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World Journal of Gastroenterology 2018年第37期24卷 4291-4296页

作者： Hideki Ishimaru Minoru Morikawa takayuki sakugawa Ichiro Sakamoto Yasuhide Motoyoshi Yohei Ikebe Masataka Uetani Department of Radiology Nagasaki University HospitalNagasaki 852-8501Japan Department of Radiology Nagasaki Harbor Medical CancerNagasaki 850-8555Japan Department of Gastroenterology Nagasaki Harbor Medical CancerNagasaki 850-8555Japan Department of Radiological Sciences Nagasaki University Graduate School of Biomedical SciencesNagasaki 852-8501Japan

A male patient underwent conventional transcatheter chemoembolization for advanced recurrent hepatocellular carcinoma(HCC). Even after the injection of 7 m L of lipiodol followed by gelatin sponge particles, the flow of feeding arteries did not slow down. A repeat angiography revealed a newly developed vascular lake draining into systemic veins; however, embolization was continued without taking noticing of the vascular lake. The patient's level of consciousness deteriorated immediately after the procedure, and non-contrast computed tomography revealed pulmonary and cerebral lipiodol embolisms. The patient's level of consciousness gradually improved after 8 wk in intensive care. In this case, a vascular lake emerged during chemoembolization and drained into systemic veins, offering a pathway carrying lipiodol to pulmonary vessels, the most likely cause of this serious complication. We should be aware that vascular lakes in HCC may drain into systemic veins and can cause intratumoral arteriovenous shunts.

关键词： Transcatheter arterial chemoembolization Arteriovenous shunt Hepatocellular carcinoma Vascular lake Cerebral embolism

Temporal trends in organophosphorus pesticides use and concentrations in river water in Japan, and risk assessment

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Journal of Environmental Sciences 2019年第5期31卷 135-152页

作者： Aly Derbalah Russel Chidya Waqar Jadoon Hiroshi sakugawa Graduate School of Biosphere Science 1-7-1 Pesticides Chemistry and Toxicology Department Faculty of Agriculture Kafrelsheikh University Department of Water Resources Management and Development Faculty of Environmental Sciences Mzuzu University

We reviewed organophosphorus pesticide use in Japan between 1982 and 2016 using data from the National Institute of Environmental Studies. Organophosphorus pesticide concentrations in river water throughout Japan were taken from the literature, and risk assessments were performed for some organophosphorus pesticides based on risk quotients and hazard quotients. Assessments were performed for 20 common pesticides,including insecticides, fungicides, and herbicides. The amounts used decreased in the order: insecticides > herbicides > fungicides. Organophosphorus insecticide and fungicide use have decreased over the last four decades, but organophosphorus herbicide use has increased. During this period, annual organophosphorus pesticide use was the highest for chlorpyrifos(105,263 tons/year) and the lowest for glyphosate-sodium(8 tons/year). The ecotoxicological risk assessment indicated that diazinon and fenitrothion posed strong risks to the Japanese aquatic environment, and chlorpyrifos and malathion have moderate risks. None of the pesticides that were assessed posed significant risks to *** use of organophosphorus pesticides in Japan may cause strong risks to aquatic environments. These risks should be reassessed periodically.

关键词： Organophosphorus Pesticide residue Risk quotient Hazard quotient Japan Water

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Simultaneous photoinduced generation of Fe^(2+) and H_2O_2 in rivers:An indicator for photo-Fenton reaction

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Journal of Environmental Sciences 2016年第9期28卷 34-38页

作者： Khan M.G.Mostofa Hiroshi sakugawa Institute of Surface-Earth System Science Tianjin University Graduate School of Biosphere Science Department of Environmental Dynamics and ManagementHiroshima University

The photo-Fenton reaction is a key source of the highly reactive hydroxyl radical（HOU） that is produced by the reaction of simultaneous photo-induced generation of Fe^（2＋）-dissolved organic matter（DOM） with H_2O_2 in sunlit surface waters as well as in the treatment of organic pollutants in the advanced oxidation processes（AOPs）.Concentrations of both H_2O_2 and Fe^（2＋）-DOM were dependent on time and total solar intensity flux,and their levels were highest in the diurnal samples collected at noon compared with the samples collected during the period before sunrise and after sunset.H_2O_2 and Fe^（2＋）-DOM concentrations during monthly readings were also found higher in comparison with the diurnal samples,shortly before sunrise or after sunset.A π-electron bonding system is formed between Fe and the functional groups in DOM（Fe-DOM）,through electron donation from the functional groups of DOM to an empty d-orbital of *** π-electron is loosely bound and is highly susceptible to a rapid excitation upon light exposure that will provide better understanding of the formation of aqueous electrons,superoxide radical anions,H_2O_2 and finally,photo-Fenton reactions,*** results imply that simultaneous generation of H_2O_2 and Fe^（2＋）-DOM upon sunlight exposure during the daytime is most likely to be the key photo-Fenton reaction pathway,taking place in surface waters.

