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A New Approach to Graph Recognition and Applications to Distance-Hereditary Graphs

Journal of Computer Science & Technology 2009年第3期24卷 517-533页

作者： Shin-ichi Nakano Ryuhei Uehara takeaki uno Department of Computer Science Faculty of EngineeringGunma UniversityGunma 376-8515Japan School of Information Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1292Japan National Institute of Informatics Tokyo 101-8430Japan

Algorithms used in data mining and bioinformatics have to deal with huge amount of data efficiently. In many applications, the data are supposed to have explicit or implicit structures. To develop efficient algorithms for such data, we have to propose possible structure models and test if the models are feasible. Hence, it is important to make a compact model for structured data, and enumerate all instances efficiently. There are few graph classes besides trees that can be used for a model. In this paper, we investigate distance-hereditary graphs. This class of graphs consists of isometric graphs and hence contains trees and cographs. First, a canonical and compact tree representation of the class is proposed. The tree representation can be constructed in linear time by using prefix trees. Usually, prefix trees are used to maintain a set of strings. In our algorithm, the prefix trees are used to maintain the neighborhood of vertices, which is a new approach unlike the lexicographically breadth-first search used in other studies. Based on the canonical tree representation, efficient algorithms for the distance-hereditary graphs are proposed, including linear time algorithms for graph recognition and graph isomorphism and an efficient enumeration algorithm. An efficient coding for the tree representation is also presented; it requires [3.59n] bits for a distance-hereditary graph of n vertices and 3n bits for a cograph. The results of coding improve previously known upper bounds （both are 2^O（nlogn）） of the number of distance-hereditary graphs and cographs to 2^[3.59n] and 2^3n, respectively.

关键词： algorithmic graph theory cograph distance-hereditary graph prefix tree tree representation

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Coprophilous myxomycetes: Recent advances and future research directions

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Fungal Diversity 2013年第2期59卷 85-90页

作者： uno Eliasson Department of Biological and Environmental Sciences University of GothenburgBox 46140530 GothenburgSweden

Species of myxomycetes are adapted to different ecological niches and occupy different *** majority of species have a wide ecological amplitude and may be found on various kinds of *** species have narrower ecological niches and are restricted to or mainly found on one special kind of *** species grow on dung or on a substratum in close contact with *** vast majority of records stem from moist chamber cultures on dung from herbivorous mammals,but several species have also been recorded on droppings from birds.A limited number of species can be regarded as truly coprophilous in that they have predominantly or in some cases only been recorded on *** of these species are known from very few collections and their dependence on dung may therefore be difficult to *** correlation is absolute and species regarded as coprophilous may sometimes,although rarely,turn up on other types of *** is rich in bacteria and nutrients and is a favourable substratum for *** species normally inhabiting other habitats are occasionally found on dung,and up to now about 114 species have been reported from this kind of substratum,a number that will continue to *** least three species,Licea alexopouli,Kelleromyxa fimicola and Trichia brunnea,have thick-walled spores,a possible adaptation to passing through the intestinal tract of a herbivore before germination can take place.

关键词： Coprophilous myxomycetes Herbivorous animals Ecological adaptations Trichia brunnea Kelleromyxa

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Approaches to Stable Operation of Shaftless Centrifugal Pump

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Journal of Thermal Science 2009年第1期18卷 48-53页

作者： Ryunosuke Kawashima Mitsuo uno Toshiaki Kanemoto Department of mechanical engineering Kyushu Kyoritsu University 1-8 Jiyugaoka Faculty engineering Kyushu Institute of Technology

The shaft-less impeller of the centrifugal pump, which is driven by the magnetic induction, was developed. Theimpeller rotates under the floating condition without any control device. The floating condition of the impeller isrealized by utilizing the pressure in pump casing. The pump performance and the rotational behavior of the impellerwere investigated experimentally. It has found that the floating position of the impeller become quite unstablein a partial flow rate operation. And the pressure distribution at the casing wall affects the rotational posture ofthe impeller. This paper presents the effect of the casing treatment on the rotational posture of the impeller and thepressure distribution. The reasonable casing treatment is available for the stable rotational posture of the impeller.

关键词： Centrifugal pump Impeller Magnetic induction Casing treatment Passive control

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Does flexible small-diameter colonoscope reduce insertion pain during colonoscopy?

