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Management Studies 2017年第3期5卷 219-233页

作者： Ai hayakawa Masato Oguchi Saneyasu Yamaguchi Ochanomizu University Tokyo Japan Kogakuin University Tokyo Japan

Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on Malignant Progression and Metastasis of Tumor Cells

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World Journal of Traditional Chinese Medicine 2017年第4期3卷 26-45页

作者： lkuo Saiki Satoru Yokoyama Yoshihiro hayakawa University of Toyama Division of Pathogenic Biochemistry Institute of Natural Medicine University of Toyama

A Japanese herbal(Kampo,汉方)medicine,十全大补汤(juzentaihoto/Shi-Quan-Da-Bu-Tang),is one of the nourishing agents, a so-called"补剂(Hozai/Bu-Ji)," that is used for improving disturbance and imbalances in the homeostatic condition of the body. This formulation is orally administered to patients in various weakened states, including postsurgery patients and patients with chronic illness, where it can alleviate general symptoms such as extreme fatigue, pale complexion, loss of appetite, dry or scaly skin, night sweating, and dryness of the ***, juzentaihoto/Shi-Quan-Da-Bu-Tang has been shown to have a variety of biological activities, including activation of natural killer cells and macrophages, cytokine induction, antibody production, antitumor effects in combination with surgical excision or other drugs, and protection against the adverse effects of anticancer drugs and radiation, including immunosuppression and bone marrow toxicity. This article focuses on the antitumor and antimetastatic properties of some Kampo medicines and mainly describes the effects of juzentaihoto and its related formulations on tumor development, progression, and metastasis in vivo. We also discuss the inhibitory mechanism of action and the importance of the prescription and constituent crude drugs in determining the efficacy.

关键词： Epithelial-to-mesenchymal transition high-performance liquid chromatography pattern analysis Japanese herbal(Kampo) medicine juzentaihoto/Shi-Quan-Da-Bu-Tang macrophages malignant progression natural killer cells shimotsuto/Si-Wu-Tang tumor metastasis tumor vaccine

Hyperbaric Oxygen Stimulates the Proliferation and Differentiation of Raw264.7 Cells

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Open Journal of Stomatology 2015年第12期5卷 309-320页

作者： Tomotaka Sugi Masanori Sasaki Takahiro Yamashiro takaoki Tsuneyoshi Arioka Masaki Akihiko Matsumoto Kumamaru Wataru Nakano Hiroyuki Mori Yoshihide Section of Oral and Maxillofacial Surgery Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu University Japan

Background: Hyperbaric Oxygen (HBO) Therapy improves the outcome of various types of sugery, such as postoperative bone grafts, fixation of jaw fractures, and osteoplasty of jaw deformities. Therefore, it is important to determine the effects of HBO on bone regeneration. The purpose of this study was to clarify the influence of a hyperbaric oxygen environment on bone regeneration at the osteoclastogenic cytokines level. Sample & Methods: RAW264.7 cells were stimulated under the various conditions by using a hyperbaric oxygen chamber. We evaluated the ability of the RAW264.7 macrophages to proliferate, differentiate and produce various osteoclastogenic cyto-kines. Results: A hyperbaric oxygen (HBO) environment and high concentration oxygen (HCO) environment increase cellular proliferation in a time-dependent manner. On the other hand, a HCO environment and a hyperbaric with room air (HBA) environment enhanced the differentiation of RAW264.7 cells. In addition, NFATc1 and c-Fos were increased by both the HBA environment and HCO environment. However, the effects of HBA and HCO environments were in contrast with each other with regard to RANK, TNF-α, C-FMS and TRAP. Conclusions: It was suggested that a HBO environment influenced the bone regeneration by altering osteoclastogenic cytokines level, and that a HCO environment and HBA environment acted independently on the proliferation and differentiation of macrophages and the secretion of osteoclastogenic cytokines, and that they acted in concert in a hyperbaric oxygen environment to induce conditions favoring regeneration.

