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Mizoribine in the treatment of pediatric-onset glomerular disease

World Journal of Pediatrics 2015年第2期11卷 108-112页

作者： Hiroshi tanaka Kazushi Tsuruga Taddatsu Imaizumi Department of School Health Science Faculty of EducationHirosaki UniversityHirosaki 036-8560Japan Department of Pediatrics Hirosaki University HospitalHirosaki 036-8563Japan Department of Vacular Biology Graduate School of MedicineHirosaki UniversityHirosaki 036-8562Japan

Background:Mizoribine(MZR)is a selective inhibitor of inosine monophosphate dehydrogenase,a key enzyme in the pathway responsible for de novo synthesis of guanine *** an immunosuppressant,MZR has been used successfully without any serious adverse effects in the treatment of renal diseases in children as well as *** its immunosuppressive effect,MZR has been reported to ameliorate tubulointerstitial fibrosis in rats via suppression of macrophage *** Sources:In this review,we summarize reported possible benefits of MZR in the treatment of pediatric-onset glomerular ***:We recently observed that MZR itself selectively attenuates the expression of monocyte chemoattractant protein-1 at both the mRNA and protein levels in human mesangial *** MZR binds specifically to 14-3-3 proteins and heat shock protein 60,both of which are reportedly expressed in inflamed glomeruli,MZR may bind directly to inflamed glomerular cells,thereby possibly preventing progressive damage from glomerulonephritis through a suppressive effect on activated macrophages and intrinsic renal ***,it has recently been reported that MZR directly prevents podocyte injury through correction of the intracellular energy balance and nephrin biogenesis in cultured podocyte and rat models,suggesting a direct anti-proteinuric effect of ***:These beneficial mechanisms of action of MZR as well as its immunosuppressive effect would warrant its use in the treatment of pediatric-onset glomerular *** further studies remain to be done,we believe that MZR may be an attractive treatment of choice for children with glomerular diseases from a histologic as well as clinical standpoint.

关键词： macrophage infiltration mesangial cells mizoribine monocyte chemoattractant protein-1 podocytes

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Significance of preoperatively observed detrusor overactivity as a predictor of continence status early after robot-assisted radical prostatectomy

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Asian Journal of Andrology 2014年第6期16卷 869-872页

作者： Akihiro Yanagiuchi Hideaki Miyake Kazushi tanaka Masato Fujisawa Division of Urology Kobe University Graduate School of Medicine 7-5-1 Kusunoki-Cho Chuo-Ku Kobe Japan.

Several recent studies have reported the involvement of bladder dysfunction in the delayed recovery of urinary continence following radical prostatectomy （RP）. The objective of this study was to investigate the significance of detrusor overactivity （DO） as a predictor of the early continence status following robot-assisted RP （RARP）. This study included 84 consecutive patients with prostate cancer undergoing RARP. Urodynamic studies, including filling cystometry, pressure flow study, electromyogram of the external urethral sphincter and urethral pressure profile, were performed in these patients before surgery. Urinary continence was defined as the use of either no or one pad per day as a precaution only. DO was preoperatively observed in 30 patients （35.7%）, and 55 （65.5%） and 34 （40.5%） were judged to be incontinent 1 and 3 months after RARP, respectively. At both 1 and 3 months after RARP, the incidences of incontinence in patients with DO were significantly higher than in those without DO. Of several demographic and urodynamic parameters, univariate analyses identified DO and maximal urethral closure pressure （MUCP） as significant predictors of the continence status at both 1 and 3 months after RARP. Furthermore, DO and MUCP appeared to be independently associated with the continence at both I and 3 months after RARP on multivariate analysis. These findings suggest that preoperatively observed DO could be a significant predictor of urinary incontinence early after RARP; therefore, it is recommended to perform urodynamic studies for patients who are scheduled to undergo RARP in order to comprehensively evaluate their preoperative vesicourethral functions.

关键词： detrusor overactivity robot-assisted radical prostatectomy urinary incontinence

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Cyclic behavior of soils and numerical analyses in cold regions and seismic zones

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Research in Cold and Arid Regions 2015年第5期7卷 492-502页

作者： Tadatsugu tanaka The Japan Association of Rural Resource Recycling Solutions

The solutions of boundary value problems involving strain-softening material property contain serious difficulties from both modeling of strain-localization and a viewpoint of numerical procedure. Mesh size-dependent hardening modulus is considered to alleviate the mesh size-dependency of the solution. The elasto-plastic soil model with kinematic hardening model considering the cumulative deformation by cyclic loading is developed. In finite element analyses, the dynamic relaxation method combined with the generalized return-mapping algorithm is applied to the static drained and un-drained tri-axial tests and plane strain tests. The cyclic behavior of retaining wall problems by freeze and thaw in cold regions is also analyzed. Finally the dynamic progressive failure analysis of rockfill dam is carried out.