关键词： Photo-Fenton reaction Fe^(3+) Fe^(2+) Dissolved organic matter H_2O_2 Light

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Predictors of residual force enhancement in voluntary contractions of elbow flexors

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Journal of Sport and Health Science 2018年第3期7卷 318-325页

作者： Heiliane de Brito Fontana Daiani de Campos Raphael Luiz sakugawa Biological Sciences Center Federal University of Santa CatarinaCampus Reitor Joao David Ferreira LimaFlorianopoilsSC 88040-900Brazil Biomechanic Laboratory Federal University of Santa CatarinaCampus Reitor Joao David Ferreira LimaFlorianopolisSC 88040-900Brazil

Background:The steady-state increase in muscle force generating potential following a lengthening contraction is called residual force enhancement(RFE).In this study,we aimed to test for differences in torque,electromyographic activity(EMG),and the associated neuromuscular efficiency(NME)between isometric voluntary contractions of elbow flexors preceded and not preceded by a lengthening *** dependence of such differences on(i)stretch amplitude,(ii)the region of the force-length(FxL)relationship where contraction occurs,and(iii)the individual's ability to produce(negative)work during the stretch was ***:Sixteen healthy adults participated in the *** flexor torque,angle,and biceps brachii EMG for purely isometric contractions(reference contractions)and for isometric contractions preceded by active stretches of 20°and 40°were measured at the ascending,plateau,and descending regions of subject-specific FxL *** contractions were performed in an isokinetic ***-factor(stretch×FxL region)repeated measures analysis of variance ANOVAs was used to analyze the effect of active stretch on EMG,torque,and NME across *** relationships between mechanical work during stretch-calculated as the torque-angular displacement integral-and the changes in EMG,torque,and NME were analyzed using Pearson ***:In general,torque,EMG,and NME following active stretches differed from the values observed for the purely isometric reference *** although the detailed effects of active stretch on torque and EMG differed between regions of the FxL relationship,NME increased by about 19%for all muscle *** to 30%of the interindividual variability in torque generating potential change in response to active stretching was accounted for by differences in(negative)work capacity between ***:Our results suggest that(i)RFE contributes to"flatten"the elbow flexor torque-angle relationship,favoring

关键词： Force-length History-dependent properties Neuromuscular efficiency Upper limb Voluntary contractions

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12 Cool Ways to Use Rubber Bands

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英语画刊（高三·社会综合版） 2012年第11期 22-23页

作者： Yumi sakugawa

如果你还以为皮筋是非常不起眼的东西，那么就来看看日本女孩由美能赋予小小的皮筋什么不一样的生命吧。

关键词：高中英语课外阅读阅读材料

A single nucleotide polymorphism in SPA TA17 may be a genetic risk factor for Japanese patients with meiotic arrest

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Asian Journal of Andrology 2009年第5期11卷 623-628,I0004,I0005页

作者： Toshinobu Miyamoto[日本] Akira Tsujimura[日本] Yasushi Miyagawa[日本] Eitetsu Koh[日本] Naoko sakugawa[日本] Hiroe Miyakawa[日本] Hisashi Sato[日本] Mikio Namiki[日本] Akihiko Okuyama[日本] Kazuo Sengoku[日本] Department of Obstetrics and Gynecology Asahikawa Medical College Asahikawa Hokkaido 078-851 O Japan＂ Department of Urology Graduate School of Medicine Osaka University Suita 565-0871 Japan＂ Department of Integrated Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa920-8641 Japan

Genetic mechanisms have been implicated as a cause of some cases of male infertility. Recently, 10 novel genes involved in human spermatogenesis were identified by microarray analysis of human testicular tissue. One of these is spermatogenesis-associated 17 （SPATA17）. To investigate whether defects in the SPATA17 gene are associated with azoospermia due to meiotic arrest, a mutational analysis was conducted, in which the SPATA17 coding regions of 18 Japanese patients with this condition were sequenced. A statistical analysis was carried out that included 18 patients with meiotic arrest, 20 patients with Sertoli-cell-only syndrome （SCOS） and 96 healthy control men. No mutations were found in SPA TA17. However, three coding single nucleotide polymorphisms （cSNPs： SNP 1-SNP3） were detected in the patients with meiotic arrest. No significant differences in the genotype or allele frequencies of SNP1 and SNP2 were found between patients with meiotic arrest and the others. However, the frequency of the SNP3 allele was significantly elevated in the meiotic arrest group （P 〈 0.05）. This study suggests that SPATA17 may play a critical role in human spermatogenesis, especially in meiosis.

