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Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats

World Journal of Gastroenterology 2011年第17期17卷 2223-2228页

作者： Tomohiro Kudo Shinichi Okamura Yajing Zhang takashige masuo Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Gunma 371-8511 Japan Department of Medical Informatics and Decision Sciences Gunma University School of Medicine Gunma 371-8511 Japan

AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium *** with colitis were intrarectally administered GL-p or *** extent of colitis was evaluated based on body weight gain,colon wet weight,and macroscopic damage *** expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by cytokine antibody array *** effect of GL-p on myeloperoxidase(MPO) activity in the inflamed mucosa and purified enzyme was ***:GL-p treatment significantly ameliorated the extent of colitis compared to sham treatment with *** antibody array analysis showed that GL-p treatment significantly decreased the expression levels of pro-inflammatory cytokines and chemokines,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α,cytokine-induced neutrophil chemoattractant-2,and monocyte chemoattractant protein-1 in the inflamed ***,GL-p inhibited the oxidative activity of mucosal and purified ***:GL-p enema has a therapeutic effect on experimental colitis in rats and may be useful in the treatment of UC.

关键词： Glycyrrhizin 大肠炎葡聚糖钠硫酸盐 Ulcerative 大肠炎 Cytokine Chemokine 蛋白质数组 Myeloperoxidase 灌肠 Carboxymethylcellulose

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Concordance of ulcerative colitis in monozygotic twin sisters

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World Journal of Gastroenterology 2005年第47期11卷 7547-7549页

作者： Madoka Horiya Satoru Kakizaki Katsunobu Teshigawara Yuki Kikuchi Tetsu Hashida Yoshio Tomizawa Tomohiro Iida takashige masuo Hitoshi Takagi Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan

The etiology of inflammatory bowel disease is multifacto rial and appears to combine both genetic and environmental factors. We experienced here a rare occurrence of woman monozygotic twins with ulcerative colitis (UC). A 45-year-old woman (the elder monozygotic twin) was admitted to our hospital because of bloody diarrhea occurring over 10 times per day, abdominal pain and fever. She was diagnosed as UC at the age of 22, and repeated the relapse and remission. She was diagnosed as relapse of UC and total colitis type. Her younger monozygotic twin sister also suffered from UC at the age of 22. Human leukocyte antigen was examined serologically with DNA type in both patients. DRB1*1502, which was previously shown to be dominant in Japanese patients with UC, was not observed in this case. Although the concordance in monozygotic twin in UC is reported to be 6.3-18.8%, the concordant case like this is relatively rare. We report this rare case of UC and the previously reported cases are also discussed.

关键词：肠疾病溃疡疾病单卵细胞病理机制

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