检索结果-南通市图书馆

Pharmacological characterizationof synthetic cannabinoid MAM-2201：radioligand binding and abuse-related effects

中国药理学与毒理学杂志 2017年第10期31卷 1016-1017页

作者： William E FANTEGROSSI Aaron JANOWSKY Amy J ESHLEMAN Lauren N RUSSELL Saki FUKUDA Jyoti GOGOI Cassandra PRIOLEAU Ambuja S BALE Srihari R TELLA Merle G PAULE takato hiranita Department of Pharmacology and Toxicology College of Medicine University of Arkansas for Medical Sciences AR 72207 Division of Neurotoxicology National Center for Toxicological Research Food and Drug Administration AR 72079 Departments of Psychiatry and Behavioral Neuroscience Oregon Health & Science University Portland OR 97239-3098 VA Portland Health Care System Portland OR 97239 Drug and Chemical Evaluation Section Drug Enforcement Administration

OBJECTIVE Over 30% of all new psychoactive substances identified by the UN Office on Drugs and Crime in 2016 were synthetic *** recent emergence of MAM-2201 on the illicit market is troubling because this drug has no precedent in either the scientific or patent literature,and appears to be a novel compound developed specifically as a "graymarket" drug of abuse bystructurally combining the known synthetic cannabinoids JWH-122 and *** is currently no published information regarding the pharmacology of *** The present studies characterized cannabinoid-like effects of MAM-2201 in vitro(interactions with cannabinoid type 1 receptors[CB1 Rs]) and in vivo(in mice and rats).RESULTS In a radioligand binding assay using [3 H]CP55,940 in HEK cell membranes transfected with the CB1 R,MAM-2201(K i=5.4 nmol·L^(-1)),had higher binding affinity than WIN 55,212-2(K i=80 nmol·L^(-1)),and D9-THC(K i=8.3 nmol·L^(-1)).The E max values for MAM-2201 and WIN 55,212-2 in an assay of agonist inhibition of forskolin-stimulated c AMP were 85%(EC50=0.45 nmol·L^(-1)) and 95%,respectively,as compared with the D9-THC E max of 74%.In mice,MAM-2201(0.003-1.0 mg·kg^(-1),IP) produced dose-dependent cannabimimetic effects which were both more potent and more effective than those of ***-2201 and D9-THC dose-dependently produced hypothermia:ED50=0.287 and 25.4 mg·kg^(-1),analgesia:ED50=0.125 and 29.4 mg·kg^(-1),and catalepsy:ED50=0.301 and18.9 mg·kg^(-1) in adult male CD1 ***,MAM-2201 also elicited convulsant effects at a dose of 1.0 mg·kg^(-1) in 8/8 murine *** rats,MAM-2201 produced dose-dependent D9-THC-like interoceptive effects in subjects trained to discriminate 3.0 mg·kg^(-1)(IP) D9-THC from *** MAM-2201 binds CB1 Rs with high affinity and agonist efficacy,and functions as a potent cannabinoid agonist in vivo across several complementary measures of cannabinoid activity in two rodent species.

关键词： cannabinoid CB1 receptor behavior abuse liability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photoperiodic flowering in Arabidopsis:Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T

引用

Plant Communications 2023年第3期4卷 47-65页

作者： Hiroshi Takagi Andrew K.Hempton takato Imaizumi Department of Biology University of WashingtonSeattleWA 98195-1800USA Center for Gene Research Nagoya UniversityNagoya 464-8602Japan

The timing of flowering affects the success of sexual *** developmental event also determines crop yield,biomass,and ***,this mechanism has been targeted for improvement along with crop *** underlying mechanisms of flowering are highly conserved in *** to these mechanisms is how environmental and endogenous conditions control transcriptional regulation of the FLOWERING LOCUS T(FT)gene,which initiates floral development under long-day conditions in *** the identification of FT as florigen,efforts have been made to understand the regulatory mechanisms of FT *** many transcriptional regulators have been shown to directly influence FT,the question of how they coordinately control the spatiotemporal expression patterns of FT still requires further *** FT regulators,CONSTANS(CO)is the primary one whose protein stability is tightly controlled by phosphorylation and ubiquitination/proteasome-mediated *** addition,various CO interaction partners,some of them previously identified as FT transcriptional regulators,positively or negatively modulate CO protein *** FT promoter possesses several transcriptional regulatory"blocks,"highly conserved regions among Brassicaceae *** transcription factors bind to specific blocks and affect FT expression,often causing topological changes in FT chromatin structure,such as the formation of DNA *** discuss the current understanding of the regulation of FT expression mainly in Arabidopsis and propose future directions related to this topic.

