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Applicability of Mean Field Approximation to Numerical Experiments of Thermal Convection during the Cooling Period of Lake Biwa

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Journal of Energy and Power Engineering 2013年第12期7卷 2220-2226页

作者： takashi hosoda Frederick Malembeka Department of Urban Management Graduate School of Engineering Kyoto Universi~ Kyoto 615-8540 Japan Department of Civil Engineering Arusha Technical College Arusha 296 Tanzania

This paper describes the applicability of a stochastic model to the numerical experiments of thermal convection carried out under the condition of the northern part of Lake Biwa, Shiga Prefecture, Japan. It was shown in the previous study that the temporal changes of vertical water temperature distributions during the cooling period between September and February can be reproduced by a simple 3D-CFD model. It was also pointed out that the spatial distributions of cooled water body sinking to the bottom due to water surface cooling represent similar features of forest gap distribution, which can be clarified by a stochastic model. The basic features of numerical experiments on thermal convection such as the spatial distribution of cooled water body are firstly shown with several cooling rates at water surface. Then, a stochastic model, which was originally introduced to explain forest gap dynamics, is shown with its MFA （mean field approximation） as first approximation of stochastic model. It is pointed out through the comparison of theoretical results by MFA with tuned model constants to numerical experiments that MFA with some refinement can be applicable to reproduce the basic features of simulated results to some extent, although further investigations are required to clarify the applicability of the model to more detailed mechanism of thermal convection such as size distribution of cooled water body, phase change of flow pattern, etc..

关键词： Thermal convection lake hydrodynamics Lake Biwa stochastic model.

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Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

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World Journal of Hepatology 2022年第7期14卷 1480-1494页

作者： Masato Nakai Kenichi Morikawa Shunichi hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi takashi Kitagataya Ren Yamada Masatsugu Ohara Takuya Sho Goki Suda Koji Ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent *** To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage *** In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and *** contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically ***-three patients were HCV-positive and 77 were *** In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after *** HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative *** In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival ***-sarcopenia contributed to the poor prognosis independently in HCV-negative *** factors might be useful recurrence and prognostic markers for early-stage primary HCC.

关键词： Mac-2 binding protein Mac-2 binding protein glycosylation isomer Pre-sarcopenia Primary hepatocellular carcinoma Radiofrequency ablation

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