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Computer Modeling in Engineering & Sciences 2018年第9期116卷 349-363页

作者： Mizuma takehito Takei Amane University of Miyazaki 1-1Gakuen Kibanadai-nishiMiyazaki-shiMiyazakiJapan

A matrix equation solved in an eddy current analysis,??-??method based on a domain decomposition method becomes a complex symmetric *** general,iterative method is used as the *** of iterative method in an interface problem is improved by increasing an accuracy of a solution of an iterative method of a subdomain ***,it is difficult to improve the convergence by using a small convergence criterion in the subdomain ***,authors propose a method to introduce double-double precision into the interface problem and the subdomain *** proposed method improves the convergence of the interface *** this paper,first,we describe proposed ***,we confirm validity of the method by using Team Workshop Problem 7,standard model for eddy current ***,we show effectiveness of the method from two numerical results.

关键词： Double-double precision domain decomposition method eddy current analysis parallel finite element method

Up-grading of natural ilmenite ore by combining oxidation and acid leaching

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 729-736页

作者： takehito Hiraki Yuichi Maruyama Yuta Suzuki Satoshi Iloh Tetsuya Nagasaka Department of Metallurgy Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan Toho Titanium Co. Ltd.Kanagawa 253-8510Japan Fanuc Co. Ltd.Oshino-muraYamanashi 401-0511Japan Before retirement:Graduate School of Environmental Studies Tohoku UniversitySendai 980-8579Japan

Rutile （TiO2） is heavily used in pigments mid colormlts, mid the most abundmlt source of rutile is ilmeinte. Upon oxidation of ilmeinte, mtile cml be formed wiffl modest energy consumption; furfflermore, after leaching, only a few byproducts are formed. Unfortunate- ly, one drawback is file necessarily long oxidative process of typically used mefflods. In fflis study, we show fflat a fluidized bed reactor cml be used to oxidize ilmeinte ore to rapidly form ruffle mid pseudobrookite （Fe2TiOs） phases. Ilmeinte was oxidized wiffl 5vo1% 02 in Ar at temperatures of 1173 K or 1223 K mid subsequently leached using a diluted H2SO4 solution to dissolve file pseudobrookite phase. The effects of acid concentration, temperature, mid cooling rate after oxidation were investigated. We show fflat file ilmeinte was rapidly oxidized to form rutile mid pseudobrookite phases at 1173 mid 1223 K in a 5vo1% O2/95vo1% Ar environment wifflin 40 min. The fmal maximum mtile yield was 84.2mo1% after leaching in （1 ＋ 1） H2SO4 solution at 393 K for 12 h.

关键词： ilmenite oxidation fluidized bed reactor acid leaching rutile pseudobrookite

Effect of pore water chemistry on anisotropic behavior of clayey soil and possible application in underground construction

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Underground Space 2016年第2期1卷 114-123页

作者： Jinchun Chai takehito Negami Kosuke Aiga Takenori Hino Graduate School of Science and Engineering Saga University1 HonjyoSaga 840-8502Japan Institute of Lowland and Marine Research Saga University1 HonjyoSaga 840-8502Japan

The effect of pore water chemistry on anisotropic behavior of consolidation and shear strength of reconstituted Ariake clay has been investigated *** types of chemicals added into the pore water of the soil for enhancing flocculation microstructure of soil particles are sodium chloride(salt)(NaCl),and calcium chloride(CaCl_(2));and two dispersants added are sodium triphosphate(Na_(5)-P_(3)O_(10))and sodium hexametaphosphate(Na_(6)P_(6)O_(18)),*** concentrations of these chemicals in pore water were 2-3%.Degrees of anisotropy of the coefficient of consolidation and undrained shear strength decreased with adding NaCl and CaCl_(2),but increased with adding the *** of anisotropy also increased with one-dimensional(1D)deformation and the samples with dispersive additives had higher increase *** has been confirmed qualitatively by scanning electron microscopy(SEM)images that adding dispersive chemicals promoted the formation of dispersive microstructure and increased the degree of anisotropy,and the chemicals enhancing flocculent microstructure had an inverse *** possible application of the findings to underground construction has been discussed also.

