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Clinical study using novel endoscopic system for measuring size of gastrointestinal lesion

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World Journal of Gastroenterology 2014年第14期20卷 4050-4058页

作者： Kiyoshi Oka takeshi Seki Tomohiro Akatsu Takao Wakabayashi Kazuo Inui Junji Yoshino OK Fiber Technology Co. Ltd. Graduate School of engineering and Resource Science Akita University A-tech Co. Ltd. Department of Internal Medicine Banbuntane Hotokukai HospitalFujita Health University

AIM: To verify the performance of a lesion size measurement system through a clinical study.

关键词： Lesion size Non-contact measurement Endoscope Grid scale Low level laser

Cell-free synthesis of stable isotope-labeled internal standards for targeted quantitative proteomics

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Synthetic and Systems Biotechnology 2018年第2期3卷 97-104页

作者： Ryohei Narumi Keiko Masuda takeshi Tomonaga Jun Adachi Hiroki RUeda Yoshihiro Shimizu Laboratory of Proteome Research National Institutes of Biomedical InnovationHealth and Nutrition7-6-8Satio-AsagiIbarakiOsaka 567-0085Japan Laboratory for Single Cell Mass Spectrometry RIKEN Quantitative Biology Center(QBiC)6-2-3FuruedaiSuitaOsaka 565-0874Japan Department of Systems Pharmacology Graduate School of MedicineThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Laboratory for Synthetic Biology RIKEN Quantitative Biology Center(QBiC)6-2-3FuruedaiSuitaOsaka 565-0874Japan Laboratory for Cell-Free Protein Synthesis RIKEN Quantitative Biology Center(QBiC)6-2-3FuruedaiSuitaOsaka 565-0874Japan

High-sensitivity mass spectrometry approaches using selected reaction monitoring(SRM)or multiple reaction monitoring(MRM)methods are powerful tools for targeted quantitative proteomics-based investigation of dynamics in specific biological *** high-sensitivity detection of lowabundance proteins and their quantification using this technique employ stable isotope-labeled peptide internal ***,there are various ways for preparing standards,including chemical peptide synthesis,cellular protein expression,and cell-free protein or peptide ***-free protein synthesis(CFPS)or in vitro translation(IVT)systems in particular provide high-throughput and low-cost preparation methods,and various cell types and reconstituted forms are now commercially ***,we review the use of such systems for precise and reliable protein quantification.

关键词： Absolute quantification Mass spectrometry Cell-free protein synthesis system In vitro translation Targeted quantitative proteomics PURE system

Oral granuloma in a pediatric patient with chronic graft-versus-host disease:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5663-5669页

作者： Atsushi Uesugi Fumihiko Tsushima Makoto Kodama takeshi Kuroshima Jinkyo Sakurai Hiroyuki Harada Oral and Maxillofacial Surgery Tokyo Medical and Dental UniversityTokyo 113-8549Japan Human Pathology Tokyo Medical and Dental UniversityTokyo 113-8510Japan

BACKGROUND Oral mucositis is often observed with graft-versus-host disease(GVHD);however,the occurrence of oral granuloma is *** rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those *** case is the youngest pediatric patient with granuloma associated with *** SUMMARY The patient was a 1-year and 5-mo-old girl who presented to our department for the management of oral *** the age of 5 mo,she was diagnosed with primary immunodeficiency disease,cord blood transplant was performed at 11 mo and bone marrow transplant at 1 year of *** transplantation,GVHD and oral mucositis developed,and tacrolimus was ***,nodules appeared on the lower lip and buccal mucosa,which spontaneously ***,a new nodule appeared on the left lateral border of the *** was performed and the histopathological diagnosis was *** origin of these nodules were considered to be the fibroblasts activated under inflammation caused by GVHD because the calcineurin inhibitor tacrolimus acted on their *** It is very important to distinguish oral granulomatous lesions from malignancies if GVHD is present at the base and if immunosuppressive agents and steroids are being administered.