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World Journal of Gastroenterology 2000年第5期6卷 659-663页

作者： Yoshiharu uno Akihiro Munakata First Department of Medicine School of MedicineHirosaki University036- 8216Japan

AIM It is well known that colonoscopy can bedifficult due to abdominal pain induced duringcolonoscope insertion,if sedative agents are ***,an extra-flexible,small-diameter colonoscope(CF-SV,Olympus Inc.,Japan)was developed in order to improve safetyand *** aim of this study was toaccess the usefulness of the *** One hundred patients undergoingsigmoidoscopy were recruited and colonoscopywas performed by one ***,a routine-type colonoscope(CF-2301)was inserted into the colon *** the patient complained ofabdominal pain(even if mild),the scope wasnot advanced further and was withdrawn afterthe anatomic location of its tip was ***,the CF-SV was inserteduntil it reached the cecun or the site whereabdominal pain *** abdominalsurgery and abdominal disease were consideredas unfavorable factors(UF)and the relationshipbetween abdominal pain and UF,age and genderwere ***,the colonicinsertion pressures in 36 patients with abdominalpain were measured with a force *** Thirty-four cases(34%)felt no painwith the CF-2301 and successful pancolon-0scopies to the cecum were ***-six cases(66%)complained of abdominal *** procedure was painless for 47% of men and24% of women,*** CF-2301 scopefailed to reach the sigmoid-descending colon junctions in 59(89.4%)of the 66 patientscomplaining of abdominal ***,CF-SVreached proximal area in 94.9% of those whofailed with *** median pressure forpain-inducing was 700 g/cm^*** Unsedated patients with UFwere prone to complain of pain when thestandard-type CF-2301 scope was *** developed extra-flexible CF-SV is usefulfor the aged and for those with UF or being proneto suffer from abdominal *** agentsmay be unnecessary if this new type ofcolonoscope is used.

关键词： colonoscopy abdominal pain flexible colonoscope insertion pressure unfavorable factors sigmoidoscopy

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Development of Simulation System for the Disaster Evacuation Based on Multi-Agent Model Using

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Tsinghua Science and Technology 2008年第S1期13卷 348-353页

作者： GISKeisuke uno Kazuo Kashiyama Department of Civil Engineering Chuo University

This paper presents a simulation system for the disaster evacuation based on multi-agent model considering geographical information. This system consists of three parts, the modeling for the land and buildings using GIS data, the analysis of disaster evacuation using multi-agent model, and the visualization for the numerical results using the virtual reality technique. By introducing the numerical solver of the natural disaster to the present system, it is possible to evaluate not only the damage of structure but also the damage of human being. Furthermore, it is possible to investigate the appropriate evacuation route by the simulation. The Dijkstra algorithm is used to obtain shortest route to the refuge. In addition, the visualization using virtual reality technique is curried out to understand the feeling of refugee. The present system is applied to the evacuation analysis by the flood flow in urban area and is shown to be a useful tool to investigate the damage by natural disasters.

关键词： multi-agent model GIS virtual reality evacuation analysis flood flow

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Endoscopic ultrasound-guided drainage of postoperative intra-abdominal abscesses

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World Journal of Gastroenterology 2015年第11期21卷 3402-3408页

作者： Koichiro Mandai Koji uno Kenjiro Yasuda Department of Gastroenterology Kyoto Second Red Cross Hospital

Although endoscopic ultrasound(EUS)-guided drainage has become the standard procedure for pancreatic pseudocysts in recent years and is generally regarded as a safe and effective method,there have been few reports of EUS-guided drainage of postoperative intra-abdominal *** we report our experience with 4 cases of postoperative intraabdominal abscesses for which EUS-guided drainage was performed between May 2011 and May *** pancreatectomy had been performed in 3 cases,whereas low anterior resection for rectal cancer was performed in the remaining *** patients underwent transgastric naso-cystic drainage,which resulted in clinical improvement without complications,even when performed within 4 wk after *** average,the naso-cystic drain was removed 10 d after placement,with no abscess *** on these findings,we believe that EUS-guided drainage of postoperative intraabdominal abscesses is a safe and effective method,although further large-scale investigations are required to confirm our findings.

关键词： Postoperative intra-abdominal abscess Endoscopic u

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Novel role of toll-like receptors in Helicobacter pylori-induced gastric malignancy

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World Journal of Gastroenterology 2014年第18期20卷 5244-5251页

作者： Kaname uno Katsuaki Kato Tooru Shimosegawa Division of Gastroenterology Tohoku UniversityMiyagi 981-8574Japan Center of Cancer Screening Miyagi Cancer SocietyMiyagi 980-0011Japan

Helicobacter pylori(***)infects the human stomach during infancy and develops into chronic *** majority of *** tend to colonize within the mucous gel layer of the *** lacks its own immune function,thus innateimmunity as the first line of defense is vital for specificimmunity against *** review recent discoveries in the pathophysiologic roles of toll-like receptors(TLRs),mainly TLR2 and TLR4,in ***-induced *** addition,the TLR pathways activated ***-induced inflammation have been shown to beclosely associated not only with gastric carcinogenesis,but also with formation of the tumor microenvironmentthrough the production of pro-inflammatory cytokines,chemokines,and reactive oxygen *** correlation between single nucleotide polymorphisms of TLRs and gastric cancer risk remains unclear,a recent study demonstrated that STAT3-driven upregulation of TLR2 might promote gastric tumorigenesis independent of *** research onthe regulation of TLRs in ***-associated gastriccarcinogenesis will uncover diagnostic/predictive biomarkers and therapeutic targets for gastric cancer.

