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Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1070-1077页

作者： Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki Tomohiro Ogawa Takahisa Yamasaki takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine NishinomiyaHyogo 663-8501 Japan Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Division of Gastroenterology Department of Internal Medicine Hyogo College of MedicineNishinomiyaHyogo 663-8501 Japan

AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD.

关键词： Gastric cancer Signet ring cell carcinoma Narrow-b

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莫苯唑酸对牛脂促进的大鼠结肠癌发生的影响

世界华人消化杂志 2010年第17期18卷 1767-1772页

作者：苗鲁杰白石良介藤濑剛弘柿本隆志岩切龙一藤本一真施瑞华李学良南京医科大学第一附属医院消化科江苏省南京市210029 日本国立佐贺大学医学部消化器内科

目的:探讨环氧化酶-1(COX-1)选择性抑制剂莫苯唑酸对牛脂促进的大鼠结肠癌发生的作用.方法:SD♂大鼠共108只.腹腔注射AOM(azoxymethane)后予不同牛脂含量饲料(混合0.12%莫苯唑酸)12wk,通过对结肠总ACF及多隐窝ACF(≥4个异常隐窝/病灶)计... 详细信息

目的:探讨环氧化酶-1(COX-1)选择性抑制剂莫苯唑酸对牛脂促进的大鼠结肠癌发生的作用.方法:SD♂大鼠共108只.腹腔注射AOM(azoxymethane)后予不同牛脂含量饲料(混合0.12%莫苯唑酸)12wk,通过对结肠总ACF及多隐窝ACF(≥4个异常隐窝/病灶)计数,评估莫苯唑酸对结肠肿瘤形成早期的影响;腹腔注射生理盐水或AOM后予以10%牛脂饲料(混合0.12%莫苯唑酸)44wk,观察莫苯唑酸对肿瘤发病率及数量的影响.BrdU评估肿瘤周围外观正常黏膜的增殖状况,Westernblot检测黏膜β-catenin的表达,探讨莫苯唑酸影响肿瘤发生的可能机制.结果:12wk时,莫苯唑酸组ACF尤其是多隐窝ACF显著低于对照组(P<0.05).44wk时莫苯唑酸组肿瘤发病率及平均肿瘤数量分别为66.7%和2.5±2.3,低于对照组(100%、5.3±1.2)(P<0.05);莫苯唑酸组隐窝增殖细胞的数量均显示出下降趋势(5±0.82vs3.25±0.50;7.75±0.96vs4.75±0.50,均P<0.05),且表现出趋向于生理分布的变化.β-catenin表达均低于对照组(P<0.05).结论:莫苯唑酸可有效抑制牛脂促进的大鼠结肠癌发生,这可能与结肠隐窝上皮细胞β-catenin的表达及增殖受到抑制有关.

关键词：异常隐窝灶环氧化酶-1 β-catenin

Prophylactic lateral pelvic lymph node dissection in stage Ⅳ low rectal cancer

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World Journal of Clinical Oncology 2017年第5期8卷 412-419页

作者： Hiroshi Tamura Yoshifumi Shimada Hitoshi Kameyama Ryoma Yagi Yosuke Tajima Takuma Okamura Mae Nakano Masato Nakano Masayuki Nagahashi Jun Sakata takashi Kobayashi Shin-ichi Kosugi Hitoshi Nogami Satoshi Maruyama Yasumasa Takii Toshifumi Wakai Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Department of Digestive and General Surgery Uonuma Institute of Community MedicineNiigata University Medical and Dental Hospital Department of Surgery Niigata Cancer Center Hospital

AIM To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage Ⅳ low rectal *** We selected 71 consecutive stage Ⅳ low rectal cancer patients who underwent primary tumor resection,and enrolled 50 of these 71 patients without clinical LPLN *** patients had distant metastasis such as liver,lung,peritoneum,and paraaortic *** LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography *** patients underwent primary tumor resection,27 patients underwent total mesorectal excision(TME) with LPLND(LPLND group),and 23 patients underwent only TME(TME group).Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group.R0 resection of both primary and metastatic sites was achieved in 20 of 50 *** evaluated possible prognostic factors for 5-year overall survival (OS),and compared 5-year cumulative local recurrence between the LPLND and TME *** For OS,univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%,P = 0.523); multivariate analysis revealed that R0 resection was an independent prognostic *** cumulative local recurrence,the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%,P = 0.833).CONCLUSION Prophylactic LPLND shows no oncological benefits in patients with Stage Ⅳ low rectal cancer without clinical LPLN metastasis.