关键词： Oral granuloma Graft-versus-host disease Bone marrow transplantation Primary immunodeficiency disease Tacrolimus Case report

Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum:A case report and review of literature

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World Journal of Gastroenterology 2021年第1期27卷 129-142页

作者： takeshi Okamoto Takaaki Yoshimoto Nobuyuki Ohike Aoi Fujikawa Takayoshi Kanie Katsuyuki Fukuda Department of Gastroenterology St.Luke's International HospitalTokyo 104-8560Japan Department of Pathology Shizuoka Cancer CenterShizuoka 411-8777Japan Department of Surgery St.Luke’s International HospitalTokyo 104-8560Japan Department of Cardiology St.Luke’s International HospitalTokyo 104-8560Japan

BACKGROUND Gastric gastrinoma and spontaneous tumor regression are both very rarely *** report the first case of spontaneous regression of gastric *** SUMMARY A 37-year-old man with a 9-year history of chronic abdominal pain was referred for evaluation of an 8 cm mass in the lesser omentum discovered incidentally on abdominal computed *** tumor was diagnosed as grade 2 neuroendocrine neoplasm(NEN)on endoscopic ultrasound-guided fine-needle *** esophagogastroduodenoscopy revealed a 7 mm red polypoid lesion with central depression in the gastric antrum,also confirmed to be a grade 2 *** removal of the abdominal mass confirmed it to be a metastatic gastrinoma *** gastric lesion was subsequently diagnosed as primary gastric *** months later,the gastric lesion had disappeared without *** patient remains symptom-free with normal fasting serum gastrin and no recurrence of gastrinoma during 36 mo of *** Gastric gastrinoma may arise as a polypoid lesion in the gastric *** regression can rarely occur after biopsy.

关键词： Neuroendocrine neoplasm Functional tumor Biopsy Gastrin Stomach Case report

Radiologic-pathologic correlation of three-dimensional shear-wave elastographic findings in assessing the liver ablation volume after radiofrequency ablation

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World Journal of Gastroenterology 2014年第33期20卷 11850-11855页

作者： Katsutoshi Sugimoto Hisashi Oshiro Saori Ogawa Mitsuyoshi Honjo takeshi Hara Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo 160-0023 Japan Department of Pathology Tokyo Medical University Tokyo 160-0023 Japan Department of Intelligent Image Information Gifu University Graduate School of Medicine Gifu 501-1193 Japan

AIM: To evaluate the usefulness of three-dimensional (3D) shear-wave elastography (SWE) in assessing the liver ablation volume after radiofrequency (RF) ablation.

关键词： Radiofrequency ablation Liver Ultrasound Shear-wave elastography Three-dimensional

Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome

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World Journal of Gastroenterology 2017年第13期23卷 2443-2447页

作者： Sanya Wadhwa Tae Hun Kim Leah Lin Gary Kanel takeshi Saito Department of Medicine Keck School of MedicineUniversity of Southern California Department of Pathology University of Southern CaliforniaKeck School of Medicine Department of Radiology University of Southern CaliforniaKeck School of Medicine Department of Medicine Molecular Microbiology and Immunologyand PathologyDivision of Gastrointestinal and Liver DiseasesKeck School of Medicine of USCUniversity of Southern California

Hepatic angiosarcoma is a mesenchymal tumor originating from liver sinusoidal endothelial cells. It is an extremely rare malignant neoplasm accounting for less than 1% of primary malignant liver tumors. The deregulated coagulopathy that can be seen in hepatic angiosarcoma fulfills the clinical diagnostic criteria of disseminated intravascular coagulation. However, the mechanism that governs this coagulopathy has been poorly understood. This case report provides histological evidence of the consumption of coagulation factors along with trapped platelets occurring within the tumor, which is the foundation for the concept of Kasabach-Merritt syndrome(KMS). KMS is characterized by thrombocytopenia and hyperconsumption of coagulation factors within a vascular tumor. However, KMS associated with angiosarcoma has not been well recognized. This case report describes, for the first time, the histological evidence of KMS that occurred in an extremely rare mesenchymal malignant tumor of the liver.