关键词： Hyperbaric Oxygen Therapy Bone Regeneration Osteoclast RAW264.7

Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsy

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World Journal of Gastroenterology 2007年第15期13卷 2179-2182页

作者： Atsushi Minami Shinji Hirose Tomohiro Nomoto Shoichiro hayakawa Internal Medicine Kawasaki Kyodo Hospital 2-1-5 Sakuramoto Kawasaki City 210-0833Japan

瞄准：介绍一个新方法：小内视镜的括约肌切开术(ES ) 与内视镜的乳突的大汽球膨胀(SES + EPLBD ) 结合了与大胆汁的石头对待病人。方法：大胆汁的石头的检索在 88 个病人被执行。吝啬的石头尺寸是 3 公里和石头的吝啬的数字是的 14 +/-... 详细信息

瞄准：介绍一个新方法：小内视镜的括约肌切开术(ES ) 与内视镜的乳突的大汽球膨胀(SES + EPLBD ) 结合了与大胆汁的石头对待病人。方法：大胆汁的石头的检索在 88 个病人被执行。吝啬的石头尺寸是 3 公里和石头的吝啬的数字是的 14 +/- 2.5 +/- 3.5。第一，有一个小切口的 ES 被执行。下次，内视镜的乳突的膨胀与一个大汽球被执行慢慢地匹配胆汁管的尺寸。石头然后与一个汽球和一个篮子从胆汁的管被检索。结果：没有需要，石头检索在除了一个膀胱的管石头盒子的所有情况中是成功的压碎大石头。吝啬的过程时间是 30 +/- 5 min。与一个大汽球扩大乳突的孔使没有压碎他们，顺利移开大石头可能。在有大汽球的膨胀以后，有流着，而是没有穿孔的一些例子。procedural 以后胰腺炎(1%) 的一个例子发生了。结论：没有机械碎石术的使用， SES + EPLBD 为大胆汁的石头的检索是有效的。

关键词：大结石小括约肌切开术乳突扩张气球扩张法胆管结石

Hydrogen Production Technologies Overview

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Journal of Power and Energy Engineering 2019年第1期7卷 107-154页

作者： Mostafa El-Shafie Shinji Kambara Yukio hayakawa Environmental and Renewable Energy Systems Division Gifu University Gifu City Japan

Hydrogen energy became the most significant energy as the current demand gradually starts to increase. Hydrogen energy is an important key solution to tackle the global temperature rise. The key important factor of hydrogen production is the hydrogen economy. Hydrogen production technologies are commercially available, while some of these technologies are still under development. This paper reviews the hydrogen production technologies from both fossil and non-fossil fuels such as (steam reforming, partial oxidation, auto thermal, pyrolysis, and plasma technology). Additionally, water electrolysis technology was reviewed. Water electrolysis can be combined with the renewable energy to get eco-friendly technology. Currently, the maximum hydrogen fuel productions were registered from the steam reforming, gasification, and partial oxidation technologies using fossil fuels. These technologies have different challenges such as the total energy consumption and carbon emissions to the environment are still too high. A novel non-fossil fuel method [ammonia NH3] for hydrogen production using plasma technology was reviewed. Ammonia decomposition using plasma technology without and with a catalyst to produce pure hydrogen was considered as compared case studies. It was showed that the efficiency of ammonia decomposition using the catalyst was higher than ammonia decomposition without the catalyst. The maximum hydrogen energy efficiency obtained from the developed ammonia decomposition system was 28.3% with a hydrogen purity of 99.99%. The development of ammonia decomposition processes is continues for hydrogen production, and it will likely become commercial and be used as a pure hydrogen energy source.

关键词： Hydrogen Technology Hydrogen Production Steam Reforming Plasma Ammonia Decomposition

A Study on the Correlation of Milk Yield of Cows with Seismicity and ULF Magnetic Field Variations

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Open Journal of Earthquake Research 2016年第4期5卷 206-218页

作者： Masashi hayakawa Tomokazu Asano Alexander Schekotov Hiroyuki Yamauchi hayakawa Institute of Seismo Electromagnetics Co. Ltd. University of Electro-Communications (UEC) Incubation Center Chofu Japan Advanced Wireless & Communications Research Center UEC Chofu Japan Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Department of Human and Animal-Plant Relationships Azabu University Sagamihara Japan

A statistical study on the basis of one-year data of 2014 has been performed in order to find whether abnormal animal behavior is related with seismic activity and also whether the ULF (Ultra Low Frequency) electromagnetic radiation might be a possible sensory mechanism of abnormal animal behavior. Abnormal animal behavior has been studied with the use of digitally recorded milk yield of cows at Ibaraki Prefecture Livestock Station, and the ULF magnetic field changes have been studied with the data at a magnetic observatory of Kakioka. As the result of correlation analyses, clear responses are observed for both the milk yield of cows and ULF magnetic field changes (both ULF radiation (ULF emissions from the lithosphere) and ULF depression (as an indicator of lower ionospheric perturbations)) for most powerful and not distant earthquakes (EQs) with magnitude > 6, that is, the milk yield of cows is found to exhibit a conspicuous depletion about 17 - 18 days before an EQ, though the correlation coefficient is not so big. Another important objective in this paper is to identify that ULF radiation is the main agent of abnormal behavior so that we have compared the temporal evolutions of milk yield of cows, ULF radiation and ULF depression for three major EQs. As a result, it is found that ULF radiation happens, at least, during the periods of abnormal depletion of milk yield of cows.

