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Neural regeneration by regionally induced stem cells within poststroke brains: Novel therapy perspectives for stroke patients

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World Journal of Stem Cells 2019年第8期11卷 452-463页

作者： takayuki Nakagomi Toshinori Takagi Mikiya Beppu Shinichi Yoshimura Tomohiro Matsuyama Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Therapeutic Progress in Brain Diseases Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Neurosurgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan

Ischemic stroke is a critical disease which causes serious neurological functional loss such as paresis. Hope for novel therapies is based on the increasing evidence of the presence of stem cell populations in the central nervous system (CNS) and the development of stem-cell-based therapies for stroke patients. Although mesenchymal stem cells (MSCs) represented initially a promising cell source, only a few transplanted MSCs were present near the injured areas of the CNS. Thus, regional stem cells that are present and/or induced in the CNS may be ideal when considering a treatment following ischemic stroke. In this context, we have recently showed that injury/ischemia-induced neural stem/progenitor cells (iNSPCs) and injury/ischemia-induced multipotent stem cells (iSCs) are present within post-stroke human brains and post-stroke mouse brains. This indicates that iNSPCs/iSCs could be developed for clinical applications treating patients with stroke. The present study introduces the traits of mouse and human iNSPCs, with a focus on the future perspective for CNS regenerative therapies using novel iNSPCs/iSCs.

关键词： Ischemic stroke Stroke patients Central nervous system Neural stem/progenitor cells Multipotent stem cells Stem-cell-based therapies

Two-Dimensional Super High Density Multi-Fiber Connector

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光学学报 2003年第S1期23卷 285-286页

作者： Takashi Shigenaga Katsuki Suematsu Masao Shinoda takayuki Ando The Furukawa Electric Co. Ltd.The Furukawa Electric Co. Ltd.The Furukawa Electric Co. Ltd.The Furukawa Electric Co. Ltd.

We have developed 32-fiber and 60-fiber super high density multi fiber connector. This 32-fiber connector can be applicable for single-mode fiber and 60-fiber connector for multi-mode fiber. We have also established P... 详细信息

关键词： that in et have be MT high Two-Dimensional Super High Density Multi-Fiber Connector of

Experimental and numerical study of water sprayed turbulent combustion: Proposal of a neural network modeling for five-dimensional flamelet approach

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Energy and AI 2021年第3期5卷 316-324页

作者： Takafumi Honzawa Reo Kai Kotaro Hori Makoto Seino takayuki Nishiie Ryoichi Kurose Department of Mechanical Engineering and Science Graduate School of EngineeringKyoto UniversityKyoto daigaku-KatsuraNishikyo-kuKyoto 615-8540Japan Tokyo Gas Co. Ltd.1-7-7 Suehiro-choTsurumi-kuYokohamaKanagawa 230-0045Japan Numerical Flow Designing Co. Ltd.1-10-10Higashi-GotandaShinagawa-kuTokyo 141-0022Japan

Owing to the increasing worldwide demand for natural gas,the development of a large submerged combustion vaporizer is *** burner is equipped with a water spray nozzle to reduce nitrogen oxides,and a practi-cal simulation method is required for the optimal *** non-adiabatic flamelet approach can predict the combustion emissions and is useful for reducing simulation ***,as the number of control variables increases,the database requires larger memory and cannot be dealt with by general *** this study,an artificial neural network(ANN)model based on a five-dimensional flamelet database,which includes the effects of heat loss and vapor concentration by sprayed water evaporation,is ***,large eddy sim-ulations(LESs)for turbulent combustion fields with and without water spray are conducted employing flamelet generated manifold(FGM)approach with this ANN model,and the validity is *** comparison,a lab-scale burner equipped with a water spray nozzle is manufactured,and combustion experiments with and without water spray are *** results show that CO,NO,temperature,and reaction rate of progress variable predicted by the present ANN model are in good agreement with those of a five-dimensional flamelet *** the condition without water spray,the flame behavior predicted by the LES employing the FGM/ANN ap-proach is in good agreement with that employing the conventional FGM approach,while indicating much lower memory,although there appeared some quantitative discrepancies in the temperature against the experiment probably partially because of the insufficiency of the FGM approach for the present complex flame *** the condition with water spray,the LES employing the FGM/ANN approach is able to capture the effect of the water spray on the flame behavior in the experiment,such that the water spray decreases the temperature,which causes the decrease in NO but increase in CO.

