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Superinfective Hepatitis E Virus Infection Aggravates Hepatocytes Injury in Chronic Hepatitis B

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Current Medical Science 2019年第5期39卷 719-726页

作者： Semvua Bukheti Kilonzo Yong-ii WANG Qun-qun JIANG Wen-yu WU Peng WANG Qin NING Mei-fang HAN Department and Institute of Infectious Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Hepatitis E virus(HEV)infection is a major cause of morbidity in endemic *** consequences among chronic hepatitis B(CHB)patients have been *** aim of this study was to assess the impact of superinfective HEV infection(acute and past)on virological and clinical features of patients with CHB ***,biochemical,virological and immunological data of 153 CHB patients including 98 with hepatitis B virus(HBV)monoinfection and 55 with HBV-HEV superinfection with both HEV and HBV infection was retrospectively investigated and analyzed in this study conducted in Wuhan,*** overall anti-HEV IgG seroprevalence was found to be 35.9% in CHB ***-HEV superinfection patients showed significantly higher rate of complications(ascites,hepato-renal syndrome&encephalopathy)(all with P=0.04),cirrhosis(P<0.001)and acute-on-chronic liver failure(P<0.001)than HBV monoinfection *** also displayed elevated ALTs(P<0.001)and total serum bilirubin(P<0.001)with diminished albumin(P<0.001)and HBV viral load(P<0.001).Cytokines assay revealed increased expression of IL-6(P=0.02),IL-10(P=0.009)and TNF-α(P=0.003)in HBVHEV superinfection patients compared to HBV monoinfection *** study demonstrated that HEV superinfection in CHB patients was associated with progressive clinical manifestation,which is likely due to the enhanced expression of cytokines related with hepatocytes *** was also associated with repressed HBV replication,but the underlying mechanism requires further investigation.

关键词： hepatitis E hepatitis B superinfection liver failure replication

Succinate: A microbial product that modulates Drosophila nutritional physiology

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Insect Science 2022年第1期29卷 315-318页

作者： Freya Q.Zhang John G.McMullen ii Angela E.Douglas Nana Y.D.Ankrah Department of Entomology Cornell UniversityIthacaNY 14853USA Department of Molecular Biology and Genetics Cornell UniversityIthacaNY 14853USA Department of Biological Sciences State University of New York at PlattsburghPlattsburghNY 12901USA

Dear Editor,Gut microorganisms process food in animal guts and release many metabolic by-products,which are predicted to influence host physiological processes such as energy and lipid ***,we investigate how succi-nate,a TCA cycle intermediate that is a major predicted release product of gut bacteria in Drosophila,influences the nutritional physiology of its Drosophila *** ad-ministered succinate as a dietary supplement to microbe-free Drosophila,and quantified key nutritional *** succinate significantly reduced fly lipid levels by up to~50%.This response was not replicated in paral-lel experiments conducted with dietary fumarate supple-ment,indicating that it could not be attributed to a gen-eral effect of TCA *** hypothesize that microbe-derived succinate may contribute to the reduced lipid content of Drosophila bearing gut bacteria,relative to axenic *** generally,this study high-lights the importance of microbial-derived metabolites as regulators of host metabolism.

关键词： release intermediate attributed

基于多层次神经网络与多点位的核电站高压开关设备无线测温方法

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环境技术 2024年第5期42卷 182-187页

作者：曹双华翁黎明陈锋刘双洪诗鑫凌世情核电运行研究(上海)有限公司上海200125 三门核电有限公司台州317100 中核国电漳州有限公司漳州363300

光线条件、视角和拍摄距离等因素影响下,温感成像质量较差,且数据泄露或被篡改的风险较大,高压开关设备温度信息存在偏差或不稳定线性,导致无线测温过程的温度拟合增益系数较低。为此,提出基于多层次神经网络与多点位的核电站高压开关... 详细信息

光线条件、视角和拍摄距离等因素影响下,温感成像质量较差,且数据泄露或被篡改的风险较大,高压开关设备温度信息存在偏差或不稳定线性,导致无线测温过程的温度拟合增益系数较低。为此,提出基于多层次神经网络与多点位的核电站高压开关设备无线测温方法。通过放射性结构的拍摄点位布设方案,获取温感图像,并对其进行灰度阈值分割处理;采用领域平均法,结合多点位需求,对获取到的二值温感图像进行平滑处理,并构建多层次神经网络,将二值温感图像作为输入,通过卷积层以及激活函数,增强其非线性映射能力,分析与计算具有平滑期望值的无线测温结果即设备表面的温度值预测值。实验结果表明,该方法应用后,测温结果的温度拟合增益系数更高,具备更为理想的测温精度,为核电站高压开关设备的无线测温提供了准确、可靠的技术支持。

关键词：神经网络核电站开关设备无线测温温感图像

Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands

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World Journal of Gastroenterology 2017年第38期23卷 7047-7053页

作者： Shigeo Manabe Ken-ichi Mukaisho takayuki Yasuoka Fumitaka Usui Tatsuzo Matsuyama Ikuhiro Hirata Yoshio Boku Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Department of Pathology Shiga University of Medical Science Fujita Clinic

Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type ii gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG.

