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A Fundamental Study of a Computer Player Giving Fun to the Opponent

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Journal of Computer and Communications 2018年第1期6卷 32-41页

作者： Yuki Takaoka takashi kawakami Ryosuke Ooe The Graduate School of Engineering Hokkaido University of Science Sapporo Japan Computer Science Hokkaido University of Science Sapporo Japan

In this research, we aim to create a computer player that gives fun to the opponent. Research on game AI has spread widely in recent years, and many games are being studied. Some of those studies have made remarkable results. Game research is aimed at strengthening computer players. However, it is unknown whether a computer player who is too strong is good. There may also be opponents who think that a computer player is not interesting if it is too strong. Therefore, we thought whether we could create a computer player who entertains the opponent while maintaining a certain degree of strength. To realize this idea, we use the Monte Carlo Tree Search. We tried to create a computer player that gives fun to the opponent by improving the Monte Carlo Tree Search. As a result of some experiments, we succeeded in giving fun, although it was a first step. On the other hand, many problems were found through experiments. In future, it is necessary to solve these problems.

关键词： Giving Fun Imperfect Information Game UCB Applied to Tree

An Acoustic Events Recognition for Robotic Systems Based on a Deep Learning Method

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Journal of Computer and Communications 2015年第11期3卷 46-51页

作者： Tadaaki Niwa takashi kawakami Ryosuke Ooe Tamotsu Mitamura Masahiro Kinoshita Masaaki Wajima Graduate School of Engineering Hokkaido University of Science Sapporo Japan Faculty of Engineering Hokkaido University of Science Sapporo Japan Faculty of Future Design Hokkaido University of Science Sapporo Japan

In this paper, we provide a new approach to classify and recognize the acoustic events for multiple autonomous robots systems based on the deep learning mechanisms. For disaster response robotic systems, recognizing certain acoustic events in the noisy environment is very effective to perform a given operation. As a new approach, trained deep learning networks which are constructed by RBMs, classify the acoustic events from input waveform signals. From the experimental results, usefulness of our approach is discussed and verified.

关键词： Acoustic Events Recognition Deep Learning Restricted Boltzmann Machine

A Study on Diagnostic Assist Systems of Chronic Obstructive Pulmonary Disease from Medical Images by Deep Learning

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Journal of Computer and Communications 2018年第1期6卷 21-31页

作者： Toru Kimura takashi kawakami Akihiro Kikuchi Ryosuke Ooev Masaki Akiyama Hiroyuki Horikoshi Faculty of Engineering Hokkaido University of Science Sapporo Japan Department of Radiology Gunma Prefecture Cancer Center Gunma Japan

In this paper, we propose new diagnostic assist systems of medical images using deep learning algorithms. Specifically, we aim to develop a diagnostic support system for the very early stage of chronic obstructive pulmonary disease (COPD) based on the CT images. It is said that COPD is a disease that develops due to long-term smoking, and it is said that there are a large number of latent onset reserve forces. By discovering this COPD in the very early period 0 and improving the living conditions, subsequent severity can be avoided in many cases, so a system that will help diagnosis by professional radiologists is needed. We show the some experimental results examined by the constructed system.

关键词： Deep Learning CT Images Diagnostic Assist Systems Chronic Obstructive Pulmonary Disease

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多家外国电动车瞄准中产消费者

多家外国电动车瞄准中产消费者

LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification

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作者： takashi kawakami 胡安·费利佩·穆尼奥斯陈康

日本《日经亚洲评论》5月15日文章，原题：比特斯拉便宜：本田瞄准中国的中产消费者本田正在中国市场全力以赴，这家日本汽车制造商刚刚在中国推出了面向这一世界最大电动汽车市场的纯电车型。该公司去年在中国售出156万辆新车，同比下... 详细信息

日本《日经亚洲评论》5月15日文章，原题：比特斯拉便宜：本田瞄准中国的中产消费者本田正在中国市场全力以赴，这家日本汽车制造商刚刚在中国推出了面向这一世界最大电动汽车市场的纯电车型。该公司去年在中国售出156万辆新车，同比下降4%，其中大部分是燃油车和混合动力车型......

关键词：纯电动汽车电动车汽车制造商消费者

来源： cnki报纸评论

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Journal of Pharmaceutical Analysis 2022年第6期12卷 852-859页

作者： takashi Mochizuki Kaito Shibata Takafumi Naito Kumiko Shimoyama Noriyoshi Ogawa Masato Maekawa Junichi kawakami Department of Hospital Pharmacy Hamamatsu University School of MedicineHamamatsu431-3192Japan Department of Pharmacy Shinshu University HospitalMatsumotoNagano390-8621Japan Third Division Department of Internal MedicineHamamatsu University School of MedicineHamamatsu431-3192Japan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsu431-3192Japan

