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A Breakthrough in Pressure Generation by a Kawai-Type Multi-Anvil Apparatus with Tungsten Carbide Anvils

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Engineering 2019年第3期5卷 434-440页

作者： takayuki Ishii Zhaodong Liu Tomoo Katsura Bayerisches Geoinstitut University of Bayreuth Bayreuth 95440 Germany State Key Laboratory of Superhard Materials Jilin University Changchun 130012 China Center for High Pressure Science and Technology Advanced Research Beijing 100094 China

Expansion of the pressure range of Kawai-type multi-anvil presses (KMAPs) with tungsten carbide (WC) anvils is called for, especially in the field of Earth science. However, no significant progress in pressure generation has been made for 40 years. Our recent studies have expanded the pressure generation of a KMAP with WC anvils to 65 GPa, which is the world record for high-pressure generation in this device and is more than 2.5 times higher than conventional pressure generation. We have also successfully generated pressures of about 50 GPa at high temperatures. This work reviews our recently developed technology for high-pressure generation. High-pressure generation at room temperature and at high temperature was attained by integration of the following techniques:① a precisely aligned guideblock system,② a high degree of hardness of the second-stage anvils,③ tapering of the second-stage anvil faces,④ a high-pressure cell consisting of materials with a high bulk modulus, and ⑤ high thermal insulation of the furnace. Our high-pressure technology will facilitate investigation of the phase stability and physical properties of materials under the conditions of the upper part of the lower mantle, and will permit the synthesis and characterization of novel materials.

关键词： High pressure Multi-anvil apparatus Tungsten carbide anvil Sintered diamond Lower mantle

Left paraduodenal hernia in an adult complicated by ascending colon cancer: A case report

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World Journal of Gastroenterology 2006年第11期12卷 1795-1797页

作者： Kiyotaka Kurachi Toshio Nakamura Tadataka Hayashi Yosuke Asai takayuki Kashiwabara Akihito Nakajima Shohachi Suzuki Hiroyuki Konno Second Department of Surgery Hamamatsu University School of Medicine HamamatsuJapan

Paraduodenal hernia is the most common internal hernia. The clinical symptoms of paraduodenal hernia may be intermittent and nonspecific. Therefore, it is difficult to diagnose preoperatively. Abdominal computed tomography （CT） scan currently plays an important role in the evaluation and management of paraduodenal hernia before surgical operation. We report one unique case of preoperatively diagnosed left paraduodenal hernia complicated by advanced ascending colon cancer and reviews of Japanese literature.

关键词： Paraduodenal hernia Internal hernia Colonic malrotaion

Analysis of metabolic alterations in Arabidopsis following changes in the carbon dioxide and oxygen partial pressures

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Journal of Integrative Plant Biology 2014年第9期56卷 941-959页

作者： Alexandra Florian Stefan Timm Zoran Nikoloski takayuki Tohge Hermann Bauwe Wagner L.Araujo Alisdair R.Fernie Max Planck Institute for Molecular Plant Physiology Department of Plant Physiology University of Rostock Max-Planck Partner group at the Departament of Plant Biology Federal University of Vicosa

As sessile organisms,plants are subject to a multitude of environmental variations including several which directly affect their interaction with the *** the indiscriminant nature of Rubisco,the relative rates of photosynthesis and photorespiration are known to be responsive to changes in gas ***,comprehensive profiling methods have not yet been applied in order to characterize the wider consequences of these changes on primary metabolism in ***,although transcriptional profiling has revealed that a subset of photorespiratory enzymes are co-expressed,whether transcriptional responses play a role in short-term responses to atmospheric compositional changes remains *** address these questions,plants Arabidopsis thaliana（Arabidopsis） ecotype Columbia（Col-O） grown under normal air conditions were transferred to different CO_2 and O_2 concentrations and characterized at the physiological,molecular,and metabolic levels following this *** results reveal alterations in the components,which are directly involved in,or supporting,photorespiration,including transcripts and metabolite *** results further highlight that the majority of the regulation of these pathways is not mediated at the level of transcription and that the photorespiratory pathway is essential also in conditions in which flux through the pathway is minimized,yet suggest that flux through this pathway is not mediated at the level of transcription.