关键词： azoospermia meiosis polymorphism SNP SPATA17

Flexible Control of Pulsed Power for Biomedical Applications Using PC

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Journal of Chemistry and Chemical Engineering 2011年第5期5卷 410-412页

作者： Masahiro Akiyama Mamoru Suemitsu Eri Shiraishi Yasuhiro Ohshima Takahisa Ueno Takashi sakugawa Hidenori Akiyama Ichinoseki National College of Technology Takanashi Hagisho lchinoseki-shi 021-8511 Japan Graduate School of Science and Technology Kumamoto University Kurokami Kumamoto 2-39-1 Japan Faculty of Enginnering Sojo University Ikeda Kumamoto 4-22-1 Japan Oita National College of Technology Maki Oita 1666 Japan

This work aims to control pulsed power for biomedical fields, which demands sensitive parameters. The pulsed power consists of a voltage rise time of less than 50 ns and charging energy to 1.0 J/pulse; also, the pulse control area includes pulse interval pulse shot number, output voltage. To achieve this system, a pulsed power system exists including software running on PC, universal serial bus （UgB~ for connection, and FPGA controller. Using the software for complex control of pulsed power will enable expansion into various fields with easy operation.

关键词： Pulsed power bioelectrics. FPGA MPC industrial application flexible control.

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地下空间内工作的心理效应

地下空间与工程学报 1991年第2期 164-170页

作者： Yuji Wada,Hinako sakugawa,宋伟工程兵工程学院日本日本

尽管已进行了一些有关地下空间内工作的心理效应研究,却很少有这种效应的试验和定量分析。本文介绍了日本地下空间(如:地铁车站、购物中心)内工作的心理效应,分析了地面及地下几个实验室空间的心理和生理效应,测量了几个环境系统(如阳... 详细信息

尽管已进行了一些有关地下空间内工作的心理效应研究,却很少有这种效应的试验和定量分析。本文介绍了日本地下空间(如:地铁车站、购物中心)内工作的心理效应,分析了地面及地下几个实验室空间的心理和生理效应,测量了几个环境系统(如阳光导向系统,闭路电视)的效果。作者认为;各种条件下地下空间内工作的心理效应和实验室“转换效应”十分明显。

关键词：地下可接受性地下空间心理效应

Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2005年第2期11卷 255-259页

作者： Hiroshi sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito First Department of Internal Medicine Faculty of MedicineSchool of MedicineUniversity of the RyukyusOkinawaJapan

AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease. However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type VI collagen 7S domain and hyaluronic acid. METHODS: One hundred and twelve patients with histologically proven NAFLD were studied. RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type VI collagen 75 domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type VI collagen 7S domain, 86% and hyaluronic acid, 92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type VI collagen 7S domain (≥5.0 ng/mL), 84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis. CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis.

关键词： Liver fibrosis Nonalcoholic fatty liver disease Collagen type IV Hyaluronic acid

Classifying genotype F of hepatitis B virus into F1 and F2 subtypes

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World Journal of Gastroenterology 2005年第40期11卷 6295-6304页

作者： Hideaki Kato Kei Fujiwara Robert G. Gish Hiroshi sakugawa Hiroshi Yoshizawa Fuminaka Sugauchi Etsuro Orito Ryuzo Ueda Yasuhito Tanaka Takanobu Kato Yuzo Miyakawa Masashi Mizokami Department of Internal Medicine and Molecular Science Hepatology and Gastroenterology First Department of Medicine Department of Epidemiology and Control of Infectious Diseases Department of Clinical Molecular Informative Medicine Miyakawa Memorial Research Foundation

AIM： To explore the propriety of providing hepatitis B virus （HBV） genotypes F and H with two distinct genotypes. METHODS： Eleven HBV isolates of genotype F （HBV/F） were recovered from patients living in San Francisco, Japan, Panama, and Venezuela, and their full-length sequences were determined. Phylogenetic analysis was carded out among them along with HBV isolates previously reported. RESULTS： Seven of them clustered with reported HBV/F Isolates in the phylogenetic tree constructed on the entire genomic sequence. The remaining four flocked on another branch along with three HBV isolates formerly reported as genotype H. These seven HBV isolates, including the four in this study and the three reported, had a sequence divergence of 7.3-9.5% from the other HBV/F isolates, and differed by 〉13.7% from HBV isolates of the other six genotypes （A-E and G）. Based on a marked genomic divergence, falling just short of 〉8% separating the seven genotypes, these seven HBV/F isolates were classified into F2 subtype and the former seven into F1 subtype provisionally. In a pairwise comparison of the S-gene sequences among the 7 HBV/F2 isolates and against 47 HBV/F1 isolates as well as 136 representing the other six genotypes （A-E and G）, two clusters separated by distinct genetic distances ***： Based on these analyses, dassifying HBV/ F isolates into two subtypes （F1 and F2） would be more appropriate than providing them with two distinct genotypes （F and H）.

关键词： Genotypes Hepatitis B virus Phylogeneticanalysis Subtypes