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Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

World Journal of Gastroenterology 2019年第10期25卷 1248-1257页

作者： Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki kawashima Masato Nakaguro Masahiro Nakatochi Yoshiki Hirooka Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Department of Endoscopy Nagoya University Hospital Department of Pathology and Laboratory Medicine Nagoya University Hospital Division of Data Science Data Coordinating CenterDepartment of Advanced MedicineNagoya University Hospital

BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal *** To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological *** Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological *** LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis.

关键词： Linked color imaging Early gastric cancer Endoscopic submucosal dissection Vessel density Color difference

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Diagnostic performance of endoscopic classifications for neoplastic lesions in patients with ulcerative colitis:A retrospective casecontrol study

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World Journal of Gastroenterology 2022年第10期28卷 1055-1066页

作者： Yuichi Kida Takeshi Yamamura Keiko Maeda Tsunaki Sawada Eri Ishikawa Yasuyuki Mizutani Naomi Kakushima Kazuhiro Furukawa Takuya Ishikawa Eizaburo Ohno Hiroki kawashima Masanao Nakamura Masatoshi Ishigami Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya 466-8550AichiJapan Department of Endoscopy Nagoya University HospitalNagoya 466-8560AichiJapan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

BACKGROUND It is unclear whether the Japan Narrow-Band Imaging Expert Team(JNET)classification and pit pattern classification are applicable for diagnosing neoplastic lesions in patients with ulcerative colitis(UC).AIM To clarify the diagnostic performance of these classifications for neoplastic lesions in patients with *** This study was conducted as a single-center,retrospective case-control ***-one lesions in 19 patients with UC-associated neoplasms(UCAN)and 23 lesions in 22 UC patients with sporadic neoplasms(SN),evaluated by magnifying image-enhanced endoscopy,were retrospectively and separately assessed by six endoscopists(three experts,three non-experts),using the JNET and pit pattern *** results were compared with the pathological diagnoses to evaluate the diagnostic ***-and intra-observer agreements were *** In this study,JNET type 2 A and pit pattern typeⅢ/Ⅳwere used as indicators of low-grade dysplasia,JNET type 2 B and pit pattern typeⅥlow irregularity were used as indicators of highgrade dysplasia to shallow submucosal invasive carcinoma,JNET type 3 and pit pattern typeⅥhigh irregularity/VN were used as indicators of deep submucosal invasive *** the UCAN group,JNET type 2 A and pit pattern typeⅢ/Ⅳhad a low positive predictive value(PPV;50.0%and 40.0%,respectively);however,they had a high negative predictive value(NPV;94.7%and 100%,respectively).Conversely,in the SN group,JNET type 2 A and pit pattern typeⅢ/Ⅳhad a high PPV(100%for both)but a low NPV(63.6%and 77.8%,respectively).In both groups,JNET type 3 and pit pattern typeⅥ-high irregularity/VN showed high *** interobserver agreement of JNET classification and pit pattern classification for UCAN among experts were 0.401 and 0.364,in the same manner for SN,0.666 and 0.597,*** intra-observer agreements of JNET classification and pit pattern classification for UCAN among experts were 0.387,0.454,for SN,0.803 and

关键词： Diagnostic performance Japan Narrow-Band Imaging Expert Team classification Pit pattern classification Sporadic neoplasms Ulcerative colitis Ulcerative colitis-associated neoplasms

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Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study

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World Journal of Gastroenterology 2020年第10期26卷 1056-1066页

作者： Ryo Nishio Hiroki kawashima Masanao Nakamura Eizaburo Ohno Takuya Ishikawa Takeshi Yamamura Keiko Maeda Tsunaki Sawada Hiroyuki Tanaka Daisuke Sakai Ryoji Miyahara Masatoshi Ishigami Yoshiki Hirooka Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineAichi PrefectureNagoya 4668550Japan Department of Endoscopy Nagoya University HospitalAichi PrefectureNagoya 4668550Japan Department of Liver Biliary Tract and Pancreas DiseasesFujita Health University HospitalAichi PrefectureToyoake 4701192Japan

