检索结果-南通市图书馆

维普期刊数据库

The cardiovascular action of hexarelin

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2014年第3期11卷 253-258页

作者： Yuanjie MAO takeshi Tokudome Ichiro Kishimoto Department of Biochemistry National Cerebral and Cardiovascular Center Suita 0saka 565-8565 Japan Department of Medicine Prince George's Hospital Center Cheverly Maryland 20785 USA Department of Endocrinology and Metabolism National Cerebral and Cardiovascular Center Sulfa Osaka 565-8565 Japan

Hexarelin, a synthetic growth hormone-releasing peptide, can bind to and activate the growth hormone secretagogue receptor （GHSR） in the brain similar to its natural analog ghrelin. However, the peripheral distribution of GHSR in the heart and blood vessels suggests that hexarelin might have direct cardiovascular actions beyond growth hormone release and neuroendocrine effects. Furthermore, the non-GHSR CD36 had been demonstrated to be a specific cardiac receptor for hexarelin and to mediate its cardioprotective effects. When compared with ghrelin, hexarelin is chemically more stable and functionally more potent. Therefore, it may be a promising therapeutic agent for some car-diovascular conditions. In this concise review, we discuss the current evidence for the cardiovascular action of hexarelin.

关键词： Hexarelin Cardiovascular disease Growth hormone secretagogue receptor CD36

Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y Y5 receptor subclass

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第41期14卷 6312-6317页

作者： Hiroshi Higuchi takeshi Niki Tomohiro Shiiya Division of Pharmacology Niigata University Graduate School of Medical and Dental Sciences

Neuropeptide Y (NPY) is a potent neurotransmitter for feeding. Besides NPY, orexigenic neuropeptides such as agouti-related protein (AgRP), and anorexi- genic neuropeptides such as α-melatonin stimulating hormone (MSH) and cocaine-amphetamine-regulated transcript (CART) are also involved in central feeding regulation. During fasting, NPY and AgRP gene expressions are up-regulated and POMC and CART gene ex- pressions are down-regulated in hypothalamus. Based on the network of peptidergic neurons, the former are involved in positive feeding regulation, and the latter are involved in negative feeding, which exert these feeding-regulated peptides especially in paraventricular nucleus (PVN). To clarify the compensatory mecha- nism of knock-out of NPY system on feeding, change in gene expressions of appetite-related neuropeptides and the feeding behavior was studied in NPY Y5-KO mice. Food intake was increased in Y5-KO mice. Fasting increased the amounts of food and water intake in the KO mice more profoundly. These data indicated the compensatory phenomenon of feeding behavior in Y5-KO mice. RT-PCR and ISH suggested that the compensation of feeding is due to change in gene expressions of AgRP, CART and POMC in hypothalamus. Thus, these fi ndings indicated that the compensatory mechanism involves change in POMC/CART gene expression in arcuate nucleus (ARC). The POMC/CART gene expression is important for central compensatory regulation in feeding behavior.

关键词： Neuropeptide Y Y5 receptor Feeding Arcuate nucleus Knockout mice

Availability of MCNP & MATLAB for reconstructing the water-vapor two-phase flow pattern in neutron radiography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2008年第5期19卷 282-289页

作者： FENG Qixi FENG Quanke takeshi Kawai School of Energy and Power Engineering Xi＇an Jiaotong University Xi＇an 710049 China

The China Advanced Research Reactor (CARR) is scheduled to be operated in the autumn of *** this paper,we report preparations for installing the neutron radiography instrument (NRI) and for utilizing it efficiently. The 2-D relative neutron intensity profiles for the water-vapor two-phase flow inside the robe were obtained using the MCNP code without influence of y-ray and *** MCNP simulation of the 2-D neutron intensity profile for the water-vapor two-phase flow was *** simulated 2-D neutron intensity profiles could be used as the benchmark data base by calibrating part of the data measured by the *** 3-D objective images allow us to understand the flow pattern more clearly and it is reconstructed using the MATLAB through the threshold transformation *** thus it is concluded that the MCNP code and the MATLAB are very useful for constructing the benchmark data base for the investigation of the water-vapor two-phase flow using the CARR-NRI.

