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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli Guo takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli Guo Chikako Harada takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

Surface modification and characterization of F-Co doped spinel LiMn_2O_4

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Rare Metals 2006年第Z1期25卷 33-38页

作者： WATANABE takayuki Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259 Nagatsuta Yokomaha 226-8502 Japan

Spinel LiCo0.09Mn1.91O3.92F0.08 as cathode material was modified with LiCoO2 by the sol-gel method, and the crystal structure, morphology and electrochemical performance were characterized with XRD, SEM, EDS, AAS and charge-discharge test in this paper. The results show that a good clad coated on parent material can be synthesized by the sol-gel method, and the materials with modification have perfect spinel structure. LiCo0.09Mn1.91O3.92F0.08 materials coated by LiCoO2 improve the stability of crystal structure and decrease the dissolution of Mn into electrolyte. With the LiCoO2 content increasing, the specific capacity and cycle performance of samples are improved. The capacity loss is also suppressed distinctly even at 55 ℃.

关键词： lithium ion batteries spinel LiMn2O4 ion doping surface coating

Prevention of recurrence after surgery for Crohn's disease: Efficacy of infliximab

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World Journal of Gastroenterology 2010年第43期16卷 5405-5410页

作者： takayuki Yamamoto Inflammatory Bowel Disease Center and Department of Surgery Yokkaichi Social Insurance Hospital

After surgery for Crohn's disease (CD), early endoscopic lesions are frequently observed despite no symptomatic recurrence. The severity of lesions found at postoperative endoscopy is reported to be a strong predictive factor for future clinical recurrence. If endoscopic lesions in the early postoperative period can be reduced with medications, symptomatic recurrence will likely be delayed and decreased. Before the introduction of biologic therapies, various medications were used for the maintenance of clinical remission after surgery; however, few demonstrated consistent efficacy. Infliximab is a recombinant anti-tumor necrosis factor-α antibody. Although infliximab is one of the most effective medications in the management of CD, its efficacy for early endoscopic lesions after surgery has not yet been assessed. The author and colleagues recently conducted a prospective study in order to investigate the impact of infliximab on early endoscopic lesions after resection for CD. We found that infliximab therapy showed clear suppressive effects on clinical and endoscopic disease activity in patients with early endoscopic lesions after resection.

关键词： Crohn’s disease Postoperative recurrence Endoscopic lesion Infliximab

Factors affecting recurrence after surgery for Crohn's disease

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World Journal of Gastroenterology 2005年第26期11卷 3971-3979页

作者： takayuki Yamamoto Inflammatory Bowel Disease Center and Department of Surgery Yokkaichi Social Insurance Hospital YokkaichiMie 510-0016Japan

Although in Crohn's disease post-operative recurrence is common, the determinants of disease recurrence remain speculative. The aim of this study was to examine factors affecting post-operative recurrence of Crohn's disease. A Medline-based literature review was carried out. The following factors were investigated: age at onset of disease, sex, family history of Crohn's disease,smoking, duration of Crohn's disease before surgery,prophylactic medical treatment (corticosteroids, 5-amino salicylic acid [5-ASA] and immunosuppressants),anatomical site of involvement, indication for surgery (perforating or non-perforating disease), length of resected bowel, anast-omotic technique, presence of granuloma in the specimen, involvement of disease at the resection margin, blood transfusions and postoperative complications. Smoking significantly increases the risk of recurrence (risk is approximately twice as high), especially in women and heavy smokers. Quitting smoking reduces the post-operative recurrence rate. A number of studies have shown a higher risk when the duration of the disease before surgery was short. There were, however, different definitions of 'short' among the studies. Prophylactic cortic-osteroids therapy is not effective in reducing the post-operative recurrence. A number of randomized controlled trials offered evidence of the efficacy of 5-ASA (mesalazine) in reducing post-operative recurrence. Recently, the thera-peutic efficacy of immunosuppressive drugs (azathioprine and 6-mercaptopurine) in the prevention of post-operative recurrence has been investigated and several studies have reported that these drugs might help prevent the recurrence. Further clinical trials would be necessary to evaluate the prophylactic efficacy of *** studies showed a higher recurrence rate in patients with perforating disease than in those with non-perforating disease. However, evidence for differing recurrence rates in perforating and non-perforating dis

关键词： Crohn's disease Post-operative recurrence Predictive factors Resection Surgery

Decomposition of Glycerine by Water Plasmas at Atmospheric Pressure

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Plasma Science and Technology 2013年第4期15卷 357-361页