The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry(LC-MS/MS)method has not been widely applied in clinical settings because of its time-consuming and costly sample *** present study aimed to develop a validated LC-MS/MS method for detecting serum tocilizumab by utilizing immobilized trypsin without an immunoglobulin G purification step and evaluate its applicability in the treatment of rheumatoid arthritis(RA)patients administered intravenously or subcutaneously with *** tocilizumab-derived signature peptide was deciphered using a nano-LC system coupled to a hybrid quadrupole-orbitrap mass *** serum tocilizumab was rapidly digested by immobilized trypsin for 30 *** chromatographic peak of the signature peptide and that of the internal standard were separated from the serum digests for a total run time of 15 *** calibration curve of serum tocilizumab concentration was linear with a range of 2-200 μg/*** intra-and inter-day accuracy and relative standard deviation(RSD)were 90.7%-109.4%and<10%,*** serum tocilizumab concentrations in the RA patients receiving intravenous and subcutaneous injections were 5.8-28.9 and 2.4-63.5 μg/mL,*** serum tocilizumab concentrations using the current method positively correlated with those using the enzyme-linked immunosorbent assay,although a systematic error was observed between these *** conclusion,a validated LC-MS/MS method with minimal sample pretreatments for monitoring serum tocilizumab concentrations in RA patients was developed.

关键词： Tocilizumab LC-MS/MS Immobilized trypsin IgG purification Proteomics Rheumatoid arthritis

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

Third-line therapies in patients with Kawasaki disease refractory to first-and second-line intravenous immunoglobulin therapy

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World Journal of Pediatrics 2022年第11期18卷 781-785页

作者： takashi Furuta Hiroki Yasudo Seigo Okada Yuji Ohnishi Akiko kawakami-Miyake Yasuo Suzuki Shouichi Ohga Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi755-8505Japan Department of Pediatrics Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan

Kawasaki disease(KD)is an acute febrile ilness characterized by systemic vasculitis affecting the small-and mediumsized arteries in children [1,2].One of the most critical complications of KD is the development of coronary artery lesions(CALs)approximately after 12 days of ilness,which may lead to myocardial infarction[3].High-dose intravenous immunoglobulin(IVIG)and oral administration of aspirin have been established as the first-line therapy for KD[4,5].

关键词： intravenous acute immunoglobulin

Refractory ulcerative colitis accompanied with cytomegalovirus colitis and multiple liver abscesses: A case report

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World Journal of Gastroenterology 2005年第33期11卷 5241-5244页

作者： Takuya Inoue Ichiro Hirata Yutaro Egashira Kumi Ishida Ken kawakami Eijiro Morita Naoko Murano Shingo Yasumoto Mitsuyuki Murano Ken Toshina takashi Nishikawa Norihiro Hamamoto Ken Nakagawa Ken-Ichi Katsu The Second Department of Internal Medicine Osaka Medical College 2-7 DaigakuchoTakatsuki City Osaka 569-8686 Japan Department of Pathology Osaka Medical College Takatsuki City Osaka 569-8686 Japan The Second Department of Internal Medicine Osaka Medical College 2-7 Daigakucho Takatsuki City Osaka 569-8686 Japan

Various hepato-biliary complications are an increased incidence in patients with inflammatory bowel disease,and portal bacteremia is well documented in patients with ulcerative colitis (UC). However, few reports mention UC in association with liver abscesses. Recently, there are several reports describing cytomegalovirus (CMV) infection in association with disease exacerbation and steroid refractoriness in patients with UC. Here we present a case of refractory UC accompanied with multiple liver abscesses and CMV colitis. The patient, a 72-year-old male, with a five-year history of repeated admissions to our hospital for UC, presented with an exacerbation of his *** performed on admission suggested that his UC was exacerbated, then he was given prednisolone and mesalazine orally, and betamethasone ***, he had exacerbated symptoms. Repeat sigmoidoscopy revealed multiple longitudinal ulcers and pseudopolyps in the rectosigmoid colon. Although immunohistochemical staining of biopsy specimens and the serum testing for antigenemia were negative on admission and after the repeat sigmoidoscopy, they became histologically positive for CMV. Nonetheless, the patient developed spiking fevers, soon after ganciclovir was administered. Laboratory studies revealed an increased white cell count with left shift, and Enterococcus fecalis grew in blood cultures. An abdominal computed tomography (CT) scan was obtained and the diagnosis of liver abscesses associated with UC was made, based on CT results. The hepatic abscesses were successfully treated with intravenous meropenem for 6 wk, without further percutaneous drainage. To our knowledge, this is the first reported case of multiple liver abscesses that develop during UC exacerbation complicated by CMV colitis.

关键词： Uver abscess Ulcerative colitis Cytomegalovirusinfection Inflammatory bowel disease

Circulating immunocompetent cell profiles during oral cyclosporin therapy for immunoglobulin-resistant Kawasaki disease

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World Journal of Pediatrics 2021年第6期17卷 671-673页

作者： Seigo Okada Yuji Ohnishitakashi Furuta Yasuo Suzuki Akiko kawakami-Miyake Chie Matsuguma Takako Waniishi Hiroki Yasudo Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi 755-8505Japan

Although the standard treatment for Kawasaki disease(KD)is intravenous immunoglobulin(IVIG)combined with oral aspirin,18%of 1st IVIG is refractory[1].Recently,the efficacy of immunomodulatory drugs for IVIG-resistant KD,such as prednisolone,infliximab(IFX),and cyclosporine(CsA),has been reported[2-5].However,optimal immunomodulatory therapy for IVIG-resistant KD has not yet been established.

关键词： immuno drugs immunoglobulin