关键词：核反应堆中国先进研究堆中子X射线照相术水汽两相流

维普期刊数据库

SUBSTITUENT EFFECTS OF tert-BUTYL GROUPS ON FLUORENYL LIGAND OF [t-BuNSiMe2Flu] ZrMe2

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2008年第5期26卷 575-578页

作者： Yuushou Nakayama takeshi Shiono Department of Applied Chemistry Graduate School of EngineeringHiroshima UniversityHigashi-Hiroshima 739-8527Japan

[t-BuNSiMe_2(2,7-t-Bu_2Flu)]ZrMe_2 and[t-BuNSiMe_2(3,6-t-Bu_2Flu)]ZrMe_2 were synthesized,and the solid structure of complex[t-BuNSiMe_2(2,7-t-Bu_2Flu)]ZrMe_2 was elucidated by single crystal X-ray *** complexes were applied for propylene polymerization using dried modified methylaluminoxane as a cocatalyst at 0℃and 20℃in *** systems did not show activity at 0℃,but they conducted the polymerization at 20℃.The introduction of t-butyl substituents to the fluorenyl ligand improved the activ...

关键词： Single-site catalyst Zirconium complex Propylene Polymerization Syndiospecificity.

维普期刊数据库

Commonalities and differences between Brassica and Arabidopsis self-incompatibility

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2014年第1期1卷 40-44页

作者： Masaya Yamamoto takeshi Nishio Graduate School of Agricultural Science Tohoku UniversitySendai 981-8555Japan

In higher plants,the self-incompatibility mechanism is important for inhibition of self-fertilization and facilitation of *** Brassicaceae,the self-incompatibility response is mediated by allele-specific interaction of the stigma-localized S-locus receptor kinase(SRK)with the pollen coat-localized ligand(SCR/SP11).All self-incompatible Brassicaceae plants analyzed have been found to have the SRK and SCR/SP11 genes in the S-locus *** Arabidopsis thaliana is self-compatible,transformation with functional SRK-SCR genes from self-incompatible Arabidopsis species confers the self-incompatibility phenotype to *** allele-specific interaction between SRK and SCR activates the downstream signaling cascade of *** two-hybrid analysis with a kinase domain of SRK as bait and genetic analysis suggested several candidate components of self-incompatibility signaling in ***,*** genes orthologous to the identified genes for Brassica self-incompatibility signaling were evaluated by using a self-incompatible transgenic *** plant and these orthologous genes were found not to be involved in self-incompatibility signaling in the transgenic *** this review,we describe common and different aspects of S-locus genomic regions and self-incompatibility signaling between Brassica and Arabidopsis.

关键词： Arabidopsis interaction analysis

A regression model-based method for indoor positioning with compound location fingerprints

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2019年第2期22卷 107-113,I0003页

作者： Tomofumi Takayama takeshi Umezawa Nobuyoshi Komuro Noritaka Osawa Hewlett-Packard Japan LtdTokyoJapan Graduate School of Engineering Chiba UniversityChibaJapan

This paper proposed and evaluated an estimation method for indoor *** method combines location fingerprinting and dead reckoning differently from the conventional *** uses compound location fingerprints,which are composed of radio fingerprints at multiple points of time,that is,at multiple positions,and displacements between them estimated by dead *** avoid errors accumulated from dead reckoning,the method uses short-range dead *** method was evaluated using 16 Bluetooth beacons installed in a student room with the dimensions of 11×5 m with furniture *** Received Signal Strength Indicator(RSSI)values of the beacons were collected at 30 measuring points,which were points at the intersections on a 1×1 m grid with no obstacles.A compound location fingerprint is composed of RSSI vectors at two points and a displacement vector between *** Forests(RF)was used to build regression models to estimate positions from location *** root mean square error of position estimation was 0.87 m using 16 Bluetooth *** error is lower than that received with a single-point baseline model,where a feature vector is composed of only RSSI values at one *** results suggest that the proposed method is effective for indoor positioning.

