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Streamline pair selection for comparative flow field visualization

Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 215-226页

作者： Shoko Sawada Takayuki Itoh takashi misaka Shigeru Obayashi Tobias Czauderna Kingsley Stephens Ochanomizu University 2-1-1 OtsukaBunkyo-kuTokyo 1128610Japan Tohoku University 2-1-1 KatahiraAoba-kuSendaiMiyagi 9808577Japan Monash University Wellington RoadClaytonVictoriaAustralia

Fluid dynamics simulation is often repeated under varying *** leads to a generation of large amounts of results,which are difficult to *** compare results under different conditions,it is effective to overlap the streamlines generated from each condition in a single three-dimensional *** is a curved line,which represents a wind *** paper presents a technique to automatically select and visualize important streamlines that are suitable for the comparison of the simulation ***,we present an implementation to observe the flow fields in virtual reality spaces.

关键词： Computational fluid dynamics Streamline selection Comparative flow field visualization Virtual reality

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Maintenance time of sedative effects after an intravenous infusion of diazepam: A guide for endoscopy using diazepam

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World Journal of Gastroenterology 2008年第33期14卷 5197-5203页

作者： Mitsushige Sugimoto Takahisa Furuta Akiko Nakamura Naohito Shirai Mutsuhiro Ikuma Shingen misaka Shinya Uchida Hiroshi Watanabe Kyoichi Ohashi takashi Ishizaki Akira Hishida First Department of Medicine Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Center for Clinical Research Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Department of Gastroenterology Enshu General Hospital1-1-1 Tyuou Naka-ku Hamamatsu 430-0929 Japan Department of Pharmacoki-netics and Pharmacodynamics School of Pharmaceutics Sciences University of Shizuoka52-1 Yada Suruga-ku Shizuoka 422-8526 Japan Department of Clinical Pharmacology and Therapeutics Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Department of Clinical Pharmacology and Therapeutics Oita University1-1 Idaigaoka Hazama Yufu 879-5593 Japan

AIM: To examine whether the sedative effects assessed by psychomotor tests would depend on the cytochrome P450 (CYP ) 2C19 genotypes after an infusion regimen of diazepam commonly used forgastrointestinal endoscopy in Japan. METHODS: Fifteen healthy Japanese volunteers consisting of three different CYP2C19 genotype groups underwent a critical ? icker fusion test, an eye movement analysis and a postural sway test as a test for physical sedative effects, and a visual analog scale (VAS) symptom assessment method as a test for mental sedative effects during the 336 h period after the intravenous infusion of diazepam (5 mg). RESULTS: The physical sedative effects assessed by the critical flicker test continued for 1 h (t values of 5 min, 30 min and 60 min later: 4.35, 5.00 and 3.19, respectively) and those by the moving radial area of a postural sway test continued for 3 h (t values of 5 h, 30 h, 60 min and 3 h later: -4.05, -3.42, -2.17 and -2.58, respectively), which changed significantly compared with the baseline level before infusion (P < 0.05). On the other hand, the mental sedative effects by the VAS method improved within 1 h. The CYP2C19 genotype-dependent differences in the postinfusion sedative effects were not observed in any of the four psychomotor function tests. CONCLUSION: With the psychomotor tests, the objective sedative effects of diazepam continued for 1 h to 3 h irrespective of CYP2C19 genotype status and the subjective sedative symptoms improved within 1 h. Up to 3 h of clinical care appears to be required after the infusion of diazepam, although patients feel subjectively improved.

关键词： Diazepam Sedation cytochrome P450(CYP) 2C19 Endoscopy Complication Critical flicker fusion test Eye movement analysis Postural sway test Visual analog scale

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Prognostic factors in heart failure patients with cardiac cachexia

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Journal of Geriatric Cardiology 2020年第1期17卷 26-34页

作者： Yu Sato Akiomi Yoshihisa Yusuke Kimishima Tetsuro Yokokawa Satoshi Abe Takeshi Shimizu Tomofumi misaka Shinya Yamada Takamasa Sato takashi Kaneshiro Masayoshi Oikawa Atsushi Kobayashi Takayoshi Yamaki Hiroyuki Kunii Yasuchika Takeishi Department of Cardiovascular Medicine Fukushima Medical UniversityFukushimaJapan Department of Advanced Cardiac Therapeutics Fukushima Medical UniversityFukushimaJapan

