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由柏木制备纳米孔结构炭材料Ⅰ. 制备与孔结构(英文)

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新型炭材料 2007年第3期22卷 199-205页

作者： Eiki Ito Ikuyoshi Kouchi Sylwia Mozia Masaharu Okuda Takashi Nakano Masahiro Toyoda Michio Inagaki Faculty of Engineering Aichi Institute of TechnologyYakusaToyota 470-0392JapanIntellectual Property Bank Corp.ToranomonMinato-kuTokyo 105-0001Japan Japan Intellectual Property Bank Corp.ToranomonMinato-kuTokyo 105-0001Japan Faculty of Engineering Oita UniversityDannoharu 700Oita 870-1192JapanShimizu Corp.Environ.Solution Div.ShibauraMinato-kuTokyo 105-8007Japan Shimizu Corp. Environ.Solution Div.ShibauraMinato-kuTokyo 105-8007Japan Faculty of Engineering Oita UniversityDannoharu 700Oita 870-1192Japan Faculty of Engineering Aichi Institute of TechnologyYakusaToyota 470-0392

柏木条经过热蒸气处理,成功地制备了纳米孔炭,无需另行活化,比表面积就可达1000m2/g以上。如果在800℃～870℃炭化,柏木炭外表面积可达400m2/g以上,与同样温度在氩气中炭化得到的柏木炭相比,后者微孔面积仅为30m2/g～40m2/g。在900℃以... 详细信息

柏木条经过热蒸气处理,成功地制备了纳米孔炭,无需另行活化,比表面积就可达1000m2/g以上。如果在800℃～870℃炭化,柏木炭外表面积可达400m2/g以上,与同样温度在氩气中炭化得到的柏木炭相比,后者微孔面积仅为30m2/g～40m2/g。在900℃以上炭化得到的柏木炭,微孔表面积高达800m2/g以上,外表面积约为150m2/g。柏木炭的孔结构可以通过调节过热蒸气的温度得到控制。

关键词：柏木炭微孔中孔炭化过热蒸气

用于制造高效低成本太阳能电池的单晶种铸造大型单晶硅

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Engineering 2015年第3期1卷 206-217页

作者： Bing Gao Satoshi nakano Hirofumi Harada Yoshiji Miyamura takashi Sekiguchi Koichi Kakimoto Research Institute for Applied Mechanics Kyushu University National Institute for Materials Science

为了能以低成本生产优质大型单晶硅,笔者提出了单晶种铸造技术。这项技术的实施,必须解决两个问题,即坩埚壁上的多晶成核问题和晶体内的位错增殖问题。在本文中,笔者尝试通过数值分析法来解决这两个问题。根据数值分析得出的优化熔炉结... 详细信息

为了能以低成本生产优质大型单晶硅,笔者提出了单晶种铸造技术。这项技术的实施,必须解决两个问题,即坩埚壁上的多晶成核问题和晶体内的位错增殖问题。在本文中,笔者尝试通过数值分析法来解决这两个问题。根据数值分析得出的优化熔炉结构和工况进行了实验,在实验中采用单晶种铸造技术来生长单晶硅。实验结果表明,该技术远优于常用的高性能多晶和准单晶铸造技术。

关键词：单晶种铸造单晶硅多晶成核位错增殖多晶硅

Roles of rare earth oxide additives in millimeter-wave sintering of AlN

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Journal of Rare Earths 2008年第2期26卷 141-145页

作者： Yukio Makino takashi Yoshioka Hiromi nakano Toshiyuki Ueno Shoji Miyake Osaka University 11-1 Mihogaoka IbarakiOsaka 567-0047 Japan Shimane Institute for Industrial Technology 1 Hokuryo-cho Matsue Simane 690-0816 Japan Ryukoku University Seta Otsu Shiga 520-2194 Japan Kinki University 3-4-1 Kowakae Higashi-OsakaOsaka 577-8502 Japan

Roles of rare earth oxide （RE2O3） additives in millimeter-wave（MM） sintering of AIN were investigated from the standpoints of phase diagram, heating characteristics of rare earth oxides, and morphology of intergranular oxide phase. In the millimeter-wave sintering of AIN, densification temperature decreased with the decrease of the ionic radius of rare earth ion and was closely related with the eutectic temperature in the RE2Oa-Al2O3 binary system. The lowest densification temperature in the millimeter-wave sintering of AIN with Yb2O3 additive was attributed to the largest heating rate of Yb2O3-Al2O3 binary oxide under millimeter-wave radiation. Furthermore, the lowest densification temperature could be attained while selecting the Yb2O3 content so as to form the intergranular phase with the eutectic composition in the Yb2O3-Al2O3 binary system. The result showed good agreement with the above mentioned during the sintering of Si3N4 with Yb2O3-Al2O3 additive. From TEM observation, it was verified that film-like intergranular oxide phase formed under millimeter-wave radiation was favorable for attaining high thermal conductivity in the Yb2O3 added AINs.