关键词： photoperiodic flowering Arabidopsis thaliana circadian clock photoreceptor CONSTANS FLOWERING LOCUS T

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2q37.3 Deletion with Complex Heart Defects Suggesting Interruption of Early Ventricular Looping

引用

Congenital Heart Disease 2022年第2期17卷 141-146页

作者： Sanam Safi takato Yamasaki David JGlidden Stephen PSanders Chrystalle Katte Carreon The Cardiac Registry Departments of CardiologyPathologyand Cardiac SurgeryBoston Children’s HospitalBostonUSA Department of Cardiology Gentofte University HospitalCopenhagenDenmark Department of Thoracic and Cardiovascular Surgery Mie University Graduate School of MedicineMieJapan Department of Pathology Cascade Pathology Services/Legacy HealthPortlandUSA Department of Pediatrics Boston Children’s Hospital and Harvard Medical SchoolBostonUSA Department of Pathology Boston Children’s Hospital and Harvard Medical SchoolBostonUSA

A maternally inherited 828 kb microdeletion of 2q37.3 manifested in a 3-week-old premature boy as left juxtaposition of the atrial appendages associated with tricuspid atresia,double outlet infundibulum,subvalvar pulmonary atresia,large secundum atrial septal defect,and right aortic arch with mirror-image branching,consistent with developmental arrest early in heart *** the best of our knowledge,no previous 2q37 deletion syndrome has been reported with such a severe cardiac ***,this case adds to the cardiac phenotypes identified in 2q37 deletion syndrome.

关键词： 2q37.3 deletion tricuspid atresia double outlet infundibulum juxtaposition of the atrial appendages right aortic arch subvalvar pulmonary atresia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Do predators prefer toxic animals?A case of chemical discrimination by an Asian snake that sequesters firefly toxins

引用

Current Zoology 2022年第6期68卷 627-634页

作者： Masaya FUKUDA Rinako UJIIE takato INOUE Qin CHEN Chengquan CAO Li DING Naoki MORI Akira MORI Department of Zoology Graduate School of ScienceKyoto UniversityKyoto 606-8502Japan Department of Applied Life Science Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China College of Life Sciences Leshan Normal UniversityLeshanSichuan 614000China

Several Asian natricine snakes of the genus Rhabdophis feed on toads and sequester steroidal cardiac toxins known as bufadienolides(BDs)from them.A recent study revealed that species of the Rhabdophis nuchalis Group ingest lampyrine fireflies to sequester *** several species of fireflies are distributed in the habitat of the *** Group,only lampyrine fireflies,which have BDs,are included in the diet of these ***,we hypothesized that the *** Group chemically distinguishes fireflies that have BDs from those that do not have *** also predicted that the *** Group detects BDs as the chemical cue of toxin *** test these predictions,we conducted 3 behavioral experiments using Rhabdophis chiwen,which belongs to the *** *** the first experiment,*** showed a moderate tongue flicking response to cinobufagin,a compound of *** the other hand,the snake showed a higher response to the chemical stimuli of lampyrine fireflies(BD fireflies)than those of lucioline fireflies(non-BD fireflies).In the second experiment,in which we provided live BD and non-BD fireflies,the snake voluntarily consumed only the *** the third,a Y-maze experiment,the snake tended to select the chemical trail of BD fireflies more frequently than that of non-BD *** results demonstrated that *** discriminates BD fireflies from non-BD fireflies,but the prediction that BDs are involved in this discrimination was not fully *** identify the proximate mechanisms of the recognition of novel toxic prey in the *** Group,further investigation is necessary.

