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Optimal treatment strategies for hepatic portal venous gas:A retrospective assessment

World Journal of Gastroenterology 2020年第14期26卷 1628-1637页

作者： Masanori Gonda Tatsuya Osuga Yoshihiro Ikura Kazunori Hasegawa Kentaro Kawasaki takatoshi Nakashima Department of Gastroenterology Takatsuki General HospitalTakatsuki 5691192Japan Department of Pathology Takatsuki General HospitalTakatsuki 5691192Japan Department of Surgery Takatsuki General HospitalTakatsuki 5691192Japan

BACKGROUND Hepatic portal venous gas(HPVG)generally indicates poor prognoses in patients with serious intestinal *** surgical removal of the damaged portion is effective,some patients can recover with conservative *** To establish an optimal treatment strategy for HPVG,we attempted to generate computed tomography(CT)-based criteria for determining surgical indication,and explored reliable prognostic factors in non-surgical *** Thirty-four cases of HPVG(patients aged 34-99 years)were *** for surgery had been determined mainly by CT findings(***-air,embolism,lack of contrast enhancement of the intestinal wall,and intestinal pneumatosis).The clinical data,including treatment outcomes,were analyzed separately for the surgical cases and non-surgical *** Laparotomy was performed in eight cases(surgical cases).Seven patients(87.5%)survived but one(12.5%)*** each case,severe intestinal damage was confirmed during surgery,and the necrotic portion,if present,was ***-occlusive mesenteric ischemia was the most common cause(n=4).Twentysix cases were treated conservatively(non-surgical cases).Surgical treatments had been required for twelve but were abandoned because of the patients’poor general ***,however,three(25%)of the twelve inoperable patients *** remaining 14 of the 26 cases were diagnosed originally as being sufficiently cured by conservative treatments,and only one patient(7%)*** analyses of the fatal(n=10)and recovery(n=16)cases revealed that ascites,peritoneal irritation signs,and shock were significantly more frequent in the fatal *** mortality was 90%if two or all of these three clinical findings were *** HPVG related to intestinal necrosis requires surgery,and our CT-based criteria are probably useful to determine the surgical *** non-surgical cases,ascites,peritoneal irritation signs and shock were closely associated

关键词： Hepatic portal venous gas Surgical treatment Conservative treatment Computed tomography Intestinal necrosis Prognostic factor

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The impact of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)on liver tumors with unusual indications

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 477-480页

作者： Kensuke Yamamura Toru Beppu Tatsunori Miyata Shinichi Akahoshi takatoshi Ishiko Department of Surgery Yamaga City Medical CenterYamagaJapan Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamotoJapan

An associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has been developed as a novel surgical technique for patients with insufficient future liver remnant volume even after portal vein embolization(PVE)±hepatic arterial or venous embolization or conventional two-stage hepatectomy(TSH)(1-5).ALPPS was thought to be a breakthrough but high-risk procedure;however,it recently became a safer technique after the developing phase(1-3).Conversion surgery is strongly recommended for patients with initially unresectable liver tumors that are deemed resectable by systemic chemotherapy or hepatic arterial chemotherapy/embolization(6,7).The primarily targeted diseases are colorectal liver metastases(CRLM)and hepatocellular carcinoma(HCC).ALPPS is indicated for patients undergoing not only primary surgery but also conversion surgery.

关键词： ALPPS chemotherapy hepatectomy

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A novel comprehensive ALPPS preoperative risk assessment (CAPRA) score is beneficial in creating a treatment strategy for advanced liver malignancy

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 287-290页

作者： Kensuke Yamamura Toru Beppu Tatsunori Miyata Hirohisa Okabe Katsunori Imai takatoshi Ishiko Department of Surgery Yamaga City Medical CenterYamagaJapan Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamotoJapan

Curability and safety are essential for patients with advanced liver malignancy undergoing extended liver *** the future liver remnant(FLR)volume is insufficient,portal embolization with or without hepatic arterial or venous embolization or a conventional two-stage hepatectomy(TSH)can be performed(1,2).Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)was introduced in 2007.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) comprehensive ALPPS preoperative risk assessment(CAPRA)score mortality

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Successful restructuring of the banking system is critically important

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中国金融家 2004年第7期 75-76页

作者： takatoshi Kato Deputy managing Director of the International Monetary Fund

China has been one of the bright spots of the global economy over the last Several years. Indeed, China’s foresight in opening its markets to international trade and joining the WTO has resulted in an on-going dramatic and rapid integration of China into the world economy. In particular, this process is providing substantial benefits to China and to the Asian region. To foster sustained strong economic growth in China, successful restructuring of the banking system is critically important. The overall size of the banking system relative to GDP,

关键词： In Successful restructuring of the banking system is critically important rate

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Productivity Growth in the Chinese Economy by Industry and the Role of Foreign Capital