BACKGROUND Double-balloon endoscopic retrograde cholangiography (DB-ERC) is widely performed for biliary diseases after reconstruction in gastrointestinal surgery,but there are few reports on DB-ERC after hepatectomy or living donor liver transplantation (LDLT).AIM To examine the success rates and safety of DB-ERC after hepatectomy or LDLT METHODS The study was performed retrospectively in 26 patients (45 procedures) who underwent hepatectomy or LDLT (liver operation:LO group) and 40 control patients (59 procedures) who underwent pancreatoduodenectomy (control group).The technical success (endoscope reaching the choledochojejunostomy site),diagnostic success (performance of cholangiography),therapeutic success(completed interventions) and overall success rates,insertion and procedure(completion of DB-ERC) time,and adverse events were compared between these *** There were no significant differences between LO and control groups in the technical [93.3%(42/45) vs 96.6%(57/59),P=0.439],diagnostic [83.3%(35/42) vs83.6%(46/55),P=0.968],therapeutic [97.0%(32/33) vs 97.7%(43/44),P=0.836],and overall [75.6%(34/45) vs 79.7%(47/59),P=0.617] success *** median insertion time (22 vs 14 min,P <0.001) and procedure time (43.5 vs 30 min,P=0.033) were significantly longer in the LO *** incidence of adverse events showed no significant difference [11.1%(5/45) vs 6.8%(4/59),P=0.670].CONCLUSION DB-ERC after liver operation is safe and useful but longer time is required,so should be performed with particular care.

关键词： Biliary tract diseases Double-balloon enteroscopy Endoscopic retrograde cholangiopancreatography Hepatectomy Liver transplantation Risk management

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Trend of Invasive Streptococcus agalactiae at Tertiary Care Hospital in Japan

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Journal of Biosciences and Medicines 2016年第3期4卷 15-20页

作者： Masaaki Minami Hideki Nishiyama Shinobu Ikegami Takuya Hattori Makoto kawashima Michio Ohta Department of Bacteriology Graduate School of Medical Sciences Nagoya City University Nagoya Japan Department of Clinical Laboratory Japanese Red Cross Nagoya Daiichi Hospital Nagoya Japan Department of Clinical Laboratory Japanese Red Cross Nagoya Daini Hospital Nagoya Japan School of Nursing Sugiyama Jyogakuen University Nagoya Japan

Streptococcus agalactiae causes various severe infectious diseases such as sepsis, meningitis, and streptococcal toxic shock-like syndrome. Though Streptococcus agalactiae infection has been increasing recently, the comprehensive characteristic investigation of invasive Streptococcus agalactiae isolated in tertiary care hospitals has not been nearly performed in Japan. In this study, we investigated the clinical characteristics and antimicrobial susceptible patterns of 88 Streptococcus agalactiae isolated at two tertiary care hospitals during 2009-2015 in Japan. There was no significant differences between genders in our study. Two-third Streptococcus agalactiae were isolated from over age 60. Total mortality rate was 19% and invasive Streptococcus agalactiae-associated death cases have occurred every year after 2011. All Streptococcus agalactiae were completely susceptible toampicillin. Total non-susceptible rates of erythromycin, minocycline, levofloxacin and trimethoprim-sulfamethoxazole in this study were approximately 30%, 44%, 37%, and 7%, respectively. Our results suggest the need for continuous antimicrobial susceptibility survey of Streptococcus agalactiae.