关键词： Prophylactic lateral pelvic lymph node dissection StageⅣ Low rectal cancer

Hepatocellular carcinoma recurrence in HCV patients treated with direct-acting antivirals after curative treatment

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Hepatoma Research 2019年第5期5卷 26-36页

作者： Shinichiro Nakamura Kazuhiro Nouso Hiroyuki Okada Hideki Onishi Shin-ichi Fujioka YasuyukiAraki Shouta Iwadou takashi Kumada Hidenori Toyoda Kenta Motomura Kazuya Kariyama Haruhiko Kobashi Toshihiko Kaneyoshi Masaharu Ando Akio Moriya Hideaki Taniguchi YouichiMorimoto Hiroaki Hagihara Masatoshi Tanaka Okayama University Graduate School of Medicine Dentistry and Pharmaceutical SciencesOkayama 700-8558Japan Okayama Saiseikai General Hospital Okayama 700-8558Japan Hiroshima City Hiroshima Citizens Hospital Hiroshima 731-0293Japan Ogaki Municipal Hospital Gifu 503-8502Japan Iizuka Hospital Fukuoka 820-8505Japan Okayama City Hospital Okayama 700-8557Japan Okayama Red Cross General Hospital Okayama 700-8607Japan Fukuyama Medical Center Hiroshima 720-8520Japan Mitoyo General Hospital Kagawa 769-1695Japan Tottori Municipal Hospital Tottori 680-8501Japan Kurashiki Central Hospital Okayama 710-8602Japan Sumitomo Besshi Hospital Ehime 792-8543Japan Yokokura Hospital Fukuoka 839-0215Japan Japanese Red Cross Society Himeji Hospital Hyogo 670-8540Japan

Aim:The increased risk of hepatocellular carcinoma(HCC)recurrence in hepatitis C virus(HCV)-infected patients treated with direct-acting antivirals(DAAs)after curative treatment for HCC is *** purpose of this study was to examine the risk of HCC recurrence after DAA ***:We conducted a retrospective cohort study of 312 consecutive patients with HCV-related HCC who received DAA therapy in participating institutions between September 2014 and July *** patients received curative ;hepatectomy or radio-frequency *** calculated the annual incidence of HCC recurrence after DAA therapy and identified the risk factors for HCC recurrence using Cox regression ***:The median age was 74 years old,and a sustained virological response was achieved by 288 *** 3-year-overall survival rate was 95.4%in a median follow-up period of 855 *** recurred in 135 *** 1-,2-and 3-year recurrence rates were 18.3%,38.8%and 55.4%,respectively.A multivariate analysis revealed that the following factors were associated with HCC recurrence:multiple tumors at the first HCC treatment[hazard ratio(HR)=2.21;95%CI:1.41-3.49],a history of multiple treatments for HCC(HR=1.97;95%CI:1.28-3.02),andα-fetoprotein(AFP-L3)≥10%at the initiation of DAA therapy(HR=4.74;95%CI:2.10-10.7).Conclusion:Among patients treated with DAAs after the curative treatment of HCC,multiple tumors at the first HCC treatment,multiple prior HCC treatments and a high AFP-L3 level before DAA therapy were associated with recurrence,and the rate of recurrence was comparable to that before the DAA era.

关键词： Hepatocellular carcinoma hepatitis C virus direct-acting antiviral recurrence

淫羊藿苷及其肠菌代谢产物对THP-1细胞分泌细胞因子的影响

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药学学报 2000年第4期35卷 245-248页

作者：刘铁汉王本祥王毅吴立军南陆彦永田年池岛乔长春中医学院附属医院新药研究中心长春130021 沈阳药科大学天然药物研究室沈阳110015 横滨市立大学医学部寄生虫学教研室滨松医科大学微生物教研室

目的 :比较淫羊藿苷及其肠菌代谢产物对人组织细胞瘤THP 1细胞分泌 4种细胞因子的影响。方法 :放射免疫测定方法 (RIA)。结果 :在LPS和PMA存在下 ,淫羊藿苷及其肠菌代谢产物 (宝藿苷I和淫羊藿苷元 )对IL 6的产生有促进作用 ,代谢物的作... 详细信息