Objective To clarify whether cardiac cachexia(CC)alters the prognostic impact of other general risk factors in patients with heart failure(HF).Methods This was an observational *** was defined as the combination of a body mass index of5 mg/L;hemoglobin<12 g/dL;and/or albumin<3.2 g/d *** divided 1608 hospitalized HF patients into a CC group(n=176,10.9%)and a non-CC group(n=1432,89.1%).The primary endpoints were cardiac event and all-cause *** The presence of CC showed significant interactions with other risk factors including cancer,estimated glomerular filtration rate(eGFR),and sodium in predicting these *** Cox proportional analysis revealed that use of a blockers[hazard ratio(HR)=1.900,95%confidence interval(CI):1.045–3.455,P=0.035]and eGFR(HR=0.989,95%CI:0.980–0.998,P=0.018)were independent predictors of cardiac event in the CC group,while age(HR=1.020,95%CI:1.002–1.039,P=0.029)and hemoglobin(HR=0.844,95%CI:0.734–0.970,P=0.017)were independent predictors of all-cause *** survival classification and regression tree analysis showed the optimal cut-off points for cardiac event(eGFR:59.9 m L/min per 1.73 m^2)and all-cause death(age,83 years old;hemoglobin,10.1 g/dL)in the CC *** In predicting prognosis,CC showed interactions with several risk *** function,age,and hemoglobin were pivotal markers in HF patients with CC.

关键词： Body mass index Cachexia Heart failure Mortality Prognosis

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门控SPECT心肌灌注显像评估左心室机械不同步时采集轨道对相位分析的影响

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中华核医学与分子影像杂志 2017年第11期37卷 751-751页

作者：李梦婷兰晓莉 Tomofumi misaka Makoto Hosono takashi Kudo Takamichi Ito Tsutomu Syomura Masanobu Uemura Kaoru Okajima 华中科技大学同济医学院附属协和医院核医学科 Faculty of Medicine Institute of Advanced Clinical MedicineKindai University

目的通过门控SPECT心肌灌注成像（MPI）的相位分析获得的左心室（LV）不同步参数与采集轨道间的关联尚不清楚。该研究旨在评估LV不同步参数对采集轨道的依赖性。方法 99例接受;Tl门控SPECT MPI的患者被分为轻度低灌注组和重度低灌注组... 详细信息

目的通过门控SPECT心肌灌注成像（MPI）的相位分析获得的左心室（LV）不同步参数与采集轨道间的关联尚不清楚。该研究旨在评估LV不同步参数对采集轨道的依赖性。方法 99例接受;Tl门控SPECT MPI的患者被分为轻度低灌注组和重度低灌注组。44例接受;Tc;-替曲膦门控SPECT MPI的患者被分为轻度低灌注组和重度低灌注组。;Tl显像的重度低灌注组又分为下壁和非下壁低灌注亚组,前间壁和非前间壁低灌注亚组。重建360°采集轨道（360°图像）和180°采集轨道（180°图像）的门控SPECT MPI数据,比较直方图带宽（HBW）和相位标准差（PSD）。结果重度低灌注组中,;Tl的360°和180°图像相比,HBW和PSD在整体上（HBW:34.8±16.6与29.1±10.2;PSD:8.8±4.9与7.0±2.3,均P<0.05）及下壁间（HBW:29.5±15.5与23.3±9.0;PSD:7.6±4.6与5.6±2.4,均P<0.001）均有差异,且重度低灌注组中所有亚组的下壁也均有差异。与此相反,在;Tc;的360°和180°图像间,没有节段在HBW或PSD上有差异。结论在重度心肌低灌注患者中,采集轨道不同对经;Tl门控SPECT MPI采集的下壁HBW和PSD有显著影响。

关键词：左心室机械不同步门控SPECT心肌灌注显像相位分析采集轨道

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