关键词： Indoor positioning integrated estimation radio fingerprinting dead reckoning machine learning non-linear regression

Does endoscopic ultrasound-guided biliary drainage really have clinical impact?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第4期21卷 1049-1052页

作者： takeshi Ogura Kazuhide Higuchi Second Department of Internal Medicine Osaka Medical CollegeOsaka 569-8686Japan

The well established, gold standard method for treatment of obstructive jaundice involves biliary drainage under endoscopic retrograde cholangiopancreatography(ERCP) performed by pancreatobiliary endoscopists. Recently, interventions using endoscopic ultrasound(EUS) have been developed not only for obtaining cytological and histological diagnosis, but also for biliary drainage as alternative method. EUS-guided biliary drainage(EUSBD) was first reported by Giovannini et al. EUS-BD broadly includes EUS-guided rendezvous technique, EUS-guided choledochoduodenostomy, and EUS-guided hepaticogastrostomy. More recently, EUS-guided antegrade stenting and EUS-guided gallbladder drainage have also been reported. many case reports, series, and retrospective studies on EUS-BD have been reported. However, because prospective studies and comparisons between the different biliary drainage methods have not been reported, the technical success, functional success, adverse events, and stent patency with long-term follow up of EUS-BD are still unclear. Therefore, prospective, randomized controlled studies addressing these issues are needed. Despite this, EUSBD undoubtedly is clinically useful as an alternative biliary drainage method. EUS-BD has the potential to be a first-line biliary drainage method instead of ERCP if results of clinical trials are favorable and the technique is simplified.

关键词： Endoscopic ultrasound Endoscopic ultrasoundguided

Information gathering and evaluation of data quality for safety assessment of chemicals-2013 abstract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2013年第3期 508-509页

作者： takeshi Morita Division of Safety Information on Drug Food and ChemicalsNational Institute of Health SciencesTokyo 158-8501Japan

It is important to review existing toxicity data of chemicals as well as conduct of toxicity *** provides toxicological information on similar class of chemicals,and avoids unnecessary tests.A critical first step is to assemble all of the available information on the *** are many information sources of data on physic-chemical properties or mammalian toxicity(e.g.,human data,in vivo or in vitro studies,in silico outputs).The sources include review docu-ments,databanks / databases,published literature,in house company data,or output from internet search *** vary in many aspects,including quality,covering fields,extent of peer review,the time-spans of covered,number of chemicals addressed and the extent of ***,the second step is to evaluate data quality including reliability,relevance and *** of GLP studies in accordance with standardtest guideline are considered to be reliable and *** judgment in a weight of evidence approach will be needed for determination of toxicity of *** quality and consistency of the data,study design,mechanism or mode of action,dose-effect relationships and biological relevance should be taken into *** of useful information sources and key points of data quality will be presented and discussed.

关键词： Information gathering and evaluation of data quality for safety assessment of chemicals-2013 abstract data

Power Doppler ultrasonographic assessment of the ankle in patients with inflammatory rheumatic diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2014年第5期5卷 574-584页

作者： takeshi Suzuki Division of Rheumatology Mitsui Memorial Hospital

Ankle involvement is frequent in patients with inflammatory rheumatic diseases, but accurate evaluation by physical examination is often difficult because of the complex anatomical structures of the ankle. Over the last decade, ultrasound(US) has become a practical imaging tool for the assessment of articular and periarticular pathologies, including joint synovitis, tenosynovitis, and enthesitis in rheumatic diseases. Progress in power Doppler(PD) technology has enabled evaluation of the strength of ongoing inflammation. PDUS is very useful for identifying the location and kind of pathologies in rheumatic ankles as well as for distinguishing between inflammatory processes and degenerative changes or between active inflammation and residual damage. The aim of this paper is to illustrate the US assessment of ankle lesions in patients with inflammatory rheumatic diseases, including rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus, focusing on the utility of PDUS.

关键词： Ankle Power Doppler Ultrasound Rheumatoid arthritis Psoriatic arthritis Spondyloarthritis Tenosynovitis Enthesitis