关键词： Streptococcus agalactiae Susceptibility Antimicrobial Resistance Epidemiology

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Quantitative Assessment of Chronic Skin Reactions Including Erythema and Pigmentation after Breast Conserving Therapy

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Advances in Breast Cancer Research 2016年第3期5卷 121-128页

作者： Miho kawashima Miwako Nozaki Kazuhiro Komazaki Ryuko Yamamuro Kazuo Ishizuna Makoto Kojima Department of Radiology Dokkyo Medical University Koshigaya Hospital Saitama Japan Breast Center Dokkyo Medical University Koshigaya Hospital Saitama Japan

Purpose: To evaluate long-term skin reactions following breast-conserving therapy by using the melanin-erythema index meter. Patients and Methods: 164 patients were followed for at least three years after breast-conserving therapy. For both the erythema and the melanin indices, the ratio of the irradiated-side index to the non-irradiated-side index was calculated. The time course of index ratios alternation was examined. Influences from additional therapies and patients’ age were also evaluated. Result: Both erythema and melanin index ratios of the breast skin were recovered to pre-radiation level three years after radiotherapy. However, both index ratios of the area administrated with 10-Gy boost irradiation were still high even after five years after radiotherapy. Endocrine therapy, chemotherapy and age had no significant influence on skin color reactions three years after radiotherapy. Conclusion: Quantitative assessment using the melanin-erythema index meter demonstrated that chronic skin reactions following breast conserving therapy had recovered to pre-radiation level for three years after irradiation except for the 10-Gy boost irradiated area.

关键词： Breast Cancer Erythema Index Melanin Index Breast-Conserving Therapy

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Microstructures and Photovoltaic Properties of Polysilane/C<sub>60</sub>-Based Solar Cells

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Materials Sciences and Applications 2012年第8期3卷 557-561页

作者： Atsushi kawashima Takeo Oku Atsushi Suzuki Kenji Kikuchi Shiomi Kikuchi Department of Materials Science The University of Shiga Prefecture Hikone Japan

Polysilane/C60-based solar cells were fabricated and investigated. Two-types of devices with bulk heterojunction and heterojunction structures were examined and characterized. Addition of silicon-based polymer to the organic solar cells improved the conversion efficiency by wide optical absorption and high carrier mobility. Microstructures of the solar cells were investigated by using X-ray diffraction and transmission electron microscopy. Energy levels in the present solar cells were discussed.

关键词： Bulk Heterojunction Polysilane Fullerene Microstructure

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20世纪以来中国外交史研究:以日本为中心

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社会科学研究 2011年第1期 134-144页

作者：川岛真东京大学综合文化研究科

随着中国在国际舞台上发挥出日益重要的影响力,一度沉寂的中国外交史与东亚国际政治史的相关研究再趋活跃。但由于受限于方法论上未对中国视角予以足够重视,以及中国自身档案利用上的不足,有关中国外交史的实证型研究仍不多见。笔者认为... 详细信息

随着中国在国际舞台上发挥出日益重要的影响力,一度沉寂的中国外交史与东亚国际政治史的相关研究再趋活跃。但由于受限于方法论上未对中国视角予以足够重视,以及中国自身档案利用上的不足,有关中国外交史的实证型研究仍不多见。笔者认为,通过整合从中国视角出发的东亚国际政治史与以往从外部展望的中国历史,将会形成崭新的东亚国际政治史。只有这样,由全球化、地区化等主要元素构成的目前的中国外交史才能成为具有历史视野的研究。本文通过梳理19世纪至20世纪初中国外交史及以中国为舞台的东亚国际政治史的研究,重新审视了研究史上的成果和课题,并结合近年来史料利用等研究环境的变化,展望今后的研究方向。

关键词：中国外交史东亚国际政治史中国视角

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Laparoscopic Choledochoduodenostomy for Biliary Alleviation

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Surgical Science 2017年第2期8卷 65-72页

作者： Hirotaka Okamoto Suguru Maruyama Kazunori Takahashi Kenji kawashima Toshio Fukasawa Hideki Fujii Department of Surgery Tsuru Municipal Hospital Tsuru Japan Gastrointestinal & Breast Endocrine Surgery Faculty of Medicine University of Yamanashi Yamanashi Japan