关键词： Anisotropy Pore water chemistry Clay Consolidation Shear strength SEM image Underground construction

Remolded Undrained Strength of Soils

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海洋工程：英文版 2003年第1期17卷 133-142页

作者：洪振舜刘汉龙 NEGAMI takehito Institute of Geotechnical Engineering Southeast University Geotechnical Institute Hohai University Department of Civil Engineering Saga University

Extensive data of undrained shear strength for various remolded soils are compiled to normalize the remolded undrained strength. Remolded soils have a wide spectrum of liquid limits ranging from 25% to 412%. It is found that the remolded undrained strength is a function of water content and liquid limit. Furthermore, a simple index designated as normalized water content w * is introduced for normalizing remolded undrained strength for various soils. The normalized water content w * is the ratio of water content to liquid limit. The relationship between the remolded undrained strength and the normalized water content can be expressed by a simple equation. The new simple equation is not only valuable theoretically for helping in assessing the in situ mechanical behavior, but also useful to ocean engineering practice.

关键词： critical state line liquid limit normalized water content remolded undrained strength water content

Pneumococcal infection transmission between family members with congenital asplenia: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4277-4284页

作者： Jumpei Shibata Kazuhiro Hiramatsu Tuneaki Kenzaka takehito Kato Department of General Surgery Toyohashi Municipal Hospital50 Aza Hachiken NishiAotake-ChoAichi 4418570ToyohashiJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineHyogo 6520032KobeJapan

BACKGROUND Asplenia,the lack of a spleen,can be congenital and increases susceptibility to severe infections caused by encapsulated bacteria,such as Streptococcus pneumoniae(***).We report two cases of severe pneumococcal infection in two asplenic family members living in the same *** SUMMARY Patient 1,a 38-year-old man with a history of congenital hepatitis B infection and hypospadias,was brought to our emergency department with complaints of cyanosis,cough,and edema of his *** was clinically diagnosed as hyposplenic with overwhelming pneumococcal *** was admitted to the intensive care unit and was administered antibiotics and catecholaminergic therapy but died 2 h after *** 2,a 63-year-old woman with a history of type 2 diabetes,was brought to our emergency department one month after admission of Patient *** was diagnosed as asplenic with overwhelming pneumococcal ***-taking revealed that she was the mother of Patient 1 and the two had lived in the same *** was admitted to the intensive care unit and was rapidly provided antibiotics and catecholaminergic intervention but died one day after *** Pneumococcal bacteremia caused by virulent *** may be transmitted within *** residents of households where individuals with pneumococcal bacteremia are living should be educated about the risk of *** members of patients with congenital asplenia/hyposplenia,all family members should be examined to assess their splenic function.

关键词： Streptococcus pneumoniae Pneumococcal infection Asplenia Hyposplenia Isolated congenital asplenia Septic shock Case report

Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1αsignaling

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Bone Research 2022年第4期10卷 770-783页

作者： takehito Ono Ryosuke Denda Yuta Tsukahara Takashi Nakamura Kazuo Okamoto Hiroshi Takayanagi Tomoki Nakashima Department of Cell Signaling Graduate School of Medical and Dental SciencesTokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Orthopaedic Surgery The Jikei University School of Medicine3-25-8 Nishi-ShimbashiMinato-kuTokyo 105-8461Japan School of Dentistry Tokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Biochemistry Tokyo Dental CollegeKandamisakicho 2-9-18Chiyoda-kuTokyo 101-0061Japan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan

Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming *** exercise at times can be an effective remedy for frailty,but exercise therapy cannot be applied in all clinical *** is safer than exercise,but there are no drugs that reinforce both muscle and bone when administered *** medications increase the risk of adverse events;thus,there is a need for individual drugs targeting both *** this end,we established a novel sequential drug screening system and identified an aminoindazole derivative,locamidazole(LAMZ),which promotes both myogenesis and osteoblastogenesis while suppressing *** of this drug enhanced locomotor function,with muscle and bone significantly ***,LAMZ induced Mef2c and PGC-1αin a calcium signaling–dependent *** this signaling is activated upon physical exercise,LAMZ mimics physical ***,LAMZ is a promising therapeutic drug for locomotor diseases,including sarcopenia and osteoporosis.