关键词： millimeter-wave rare earth oxide AIN, Si3N4 rapid densification selective heating heating rate thermal conductivity morphology

Use of water jet instruments in gastrointestinal endoscopy

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 122-127页

作者： Toru nakano Chiaki Sato Tadashi Sakurai takashi Kamei Atsuhiro Nakagawa Noriaki Ohuchi Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendai 980-8574Japan Department of Neurosurgery Tohoku University Graduate School of MedicineSendai 980-8574Japan

In recent years, water jet instruments have been used in the field of gastrointestinal endoscopy, mainly in two clinical situations: Investigation and treatment under endoscopic view. Injecting water jet into the gastrointestinal lumen is helpful for maintaining a clear endoscopic view, washing away blood or mucous in the lumen or on the surface of the tip of the endoscope. This contributes to reducing time and discomfort of examination. Water jet technology is an alternative method for dissecting soft tissue; this method does not harm the small vessels or cause mechanical or thermal damage. However, its use in clinical settings has been limited to the transmucosal injection of water into the submucosal layer that elevates the mucosa to prepare for endoscopic mucosal resection or endoscopic submucosal dissection, instead of tissue dissection, which may occur because of the continuous water jet. A preclinical study has been conducted using a pulsed water jet system as an alternative method for submucosal dissection by reducing intraoperative water consumption and maintenance of dissection capability. This review introduces recent studies pertaining to using a water jet in gastrointestinal endoscopy and discusses future prospects.

关键词： Endoscopy Water jet Endoscopic submucosaldissection Endoscopic mucosal resection Pulse

Combined thoracoscopic and endoscopic surgery for a large esophageal schwannoma

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World Journal of Gastroenterology 2017年第46期23卷 8256-8260页

作者： Yu Onodera Toru nakano Daisuke Takeyama Shota Maruyama Yusuke Taniyama Tadashi Sakurai Takahiro Heishi Chiaki Sato Takuro Kumagai takashi Kamei Division of Advanced Surgical Science and Technology Tohoku University Graduate School of Medicine Division of Gastroenterological and Hepatobiliarypancreatic Surgery Tohoku Medical and Pharmaceutical University

A 47-year-old woman presented to our hospital with complaints of dysphagia. Esophagogastroduodenoscopy identified a submucosal tumor in the left wall of the esophagus that was diagnosed as a benign schwannoma on biopsy. Computed tomography revealed a tumor of length 60 mm in the thoracic esophagus, with its cranial edge at the level of the aortic arch. On endoscopy, a submucosal tunnel was created 40 mm proximal to the cranial edge of the tumor, and its oral end was dissected from the mucosal and muscular layers. This was followed by the resection of the entire tumor by left-sided thoracoscopy. The esophageal defect was closed in layer by continuous suture from the thoracic side. Endoscopic closure was achieved by using clips. No postoperative complications were observed. Oral diet was resumed from postoperative day 7 and the patient was discharged on postoperative day 9. This combined approach has not been described for similar tumors. Our experience demonstrated that large esophageal tumors can be safely excised with minimally invasive surgery by using a combination of thoracoscopy and endoscopy.

关键词： Esophagus Thoracoscopy Endoscopy Schwannoma Submucosal tumor

Immunological Effects of Silica and Asbestos

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Cellular & Molecular Immunology 2007年第4期4卷 261-268页

作者： Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura Department of Hygiene Kawasaki Medical SchoolMatsushima 577Kurashiki 7010192Japan Eppley Institute for Cancer Research University of Nebraska Medical CenterOmahaNebraska 68198USA Department of Internal Medicine Kusaka Hospital1122 NishikatagamiBizen 7050021Japan Department of Respiratory Medicine Hyogo Medical College of Medicine1-1 Mukogawa-choNishinomiyaHyogo 6638131Japan Okayama Rosai Hospital 1-10-25 Chikkou-midori-machiOkayama 7028055Japan Department of Rehabilitation Faculty of Health Sciences and TechnologyKawasaki University of Medical Welfare288 MatsushimaKurashiki 7010193Japan Department of Nursing Kawasaki College of Allied Health Professions316 MatsushimaKurashiki 7010194Japan

Silicosis patients （SILs） and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular, SIL sometimes complicates autoimmune diseases such as systemic scleroderma, rheumatoid arthritis （known as Caplan syndrome）, and systemic lupus erythematoses. In addition, malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos, and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica, more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors, respectively. In addition, immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cellmediated therapies, various cytokines, and molecule-targeting therapies. In particular, as the incidence of asbestosrelated malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan, efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety.

