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Right colon cancer presenting as hemorrhagic shock

World Journal of Gastrointestinal Pathophysiology 2011年第1期2卷 15-18页

作者： Tomoyuki Iwata Kazuo Konishi Takahisa Yamazaki Katsuya Kitamura Atsushi Katagiri takashi muramoto Yutaro Kubota Yuichiro Yano Yoshiya Kobayashi Toshiko Yamochi Nobuyuki Ohike Masahiko Murakami Takehiko Gokan Nozomi Yoshikawa Michio Imawari Division of Gastroenterology Department of MedicineShowa University School of Medicine Second Department of Pathology Showa University School of Medicine First Department of Pathology Showa University School of Medicine Division of Gastroenterogical Surgery Department of SurgeryShowa University School of Medicine Department of Radiology Showa University School of Medicine Endoscopic Center Showa University HospitalShowa University School of Medicine

A 67-year-old man visited our hospital with a history of continuous hematochezia leading to hemorrhagic *** abdominal computed tomography scan re-vealed a large mass in the ascending colon invading the duodenum and pancreatic head as well as extra-vasation of blood from the gastroduodenal artery(GDA) into the *** revealed an irregular ulcerative lesion and stenosis in the ascending ***,right hemicolectomy combined with pylorus-preser ving pancreaticoduodenectomy was ***,the tumor was classified as a moderately differentiated ***,cancer cells were mainly located in the colon but had also invaded the duode-num and pancreas and involved the ***,the tumor cells were positive for cytokeratin(CK)20 and carcinoembryonic antigen(CEA)but not forCK7 and carbohydrate antigen(CA)*** patient died 23 d after the surgery because he had another episode of arterial bleeding from the anastomosis *** En bloc resection of the tumor with pancreatico duodenectomy and colectomy performed for locally advanced colon cancer can ensure long-term survival,patients undergoing these procedures should be carefully monitored,particularly when the tumor involves the main artery.

关键词： Colon cancer Hemorrhagic shock Adjacent organs invasion En bloc resection Complication

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Production of the Blood Pressure Lowing Peptides from Brown Alga(Undaria pinnatifida)

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Journal of Ocean University of China 2005年第3期4卷 209-213页

作者： Sato Minoru Oba takashi Hosokawa Takao Yamaguchi Toshiyasu Nakano Toshiki Saito Tadao muramoto Koji Kahara takashi Funayama Katsura Kobayashi Akio Nakano Takahisa Graduate School of Agricultural Science Tohoku University Aoba-Ku Sendai Miyagi 981-8555 JapanGraduate School of Agricultural Science Tohoku University Aoba-Ku Sendai Miyagi 981-8555 JapanGraduate School of Agricultural Science Tohoku University Aoba-Ku Sendai Miyagi 981-8555 JapanGraduate School of Agricultural Science Tohoku University Aoba-Ku Sendai Miyagi 981-8555 JapanGraduate School of Agricultural Science Tohoku University Aoba-Ku Sendai Miyagi 981-8555 JapanGraduate School of Agricultural Science Tohoku University Aoba-Ku Sendai Miyagi 981-8555 JapanGraduate School of Agricultural Science Tohoku University Aoba-Ku Sendai Miyagi 981-8555 JapanRiken Vitamin Co. Ltd. 2-9-18 Misaki-Cho Chiyoda-Ku Tokyo 101-8370 JapanRiken Vitamin Co. Ltd. 2-9-18 Misaki-Cho Chiyoda-Ku Tokyo 101-8370 JapanRiken Vitamin Co. Ltd. 2-9-18 Misaki-Cho Chiyoda-Ku Tokyo 101-8370 JapanRiken Vitamin Co. Ltd. 2-9-18 Misaki-Cho Chiyoda-Ku Tokyo 101-8370 Japan

Brown alga (Undaria pinnatifida) was treated with alginate lyase and hydrolyzed using 17 kinds of proteases andthe inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme (ACE) was measured. Four hydrolysateswith potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHRs). The sys-tolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by pro-tease S ’Amano’ (from Bacillus stearothermophilus) at the concentration of 10 (mg protein) (kg body weight)-1. In the 17weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressedfor 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction andHPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid compo-sition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, andLeu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. Thebrown alga hydrolysates were also confirmed to decrease the blood pressure in humans.

关键词：海藻缩氨酸抗血压药物藻酸盐水解工艺

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