关键词： Gastric adenocarcinoma of fundic gland type Heterotopic gastric glands Endoscopic submucosal dissection Paracancerous lesion Pepsinogen-I H/K-ATPase

TiO2 nanotube branched tree on a carbon nanofiber nanostructure as an anode for high energy and power lithium ion batteries

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Nano Research 2014年第4期7卷 491-501页

作者： Taeseup Song Hyungkyu Han Heechae Choi Jung Woo Lee Hyunjung Park Sangkyu Lee Won ii Park Seungchul Kim Li Liu Ungyu Paik Department of Materials Science Engineering Hanyang University Seou113 3-791 Korea Center for ComputationalScience Korea Institute of Science and Technology Seou1136-791 Korea School of Chemistry Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education Xiangtan University Xiangtan 411105 China

The inherently low electrical conductivity of TiO2-based electrodes as well as the high electrical resistance between an electrode and a current collector represents a major obstacle to their use as an anode for lithium ion batteries. In this study, we report on high-density TiO2 nanotubes （NTs） branched onto a carbon nanofiber （CNF）＂tree＂ that provide a low resistance current path between the current collector and the TiO2 NTs. Compared to a TiO2 NT array grown directly on the current collector, the branched TiO2 NTs tree, coupled with the CNF electrode, exhibited -10 times higher areal energy density and excellent rate capability （discharge capacity of -150 mA.h.g-1 at a current density of 1,000 mA·g-1）. Based on the detailed experimental results and associated theoretical analysis, we demonstrate that the introduction of CNFs with direct electric contact with the current collector enables a significant increase in areal capacity （mA·h·cm-2） as well as excellent rate capability.

关键词： titanium dioxide carbon nanofibers areal capacity lithium ion batteries

Caution Remains After Blinken's Visit

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Beijing Review 2023年第27期66卷 20-21页

作者： Thomas W.Pauken ii Asia-Pacific affairs

Taking note of *** relations in recent years,we could conclude that relations between the two most powerful nations in the world have reached disturbing new lows and that might lead to much worse yet to *** of State Antony Blinken had described ties between Beijing and Washington,***“unstable”before embarking on his two-day trip to China's capital on June 18-19.

关键词： conclude unstable Blink

Parallel Scientific Computing in C++ and MPI: A Seamless Approach to Parallel Algorithms and their Implementation 1st edition

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Do you want to keep your customers forever?

2003年

作者： Karniadakis Kirby ii

ISBN: (数字)9781107481190

ISBN: (纸本)9780521520805

Numerical algorithms, modern programming techniques, and parallel computing are often taught serially across different courses and different textbooks. The need to integrate concepts and tools usually comes only in employment or in research - after the courses are concluded - forcing the student to synthesise what is perceived to be three independent subfields into one. This book provides a seamless approach to stimulate the student simultaneously through the eyes of multiple disciplines, leading to enhanced understanding of scientific computing as a whole. The book includes both basic as well as advanced topics and places equal emphasis on the discretization of partial differential equations and on solvers. Some of the advanced topics include wavelets, high-order methods, non-symmetric systems, and parallelization of sparse systems. The material covered is suited to students from engineering, computer science, physics and mathematics.

关键词： Data transmission systems.

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Factors associated with increased incidence of severe toxicities following yttrium-90 resin microspheres in the treatment of hepatic malignancies

作者： B. Joseph Pine ii Don Peppers and Martha Rogers.

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World Journal of Gastroenterology 2016年第10期22卷 3006-3014页

作者： John D Roberson ii Andrew M Mc Donald Craig J Baden Chee Paul Lin Rojymon Jacob Omer L Burnett iiI School of Medicine University of Alabama at Birmingham Birmingham AL 35294-3412 United States Department of Radiation Oncology University of Alabama at Birmingham Birmingham AL 35233 United States Center for Clinical and Translational Science University of Alabama at Birmingham Birmingham AL 35205 United States

AIM: To further define variables associated with increased incidences of severe toxicities following administration of yttrium-90 (90Y) ***: Fifty-eight patients undergoing 79 treatments were retrospectively assessed for development of clinical and laboratory toxicity incidence following 90Y administration. Severe toxicity events were defined using Common Terminology Criteria for Adverse Events version 4.03 and defined as grade ≥ 3. Univariate logistic regression analyses were used to evaluate the effect of different factors on the incidence of severe toxicity events. Multicollinearity was assessed for all factors with P 90Y microsphere therapy.

关键词： Yttrium-90 microspheres Liver metastases Multivariate analysis Toxicity incidence Colorectal adenocarcinoma