关键词： Milk Yield of Cows Correlation Analyses Earthquake Prediction ULF Radiation ULF Depression

A comparison of lignin-degrading enzyme activities in forest floor layers across a global climatic gradient

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Soil Ecology Letters 2020年第4期2卷 281-294页

作者： Kazumichi Fujii Yuji Nakada Kiwamu Umezawa Makoto Yoshida Makoto Shibata Chie hayakawa Yoshiyuki Inagaki Takashi Kosaki Ryan Hangs Forestry and Forest Products Research Institute Tsukuba 305-8687Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyTokyo 183-8509Japan Faculty of Agriculture Kindai UniversityNara 631-8505Japan Niigata Agro-Food University Niigata 959-2702Japan Faculty of Agriculture Utsunomiya UniversityUtsunomiya 321-8505Japan Faculty of International Communication Aichi UniversityNagoya 453-8777Japan Department of Soil Science Saskatchewan UniversitySaskatchewan S7N 5A8Canada

Rapid litter turnover in tropical forests and during summer seasons might be due to increases in ligninolytic enzyme activities during warmer *** compared ligninolytic enzyme activity[lignin peroxidase(LiP),manganese peroxidase(MnP),and laccase(Lac)]in the organic layers of forest soils across a global climate *** expected,MnP activities in fresh litter layers increased with increasing air *** Mn/lignin ratios correlate positively with MnP activity and more rapid litter turnover in warmer *** contrast,LiP and Lac activities are regulated by site-specific *** activity is commonly observed in less acidic fresh litter layers,while LiP activity localizes in acidified and lignin-rich deeper organic *** widespread occurrence of MnP and an increase in MnP activities in warmer climates support efficient lignin degradation in the tropics and during summer *** Mn/lignin ratios in fresh litter could be an indicator of lignin degradability by MnPproducing fungi across global climate gradients.

关键词： Acidification Ligninolysis Litter decomposition Manganese White-rot fungi

Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract

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World Journal of Clinical Cases 2019年第1期7卷 10-18页

作者： Shinichi Takano Mitsuharu Fukasawa Hiroko Shindo Ei Takahashi Sumio Hirose Yoshimitsu Fukasawa Satoshi Kawakami Hiroshi hayakawa Hiroshi Yokomichi Makoto Kadokura Tadashi Sato Nobuyuki Enomoto First Department of Internal Medicine Faculty of Medicine University of Yamanashi Yamanashi 409-3898 Japan Department of Health Sciences Interdisciplinary Graduate School and Engineering University of Yamanashi Yamanashi 409-3898 Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP) in patients with surgically altered anatomy has been a major challenge to gastrointestinal endoscopists with low success rates for reaching the target site as well as high complication rates. The knowledge of ERCP-related risk factors is important for reducing unexpected *** To identify ERCP-related risk factors for perforation in patients with surgically altered *** The medical records of 187 patients with surgically altered anatomy who underwent ERCP at our institution between April 2009 and December 2017 were retrospectively reviewed. An analysis of patient data, including age, sex, type of reconstruction, cause of surgery, aim of ERCP, success rate of reaching target site,success rate of procedure, adverse events, type of scope, time to reach the target site, and duration of procedure, was performed. In patients with Billroth-Ⅱ reconstruction, additional potential risk factors were the shape of the inserted scope and whether the anastomosis was antecolic or *** All patients(n = 187) had surgical anatomy, such as Billroth-Ⅰ(n = 22), Billroth-Ⅱ(n = 33), Roux-en-Y(n = 54), Child, or Whipple reconstruction(n = 75). ERCP was performed for biliary drainage in 43 cases(23%), stone removal in 29 cases(16%),and stricture dilation of anastomosis in 59 cases(32%). The scope was unable to reach the target site in 17 cases(9%), and an aimed procedure could not be accomplished in 54 cases(29%). Adverse events were pancreatitis(3%),hyperamylasemia(10%), cholangitis(6%), cholestasis(4%), excessive sedation(1%), perforation(2%), and others(3%). Perforation occurred in three cases, all of which were in patients with Billroth-Ⅱ reconstruction; in these patients, further analysis revealed loop-shaped insertion of the scope to be a significant risk for perforation(P = 0.01).CONCLUSION Risk factors for perforation during ERCP in patients with surgically altered anatomy were Billro

