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Development of Film Dosage Forms Containing Miconazole for the Treatment of Oral Candidiasis

Pharmacology & Pharmacy 2013年第3期4卷 325-330页

作者： Yoshifumi Murata takashi isobe Kyoko Kofuji Norihisa Nishida Ryosei Kamaguchi Faculty of Pharmaceutical Science Hokuriku University Kanazawa Japan Morishita Jintan Co. Osaka Technocenter Hirakata Japan.

Film dosage forms (FDs) containing miconazole (MCZ) for the treatment of oral candidiasis were prepared using water-soluble polysaccharides, and the dissolution profiles of MCZ from the FDs were investigated. In addition, the forms were modified by the addition of a surface active agent to accelerate the drug dissolution rate. Circular films incorporating MCZ were obtained using each polysaccharide. Most FDs were easy to handle and resistant to tearing. No diffraction peaks were observed in the X-ray diffractograms of FDs. FDs prepared with sodium alginate or pullulan immediately swelled and disintegrated in aqueous medium, whereas MCZ incorporated in the FD gradually dissolved. A marked acceleration in the MCZ dissolution rate was observed when FD was prepared with polysaccharide containing a surfactant. These results confirmed that modified FDs are useful for treating localized conditions in the oral cavity, such as oral candidiasis, and that FDs can simplify the administration of drugs to patients.

关键词： Film Dosage Form Miconazole Oral Candidiasis Natural Polysaccharide Surface Active Agent

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Development of Oral Dissolving Gelatin Beads Containing Allopurinol for the Prevention and Treatment of Mucositis

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Pharmacology & Pharmacy 2012年第3期3卷 295-299页

作者： Yoshifumi Murata takashi isobe Kyoko Kofuji Masafumi Mizutani Ryosei Kamaguchi Faculty of Pharmaceutical Science Hokuriku University Ho-3 Kanagawa-machi Kanazawa Japan Morishita Jintan Co. Osaka Technocenter 2-11-1 Tudayamate Hirakata Japan

Oral dissolving gelatin beads (GBs) containing allopurinol (AP) were prepared by the seamless capsule method and their rheological properties were examined. The release profiles of both gelatin and AP from GBs were also investigated in limited dissolution medium. GBs containing AP provided an easy-to-handle dosage form, but the physical strength of the beads immediately decreased upon contact with physiological saline at 37℃. Gelatin was released from the outer layer of GBs in physiological saline, with almost all the gelatin dissolved after 5 min, together with approximately 30% of the AP contained in the inner layer of the GB. The oral administration of GBs likely results in immediate softening of the GB upon contact with saliva. The released AP acts directly at inflammation sites, in a manner similar following oral rinsing with an AP suspension. Therefore, GBs are a useful dosage form for preventing or treating localized problems in the oral cavity, such as mucositis.

关键词： Gelatin Bead Seamless Capsule Oral Mucositis Allopurinol

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Measurement of Ion Cyclotron Emissions by Using High-Frequency Magnetic Probes in the LHD

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Plasma Science and Technology 2013年第3期15卷 209-212页

作者： Kenji SAITO Ryuhei KUMAZAWA Tetsuo SEKI Hiroshi KASAHARA Goro NOMURA Fujio SHIMPO Hiroe IGAMI Mitsutaka isobe Kunihiro OGAWA Kazuo TOI Masaki OSAKABE Masaki NISHIURA Tsuguhiro WATANABE Satoshi YAMAMOTO Makoto ICHIMURA takashi MUTOH National Institute for Fusion Science Graduate School of Engineering Nagoya University Institute of Advanced Energy Kyoto University Tsukuba University Plasma Research Center

Two pairs of high-frequency magnetic probes were installed in the Large Helical Device （LHD）. During the injection of a perpendicular neutral beam, ion cyclotron emissions （ICEs） with the fundamental frequency corresponding to the ion cyclotron frequency at the plasma edge were detected, which are the same type of ICE as measured with the former spare ion cyclotron range of frequencies （ICRF） heating antennas. This type of ICE was further investigated with regard to the phase and intensity of signals. Another type of ICE was found in the LHD, and these ICEs were synchronized with bursts of toroidicity induced Alfv^n eigenmodes （TAE） and the rise of intensity of lost ion flux. Therefore the source of these ICEs was thought to be the particles transferred from the core to the outer region of plasma by the TAE bursts. The frequency of ICEs induced by the TAE bursts increases linearly with the magnetic field strength, since the ion cyclotron frequency increases with the magnetic field strength.

关键词： LHD ICE TAE lost particle high-frequency magnetic probe

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