关键词： Carbon dioxide partial pressures gene expression metabolic profiling oxygen partial pressures

Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers

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World Journal of Gastroenterology 2006年第27期12卷 4325-4330页

作者： Masaki Kawamoto Toru Mizuguchi Tadashi Katsuramaki Minoru Nagayama Hideki Oshima Hiroyuki Kawasaki takayuki Nobuoka Yasutoshi Kimura Koichi Hirata Department of Surgery Ⅰ Sapporo Medical University HospitalSapporo Medical University School of MedicineS-1W-16Chuo-KuSapporoHokkaido 060-8543Japan

AIM： To assess the correlation between the fibrotic area （FA） as calculated by a digital image analysis （DIA）, and to compare the diagnostic accuracy of FibroScan to the other existing Liver fibrosis （LF） markers using the receiver operating curve analysis.METHODS： We recruited 30 patients who underwent a liver resection for three different etiologies including normal liver, hepatitis B, and hepatitis C. Liver stiffness was measured by using a FibroScan. The FA was then calculated by DIA to evaluate LF in order to avoid any sampling bias. RESULTS： The FA negatively correlated with Prothrombin time （PT）, platelet count, lecithin-cholesterol acyltransferase （LCAT）, and pre-albumin （ALB）. On the other hand, the findings of FibroScan correlated with similar markers. The FA positively correlated with FibroScan, serum hyaluronate level, and type Ⅳ collagen level, and aspartate transaminase to platelet ratio index （APRI）. The area under the receiver operating curve for FibroScan was higher than that for the other markers, even though the statistical significance was minimal. CONCLUSION： Our findings suggest that FibroScan can initially be used to assess LF as an alternative to a liver biopsy （LB） and serum diagnosis, because it is a safe method with comparable diagnostic accuracy regarding the existing LF markers.

关键词： Cirrhosis Digital image analysis Fibro-Scan Fibrotic area Hyaluronate Lecithin-cholesterol acyltransferase Liver fibrosis Pre-albumin

Study on control of rock fragmentation at limestone quarry

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Journal of Coal Science & Engineering(China) 2008年第3期14卷 365-368页

作者： SASAOKA Takashi SHIMADA Hideki SASAKI takayuki ICHINOSE Masatomo MATSUI Kikuo Department of Earth Resources Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan

The size distribution of a muck pile depends not on only the blasting standard but also on the mechanical properties,joint system,and crack density of the rock mass. As,the cracks in the rock masses are especially heavily developed at the limestone quar- ries in Japan,they,along with the joints,have a large impact on the effects of blasting, such as the size of the muck ***,if the joint system and/or crack density in a rock mass can be determined and quantitatively evaluated,the blasting operation can be conducted more effectively,efficiently and ***,guidelines for designing ap- propriate blasting standards based on the rock mass conditions have not yet been scien- tifically ***,blasting tests were conducted on different mines and faces, under different geological conditions and blasting standards,in order to determine the im- pacts of each factor on the effects of *** the results of a series of blast- ing tests and described the impacts of geological conditions on the size of the muck pile produced by blast.

关键词： fragmentation blasting standard blasting borehole scoping

Chrono-exercise: Time-of-day-dependent physiological responses to exercise

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Sports Medicine and Health Science 2023年第1期5卷 50-58页

作者： Hyeon-Ki Kim Zsolt Radak Masaki Takahashi takayuki Inami Shigenobu Shibata Research Center for Molecular Exercise Science University of Physical EducationBudapestHungary Institute of Physical Education Keio UniversityYokohamaJapan Chrono-nutrition Research Center Waseda UniversityTokyoJapan Institute for Liberal Arts Tokyo Institute of TechnologyTokyoJapan Faculty of Science and Engineering Waseda UniversityJapan

Exercise is an effective strategy to prevent and improve obesity and related metabolic *** increases the metabolic demand in the *** many of the metabolic health benefits of exercise depend on skeletal muscle adaptations,exercise exerts many of its metabolic effects through the liver,adipose tissue,and ***,exercise is the physiological state in which inter-organ signaling is most *** contrast,circadian rhythms in mammals are associated with the regulation of several physiological and biological functions,including body temperature,sleep-wake cycle,physical activity,hormone secretion,and metabolism,which are controlled by clock *** and lipid tolerance reportedly exhibit diurnal variations,being lower in the evening than in the ***,the effects of exercise on substrate metabolism at different times of the day may *** this review,the importance of exercise timing considerations will be outlined,incorporating a chrono-exercise perspective.