关键词： Hepatic angiosarcoma Kasabach-Merritt syndrome Vascular tumor

Median neuropathy after multiple punctures of the forearm for catheterization:A case report

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世界临床病例杂志 2023年第25期11卷 5941-5946页

作者： Tomoaki Suzuki Yuichiro Matsui Daisuke Momma takeshi Endo Norimasa Iwasaki Department of Orthopaedic Surgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Section for Clinical Education Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Center for Sports Medicine Hokkaido UniversitySapporo 060-8638Japan

BACKGROUND Neuropathy may occur at some sites after catheterization for close examination of cardiac *** the radial artery is considered a relatively uncomplicated site for catheterization,the radial artery and median nerve are in relatively close proximity,with the risk of median nerve injury depending on the angle of *** purpose of this study was to report the outcomes of surgery performed for conservative therapy-resistant median neuropathy following forearm *** SUMMARY A 50-year-old woman experienced palsy from the right thumb to the radial side of the ring finger after catheterization from the radial artery of the right *** developed at the same site and a positive tinel-like sign was seen for the median nerve area at the high level of the puncture *** conduction study showed reduced compound muscle action potentials and loss of sensory nerve action *** did not improve despite pharmacotherapy and the patient gradually developed flexion restrictions of the index and middle *** nerve injury and associated flexor tendon adhesion was diagnosed,and the patient was referred for surgery at 3 mo after *** the same area was opened,no injury to the median nerve epithelium was obvious,but the area of the positive tinel-like sign was highly adherent to surrounding tissue and to the flexor digitorum superficialis of the index and middle *** surgery was terminated with adequate adhesion *** was initiated postoperatively,improving neurological symptoms and range of motion of the *** months after surgery,the patient returned to daily activities without *** This case provides the appropriate diagnosis and treatment for a suspected peripheral nerve injury.

关键词： Catheterization Median neuropathy Surgical treatment Case report

Non-ossifying fibromas: Case series, including in uncommon upper extremity sites

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World Journal of Orthopedics 2017年第7期8卷 561-566页

作者： Akio Sakamoto Ryuzo Arai takeshi Okamoto Shuichi Matsuda Department of Orthopaedic Surgery Graduate School of Medicine Kyoto University

AIM To investigate non-ossifying fibromas(NOFs) common fibrous bone lesions in children that occur in bones of the lower *** We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities(1 proximal humerus, 1 distal radius) and the lower extremities(25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas).RESULTS Three cases had NOFs in multiple anatomical locations(femur and fibula in 1 case, femur and tibia in 2 cases). Overall, larger lesions > 4 cm and lesion expansion at the cortex were seen in 21% and 32% of cases, respectively. Multiple lesions with bilateral symmetry in the lower extremities suggest that these NOFs were developmental bone defects. Two patients suffered from fracture and were treated without surgery, one in the radius and one in the femur. Lesions in the upper extremities(i.e., humerus of a 4-year-old female and radius of a 9-year-old male) expanded at the cortex and lesion size increased with slow *** NOFs in the lower extremity had fewer clinical problems, regardless of their size and expansiveness. In these two upper extremity cases, the NOFs had aggressive biological features. It seems that there is a site specific difference, especially between the upper extremity and the lower extremity. Furthermore, NOFs in the radius are predisposed to fracture because of the slender structure of the radius and the susceptibility to stress.

关键词： Non-ossifying fibroma Humerus Radius Fibula Upper extremity

Rational arrangement of measuring shear wave speed in the liver

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World Journal of Gastroenterology 2019年第20期25卷 2503-2513页

作者： takeshi Yokoo Tsutomu Kanefuji takeshi Suda Itsuo Nagayama Takahiro Hoshi Satoshi Abe Shinichi Morita Hiroteru Kamimura Kenya Kamimura Atsunori Tsuchiya Masaaki Takamura Kazuyoshi Yagi Shuji Terai Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life Niigata University School of MedicineNiigataNiigata 951-8122Japan Division of Gastroenterology and Hepatology Niigata Tokamachi HospitalTokamachiNiigata 948-0065Japan Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami UonumaNiigata 949-7302Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan

BACKGROUND Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM To provide procedural standardization of shear wave speed measurement. METHODS Point shear wave elastography (pSWE) was measured in 781 patients, and twodimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS The CVR showed a significantly broader distribution in the left lobe (P < 0.0001),and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes.

关键词： Liver stiffness Ultrasound Shear wave elastography Acoustic radiation force impulse Heterogeneity