关键词： strain softening shear band kinematic hardening endochronic theory

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Analysis of flow around impermeable groynes on one side of symmetrical compound channel:An experimental study

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Water Science and Engineering 2010年第1期3卷 56-66页

作者： Hassan SafiAHMED Mohammad Mahdi HASAN Norio tanaka Civil Engineering Department Faculty of EngineeringSouth Valley University Graduate School of Science and Engineering Saitama University Institute for Environmental Science and Technology Saitama University

This paper presents the results of an experimental study on the influences of floodplain impermeable groynes on flow structure, velocity, and water depth around the groyne（s）. A wooden symmetrical compound channel was used. Groyne models with three different groyne relative lengths, 0.5, 0.75, and 1.0, were used on one floodplain with single and series arrangements. Analysis of the experimental results using the measured flow velocity and water depth values showed that flow structure, velocity, and water depth mainly depend on groyne relative length and the relative distance between series groynes. The flow velocity at the main channel centerline increased by about 40%, 60%, and 85%, and in other parts on the horizontal plane at the floodplain mid-water, depth by about 75%, 125%, and 175% of its original value in eases of one-side floodplain groyne（s） with relative lengths of 0.5, 0.75, and 1.0, respectively. The effective distance between two groynes in series arrangement ranges from 3 to 4 times the groyne length. Using an impermeable groyne with a large relative length in river floodplains increases the generation of eddy and roller zones downstream of the groyne, leading to more scouring and deposition. To avoid that, the groyne relative length must be kept below half the floodplain width,

关键词： impermeable groyne symmetrical compound channel floodplain flow structure

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Rapidly deforming gastric carcinosarcoma with osteoblastic component:An autopsy case report

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World Journal of Gastroenterology 2012年第30期18卷 4064-4068页

作者： Hiroshi Yoshida Noriyuki tanaka Naobumi Tochigi Yoshio Suzuki Department of Pathology Asahi General HospitalChiba 289-2511Japan

Carcinosarcomas are rare,malignant,biphasic tumors simultaneously comprising carcinoma and sarcoma in a single *** present an extremely rare case of gastric carcinosarcoma with an osteoblastic component that drastically changed its shape within 2 mo.A 59-year-old male patient presented to the emergency outpatient unit with a complaint of black *** endoscopy showed an ulcerated mass in the cardia of the lesser curvature of the *** specimens revealed only *** months later,the ulcerated lesion drastically changed its shape into an exophytic *** gastrectomy was *** the resected specimen,the gastric tumor contained both adenocarcinoma and sarcoma components with lace-like *** patient died 7 mo after the operation,and an autopsy was *** the autopsy,widespread metastases were present in the liver,lung,lymph nodes and *** this report,we describe a case of gastric carcinosarcoma and presume its tumorigenesis based on the autopsy findings.

关键词： Carcinosarcoma Stomach Osteoblastic differentiation Autopsy Tumorigenesis

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Passive Control of Condensation Shock Wave in Prandtl-Meyer Expansion Flow

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Journal of Thermal Science 2003年第1期12卷 20-26页

作者： Shigeru Matsuo Masanori tanaka Toshiaki Setoguchi Heuy-Dong Kim Department of Mechanical Engineering Saga UniversityDepartment of Mechanical Engineering Saga UniversityDepartment of Mechanical Engineering Saga UniversitySchool of Mechanical Engineering College of Natural Science Andong National University 388 1 Honjo-machi Saga-shi Saga 840-8502 Japan1 Honjo-machi Saga-shi Saga 840-8502 Japan 1 Honjo-machi Saga-shi Saga 840-8502 Japan Song-Cheon Dong Andong Kyung-Pook Korea

In this paper, the effects of the passive technique by using the slotted wall on the characteristics of a condensation shock wave generated in a Prandtl-Meyer flow were investigated experimentally. Furthermore, in order to clarify the variation of condensation properties in the flow field, Navier-Stokes equations were solved numerically using a 3rd-order MUSCL type TVD finite-difference scheme with a second-order fractional-step for time integration. Baldwin-Lomax model was used as a turbulence model in the computations. From experimental results, it was found that the shock strength on the slotted wall became weak in comparison with no passive case (solid wall), and the present passive technique was the most effective when a foot of the condensation shock wave was located at the middle of slotted wall. Furthermore, it was confirmed numerically that the passive technique was also effective for the unsteady condensation shock wave.