关键词： drugs clinical diseases

Hepatectomy for gallbladder-cancer with unclassified anomaly of right-sided ligamentum teres: A case report and review of the literature

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World Journal of Hepatology 2018年第7期10卷 523-529页

作者： Toru Goto Hiroaki Terajima takehito Yamamoto Yoichiro Uchida Department of Gastroenterological Surgery and Oncology Tazuke Kofukai Medical Research Institute Kitano Hospital

Right-sided ligamentum teres(RSLT) is a congenital anomaly in which the right umbilical ligament becomes dominant and anomalous ramifications of the hepatic vessels and biliary system are present. A male patient in his 70 s was diagnosed with advanced gallbladder cancer directly infiltrating the right hepatic duct(RHD), together with RSLT. Preoperative three-dimensional simulation of the liver based on multiple detector computed tomography images after cholangiography revealed ramifications of all segmental portal veins from the portal trunk and discordance of the arterial and biliary branching patterns of segment 8. Fusion analysis of the biliary architecture and segmental volumetry showed that the RHD drained segments 1 r, 5, 6, and 7. We successfully performed a modified right-sided hepatectomy sparing segment 8(i.e., resection of the RHD drainage territory), with negative surgical margins. This report is the first to describe major hepatectomy for advanced gallbladder cancer with RSLT.

关键词： Right-sided ligamentum teres Hepatectomy Gallbladder cancer Preoperative liver simulation Anomaly of the portal vein

Need for pancreatic stenting after sphincterotomy in patients with difficult cannulation

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World Journal of Gastroenterology 2014年第26期20卷 8617-8623页

作者： Kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi takehito Otsubo Fumio Itoh Department of Gastroenterology and Hepatology St. Marianna University School of Medicine Department of Gastroenterological and General Surgery St. Marianna University School of Medicine

AIM: To investigate the need for pancreatic stenting after endoscopic sphincterotomy (EST) in patients with difficult biliary cannulation.

关键词： Pancreatic stenting Pancreatic guidewire placement Post-endoscopic retrograde cholangiopancreatography pancreatitis Endoscopic sphincterotomy Endoscopic retrograde cholangiopancreatography

Long-term survival after resection of pancreatic cancer:A single-center retrospective analysis

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World Journal of Gastroenterology 2015年第1期21卷 262-268页

作者： takehito Yamamoto Shintaro Yagi Hiromitsu Kinoshita Yusuke Sakamoto Kazuyuki Okada Kenji Uryuhara Takeshi Morimoto Satoshi Kaihara Ryo Hosotani Department of Surgery Kobe City Medical Center General HospitalHyogo 650-0047Japan Clinical Research Center Kobe City Medical Center General HospitalHyogo 650-0047JapanChief Statistician

AIM: To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic ***: From January 2000 to December 2011,195 patients underwent pancreatic resection in our *** prognostic factors after pancreatic resection were analyzed in all 195 *** excluding the censored cases within an observational period,the clinicopathological characteristics of 20 patients who survived ≥ 5(n = 20) and < 5(n = 76) years were *** this comparison,we analyzed the patients who underwent surgery before June 2008 and were observed for more than 5 *** statistical analyses,the log-rank test was used to compare the cumulative survival rates,and the χ2 and Mann-Whitney tests were used to compare the two *** CoxHazard model was used for a multivariate analysis,and P values less than 0.05 were considered significant.A multivariate analysis was conducted on the factors that were significant in the univariate ***: The median survival for all patients was 27.1 months,and the 5-year actuarial survival rate was 34.5%.The median observational period was 595 *** the univariate analysis,the UICC stage was significantly associated with survival time,and the CA19-9 ≤ 200 U/m L,DUPAN-2 ≤ 180 U/m L,t u m o r s i ze ≤ 2 0 m m,R 0 re s e c t i o n,a b s e n c e o f lymph node metastasis,absence of extrapancreatic neural invasion,and absence of portal invasion were favorable prognostic *** multivariate analysis showed that tumor size ≤ 20 mm(HR = 0.40; 95%CI: 0.17-0.83,P = 0.012) and negative surgical margins(R0 resection)(HR = 0.48; 95%CI: 0.30-0.77,P = 0.003) were independent favorable prognostic *** the 96 patients,20 patients survived for 5 years or more,and 76 patients died within 5 years after *** of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2(79.5 vs 312.5 U/mL,P = 0.032),tumor size ≤ 20 mm(

关键词： Pancreatic cancer Long-term survival Longterm surv