachi Fumio Sakamaki Minako Satoh Eri Tomioka George Horio Rika Ogawa Asuka Naitoh Hiroya Ojiri Department of Radiology Tokyo Dental College Ichikawa General Hospital Ichikawa Japan Department of Respiratory Medicine Tokyo Dental College Ichikawa General Hospital Ichikawa Japa Department of Respiratory Medicine Tokyo Dental College Ichikawa General Hospital Ichikawa Japan Department of Respiratory Medicine Tokyo Saiseikai Central Hospital Tokyo Japan

Chest CT frequently reveals small pulmonary lesions. If there is no associated hilar or mediastinal lymphadenopathy, small-cell lung cancer (SCLC) is considered to be very early-stage. Few studies, however, have described the characteristic CT findings of very early-stage SCLC. Clarifying these findings would reduce diagnostic delay. The purpose of this study was to determine the characteristic CT findings of very earlystage SCLC. Computed tomography images obtained from 547 consecutive patients with lung cancer between 2003 and 2012 at Tokyo Dental College Ichikawa General Hospital were reviewed retrospectively. One hundred of these patients had SCLC and 447 had non-SCLC (NSCLC). These CT images, along with any that had also been obtained prior to the one on which the final diagnosis was based, were reviewed. In 5 of the cases reviewed, specific findings and a characteristic spreading pattern were identified on CT images that might have allowed a diagnosis of SCLC to have been made sooner. The findings included a sub-pleural, small nodule accompanied by daughter nodules spreading longitudinally along the bronchovascular bundle, no air bronchogram or cavitation, and background emphysematous change. These were not identified on CT images of very earlystage NCSLC, however (n = 22). Awareness of the relevance of these findings would help physicians and radiologists arrive at a differential diagnosis of small pulmonary nodules.

关键词： SCLC Small Pulmonary Nodules Beaded Appearance Bronchovascular Bundle CT Scan

Familial pancreatic cancer: Concept, management and issues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第6期23卷 935-948页

作者： Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno takeshi terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa Division of Endoscopy Shizuoka Cancer Center Clinic of Genetic Medicine Shizuoka Cancer Center Department of Surgery Kyoto University Graduate School of Medicine Division of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital Center for Gastroenterology Teine-Keijinkai Hospital Department of Surgery Tohoku University Graduate School of Medicine Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital East Department of Surgery Teikyo University School of Medicine Division of Cancer Genomics National Cancer Center Research Institute Institute for Integrated Medical Sciences Tokyo Women’s Medical University Department of Internal Medicine Kyorin University School of Medicine Division of Gastroenterology Yokohama City University Graduate School of Medicine Division of Hepatobiliary and Pancreatic Medical Oncology Kanagawa Cancer Center Department of Gastroenterology Aichi Cancer Center Hospital Department of Gastroenterology Kanazawa University Graduate School of Medicine Department of Surgery Japan Bapist Hospital Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Clinical Genetics Unit Kyoto University Graduate School of Medicine Center for Genomic Medicine Kyoto University Graduate School of Medicine Osaka Medical Center for Cancer and Cardiovascular Diseases Second Department of Internal Medicine Wakayama Medical University Department of Gastroenterology Onomichi General Hospital Department of Gastroenterology NationalKyushu Cancer Center Department of Medicine and Bioregulatory Sciences Kyushu University Graduate School of Medical Science Pancreatic Cancer Action Network Department of Gastroenterology Tohoku University Graduate School of Medicine

Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (Caucasian) and a younger onset are common also in FPC. In European countries, "anticipation" is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society.

关键词： familial pancreatic cancer registry high risk genetic surveillance

Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2019年第1期7卷 66-75页

作者： Yuta Nakai Kazuo Okamoto Asuka terashima Shogo Ehata Jun Nishida takeshi Imamura Takashi Ono Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityYushima 1-5-45Bunkyo-kuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Pathology Graduate School of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Medicine for Pathogenesis Ehime University Graduate School of MedicineShitsukawaToonEhimeJapan

Bone is one of the preferred sites for the metastasis of malignant tumours,such as breast cancer,lung cancer and malignant *** cells colonizing bone have the capacity to induce the expression of receptor activator of nuclear factor-κB ligand(RANKL),which promotes osteoclast differentiation and ***-induced osteoclastic bone resorption leads to a vicious cycle between tumours and bone cells that fuels osteolytic tumour growth,causing bone pain and ***,RANKL contributes to bone metastasis by acting as a chemoattractant to bone for tumour cells that express its receptor,*** inhibition of the RANKL–RANK pathway is a promising treatment for bone metastasis,and a human monoclonal anti-RANKL antibody,denosumab,has been used in the ***,orally available drugs targeting RANKL must be developed to increase the therapeutic benefits to *** we report the efficacy of the small-molecule RANKL inhibitor AS2676293 in treating bone metastasis using mouse *** administration of AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced ***2676293 suppressed RANKLmediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10,which is known not to trigger osteoclast *** on the results from this study,RANKL inhibition with a small-molecule compound constitutes a promising therapeutic strategy for treating bone metastasis by inhibiting both osteoclastic bone resorption and tumour migration to bone.

关键词： Bone tumours metastasis

Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第26期20卷 8729-8735页

作者： Shohei Komatsu takeshi Iwasaki Yusuke Demizu Kazuki terashima Osamu Fujii Atsushi Takebe Akihiro Toyokawa Kazuhiro Teramura Takumi Fukumoto Yonson Ku Nobukazu Fuwa Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of Medicine Department of Surgery National Hospital OrganizationKobe Medical Center Department of Radiology Hyogo Ion Beam Medical Center Department of Surgery Yodogawa Christian Hospital Department of Pathology Yodogawa Christian Hospital

Hepatic epithelioid hemangioendothelioma(HEH)is a rare neoplasm of vascular origin with variable malignant *** most patients with this condition have multiple bilobar lesions,liver transplantation is the standard treatment,and hepatectomy is much less frequently *** describe a case of a 35-yearold woman with unresectable multiple bilobar HEH successfully treated by combination treatment with hepatectomy and carbon-ion *** case is very meaningful since it demonstrated the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors.

关键词： Two-stage treatment Hepatic epithelioid hemangioendothelioma Hepatectomy Carbon-ion radiotherapy Particle radiotherapy Omental flap spacer