目的 :比较淫羊藿苷及其肠菌代谢产物对人组织细胞瘤THP 1细胞分泌 4种细胞因子的影响。方法 :放射免疫测定方法 (RIA)。结果 :在LPS和PMA存在下 ,淫羊藿苷及其肠菌代谢产物 (宝藿苷I和淫羊藿苷元 )对IL 6的产生有促进作用 ,代谢物的作用更强 ,对IL 8的产生有一定的抑制作用。当LPS和PMA不存在时 ,对IL 6的产生无明显影响 ,而对IL 8的产生则有促进作用。不论LPS和PMA存在与否 ,原苷对TNFα的产生有抑制作用 ,原苷及其肠菌代谢产物对IL 1α的产生均有明显抑制作用。结论 :在不同的实验条件下 ,淫羊藿苷及其肠菌代谢产物对各种炎症性细胞因子的产生均有特异的调节作用。

关键词：淫羊藿苷肠菌代谢物 THP-1细胞炎症

日晒消毒对温室土壤粪便性细菌污染的控制(英文)

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广西农业科学 2009年第9期40卷 1166-1171页

作者：吴圣进西原基树川崎佳荣横山明敏松浦敬染谷孝广西农业科学院微生物研究所南宁530007 佐贺大学农学部宫崎农业科研所土壤环境部

农业土壤一旦被粪便性病菌污染,将给人类带来潜在的感染病菌的风险。通过选择大肠杆菌作为粪便性病菌的模式菌接种于土壤中,在温室条件下采用日晒热消毒法对大肠杆菌进行灭菌试验,探讨日晒消毒法的生物安全控制效果。结果表明,日晒处理... 详细信息

农业土壤一旦被粪便性病菌污染,将给人类带来潜在的感染病菌的风险。通过选择大肠杆菌作为粪便性病菌的模式菌接种于土壤中,在温室条件下采用日晒热消毒法对大肠杆菌进行灭菌试验,探讨日晒消毒法的生物安全控制效果。结果表明,日晒处理使土壤温度在1周内升至40℃,并在大部分处理时期维持在40～46℃;处理区土壤中的大肠杆菌数在1周内从105cfu/g干土降至检测限以下(<0.08cfu/g干土),而对照区土壤中的大肠杆菌数在4周后仍可被检测出。由此可知,温室土壤在因施用未腐熟堆肥或动物粪便而被病菌污染时,日晒消毒是快速有效的生物安全控制手段。

关键词：土壤日晒消毒生物安全控制粪便性污染大肠杆菌

PET用于帕金森病纹状体外小神经胶质细胞活化播散的研究

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中华核医学与分子影像杂志 2017年第3期37卷 192-192页

作者：李梦婷兰晓莉唐军华中科技大学同济医学院附属协和医院核医学科武汉430022 苏州大学附属第二医院核医学科 215004

目的神经炎性胶质反应有助于推进帕金森病（PD）的退行性变过程。然而，小神经胶质细胞发展的模式仍不清楚。方法[11C]DPA713，是一种选择性小神经胶质细胞激活PET示踪剂。本研究应用[11C]DPA713 PET显像量化评估早期PD患者神经炎性变... 详细信息

目的神经炎性胶质反应有助于推进帕金森病（PD）的退行性变过程。然而，小神经胶质细胞发展的模式仍不清楚。方法[11C]DPA713，是一种选择性小神经胶质细胞激活PET示踪剂。本研究应用[11C]DPA713 PET显像量化评估早期PD患者神经炎性变中小神经胶质细胞的激活。选取11个不伴有痴呆的PD患者（Hoehn和Yahr分期为1-2期）进行2次[11C]DPA713PET扫描．2次显像时间相隔1年。通过简化的参考组织模型估算结合潜能（BPND）。应用智能体素和感兴趣区分析比较组间的BPND。结果[11C]DPA713 BPND在帕金森病患者纹状体外的枕叶、颞叶和顶叶皮质摄取呈明显增加，1年后发现在颞叶和枕叶皮质的大脑区域与显像剂结合程度更高。结论本研究结果表明，纹状体外的小神经胶质细胞活化播散是PD早期阶段病理生理变化之一。

关键词：帕金森病(PD) 小神经胶质细胞 [11C]DPA713 正电子发射断层显像术(PET)

