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Resection of a locally advanced hilar tumor and the hepatic artery after stepwise hepatic arterial embolization: A case report

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World Journal of Gastroenterology 2008年第22期14卷 3587-3590页

作者： Takuya Miura Kenichi Hakamada takashi ohata Shunji Narumi Yoshikazu Toyoki Masaki Nara Keinosuke Ishido Motonari Ohashi Harue Akasaka Hiroyuki Jin Norihito Kubo Shuichi Ono Hiroshi Kijima Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Radiology and Radiation Oncology Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Pathology and Bioscience Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Pathology and Bioscience Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan

We herein report a case of a hilar tumor with extensive invasion to the proper hepatic artery, which was successfully treated with a radical resection in a 57-year-old female patient after a stepwise hepatic arterial embolization. She underwent right colectomy and partial hepatectomy for advanced colon cancer two years ago and radiofrequency ablation therapy for a liver metastasis one year ago, respectively. A recurrent tumor was noted around the proper hepatic artery with invasion to the left hepatic duct and right hepatic artery 7 mo previously. We planned a radical resection for the patient 5 mo after the absence of tumor progression was confirmed while he was undergoing chemotherapy. To avoid surgery-related liver failure, we tried to promote the formation of collateral hepatic arteries after stepwise arterial embolizationof the posterior and anterior hepatic arteries two weeks apart. Finally, the proper hepatic artery was occluded after formation of collateral flow from the inferior phrenic and superior mesenteric arteries was confirmed. One month later, a left hepatectomy with hepatic arterial resection was successfully performed without any major complications.

关键词： Hepatic arterial embolization Stepwise Hilar tumor Arterial resection Collateral artery

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In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke

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Neural Regeneration Research 2025年第8期20卷 2309-2310页

作者： takashi Irie Taito Matsuda Department of Stem Cell Biology and Medicine Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Neurology Neurological InstituteGraduate School of Medical SciencesKyushu UniversityFukuokaJapan

Stroke causes neuronal loss,which ultimately results in persistent neurological ***,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and ischemic heart *** that year,there were 12.2 million incident strokes,101 million prevalent strokes,and 143 million disability-adjusted life-years due to stroke.

关键词： neonatal death therapeutic

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Potential of non-Western medicines in chemoradiotherapy for cervical cancer

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World Journal of Clinical Cases 2025年第2期13卷 21-23页

作者： takashi Ono Masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical *** radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’***,most treatments are supportive,with no specific treatment options available in Western ***-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical *** these potential benefits,challenges such as limited evidence and restricted application areas *** non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

关键词： Cervical cancer Radiotherapy Non-Western medicine Kampo Herbal medicine

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Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

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The stay coefficient: a novel quantification of the relationship between stay time and travel time for urban shopping behavior analysis

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Geo-Spatial Information Science 2023年第1期26卷 44-57页

作者： takashi Yamada Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityWakayamaJapan

Shoppers typically want to spend an amount of time at a destination that is proportional to the travel time required to arrive there;thus,the travel time can be considered the cost of their *** is likely to be the case across regions with different urban structures and *** purpose of this study was therefore to analyze the shopping behaviors contained in travel survey data from three metropolitan areas in Japan to identify common patterns and indicators based on travel time and stay time,thereby obtaining an understanding to inform future trade area *** the travel time and stay time associated with shopping behavior were found to be log-normally distributed regardless of metropolitan area,and four shopping behavior patterns common among the metropolitan areas were ***“stay coeffi-cient”was then defined to express the elasticity of stay time according to travel time,and its values were similar according to shopping behavior pattern regardless of metropolitan *** stay coefficient proposed in this study can therefore be applied to identify shopping behavior patterns in any urban area based on the relationship between travel time and stay time,realizing a novel approach to the analysis of and marketing for trade areas when planning the construction or renovation of commercial *** approach can help inform the decisions of urban policy makers,marketing advisors,and commercial facility operators,and should be of interest to researchers and practitioners working with geospatial,shopping,and other human behavioral characteristics.