关键词： Toll like receptors Helicobacter pylori Gastric cancer Pathogen-associated molecular patterns Damage-associated molecular patterns

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Influence evaluation of loading conditions during pressurized thermal shock transients based on thermal-hydraulics and structural analyses

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Frontiers of Mechanical Engineering 2018年第4期13卷 563-570页

作者： Jinya KATSUYAMA Shumpei uno Tadashi WATANABE Yinsheng LI Japan Atomic Energy Agency Ibaraki 319-1195 Japan Mizuho Information & Research Institute Inc. Tokyo 101-8443 Japan Fukui University Fukui 914-0055 Japan

The thermal hydraulic （TH） behavior of coo- lant water is a key factor in the structural integrity assessments on reactor pressure vessels （RPVs） of pressurized water reactors （PWRs） under pressurized thermal shock （PTS） events, because the TH behavior may affect the loading conditions in the assessment. From the viewpoint of TH behavior, configuration of plant equipment and their dimensions, and operator action time considerably influence various parameters, such as the temperature and flow rate of coolant water and inner pressure. In this study, to investigate the influence of the operator action time on TH behavior during a PTS event, we developed an analysis model for a typical Japanese PWR plant, including the RPV and the main components of both primary and secondary systems, and performed TH analyses by using a system analysis code called RELAP5. We applied two different operator action times based on the Japanese and the United States （US） rules： Operators may act after 10 min （Japanese rules） and 30 min （the US rules） after the occurrence of PTS events. Based on the results of TH analysis with different operator action times, we also performed structural analyses for evaluating thermal-stress distributions in the RPV during PTS events as loading conditions in the structural integrity assessment. From the analysis results, it was clarified that differences in operator action times significantly affect TH behavior and loading conditions, as the Japanese rule may lead to lower stresses than that under the US rule because an earlier operator action caused lower pressure in the RPV.

关键词： structural integrity reactor pressure vessel pressurized thermal shock thermal hydraulic analysis pressurized water reactor weld residual stress

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Gastric cancer development after the successful eradication of Helicobacter pylori

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World Journal of Gastrointestinal Oncology 2016年第3期8卷 271-281页

作者： Kaname uno Katsunori Iijima Tooru Shimosegawa Division of Gastroenterology Tohoku University Hospital

Gastric cancer(GC) develops as a result of inflammationassociated carcinogenesis due to Helicobacter pylori(H. pylori) infection and subsequent defects in genetic/epigenetic events. Although the indication for eradication therapy has become widespread, clinical studies have revealed its limited effects in decreasing the incidence of GC. Moreover, research on biopsy specimens obtained by conventional endoscopy has demonstrated the feasibility of the restoration of some genetic/epigenetic alterations in the gastric mucosa. Practically, the number of sporadic cases of primary/metachronous GC that emerge after successful eradication has increased, while on-going guidelines recommend eradication therapy for patients with chronic gastritis and those with background mucosa after endoscopic resection for GC. Accordingly, regular surveillance of numerous individuals who have received eradication therapy is recommended despite the lack of biomarkers. Recently, the focus has been on functional reversibility after successful eradication as another cue to elucidate the mechanisms of restoration as well as those of carcinogenesis in the gastric mucosa after H. pylori eradication. We demonstrated that Congo-red chromoendoscopy enabled the identification of the multifocal distribution of functionally irreversible mucosa compared with that of restored mucosa after successful eradication in individuals at extremely high risk for GC. Further research that uses functional imaging may provide new insights into the mechanisms of regeneration and carcinogenesis in the gastric mucosa post-eradication and may allow for the development of useful biomarkers.

关键词： Helicobacter pylori eradication Gastric cancer Congo-red chromoendoscopy Biomarker

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Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm

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World Journal of Gastroenterology 2015年第23期21卷 7120-7133页

作者： Kaname uno Katsunori Iijima Tomoyuki Koike Tooru Shimosegawa Division of Gastroenterology Tohoku University Hospital

The minimal invasiveness of endoscopic submucosal dissection(ESD) prompted us to apply this technique to large-size early esophageal squamous cell carcinoma and Barrett's adenocarcinoma, despite the limitationsin the study population and surveillance duration. A post-ESD ulceration of greater than three-fourths of esophageal circumference was advocated as an important risk factor for refractory strictures that require several sessions of dilation therapy. Most of the preoperative conditions are asymptomatic, but dilatation treatment for dysphagia associated with the stricture has potential risks of severe complications and a worsening of quality of life. Possible mechanisms of dysphasia were demonstrated based on dysmotility and pathological abnormalities at the site:(1) delayed mucosal healing;(2) severe inflammation and disorganized fibrosis with abundant extracellular matrices in the submucosa; and(3) atrophy in the muscularis proper. However, reports on the administration of anti-scarring agents, preventive dilation therapies, and regenerative medicine demonstrated limited success in stricture prevention, and there were discrepancies in the study designs and protocols of these reports. The development and consequent long-term assessments of new prophylactic technologies on the promotion of wound healing and control of the inflammatory/tumor microenvironment will require collaboration among various research fields because of the limited accuracy of preoperative staging and high-risk of local recurrence.

关键词： Esophageal stricture Dysphasia Endoscopicsubmucosal dissection

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