关键词： compressible flow Prandtl-Meyer flow condensation shock wave numerical simulation.

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Future Strategy of Breeding:Learn by Two Important Genes of Miracle Rice

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Molecular Plant 2020年第6期13卷 823-824页

作者： Kyosuke Kawai Miyako Ueguchi-tanaka Makoto Matsuoka Bioscience and Biotechnology Center Nagoya University464-8601 NagoyaJapan

In the"Analects of Confucius",there is a classic sentence that"too much is as bad as too little".The work by Wang et al.(2020)published in this issue reminds us that crop breeders should bear this sentence in mind whe... 详细信息

关键词： breed Learn she

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A tree-shaped motion strategy for robustly executing robotic assembly tasks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 986-991页

作者： Yusuke BOTA Hajime MIZUYAMA Akio NODA Tatsuya NAGATANI Ken-ichi tanaka Department of Mechanical Engineering and Science Kyoto University Yoshida-Honmachi Advanced Technology R&D Center Mitsubishi Electric Corporation 8-1-1Tsukaguchi-Honmachi

An assembly robot needs to be capable of executing an assembly task robustly under various *** attain this goal,we use a task sequence tree model originally proposed for manual *** model regards an assembly task under uncertainties as a transformation of the contact state *** concept may contain several contact states with probabilities but these are transformed through a series of task elements into the contact state concept having only the goal state at the *** transformed contact state concept can be classified according to the terminal condition of each task ***,the whole assembly task can be designed as a tree-shaped contingent strategy called a task sequence *** paper proposes a systematic approach for reconfiguring a task sequence tree model for application to a robotic assembly *** addition,by taking a 2D peg-in-hole insertion task to be performed by a robot equipped with a force sensor as an example,we confirm that the proposed approach can provide a robust motion strategy for the task and that the robot can actually execute the task robustly under bounded uncertainty according to the strategy.

关键词： Active compliant motion Contact states Motion strategy Robotic assembly Task sequence tree

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Generation of Overpressure due to Condensation in Moist Air Jet

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Journal of Thermal Science 2007年第2期16卷 145-148页

作者： Yumiko OTOBE Hideo KASHIMURA Shigeru MATSUO Masanori tanaka Toshiaki SETOGUCHI Kitakyushu National College of Technology 5-20-1 ShiiKokuraminamiKitakyushuJapan Saga University 1HonjoSagaJapan

In the present study, a computational fluid dynamics method has been applied to investigate the effects of initial degree of supersaturation at reservoir condition on under-expanded sonic jet structures, such as Mach disk location and diameter, barrel shock wave and jet boundary. The axisymmetric nozzle geometry investigated was a converging nozzle with straight part. As a result, it was found that the overpressures due to condensation generate and the characteristics of flow with generation of overpressure due to condensation in the jet were different from those without condensation.

关键词： compressible flow axisymmetric flow sonic jet Mach disk condensation humidity overpressure

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Particles Behavior in Quasi-Steady-State AC Plasmas on HT-7 Tokamak

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Plasma Science and Technology 2009年第4期11卷 422-426页

作者：揭银先高翔 Kenji tanaka 杨曜徐强高伟李建刚 Institute of Plasma Physics Chinese Academy of Sciences National Institute for Fusion Science

A quasi-stationary alternating current （AC） operation assisted by lower hybrid waves （LHW） was achieved recently in HT-7. It is found that the particle confinement time of the positive current plasma is lower than that of the negative current plasma. The particle transport coefficients are investigated in AC plasmas by a gas puff modulation method. It is observed that the particle diffusion coefficient for the positive plasma current case is almost the same as that for the negative one, but the absolute value of inward pinch velocity for the positive current plasma is much lower than Vhat of the negative one. The result of the particle transport model study is in agreement with the experimental confinement study. The intensity of Hα emission and impurities emission of CⅢ, OII and OV for the negative current plasma are much lower than that for the positive current plasma. The radiation from Hα, OⅡ, CⅢ and ECE signals from the negative to the positive current phase showed less ionization and lower parameters than those from the positive to the negative one. The difference of particle transport and confinement in AC plasmas is not predicted by the current theory.

关键词： AC plasma particle transport coefficients particle confinement time

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