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COVID-19 vaccination and liver disease

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World Journal of Gastroenterology 2022年第48期28卷 6791-6810页

作者： Sotaro Ozaka takashi Kobayashi Kazuhiro Mizukami Kazunari Murakami Department of Gastroenterology Faculty of MedicineOita UniversityYufu 879-5593OitaJapan Department of Infectious Disease Control Faculty of MedicineOita UniversityYufu 879-5593OitaJapan

Various vaccines against severe acute respiratory syndrome coronavirus 2 have been developed in response to the coronavirus disease 2019(COVID-19)global pandemic,several of which are highly effective in preventing COVID-19 in the general *** with chronic liver diseases(CLDs),particularly those with liver cirrhosis,are considered to be at a high risk for severe COVID-19 and *** the increased rates of disease severity and mortality in patients with liver disease,there is an urgent need to understand the efficacy of vaccination in this ***,the data regarding efficacy and safety of COVID-19 vaccination in patients with CLDs is ***,several organ-specific or systemic immune-mediated side effects following COVID-19 vaccination,including liver injury similar to autoimmune hepatitis,have been recently *** the number of cases of vaccine-related liver injury is increasing,its frequency,clinical course,and mechanism remain ***,we review the current findings on COVID-19 vaccination and liver disease,focusing on:(1)The impact of COVID-19 in patients with CLD;(2)The efficacy,safety,and risk-benefit profiles of COVID-19 vaccines in patients with CLD;and(3)Liver injury following COVID-19 vaccination.

关键词： COVID-19 vaccine Liver disease Side effect Liver injury Immune-related hepatitis Autoimmune hepatitis

Bioactive calcium and mangnesium phosphate bone adhesive for enhanced vascularization and bone regeneration

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Journal of Materials Science & Technology 2023年第33期164卷 246-257页

作者： Jiawei Liu Honglei Kang Wenying Wei Rong Tu takashi Goto Feng Li Honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8579Japan

Bone adhesive is a promising material for the treatment of bone fractures,which is helpful for the fast and effective reduction and fixation of broken ***,the existing adhesives bond weakly to bone tissues,and are non-absorbable,or hard to cure under wet ***,inspired by the cement-based adhesive used in the industry field,we report a bioactive calcium and magnesium phosphate bone adhesive(MPBA)with the properties of facile preparation,robust adhesion,and *** is equipped with similar strength to cancellous bones and shows reliable bonding performance for various interfaces,such as Ti6Al4V,Al2O3,and poly(ether-ether-ketone).MPBA achieves excellent bonding ability for the above interfaces with the bonding strengths of 2.28±0.47,2.32±0.15,and 1.44±0.38 MPa,***,it also shows reliable fixation ability for bovine bone *** bonding behavior to materials and bones suggests that MPBA could be used for both fracture treatment and implant ***,MPBA possesses good biological activity,which could promote the vascularization process and osteogenic ***,in vivo experiments confirmed MPBA can effectively restore bone strength and promote bone regeneration.

关键词： Fracture Calcium magnesium phosphate cement Bone adhesives

Greenhouse gas reduction of co-benefit-type wastewater treatment system for fish-processing industry: A real-scale case study in Indonesia

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Water Science and Engineering 2023年第3期16卷 271-279页

作者： Yoshiteru Hamatani Takahiro Watari Masashi Hatamoto takashi Yamaguchi Tjandra Setiadi Toshihiko Konda Nihon Suido Consultants Co. LtdTokyo 163-1122Japan Department of Civil and Environmental Engineering Nagaoka University of TechnologyNiigata 940-2188Japan Department of Chemical Engineering Hanoi University of Science and TechnologyHanoi 11615Vietnam Department of Science of Technology Innovation Nagaoka University of TechnologyNiigata 940-2188Japan Department of Chemical Engineering Institut Teknologi BandungJl.Ganesa 10Bandung 40132Indonesia

This study examined the application of co-benefit-type wastewater treatment technology in the fish-processing industry. Given that there was a dearth of information on fish-processing industrial wastewater in Indonesia, site surveys were conducted. For the entire fish-processing industry throughout the country, the dissemination rate of wastewater treatment facilities was less than 50%. Using a co-benefit approach, a real-scale swim-bed technology (SBT) and a system combining an anaerobic baffled reactor (ABR) with SBT (ABR–SBT) were installed in a fishmeal processing factory in Bali, Indonesia, and the wastewater system process performance was evaluated. In a business-as-usual scenario, the estimated chemical oxygen demand load and greenhouse gas (GHG) emissions from wastewater from the Indonesian fish-processing industry were 33 000 tons per year and 220 000 tons of equivalent CO_(2) per year, respectively. On the other hand, the GHG emissions in the co-benefit scenarios of the SBT system and ABR–SBT system were 98 149 and 26 720 tons per year, respectively. Therefore, introducing co-benefit-type wastewater treatment to Indonesia’s fish-processing industry would significantly reduce pollution loads and GHG emissions.