关键词： silica asbestos immunology Fas regulatory T cell apoptosis

Indocyanine green fluorescence and three-dimensional imaging of right gastroepiploic artery in gastric tube cancer

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World Journal of Gastroenterology 2015年第1期21卷 369-372页

作者： Toru nakano Tadashi Sakurai Shota Maruyama Yohei Ozawa takashi Kamei Go Miyata Noriaki Ohuchi Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendaiMiyagi 980-8574Japan

A 79-year-old male was admitted to our hospital for the treatment of cancer of the gastric tube.Gastrointestinal examination revealed a T1 b Union for International Cancer Control(UICC) tumor at the pyloric region of the gastric tube.Laparotomy did not reveal infiltration intothe serosa,peritoneal dissemination,regional lymph node swelling,or distant metastasis.We performed a distal gastrectomy preserving the right gastroepiploic artery by referencing the preoperative three-dimensional computed tomoangiography.We also evaluated the blood flow of the right gastroepiploic artery and in the proximal gastric tube by using indocyanine green fluorescence imaging intra-operatively and then followed with a gastrojejunal anastomosis with Roux-en-Y reconstruction.The definitive diagnosis was moderately differentiated adenocarcinoma of the gastric tube,pT 1bN 0M0,pS tage IA(UICC).His postoperative course was uneventful.Three-dimensional computed tomographic imaging is effective for assessing the course of blood vessels and the relationship with the surrounding structures.Intraoperative evaluation of blood flow of the right gastroepiploic artery and of the gastric tube in the anastomotic portion is very valuable information and could contribute to a safe gastrointestinal reconstruction.

关键词： Gastrectomy Indocyanine green Computed tomography

Liver cirrhosis in Japan:Future global trends in the era of progressive antiviral therapy

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Portal Hypertension & Cirrhosis 2022年第3期1卷 178-183页

作者： Hirayuki Enomoto Tomoyuki takashima takashi Nishimura Nobuhiro Aizawa Naoto Ikeda Yukihisa Yuri Mamiko Okamoto Kohei Yoshihara Ryota Yoshioka Shoki Kawata Shogo Ota Ryota nakano Hideyuki Shiomi Hiroko Iijima Department of Internal Medicine Division of Hepatobiliary and Pancreatic DiseaseHyogo Medical UniversityHyogoJapan

In Japan,viral hepatitis is the main cause of chronic liver diseases,including liver cirrhosis.Due to the availability of highly effective antiviral drugs in combination with antihepatitis measures,Japan has become one of the most successful countries in the world with regard to hepatitis virus elimination.In Japan,there are many elderly patients who have been infected with hepatitis C virus for a long time,and antihepatitis measures have been in place since the 2000s.Thus,the medical situation in Japan is expected to reflect the future situation in other countries where hepatitis countermeasures have been recently initiated and the infected population is aging.Our nationwide survey clarified the changes in the etiologies of liver cirrhosis in Japan.Although viral hepatitis remains a major cause of liver cirrhosis in Japan,nonviral cirrhosis is suggested to increasingly contribute to the etiologies of liver cirrhosis,as opposed to viral hepatitis‐related liver cirrhosis.The changing etiology of liver cirrhosis in Japan may help to predict future global trends in chronic liver diseases.

关键词： antihepatitis measures antiviral drugs etiology liver cirrhosis viral hepatitis

Carbon-Ion Beams Efficiently Induce Cell Killing in X-Ray Resistant Human Squamous Tongue Cancer Cells

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第3期3卷 133-142页

作者： Akihisa Takahashi Hongyu Ma Akiko Nakagawa Yukari Yoshida Tatsuaki Kanai Tatsuya Ohno Yoshikazu Kuwahara Manabu Fukumoto Takashi Nakano Advanced Scientific Research Leaders Development Unit Gunma University Gunma Japan Department of Pathology IDAC Tohoku University Sendai Japan Department of Radiation Oncology Gunma University Graduate School of Medicine Gunma Japan Gunma University Heavy Ion Medical Center Gunma Japan

In order to see whether carbon ion (C-ion) beams have a biological advantage over X-rays, studies were designed to examine the effects of C-ion beams on radiosensitivity in X-ray resistant cells. Clinically relevant X-ray resistant SAS-R cells derived from human tongue cancer SAS cells were used. The cells were exposed to X-rays or Spread-Out Bragg peak (SOBP) beam C-ions. Cell survival was measured using a modified high-density survival assay. Cell survival signaling and cell death signaling were analyzed using flow cytometry. The cells were labeled with putative cancer stem cell markers such as CD44 and CD326. SAS-R cells were 1.6 times more radioresistant than SAS cells after exposure to X-rays. Cell survival was similar in each cell line after exposure to C-ion beams. SAS-R cells displayed enhanced cell survival signaling when compared to SAS cells under normal conditions. On the other hand, the phosphorylation of AKT-related proteins decreased and polycaspase activities were enhanced when cells were irradiated with C-ion beams in both cell lines. More CD44 and CD326 positive cells were seen in SAS-R cells than in SAS cells. Moreover, the marker positive cell numbers significantly decreased after exposure to C-ion beams when compared to X-rays at iso-survival doses in SAS-R cells. C-ion beams efficiently induced cell killing in X-ray resistant cells which displayed activated cell survival signaling and contained more numerous cancer stem-like cells.

关键词： Carbon-Ion Beams X-Ray Resistant Cells Cell Survival and Death Signaling Cancer Stem-Like Cells