关键词： Neural network modeling Five-dimensional flamelet approach Water spray Large eddy simulation

SUPER TOUGH GELS WITH A DOUBLE NETWORK STRUCTURE

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Chinese Journal of Polymer Science 2009年第1期27卷 1-9页

作者： Tasuku Nakajima takayuki Kurokawa Hidemitsu Furukawa Yoshimi Tanaka Yoshihito Osada 龚剑萍 Department of Biological Sciences Graduate School of ScienceHokkaido University

Living tissues work with fantastic functions in soft and wet gel-like ***,hydrogels have attracted much attention as excellent soft and wet materials,suitable tot making artificial organs for medical ***, conventional hydrogels are mechanically too weak for practical *** have created double network (DN) hydrogels with extremely high mechanical strength in order to overcome this *** gels are interpenetrating network (IPN) hydrogels consisting of rigid polyelectrolyte and soft...

关键词： Hydrogel Toughness Fracture Necking phenomenon

Reversed portal flow: Clinical influence on the long-term outcomes in cirrhosis

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World Journal of Gastroenterology 2015年第29期21卷 8894-8902页

作者： takayuki Kondo Hitoshi Maruyama Tadashi Sekimoto Taro Shimada Masanori Takahashi Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University

AIM: To elucidate the natural history and the longitudinal outcomes in cirrhotic patients with non-forward portal flow(NFPF).METHODS: The present retrospective study consisted of 222 cirrhotic patients(120 males and 102 females; age, 61.7 ± 11.1 years). The portal hemodynamics were evaluated at baseline and during the observation period using both pulsed and color Doppler ultrasonography. The diameter(mm), flow direction, mean flow velocity(cm/s), and mean flow volume(m L/min) were assessed at the portal trunk, the splenic vein, the superior mesenteric vein, and the collateral vessels. The average values from 2 to 4 measurements were used for the data analysis. The portal flow direction was defined as follows: forward portal flow(FPF) for continuous hepatopetal flow; bidirectional flow for to-and-fro flow; and reversed flow for continuous hepatofugal flow. The bidirectional flow and the reversed flow were classified as NFPF in this study. The clinical findings and prognosis were compared between the patients with FPF and those with NFPF. The median follow-up period was 40.9 mo(range, 0.3-156.5 mo).RESULTS: Twenty-four patients(10.8%) demonstrated NFPF, accompanied by lower albumin level, worse ChildPugh scores, and model for end-stage liver disease scores. The portal hemodynamic features in the patients with NFPF were smaller diameter of the portal trunk;presence of short gastric vein, splenorenal shunt, or inferior mesenteric vein; and advanced collateral vessels(diameter > 8.7 mm, flow velocity > 10.2 cm/s, and flow volume > 310 m L/min). The cumulative incidence rates of NFPF were 6.5% at 1 year, 14.5% at 3 years, and 23.1% at 5 years. The collateral vessels characterized by flow velocity > 9.5 cm/s and those located at the splenic hilum were significant predictive factors for developing NFPF. The cumulative survival rate was significantly lower in the patients with NFPF(72.2% at 1 year, 38.5% at 3 years, 38.5% at 5 years) than in those with forward portal flow(8

关键词： Non-forward portal flow Reversed portalflow Cirrhosis Doppler ultrasound Portal hemodynamics

Streamline pair selection for comparative flow field visualization

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Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 215-226页

作者： Shoko Sawada takayuki Itoh Takashi Misaka Shigeru Obayashi Tobias Czauderna Kingsley Stephens Ochanomizu University 2-1-1 OtsukaBunkyo-kuTokyo 1128610Japan Tohoku University 2-1-1 KatahiraAoba-kuSendaiMiyagi 9808577Japan Monash University Wellington RoadClaytonVictoriaAustralia

Fluid dynamics simulation is often repeated under varying *** leads to a generation of large amounts of results,which are difficult to *** compare results under different conditions,it is effective to overlap the streamlines generated from each condition in a single three-dimensional *** is a curved line,which represents a wind *** paper presents a technique to automatically select and visualize important streamlines that are suitable for the comparison of the simulation ***,we present an implementation to observe the flow fields in virtual reality spaces.