Choledochoduodenostomy (CDD) was very useful alternatives for treatment for patients with common bile duct (CBD) stones, especially recurrent stones, giant stones with choledochal dilatation, and difficult or failed cases by endoscopic treatment. Furthermore, CDD was also applied to biliary bypass by malignant obstruction. In these days, minimal invasive laparoscopic approach is adapted in these disorders. We have conducted to perform a laparoscopic CDD for biliary alleviation for patients with endoscopic management of difficult CBD stone with choledochal dilatation. A side-to-side CDD was created intra-corporeally using water-tight running absorbable suture by handmade 4-0 monofilament with double side needles, starting from the right side of choledochus, and continued along posterior wall until the left side of the choledochus followed by anterior-wall anastomosis as the same manner. Five patients were treated successfully by this laparoscopic procedure and remained well without bile leakage and reflux cholangitis for the short-term follow-up. The median operative time and intracorporeally anastomosis time were 182 (167 - 209) min and 33 (30 - 38) min, respectively. Median blood loss was 32 (little-90) ml, median hospital stay was 7 (5 - 14) days, and median follow-up time was 18 months. Although this series was relatively small, this laparoscopic technique is feasible and safe for biliary alleviation, especially for endoscopic management of difficult or failed CBD stones, and would also potentially adapt to biliary bypass by malignant obstruction.

关键词： Laparoscopic Choledochoduodenostomy Biliary Alleviation Endoscopic Management Difficult Choledocholithiasis

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In vivo histological diagnosis for gastric cancer using endocytoscopy

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World Journal of Gastroenterology 2017年第37期23卷 6894-6901页

作者： Issei Tsurudome Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Masanobu Matsushita Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki kawashima Osamu Watanabe Masato Nakaguro Akira Satou Yoshiki Hirooka Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Department of Endoscopy Nagoya University Hospital Department of Pathology and Laboratory Medicine Nagoya University Hospital Department of Surgical Pathology Aichi Medical University Hospital

AIM To examine usefulness of virtual biopsy using endocytoscopy by comparing the in vivo endocytoscopic and histopathological images of gastric *** Endocytoscopy was performed in 30 patients with early gastric cancer. Of these, 26 patients showed well differentiated adenocarcinomas, while 4 patients showed poorly differentiated adenocarcinomas(including one signet ring cell carcinoma). Cancerous and non-cancerous areas were observed after double staining with 0.05% crystal violet and 0.1% methylene blue. The endocytoscopic images obtained were evaluated by an expert endoscopist and an expert pathologist without knowledge of patient clinical data, and endocytoscopic and histopathological diagnoses were *** The endocytoscopic images of the cancerous area were assessed as evaluable in 25(83.3%) and 27(90%) patients by endoscopist A and pathologist B, respectively, and those of the non-cancerous area as evaluable in 28(93.3%) and 23(76.7%) patients by the endoscopist and pathologist, respectively. The sensitivity, specificity, and diagnostic accuracy of gastric cancer diagnosis using evaluable endocytoscopic images were 88.0% and 92.9%, and 90.6% by endoscopist A, and 88.9% and 91.3%, and 90.0% by pathologist B, respectively. Evaluation of the diagnostic concordance rate between the endoscopist and the pathologist by inter-observer agreement calculation revealed no significant difference between the two observers. The inter-observer agreement(κ-value) for endocytoscopic diagnosis was 0.745. CONCLUSION Endocytoscopy is useful for the differentiation of cancerous from non-cancerous gastric mucosa, making it a promising tool for virtual biopsy.

关键词： Endocytoscopy Gastric cancer Virtual biopsy In vivo histopathology Magnifying endoscopy Double staining Crystal violet Methylene blue

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柴油机缸盖垫片冷却液密封橡胶

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汽车与新动力 1996年第4期 15-23页

作者： Ohkawa S Lwakata K kawashima Y 刘艾礼沈勇

介绍强载柴油机缸盖垫片密封冷却液用的一种改进型硅橡胶的开发过程。

关键词：冷却液蓄冷材料缸盖垫片硅橡胶电工橡胶密封圈柴油机压燃发动机

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