关键词： Travel survey shopping behavior travel time stay time stay coefficient trade area analysis

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The Emergent Constructive Approach to Evolinguistics:Considering Hierarchy and Intention Sharing in Linguistic Communication

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Journal of Systems Science and Systems Engineering 2020年第6期29卷 675-696页

作者： takashi Hashimoto School of Knowledge Science Japan Advanced Institute of Science and Technology(JAIST)Nomi 923-1292Japan

Evolinguistics is an attempt to clarify the origins and evolution of language and communication,thereby deepening our understanding of humans from an evolutionary *** origins of language is characterized by the biological evolution of abilities related to language and communication,and the evolution of language by the structuralization and complexification of language knowledge as well as communication systems through cultural *** Evolinguistics,two idiosyncrasies of human linguistic communication are the primary focus,namely,using hierarchically organized symbol sequences in language and sharing intentions in *** believe that the integration of these two characteristics made humans co-creative and smart,and in particular gave us knowledge co-creation *** emergent constructive approach plays an important role in this research,which is a methodology to analyze complex systems by constructing and operating the evolutionary and emergent process of complex *** studies taking this approach are introduced in this *** is a language evolution experiment in a laboratory to consider the process,mechanisms,and neural basis of symbolic communication *** other is an evolutionary simulation of recursive combination,which is thought of as the essential ability to form hierarchical structures.A hypothesis integrating intention sharing and recursive combination is discussed as an abductive reasoning mechanism for understanding others intentions.

关键词： Evolinguistics origins and evolution of language hierarchy intention sharing symbolic communication recursive combination abduction

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A time-space network based international transportation scheduling problem incorporating CO_2 emission levels

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 927-932页

作者： takashi IROHARA Department of Information and Communication Sciences Faculty of Science and TechnologySophia University

Environmental problems have received a great deal of attention in recent *** particular,CO2 emissions worsen global warming and other environmental *** transport sector accounts for 20% of the total CO2 ***,the CO2 emission reduction of the transport sector is of great *** order to reduce emissions effectively,it is necessary to change the distribution and transportation *** purpose of this study is to minimize both the transportation costs and CO2 emissions during *** model considers a transportation scheduling problem in which loads are transported from an overseas production base to three domestic demand *** need for time-space networks arises naturally to improve the *** is possible to know the distance carriers are moving,and also consider the timetables of carriers during *** choice,less-than carrier load,and domestic transportation among demand centers are considered as the three target areas to reduce CO2 emissions during the distribution *** research model was formulated as a mixed integer programming (MIP) *** achieves cost reduction,and will contribute to improvement of the natural environment.

关键词： Time-space network Timetable Transportation scheduling problem Mixed integer programming (MIP) problem Less-than carrier load

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NUMERICAL PREDICTION OF DYNAMIC PERFORMANCE OF PELTON TURBINE

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Journal of Hydrodynamics 2007年第3期19卷 356-364页

作者： KUBOTA takashi College of Electric Power South China University of Technology Guangzhou 510640 China

Different from the reaction turbines, the hydraulic performance of Pelton turbine is dynamic due to the unsteady flow in the rotating buckets in time and space. The dynamic energy efficiency of bucket ηεB and power efficiency of bucket ηPB within a short period can be predicted from the dynamic flow pattern of the free-surface sheet flow in the rotating bucket, whereas the dynamic discharge efficiency of bucket ηQB is defined as the resident discharge in the bucket at the respective moment. Under the operation of higher unit speed non than the optimum one, the power efficiency of bucket is deteriorated by the jet interference with the rear surface of bucket △Prear at the first stage of the dynamic performance, as well as the loss power due to the spilt flow from the cutout of bucket at the later stage of performance. Based on the dynamic performance prediction presented, the future possibility of the quantitative investigation for the negative scale effect of Pelton turbines was discussed.