关键词： Computational fluid dynamics Streamline selection Comparative flow field visualization Virtual reality

Intraductal papillary neoplasm of the bile duct developing in a patient with primary sclerosing cholangitis: A case report

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World Journal of Gastroenterology 2014年第42期20卷 15925-15930页

作者： Hiroyuki Hachiya Junji Kita takayuki Shiraki Yukihiro Iso Mitsugi Shimoda Keiichi Kubota Second Department of Surgery Dokkyo Medical University

We report a case of intraductal papillary neoplasm of the bile duct(IPNB) that developed in a patient with primary sclerosing cholangitis. A 46-year-old woman was admitted to our hospital with obstructive jaundice. The liver function tests demonstrated increased serum liver enzyme levels. Computed tomography showed dilatation of the intrahepatic bile ducts. Abdominal ultrasonography revealed a highly echoic protruding lesion in the posterior bile duct near the right lobe of the liver. The lesion was suspected to be IPNB, but we were unable to confirm whether it was a carcinoma. A right hepatectomy was performed, and this showed that the dilated bile duct was filled with mucin and contained several yellowish papillary tumors. Histologically, the neoplastic biliary epithelium showed papillary growth in the dilated lumen. The tumor was diagnosed as IPNB, high-grade intraepithelial neoplasia secreting abundant mucin. No recurrence has been detected 3 years after surgery.

关键词： Intraductal papillary neoplasm of the bile duct Primary sclerosing cholangitis Cholangiocarcinoma High-grade intraepithelial neoplasia Premalignant lesion

Nitrogen-bridged Ni(Ⅱ)porphyrinoid trimers with a central quinodiimine unit

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Chinese Chemical Letters 2022年第10期33卷 4545-4548页

作者： Kaisheng Wang Boyu Xiao Ling Xu Mingbo Zhou takayuki Tanaka Atsuhiro Osuka Jianxin Song College of Chemistry and Chemical Engineering Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education of China)Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceHunan Normal UniversityChangsha 410081China Department of Chemistry Graduate School of Science Kyoto UniversityKyoto 606-8502Japan

Buchwald-Hartwig amination of 5,15-dibromo and 5,10-dibromo Ni(Ⅱ)porphyrins with 5-amino Ni(Ⅱ)porphyrin gave linear and bent trimers 4Ni and 5Ni with a central quinodiimine-type Ni(Ⅱ)*** structures of 4Ni and 5Ni have been confirmed by X-ray diffraction analysis in both *** formation of unusual products 4Ni and 5Ni has been ascribed to facile oxidation of 5,15-and 5,10-amino Ni(Ⅱ)porphyrin *** of 4Ni and 5Ni under proper conditions gave NH-bridged Ni(Ⅱ)porphyrin trimers 4Ni-2H and 5Ni-2H in high *** 4Ni and 5Ni exhibit the lowest energy band as compared with 4Ni-2H and *** the bent trimer 5Ni exhibits a broad absorption tail beyond 1400 nm.

关键词： Porphyrinoid trimer Aminoporphyrins Buchwald-Hartwig amination Reduction Charge transfer

Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2018年第12期24卷 1332-1342页

作者： takayuki Shiraki Hajime Kuroda Atsuko Takada Yoshimasa Nakazato Keiichi Kubota Yasuo Imai Department of Gastroen- terological Surgery Dokkyo Medical University Department of Diagnostic Pathology Dokkyo Medical University

AIM To evaluate the usefulness of frozen section diagnosis(FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma(CCA). METHODS We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs(45 and 55 bile duct margins, respectively). The diagnosis was classified into three categories: negative, borderline(biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive. FSD in the epithelial layer, subepithelial layer, and total layer was compared with corresponding permanent section diagnosis(PSD) ***, association between FSD and local recurrence was analyzed with special reference to *** Analysis of 100 duct margins revealed that concordance rate between FSD and PSD was 68.0% in the total layer, 69.0% in the epithelial layer, and 98.0% in the subepithelial layer. The extent of remaining biliary epithelium was comparable between FSD and PSD, and more than half of the margins lost > 50% of the entire epithelium, suggesting low quality of the samples. In FSD, the rate of negative margins decreased and that of borderline and positive margins increased according to the extent of the remaining epithelium. Diagnostic discordance between FSD and PSD was observed in 31 epithelial layers and two subepithelial layers. Alteration from borderline to negative was the most frequent(20 of the 31 epithelial layers). Patients with positive margin in the total and epithelial layers by FSD demonstrated a significantly worse local recurrence-free survival(RFS) compared with patients with borderline and negative margins, which revealed comparable local RFS. Patients with borderline and negative margins in the epithelial layer by PSD also revealed comparable local RFS. These results suggested that epithelial borderline might be regarded substantially as negati

关键词： Cholangiocarcinoma Bile duct cancer Frozen section diagnosis Permanent section diagnosis Bile duct margin Biliary intraepithelial neoplasia Dysplasia Indefinite for neoplasia Borderline lesion Local recurrence