关键词： Indonesian fish-processing industry Co-benefit wastewater treatment Greenhouse gas emission mitigation Anaerobic baffled reactor Swim-bed technology

新型BTK PROTAC降解剂的设计合成及活性评价

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沈阳药科大学学报 2024年第8期41卷 1055-1066页

作者：常晏祥苏明波池岛乔白海云沈阳药科大学无涯创新学院辽宁沈阳110016 长三角药物高等研究院江苏南通226133 百极弘烨(南通)医药科技有限公司江苏南通226126

目的设计合成系列以伊布替尼类似物为布鲁顿酪氨酸激酶(bruton′s tyrosine kinase,BTK)激酶配体的蛋白降解靶向嵌合体(proteolysis targeting chimeras,PROTAC)降解剂,并初步评价其体外活性。方法以3-(4-苯氧基苯基)-1H-吡唑并[3,4-d]... 详细信息

目的设计合成系列以伊布替尼类似物为布鲁顿酪氨酸激酶(bruton′s tyrosine kinase,BTK)激酶配体的蛋白降解靶向嵌合体(proteolysis targeting chimeras,PROTAC)降解剂,并初步评价其体外活性。方法以3-(4-苯氧基苯基)-1H-吡唑并[3,4-d]嘧啶-4-胺为起始原料,通过取代、还原胺化、脱保护和水解等反应合成一系列新型PROTAC;通过MTS法和蛋白免疫印迹法(Western-blot)分别测定目标化合物对OCI-LY10细胞的增殖抑制能力和BTK降解活性;通过分子对接考察分子配体与BTK蛋白的结合模式。结果共合成了14个BTK PROTAC降解剂,大部分化合物都具有一定的体外活性,其中化合物15a表现出了较好的细胞增殖抑制活性(IC_(50)=7.15 nmol·L^(-1))和BTK降解活性(DC_(50)<10 nmol·L^(-1))。结论合成了结构新颖、活性较好的BTK PROTAC降解剂,对其构效关系进行了初步探索,可为BTK PROTAC降解剂的进一步研究提供参考。

关键词：布鲁顿酪氨酸激酶蛋白质降解靶向嵌合体蛋白降解抗肿瘤活性

Synthesis and Properties of a Through-Space Interacting Diradicaloid

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Precision Chemistry 2023年第3期1卷 183-191页

作者： Takuya Kodama Yasukazu Hirao takashi Kubo Department of Chemistry Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(ICSOTRI)Osaka UniversitySuitaOsaka 565-0871Japan

Knowledge about electronic structures is important to gain an understanding of the unique functional properties of *** this study,we synthesized and characterized a diradicaloid in which two phenalenyl radical sites are coupled antiferromagnetically via a through-space *** results of quantum chemical,physicochemical(^(1)H NMR,electronic absorption,cyclic voltammetry,SQUID,ESR),and chemical reactivity studies show that this diradicaloid has singlet diradical *** assessment of the nature of the bonding interaction between two radical sites in this species using DFT calculations demonstrates that a small spatial overlap between the two SOMOs in this diradicaloid provides an efficient electron exchange path for the singlet state to be substantially lower in energy than the triplet state.

关键词： through-space interaction phenalenyl radical singlet diradical diradicaloid antiferromagnetic interaction

The Emergent Constructive Approach to Evolinguistics:Considering Hierarchy and Intention Sharing in Linguistic Communication

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Journal of Systems Science and Systems Engineering 2020年第6期29卷 675-696页

作者： takashi Hashimoto School of Knowledge Science Japan Advanced Institute of Science and Technology(JAIST)Nomi 923-1292Japan

Evolinguistics is an attempt to clarify the origins and evolution of language and communication,thereby deepening our understanding of humans from an evolutionary *** origins of language is characterized by the biological evolution of abilities related to language and communication,and the evolution of language by the structuralization and complexification of language knowledge as well as communication systems through cultural *** Evolinguistics,two idiosyncrasies of human linguistic communication are the primary focus,namely,using hierarchically organized symbol sequences in language and sharing intentions in *** believe that the integration of these two characteristics made humans co-creative and smart,and in particular gave us knowledge co-creation *** emergent constructive approach plays an important role in this research,which is a methodology to analyze complex systems by constructing and operating the evolutionary and emergent process of complex *** studies taking this approach are introduced in this *** is a language evolution experiment in a laboratory to consider the process,mechanisms,and neural basis of symbolic communication *** other is an evolutionary simulation of recursive combination,which is thought of as the essential ability to form hierarchical structures.A hypothesis integrating intention sharing and recursive combination is discussed as an abductive reasoning mechanism for understanding others intentions.