作者： takayuki WATANABE NARENGERILE Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259 NagatsutaYokohama 226-8502 Japan

High concentration of aqueous glycerine was decomposed using a direct current （DC） plasma torch at atmospheric pressure. The torch can generate the plasma with water as the plasma-supporting gas in the absence of any additionM gas supply system and cooling devices. The results indicated that 5 mol% glycerine was completely decomposed by water plasmas at arc powers of 0.55~1.05 kW. The major products in the effluent gas were H2 （68.9%~71.1%）, CO2 （18.9%~23.0%）, and CO （0.2%~0.6%）. However, trace levels of formic acid （HCOOH） and formaldehyde （HCHO） were observed in the liquid effluent. The results indicated that the water plasma waste treatment process is capable of being an alternative green technology for organic waste decomposition.

关键词： thermal plasma water plasma glycerine decomposition

Accelerating N-Body Simulation of Self-Gravitating Systems with Limited First-Order Post-Newtonian Approximation

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Communications in Computational Physics 2019年第1期25卷 68-83页

作者： takayuki Tatekawa Department of Social Design Engineering National Institute of TechnologyKochi College200-1 Monobe-OtsuNankokuKochi 783-8508Japan Research Institute of Science and Engineering Waseda University3-4-1 OkuboShinjukuTokyo 169-8555Japan

In this study,an N-body simulation code was developed for self-gravitating systems with a limited first-order post-Newtonian *** code was applied to a special case in which the system consists of one massive object and many low-mass ***,the behavior of stars around the massive black hole could be analyzed.A graphics processing unit(GPU)was used to accelerate the code exe-cution,and it could be accelerated by several tens of times compared to a single-core CPU for N≃104 objects.

关键词： Particle simulations N-body simulations general relativity GPGPU

From Fruit Omics to Fruiting Omics: Systematic Studies of Tomato Fruiting by Metabolic Networks

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Molecular Plant 2020年第8期13卷 1114-1116页

作者： takayuki Tohge Graduate School of Biological Science Nara Institute of Science and Technology(NAIST)Ikoma 630-0192Japan

Understanding metabolic shifts and the regulatory network during fleshy fruiting in fruit crops is highly valuable for the design of crop improvement targeting better plant growth,fruit yield,stress tolerance,fruit shelf-life,nutritional quality,and health ***"fruit omics"approach,which is an integrative omics analysis focusing on fruit development and ripening,has been highly developed for tomato species after its genome was *** the current advantage of next-generation sequencing for transcriptomics and the significant development of mass spectrometry-based metabolomics,tomato fruit omics studies have provided many key insights on metabolic shifts and networks during fruit ripening with fruit organ *** studies have focused on primary metabolites as well as"specialized(secondary)metabolites,"which are phytochemicals with bioactivities that can confer health benefits and act as stress protectants,because of their usability in crop improvement.

关键词： crops specialized benefits

Synthesis and Characterization of LiCo_xMn_(2-x)O_4 Cathode Materials

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Journal of Wuhan University of Technology(Materials Science) 2007年第2期22卷 307-310页

作者：姚耀春 takayuki Watanabe Faculty of Materials and Metallurgy Engineering Kunming University of Science and Technology Department of Environmental Chemistry and Engineering Tokyo Institute of Technology4259 Nagatsuta

LiCoxMn2.04 cathode materials for lithium ion batteries were synthesized by mechanical activation-solid state reaction at 750 ℃ for 24 h in air atmosphere, and their crystal structure, morphology, element composition and electrochemical performance were characterized with XRD, SEM, ICP-AES and charge-discharge test. The experimental results show that all samples have a single spinel structure, well formed crystal shape and uniformly particle size distribution. The lattice parameters of LiCo Mn2-xO4 decrease and the average oxidation states of manganese ions increase with an increase in Co content. Compared with pure LiMn2O4, the LiCo Mn2xO4 （x=0.03-0.12） samples show a lower special capacity, but their cycling life are improved. The capacity loss of LiCo009Mn191O4 and LiCo0.1Mn1.88O4 is only 1.85% and 0.95%, respectively, after the 20th cycle. The improvement of the cycle performance is attributed to the substitution of Co at the Mn sites in the spinel structure, which suppresses the Jahn-Teller distortion and improves the structural stability.

关键词： lithium ion batteries cathode materials spinel LiMn2O4 mechanical activation-solid state method Co-doping