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China & World Economy 2005年第5期13卷 56-67页

作者： Kiyoshi Fujikawa takatoshi Watanabe Konan University Japan Faculty of Commerce Aichi-Gakuin University Japan

The purpose of this paper is to estimate total factor productivity （TFP） growth in China by industry. As well as reviewing some previous studies on TFP growth in China, the authors present their estimation of TFP growth in China for two periods, 1987-1992 and 1992-1997. During both periods, output growth was as high as double digits. However, the differences in TFP growth between these two periods were remarkable. In the first period, wide-ranging TFP growth was observed, whereas in the latter period, high TFP growth was concentrated in industries such as ＂transportation equipment＂ and ＂electric machinery＂, which are known for actively introducing foreign capital and technologies. In fact, positive relations were confirmed among TFP growth, export performance, and the introduction of foreign capital. Foreign capital made a large contribution to China＇s exportled growth.

关键词： Total Factor Productivity (TFP) input-output table foreign capital

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Modulatory Effect of Motivation on the Association of Trait Anxiety and Cognitive Performance: A Pupillometric Study

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Journal of Behavioral and Brain Science 2017年第7期7卷 273-286页

作者： takatoshi Hoshino Yoshihiko Tanno Department of Psychoinformatics Kanazawa Institute of Technology Ishikawa Japan Graduate School of Arts and Sciences The University of Tokyo Tokyo Japan

The attentional control theory (ACT) proposes that trait anxiety disrupts functional efficiency of executive control of attention relating to working memory system such as shifting. ACT also emphasizes the modulatory role of motivation in anxiety on cognitive task performance. The present study investigated the association of trait anxiety-related inefficiencies in attentional shift and working memory performance in conjunction with the level of motivation. A variation of complex span paradigm is designed to systematically manipulate the time constraint on shifting attentional focus back and forth between working memory contents and processing task was used in this study. In the experiment, participants high and low in trait anxiety were allocated either high or low motivation induction conditions, and performed a series of complex span tasks. They also completed a state anxiety measure before and after the experimental task. Motivational states were assessed by the pupil dilation, which is known to reflect the amount of cognitive effort invested on the task at hand. Results showed that, only in low motivation condition, high trait-anxious individuals exhibited greater difficulty, relative to those low in trait anxiety, in maintaining working memory contents as the task demand increased. State anxiety showed no relation to working memory performance regardless of the level of motivation and task demands. Pupillary responses revealed that, in high motivational state, high trait-anxious individuals invested more effort than those low in trait anxiety when the task demand was low, F(1, 132) = 6.65, p = 0.0110, to moderate, F(1, 132) = 8.441, p = 0.00043. In accordance with ACT, these findings suggest that motivation can modulate the association between trait anxiety and cognitive performance along with the levels of task demand. Clinical implication is briefly discussed.

关键词： Trait Anxiety Motivation Working Memory Attentional Control Theory (ACT) Pupillometry

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Loss-of-Function of a Ubiquitin-Related Modifier Promotes the Mobilization of the Active MITE mPing

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Molecular Plant 2013年第3期6卷 790-801页

作者： Takuji Tsukiyama Shota Teramoto KanakoYasuda Akira Horibata Nanako Mori Yutaka Okumoto Masayoshi Teraishi Hiroki Saito Akiko Onishi Kanako Tamura takatoshi Tanisaka Division of Agronomy and Horticulture Science Graduate School of Agriculture Kyoto University Kitashirakawa Sakyo Kyoto 606-8502 Japan Faculty of Biology-Oriented Science and Technology Kinki University Kinokawa Wakayama 649-6433 Japan

Miniature inverted-repeat transposable elements （MITEs） are widespread in both prokaryotic and eukaryotic genomes, where their copy numbers can attain several thousands. Little is known, however, about the genetic factor（s） affecting their transpositions. Here, we show that disruption of a gene encoding ubiquitin-like protein markedly enhances the transposition activity of a MITE roPing in intact rice plants without any exogenous stresses. We found that the transposition activity of roPing is far higher in the lines harboring a non-functional allele at the Rurml （Rice ubiquitin-related modifier-I） locus than in the wild-type line. Although the alteration of cytosine methylation pattern triggers the activation of transposable elements under exogenous stress conditions, the methylation degrees in the whole genome, the roPing-body region, and the roPing-flanking regions of the non-functional Rurml line were unchanged. This study provides experimental evidence for one of the models of genome shock theory that genetic accidents within cells enhance the transposition activities of transposable elements.

关键词： Oryza sativa MITE mPing ubiquitin-related modifier methylation genome shock theory.