关键词： Evolinguistics origins and evolution of language hierarchy intention sharing symbolic communication recursive combination abduction

新型Bcl-2小分子抑制剂的设计、合成与初步活性评价

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沈阳药科大学学报 2024年第7期41卷 889-899,913页

作者：王宇璇杨灿苏明波池岛乔白海云沈阳药科大学无涯创新学院辽宁沈阳110016 长三角高等研究院江苏南通226133 百极弘烨(南通)医药科技有限公司江苏南通226000

目的设计并合成一系列新型Bcl-2小分子抑制剂,测试其对Bcl-2和Bcl-2 G101V(Bcl-2突变体)与BH3-only蛋白相互作用的抑制活性,初步探究其构效关系,为后续相关研究提供参考。方法以临床化合物BGB-11417为先导化合物,通过骨架跃迁等方法,设... 详细信息

目的设计并合成一系列新型Bcl-2小分子抑制剂,测试其对Bcl-2和Bcl-2 G101V(Bcl-2突变体)与BH3-only蛋白相互作用的抑制活性,初步探究其构效关系,为后续相关研究提供参考。方法以临床化合物BGB-11417为先导化合物,通过骨架跃迁等方法,设计新型含螺环结构的Bcl-2小分子抑制剂。以苯甲醛为原料,通过取代、环化和偶联等反应合成目标化合物,并通过1H NMR和LC-MS进行结构确定。采用时间分辨荧光共振能量转移(TR-FRET)评价目标化合物对Bcl-2和Bcl-2 G101V(Bcl-2突变体)与BH3-only蛋白相互作用的抑制能力。结果共合成8个新型螺环Bcl-2小分子抑制剂,其中29a[IC_(50)(Bcl-2):0.8 nmol·L^(-1),IC_(50)(Bcl-2 G101V):55.41 nmol·L^(-1)],29d[IC_(50)(Bcl-2):0.27 nmol·L^(-1),IC_(50)(Bcl-2 G101V):18.65 nmol·L^(-1)]对Bcl-2和Bcl-2 G101V与BH3-only蛋白的相互作用有较好的抑制活性。结论建立了一种新型螺环Bcl-2小分子抑制剂合成方法,发现了对Bcl-2和Bcl-2 G101V(Bcl-2突变体)与BH3-only蛋白相互作用有较好抑制活性的新化合物,其中29d具有进一步研究的价值。

关键词：细胞凋亡 Bcl-2 家族 Bcl-2 突变蛋白小分子抑制剂分子对接

A tree detection method based on trunk point cloud section in dense plantation forest using drone Li DAR data

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Forest Ecosystems 2023年第1期10卷 37-45页

作者： Yupan Zhang Yiliu Tan Yuichi Onda Asahi Hashimoto takashi Gomi Chenwei Chiu Shodai Inokoshi Center for Research in Isotopes and Environmental Dynamics University of Tsukuba1-1-1TennodaiTsukubaIbaraki305-8572Japan Graduate School of Systems and Information Engineering University of Tsukuba1-1-1TennodaiTsukubaIbaraki305-8572Japan Department of International Environmental and Agricultural Science Tokyo University of Agriculture and Technology3-5-8SaiwaieFuchuTokyo183-8509Japan

Single-tree detection is one of the main research topics in quantifying the structural properties of forests. Drone Li DAR systems and terrestrial laser scanning systems produce high-density point clouds that offer great promise for forest inventories in limited areas. However, most studies have focused on the upper canopy layer and neglected the lower forest structure. This paper describes an innovative tree detection method using drone Li DAR data from a new perspective of the under-canopy structure. This method relies on trunk point clouds, with undercanopy sections split into heights ranging from 1 to 7 m, which were processed and compared, to determine a suitable height threshold to detect trees. The method was tested in a dense cedar plantation forest in the Aichi Prefecture, Japan, which has a stem density of 1140 stems·ha^(-1) and an average tree age of 42 years. Dense point cloud data were generated from the drone Li DAR system and terrestrial laser scanning with an average point density of 5000 and 6500 points·m^(-2), respectively. Tree detection was achieved by drawing point-cloud section projections of tree trunks at different heights and calculating the center coordinates. The results show that this trunk-section-based method significantly reduces the difficulty of tree detection in dense plantation forests with high accuracy(F1-Score=0.9395). This method can be extended to different forest scenarios or conditions by changing section parameters.

关键词： Tree detection Trunk sections Forest Drone LiDAR

Deterministic and replaceable transfer of silver flakes for microcavities

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Frontiers of physics 2023年第3期18卷 139-146页

作者： Tingting Wang Zhihao Zang Yuchen Gao Kenji Watanabe takashi Taniguchi Wei Bao Yu Ye State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Research Center for Functional Materials National Institute for Materials Science1-1 NamikiTsukuba305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba305-0044Japan Electrical&Computer Engineering University of Nebraska-LincolnLincolnNE 68588USA Yangtze Delta Institute of Optoelectronics Peking UniversityNantong 226010China

How to fabricate high-quality microcavities simply and at low cost without causing damage to environmentally sensitive active layers such as perovskites are crucial for the studies of exciton–polaritons,however,it remains challenging in the field of microcavity ***,once the top mirror is deposited,the detuning of the microcavity is fixed and there is no easy way to tune ***,we have developed a method for deterministically transferring silver mirrors,which is relatively simple and guarantees the active layer from damaging of high temperature,particle bombardment,etc.,during the deposition of the top ***,with the help of a glass probe,we demonstrate a replaceable silver transfer method to tune the detuning of the microcavity,thereby changing the coupling of photons and excitons *** developed deterministic and replaceable silver mirror transfer methods will provide the capability to fabricate high-quality and tunable microcavities and play an active role in the development of the exciton–polariton field.

关键词： silver microcavity transfer perovskite