关键词： Bufadienolides chemical preference fireflies Rhabdophis toxin sequestration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adult stem-like cells in kidney

引用

World Journal of Stem Cells 2015年第2期7卷 490-494页

作者： Keiichi Hishikawa Osamu Takase Masahiro Yoshikawa Taro Tsujimura Masaomi Nangaku Tsuyoshi takato Department of Advanced Nephrology and Regenerative Medicine the University of Tokyo Department of Oral and Maxillofacial Surgery Graduate School of MedicineUniversity of Tokyo

Human pluripotent cells are promising for treatment for kidney diseases, but the protocols for derivation of kidney cell types are still controversial. Kidney tissue regeneration is well confirmed in several lower vertebrates such as fish, and the repair of nephrons after tubular damages is commonly observed after renal injury. Even in adult mammal kidney, renal progenitorcell or system is reportedly presents suggesting that adult stem-like cells in kidney can be practical clinical targets for kidney diseases. However, it is still unclear if kidney stem cells or stem-like cells exist or not. In general, stemness is defined by several factors such as self-renewal capacity, multi-lineage potency and characteristic gene expression profiles. The definite use of stemness may be obstacle to understand kidney regeneration, and here we describe the recent broad findings of kidney regeneration and the cells that contribute regeneration.

关键词： Gene therapy Hematopoietic stem cells In vivo selection Chemical Inducer of Dimerization Chemo-selection Lentivirus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels

引用

Journal of Integrative Plant Biology 2024年第1期66卷 103-120页

作者： Hayeon Kim Hye Won Kang Dae Yeon Hwang Nayoung Lee Akane Kubota takato Imaizumi Young Hun Song Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Biology Ajou UniversitySuwon 16499Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Graduate School of Science and Technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Department of Biology University of WashingtonSeattleWA 98195USA Institute of Agricultural Life Sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FLOWERING LOCUS T(FT).In Arabidopsis,FT messenger RNA levels peak in the morning and evening under natural long-day conditions(LDs).However,the regulatory mechanisms governing morning FT induction remain poorly *** morning FT peak is absent in typical laboratory LDs characterized by high red:far-red light(R:FR)ratios and constant ***,we demonstrate that ZEITLUPE(ZTL)interacts with the FT repressors TARGET OF EATs(TOEs),thereby repressing morning FT expression in natural *** LDs with simulated sunlight(R:FR=1.0)and daily temperature cycles,which are natural LD-mimicking environmental conditions,FT transcript levels in the ztl mutant were high specifically in the morning,a pattern that was mirrored in the toe1 toe2 double *** night-to-morning temperatures increased the inhibitory effect of ZTL on morning FT expression by increasing ZTL protein levels early in the ***-red light counteracted ZTL activity by decreasing its abundance(possibly via phytochrome A(phyA))while increasing GIGANTEA(GI)levels and negatively affecting the formation of the ZTL-GI complex in the ***,the phyA-mediated high-irradiance response and GI play pivotal roles in morning FT *** findings suggest that the delicate balance between low temperature-mediated ZTL activity and the far-red light-mediated functions of phyA and GI offers plants flexibility in fine-tuning their flowering time by controlling FT expression in the morning.

关键词： far-red light FLOWERING LOCUS T flowering time GIGANTEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEITLUPE

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Champagne bottle neck sign in a patient with Moyamoya syndrome

引用

World Journal of Clinical Cases 2014年第9期2卷 474-477页

作者： Takafumi Shimogawa takato Morioka Tetsuro Sayama Takeshi Hamamura Chiharu Yasuda Shuji Arakawa Department of Neurosurgery Kyushu Rosai Hospital Department of Cerebrovascular Disease Kyushu Rosai Hospital

The champagne bottle neck(CBN) sign refers to a reduction in the diameter of the proximal portion of the internal carotid artery that resembles a CBN, and is a characteristic feature of Moyamoya disease. A 43-yearold woman with an infarction of the posterior limb of the left internal capsule was diagnosed with Moyamoya syndrome associated with Graves' disease. The CBN sign was observed bilaterally. Cerebral revascularization surgery was performed, including left-sided superficial temporal artery to middle cerebral artery anastomosis. During four years of follow-up, she maintained a euthyroid state and did not have any further cerebral ischemic events. The CBN signs remained unchanged on both sides during this time. This is the first report of the CBN sign in a patient with Moyamoya syndrome associated with Graves' disease.