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Balloon Kyphoplasty to Thoracic Vertebral Fracture with Postoperative Treatment Difficulty: A Case Report

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Open Journal of Orthopedics 2020年第10期10卷 295-302页

作者： Hiromitsu Takano Hajime Kajihara takatoshi Okuda Department of Orthopedic Surgery Koto Hospital Tokyo Japan Department of Orthopedic Surgery Juntendo University School of Medicine Tokyo Japan

In this communication, we report our experience with a case of thoracic vertebral fracture which was treated by balloon kyphoplasty and which later developed an infection at the fracture site, causing treatment difficulty. The patient was a 74-year old female with a history of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome as well as diabetes mellitus. She had been diagnosed with mycoplasma pneumonia as well as a fracture of the T12 vertebral and was admitted to the Department of Internal Medicine to receive medical/non-surgical treatment. Medical treatment was carried out and the pneumonia symptoms improved but getting out of bed was impossible due to the continuing of back pain. Therefore, T12 balloon kyphoplasty was performed in order to allow for early ambulation. Back pain started to improve immediately after surgery, but at 2 months after surgery, the back pain relapsed, and fever developed. Imaging tests revealed a vertebral osteolysis of T11-T12 and, as a measure against vertebral collapse due to postoperative infection or osteomyelitis of the thoracic spine, the feasibility of balloon kyphoplasty was considered. Antibiotic treatment was carried out, and when findings showed that the infection had resolved, posterior fusion (T9-L2) was performed using percutaneous pedicle screws. When balloon kyphoplasty for the treatment of a vertebral fracture is performed in an immunocompromised patient early after injury, the treatment needs to be chosen carefully, and the possibility of a latent vertebral osteomyelitis should be kept in mind.

关键词： Vertebral Fracture Balloon Kyphoplasty Pyogenic Spondylitis

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Remote-Plasma-Assisted Deposition of Pentacene Layer Using Atomic-Hydrogen

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Journal of Crystallization Process and Technology 2014年第1期4卷 14-19页

作者： Satoshi Yamauchi takatoshi Minakuchi Miyuki Onodera Department of Biomolecular Functional Engineering Ibaraki University Hitachi Japan

Pentacene thin layers were deposited on Si with the native oxide at 80°C by remote-plasma-assisted deposition (RPAD) using hydrogen-plasma cell to supply atomic hydrogen radicals. The deposition rate was increased by RPAD comparing to that by non-excited hydrogen gas supply whereas thermal evaporation rate of pentacene from crucible was same in the both process. DFM and XRD studies showed the grain laterally grew in the thin film phase with the size above 10 μm by RPAD. First-principles molecular orbital calculations suggested pentacene is evaporated from crucible as the trimer or larger cluster but atomic hydrogen penetrated into the cluster enhances cracking of pentacene clusters to the monomer.

关键词： Remote-Plasma-Assisted Deposition Pentacene Hydrogen Plasma Atomic Hydrogen

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Classification of Intervertebral Disc Degeneration in Low Back Pain Using Diffusional Kurtosis Imaging

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Open Journal of Radiology 2020年第2期10卷 79-89页

作者： Hiromitsu Takano Ikuho Yonezawa takatoshi Okuda Kazuo Kaneko Department of Orthopedic Surgery Koto Hospital Tokyo Japan Department of Orthopedic Surgery School of Medicine Juntendo University Tokyo Japan Department of Spine Surgery Sangubashi Spine Surgery Hospital Tokyo Japan

Degenerative disc disease is the most common cause of low back pain. Intervertebral disc abnormalities are commonly evaluated by magnetic resonance imaging (MRI), and Pfirrmann’s system involves the use of T2-weighted images (T2WI) to classify disc degeneration. However, as this classification is based on visual evaluation, it is not possible to quantify degeneration using this method. The present study was performed to establish an MRI-based intervertebral disc classification system using diffusional kurtosis imaging (DKI), to quantify intervertebral disc water content according to the Pfirrmann classification. Sagittal mean diffusional kurtosis (MK) mapping was performed for the L3/4, L4/5, and L5/S1 intervertebral discs in 32 patients (15 female, 17 male;age range, 24 - 82 years;mean age, 57.7 years). The degree of disc degeneration was assessed in the midsagittal section on T2WI according to the Pfirrmann classification (grade I - V). The relationships between MK values, which are correlated with intervertebral disc composition changes, and grade of degeneration determined using the Pfirrmann classification were analyzed. The MK values tended to decrease with increasing grade of degeneration, and differed significantly between grades I and IV, but not between grade IV and V (P < 0.05, Mann-Whitney U test). DKI is an effective means of detecting the early stages of disc degeneration. Therefore, DKI may be a useful diagnostic tool for quantitative assessment of intervertebral disc degeneration.

关键词： Diffusional Kurtosis Imaging Pfirrmann Classification Mean Diffusional Kurtosis Intervertebral Disc Degeneration Low Back Pain

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