关键词： dynamic energy efficiency dynamic discharge efficiency dynamic power efficiency rotating bucket Pelton turbine

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Aszonapyrone A Isolated from Neosartorya spinosa IFM 47025 Inhibits the NF-κB Signaling Pathway Activated by Expression of the Ependymoma-Causing Fusion Protein ZFTA-RELA

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Advances in Microbiology 2024年第9期14卷 448-467页

作者： Kazuki Ishikawa Nao Kamiya Masaki Ishii takashi Yaguchi Koji Ichinose Shinya ohata Faculty of Pharmaceutical Sciences Teikyo Heisei University Nakano Tokyo Japan Research Institute of Pharmaceutical Sciences Faculty of Pharmacy Musashino University Nishitokyo-Shi Tokyo Japan Medical Mycology Research Center Chiba University Inohana Chiba Japan

Ependymoma is a rare and chemotherapy-resistant brain tumor, which has resulted in a delay in the development of drugs to treat it. A subclass of supratentorial ependymomas (ST-EPN), designated ST-EPN-zinc finger-translocation-associated (ZFTA, ST-EPN-ZFTA), exhibits the expression of a fusion protein comprising ZFTA and v-rel reticuloendotheliosis viral oncogene homolog A (RELA), an effector transcription factor of the nuclear factor-kappa B (NF-κB) pathway (ZFTA-RELA). The expression of ZFTA-RELA results in the hyperactivation of the oncogenic NF-κB signaling pathway, which ultimately leads to the development of ST-EPN-ZFTA. To identify inhibitors of the NF-κB signaling pathway activated by the expression of ZFTA-RELA, we used a doxycycline-inducible ZFTA-RELA-expressing NF-κB reporter cell line and found that extracts of the fungus Neosartorya spinosa IFM 47025 exhibited NF-κB inhibitory activity. We identified eight compounds [aszonapyrone A (2), sartorypyrone A (3), epiheveadride (4), acetylaszonalenin (5), (R)-benzodiazepinedione (6), aszonalenin (7), sartorypyrone E (8) and (Z, Z)-N,N’-(1,2-bis[(4-methoxyphenyl)methylene]-1,2-ethanediyl)bis-formamide (9)] from N. spinosa IFM 47025 culture extract using a variety of chromatographic techniques. The structures of these compounds were identified through the analysis of various instrumental data (1D, 2D-NMR, MS, and optical rotation). The NF-κB responsive reporter assay indicated that compounds 2, 3, 5, 7, and 9 exhibited inhibitory activity. We further evaluated the inhibitory activity of these compounds against the expression of endogenous NF-κB responsive genes (CCND1, L1CAM, ICAM1, and TNF) and found that compound 2 showed significant inhibitory activity. Further studies are required to elucidate the mechanism of action of compound 2, which may serve as a lead compound for the development of a novel therapy for ST-EPN-ZFTA.

关键词： Aszonapyrone A Neosartorya spinosa NF-κB Signaling Pathway Ependymoma ZFTA-RELA

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Analysis of shopping behavior characteristics in the Keihanshin metropolitan area in Japan based on a person trip survey

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Geo-Spatial Information Science 2020年第4期23卷 305-315页

作者： takashi Yamada Takumi Hayashida Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityKinokawaWakayamaJapan

This study analyzed weekday shopping behavior from a home base to a destination using data from the 4th Keihanshin metropolitan area person trip *** first analyzed the relationships between occupation and transportation means,transportation means and travel time,and transportation means and duration of time at the *** of a chi-square test,residual analysis,and correspondence analysis confirmed that employed persons tend to travel by cars while unemployed persons tend to travel by bus or *** relationship between travel time and duration of time at the destination was also revealed according to transportation *** of a cluster analysis then classified shopping behaviors to expose four ***,multiple regression analyzed the degree to which certain variables were related to duration of time at the *** confirmed a strong relationship between duration of time at the destination and travel *** degree of this factor’s influence on other variables was also *** value of these findings is that the relationship between travel time by means of transportation and the duration of time at the destination was clarified using statistical *** then found a highly accurate equation that estimates the duration of time at a destination from the travel *** the duration of time at a destination can be estimated,it may be possible to more accurately develop the structure of rest facilities,the number of parking lots,the degree of congestion,and so on,which can be associated with the customer’s usage behavior in a shopping *** research in this paper contributes to the field of urban analysis and marketing by presenting a new effective method for person trip survey and analysis.

关键词： Person trip survey shopping behavior transportation means travel time duration of time at a destination

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