关键词： Champagne bottle neck sign Moyamoya disease Moyamoya syndrome Graves’disease Revascularization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LOV Domain-Containing Light-Dependent Protein in Arabidopsis F-Box Proteins： Degradation Modules

引用

Molecular Plant 2012年第3期5卷 573-582页

作者： Shogo Ito Young Hun Song takato Imaizumi Department of Biology Seattle WA 98195-1800 USA University of Washington Seattle WA 98195-1800 USA

Plants constantly survey the surrounding environment using several sets of photoreceptors. They can sense changes in the quantity （= intensity） and quality （=wavelength） of light and use this information to adjust their physiological responses, growth, and developmental patterns. In addition to the classical photoreceptors, such as phytochromes, crypto- chromes, and phototropins, ZEITLUPE （ZTL）, FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 （FKF1）, and LOV KELCH PROTEIN 2 （LKP2） proteins have been recently identified as blue-light photoreceptors that are important for regulation of the circadian clock and photoperiodic flowering. The ZTL/FKF1/LKP2 protein family possesses a unique combination of domains： a blue-light-absorb- ing LOV （Light, Oxygen, or Voltage） domain along with domains involved in protein degradation. Here, we summarize recent advances in our understanding of the function of the Arabidopsis ZTL/FKF1/LKP2 proteins. We summarize the distinct pho- tochemical properties of their LOV domains and discuss the molecular mechanisms by which the ZTL/FKF1/LKP2 proteins reg- ulate the circadian clock and photoperiodic flowering by controlling blue-light-dependent protein degradation.

关键词： blue light LOV domain ZTL FKF1 LKP2 photoperiodic flowering circadian clock Arabidopsis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

STUDY ON POOL-NUCLEATE BOILING HEAT TRANSFER CHARACTERISTICS BY USING ARTIFICIAL CAVITIES

STUDY ON POOL-NUCLEATE BOILING HEAT TRANSFER CHARACTERISTICS...

引用

第十三届国际核工程大会

作者： takato Sato Kogakuin University Japan

＜正＞ Since boiling heat transfer has quite a high heat transfer coefficient, it has been used as the cooling technique of a high temperature body. Thus, the boiling phenomena have been investigated in the past for more than 50 years. Even so, it is hard to say that the phenomena are fully understood. Because the boiling phenomena are affected by many

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Identification of an AP2 gene related to open flowering in diploid wheat(Triticum monococcum)

引用

Research in Cold and Arid Regions 2013年第6期5卷 677-683页

作者： ShunZong Ning Ning Wang Shun Sakuma Mohammad Pourkheirandish takato Koba Takao Komatsuda National Institute of Agrobiological Sciences (NIAS) Plant Genome Research Unit 2-1-2 Kannondai Tsukuba Ibaraki 305-8602 Japan Graduate school of Horticulture Chiba University 648 Matsudo Matsudo Chiba 271-8510 Japan

Cleistogamy involves the shedding of pollen within an enclosed flower. In barley, this trait is determined by the presence of a recessive allele at the gene Clyl, a member of the AP2 gene family. Here we show that the Clyl ortholog in einkorn （diploid） wheat （Triticum monococcum） TmAP2 shares a similar structure and identical pattern of transcription as Clyl. The transcript abundance of TmAP2 was high in the spike around the time of anthesis, but low in the leaf, plumule and radicle. The TmAP2 transcript was cleaved at its miR172 target site. Flower gaping at anthesis in einkorn wheat is induced by the expansion of the lodicules.

关键词： Triticum monococcum Hordeum vulgare lodicule microRNA172

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：