Histological diagnosis of gastric submucosal tumors: A pilot study of endoscopic ultrasonography-guided fine-needle aspiration biopsy vs mucosal cutting biopsy

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World Journal of Gastrointestinal Endoscopy 2015年第14期7卷 1142-1149页

作者： Hisatomo Ikehara Zhaoliang Li Jiro Watari Masato Taki Tomohiro Ogawa Takahisa Yamasaki takashi Kondo Fumihiko Toyoshima Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Toshihiko Tomita Tadayuki Oshima Hirokazu Fukui Ikuo Matsuda Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine Department of Surgical Pathology Hyogo College of Medicine

AIM: To compare the usefulness of endoscopic ultrasonography-guided fine-needle aspiration biopsy(EUS-FNAB) without cytology and mucosal cutting biopsy(MCB) in the histological diagnosis of gastric submucosal tumor(SMT).METHODS: We prospectively compared the diagnostic yield, feasibility, and safety of EUS-FNAB and those of MCB based on endoscopic submucosal dissection. The cases of 20 consecutive patients with gastric SMT ≥1 cm in diameter. who underwent both EUS-FNAB and MCB were ***: The histological diagnoses were gastrointestinal stromal tumors(n = 7), leiomyoma(n =6), schwannoma(n = 2), aberrant pancreas(n = 2), and one case each of glomus tumor, metastatic hepatocellular carcinoma, and no-diagnosis. The tumors' mean size was 23.6 mm. Histological diagnosis was made in 65.0% of the EUS-FNABs and 60.0% of the MCBs, a nonsignificant difference. There were no significant differences in the diagnostic yield concerning the tumor location or tumor size between the two methods. However, diagnostic specimens were significantly more frequently obtained in lesions with intraluminal growth than in those with extraluminal growth by the MCB method(P = 0.01). All four SMTs with extraluminal growth were diagnosed only by EUSFNAB(P = 0.03). No complications were found in either ***: MCB may be chosen as an alternative diagnostic modality in tumors showing the intraluminal growth pattern regardless of tumor size, whereas EUSFNAB should be performed for SMTs with extraluminal growth.

关键词： Submucosal tumor Endoscopic ultrasonography-guided

多巴胺转运体SPECT显像中显像剂分布的定量分析有助于图像的客观解读

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中华核医学与分子影像杂志 2018年第10期38卷 712-712页

作者：刘颍桦(译) 唐军(审校) 苏州大学医学部放射医学与防护学院 215123 上海交通大学医学院附属苏州九龙医院核医学科 215021

目的多巴胺转运体（DAT） SPECT显像时，显像剂分布的定量分析能在视觉分析的基础上增加其客观性。该研究旨在评估显像剂分布的定量指标——分形维数（FD）的诊断作用，并将其与常规定量指标——特异性结合率（SBR）进行比较；同时评估S... 详细信息

目的多巴胺转运体（DAT） SPECT显像时，显像剂分布的定量分析能在视觉分析的基础上增加其客观性。该研究旨在评估显像剂分布的定量指标——分形维数（FD）的诊断作用，并将其与常规定量指标——特异性结合率（SBR）进行比较；同时评估SBR/FD组合指标（SBR除以FD）的诊断价值。方法行临床研究和模型研究。临床研究纳入150例患者，其中110例帕金森综合征（PS）患者和40例非PS患者。模型研究采用纹状体模型，将纹状体腔分为尾状核和壳核。计算SBR、FD和SBR/FD，并与数据库进行比较，以评估其诊断价值。采用Mann-Whitney检验和受试者工作特征（ROC）曲线分析法分析数据。结果ROC曲线分析表明，FD具有较高的诊断效能[曲线下面积（AUC）为0.943]，其与SBR和FD （SBR/FD）联合应用比单独使用SBR有更高的诊断效能（AUC：0.964与0.899; P〈0.001）。SBR的灵敏度、特异性和准确性分别为79.1%、85.0%和80.7%，FD对应为84.5%、97.5%和88.0%，SBR/FD对应为92.7%、87.5%和91.3%。结论FD是反映DAT SPECT显像时显像剂分布的有价值的诊断指标。FD与SBR联合应用比单独应用的诊断价值更高。

关键词： 123^Ⅰ-Ioflupane 123^Ⅰ-FP-CIT DAT 分形分析分形维数