关键词： Chrono-exercise Exercise timing Inter-organ communication Circadian rhythm Energy metabolism

High Diastereoselectivity in the Conjugate Addition of Functionalized Alcohols to a Chiral(E)-Nitroalkene

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Chinese Chemical Letters 1999年第8期10卷 629-632页

作者： Qian CHENG takayuki ORITANI Alfred HASSNER (Laboratory of Applied Bioorganic Chemistry, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamaiyamachi, Aoba-ku,Sendai 981 -8855, Japan)(Department of Lab. of Applied Bioorganic Chemistry Division of Life Science Tohoku University Aoba-ku Sendai 981-8855 1-1 Tsutsumidori-Amamaiyamachi Japan Department of Chemistry Bar-Ilan University Ramat-Gan 52900 Israel

Modest to high diastereoselectivites have been observed in the conjugate addition of functionalized alcohols to chiral (E)-nitroalkene 1 depending on the presence of metal catalysts at low tempertwre. The resultS indi... 详细信息

关键词： Diastereoselectivity michael addition alcohols catalysts

Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection

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World Journal of Gastroenterology 2015年第26期21卷 8195-8202页

作者： Jun Takada Hiroshi Araki Fumito Onogi takayuki Nakanishi Masaya Kubota Takashi Ibuka Masahito Shimizu Hisataka Moriwaki Department of Gastroenterology Gifu University Graduate School of Medicine

AIM: To compare the safety and efficacy of carbon dioxide(CO2) and air insufflation during gastric endoscopic submucosal dissection(ESD).METHODS: This study involved 116 patients who underwent gastric ESD between January and December *** eliminating 29 patients who fit the exclusion criteria,87 patients,without known pulmonary dysfunction,were randomized into the CO2 insufflation(n = 36) or air insufflation(n = 51) *** ESD was performed with a CO2 regulation unit(constant rate of 1.4 L/min) used for patients undergoing CO2 *** received diazepam for conscious sedation and pentazocine for *** CO2 tension(Ptc CO2) was recorded 15 min before,during,and after ESD with *** CO2,the correlation between Ptc CO2 and procedure time,and ESD-related complications were compared between the two *** blood gases were analyzed after ESD in the first 30 patients(12 with CO2 and 18 with air insufflation) to assess the correlation between arterial blood CO2 partial pressure(Pa CO2) and Ptc ***: There were no differences in respiratoryfunctions,median sedative doses,or median procedure times between the ***,there was no significant difference in post-ESD blood gas parameters,including Pa CO2,between the CO2 and air groups(44.6 mm Hg vs 45 mm Hg).Both groups demonstrated median p H values of 7.36,and none of the patients exhibited *** significant differences were observed between the CO2 and air groups with respect to baseline Ptc CO2(39 mm Hg vs 40 mm Hg),peak Ptc CO2 during ESD(52 mm Hg vs 51 mm Hg),or median Ptc CO2 after ESD(50 mm Hg vs 50 mm Hg).There was a strong correlation between Pa CO2 and Ptc CO2(r = 0.66; P < 0.001).The incidence of Mallory-Weiss tears was significantly lower with CO2 insufflation than with air insufflation(0% vs 15.6%,P = 0.013).CO2 insufflation did not cause any adverse events,such as CO2 narcosis or gas ***: CO2 insufflation durin

关键词： Carbon dioxide Gastric endoscopic submucosaldissection Insufflation Mallory-Weiss tear Randomizedcontrolled trial

Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy

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World Journal of Gastroenterology 2012年第1期18卷 90-95页

作者： Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Hospital Department of Pathology Osaka University Hospital

An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed.

关键词： Inflammatory pseudotumor Percutaneous liver biopsy Percutaneous spleen biopsy Steroid pulse therapy