关键词： Surgically altered anatomy Billroth-Ⅱ Endoscopic retrograde cholangiopancreatography Perforation

Formation of Ionospheric Precursors of Earthquakes—Probable Mechanism and Its Substantiation

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Open Journal of Earthquake Research 2020年第2期9卷 142-169页

作者： Georgii Lizunov Tatiana Skorokhod Masashi hayakawa Valery Korepanov Space Research Institute Kyiv Ukraine hayakawa Institute of Seismo Electromagnetics Co. Ltd. Tokyo Japan Lviv Center of Institute for Space Research Lviv Ukraine

The purpose of this article is to attract the attention of the scientific community to atmospheric gravity waves (GWs) as the most likely mechanism for the transfer of energy from the surface layers of the atmosphere to space heights and describe the channel of seismic-ionospheric relations formed in this way. The article begins with a description and critical comparison of several basic mechanisms of action on the ionosphere from below: the propagation of electromagnetic radiation;the closure of the atmospheric currents through the ionosphere;the penetration of waves throughout the neutral atmosphere. A further part of the article is devoted to the analysis of theoretical and experimental information relating to the actual GWs. Simple analytical expressions are written that allow one to calculate the parameters of GWs in specific experimental situations. Specificity of GW dispersion properties and features of their propagation are analyzed on this mathematical basis, processes of amplitude amplification and dissipation of GWs with height are investigated, the mechanism of generation of ionosphere-magnetosphere current systems is described and their quantitative characteristics are determined. The experimental part presents an analysis of GWs global distribution in the thermosphere derived from the data of the instrument NACS (Neutral Atmosphere Composition Spectrometer) onboard the satellite DE-2 (NASA, 1981-1983). The statistical association of registered ionospheric disturbances with earthquakes is demonstrated. The results of DE-2 data processing are backed up by comparison with data from the DEMETER satellite (CNES, 2005-2010) whose purpose was to study the ionospheric effects of earthquakes. Specific features of GWs that characterize these waves as a factor of influence on the ionosphere from below are indicated.

关键词： Atmospheric Gravity Waves Seismic-Ionospheric Coupling Thermosphere

The technique of utilizing a single gracilis functional muscle transfer to restore quadriceps function following sarcoma surgery

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Plastic and Aesthetic Research 2019年第12期6卷 37-46页

作者： Christopher M.Nguyen Imran Ratanshi Jennifer L.Giuffre Edward W.Buchel Thomas E.J.hayakawa Section of Plastic Surgery Department of SurgeryUniversity of ManitobaWinnipeg R3A 1R9Canada The Plastic Surgery Group Fraser Health AuthoritySurreyBritish Columbia V3V 1Z2Canada

Aim:Quadriceps strength and knee extension,the most important factors limiting the ability to rise from a chair,are crucial for walking at an appropriate speed,ascending and descending stairs,and performing activities such as running,dancing,and *** of the anterior compartment of the thigh,including all four quadriceps muscles,for the treatment of a sarcoma is uncommon;however,when necessary,it is very debilitating and adversely affects a patient's quality of life without functional ***,there are a limited number of complex and difficult reconstructions to restore quadriceps function that have been described with variable *** describe a simple technique that employs a single gracilis functional muscle transfer to replace essential quadriceps ***:This is a case series describing the use of either a free or pedicled single gracilis muscle to restore quadriceps function following sarcoma ***:Four patients underwent an anterior compartment sarcoma resection that resulted in a large segmental defect and/or denervation of all four quadriceps muscles such that no quadriceps function would remain without *** four patients underwent a functional reconstruction using a single *** of the living patients achieved British Medical Research Counsel Grade 4 strength,can achieve full knee extension,are able to navigate stairs,and are able to ambulate without a *** fourth patient unfortunately was deceased in under three months following his tumor ***:Despite its small size in comparison to the quadriceps muscles,with physiotherapy and training,the gracilis muscle demonstrates the capacity to hypertrophy and replace quadriceps function following limb salvage surgery.

关键词： Knee extension re-animation functional muscle transfer free flap pedicled flap sarcoma microsurgery quadriceps reconstruction