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World Journal of Gastroenterology 2018年第2期24卷 211-215页

作者： Hirohito mori Hideki Kobara Noriko Nishiyama Tsutomu Masaki Departments of Gastroenterology and Neurology Kagawa University

AIM To evaluate appropriate and rapid polyglycolic acid sheet(PGAs) covering time using device delivery station system(DDSS).METHODS This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-month-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections(ESDs) 4 cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum(total 6 ESDs performed). DDSS(3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm^2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P?(CSL Behring K.K., Tokyo, Japan)(combination of fibringlue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during *** The covering time of PGAs(defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07(4.86-8.29) min. There was no postESD bleeding(1-7 d after ESD), and there was no perforation during *** DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multipurpose delivery station system.

关键词： Post-endoscopic submucosal dissection ulcers Bleeding Polyglycolic acid sheet Rapidly delivery Tightly attachment

Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8864-8870页

作者： Goshi Oda Tsuyoshi Nakagawa Mio mori Tomoyuki Fujioka Iichiro Onishi Department of Breast Surgery Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Radiology Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Pathology Tokyo Medical and Dental UniversityTokyo 113-8519Japan

BACKGROUND Adenomyoepithelioma(AME)of the breast is a rare type of benign breast *** AMEs show benign behavior,but reports of the malignant type are *** present the case of a patient with AME with repeated local recurrences and further malignant *** SUMMARY A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast.A core needle biopsy was *** pathological diagnosis was *** with a safety margin was performed without axillary lymph node dissection(ALND).Two years later,local recurrence developed,and the patient again underwent lumpectomy with a safety *** pathology showed malignant AME,and the margin was *** months later,local recurrence developed again in the same location,and a total mastectomy was performed without *** pathological diagnosis was malignant *** patient was disease-free for three years *** The treatment of AME requires caution,as it may exhibit repeated recurrences after local excision as well as malignant transformation.

关键词： Breast tumor Adenomyoepithelioma Malignant adenomyoepithelioma Local recurrence Malignant transformation Case report

Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity

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World Journal of Gastroenterology 2005年第38期11卷 5966-5972页

作者： Yuichi Yamazaki Satoru Kakizaki Norio Horiguchi Hitoshi Takagi Masatomo mori Masahiko Negishi Department of Medicine and Molecular Science Pharmacogenetics Section

AIM： To investigate the precise roles of CAR in CCI4- induced acute hepatotoxicity. METHODS： To prepare an acute liver injury model, CCI4 was intraperitoneally injected in CAR＋/＋ and CAR-/- mice. RESULTS： Elevation of serum alanine aminotransferase and extension of centrilobular necrosis were slightly inhibited in CAR-/- mice compared to CAR＋/＋ mice without PB. Administration of a CAR inducer, PB, revealed that CCl4-induced liver toxicity was partially inhibited in CAR-/- mice compared with CAR＋/＋ mice. On the other hand, androstanol, an inverse agonist ligand, inhibited hepatotoxicity in CAR＋/＋ but not in CAR./. mice. Thus, CAR activation caused CCl4 hepatotoxicity while CAR inhibition resulted in partial protection against CCl4-induced *** were no differences in the expression of CYP2E1, the main metabolizing enzyme for CCl4, between CAR＋/＋ and CAR./. mice. However, the expression of other CCI4-metabolizing enzymes, such as CYP2B10 and 3All, was induced by PB in CAR＋/＋ but not in CAR-/- mice. Although the main pathway of CCl4-induced acute liver injury is mediated by CYP2E1, CAR modulates its pathway via induction of CYP2B10 and 3All in the presence of activator or inhibitor. CONCLUSION： The nuclear receptor CAR modulates CCl4- induced liver injury via induction of CCl4-metabolizing enzymes in the presence of an activator. Our results suggest that drugs interacting with nuclear receptors such as PB might play critical roles in drug-induced liver injury or drug- drug interaction even though such drugs themselves are not hepatotoxic.

关键词： CAR Phenobarbital Cytochrome P450 CCl4 Drug-induced liver injury

Wetting of Au and Ag particles on monocrystalline graphite substrates

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Rare Metals 2006年第5期25卷 469-472页

作者： Joonho Lee Toshihiro Tanaka Kazufumi Seo Nobumitsu Hirai Jung-Goo Lee Hirotaro mori Department of Materials Science & Engineering Korea University5-1 Anam-dongSeongbuk-kuSeoul 136-713Republic of Korea Div.of Materials and Manufacturing Science Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Research Center for Ultra High Voltage Electron Microscopy Osaka University7-1 MihogaokaIbarakiOsaka 567-0047Japan

The wetting behavior of Au and Ag particles on a monocrystalline graphite substrate was investigated using the microscopic sessile drop method under a purified Ar atmosphere at 1300 K. The measured contact angles of the liquid Au and Ag on monocrystalline graphite substrates of （0001） face were 129° and 124°, respectively. It is believed that the interaction at the interface is dominated by the physical bonding （van der Waal＇s interaction）.

关键词： graphite microscopic sessile drop method surface structure wetting

Determination of symptoms associated with hiesho among young females using hie rating surveys

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Journal of Integrative Medicine 2018年第1期16卷 34-38页

作者： Hidetoshi mori Hiroshi Kuge Shunji Sakaguchi Tim Hideaki Tanaka Junji Miyazaki Faculty of Health Sciences Course of Acupuncture and Moxibustion Tsukuba University of Technology Tsukuba 305-8521 Japan Department of Anesthesiology Osaka Medical College Hospital Osaka 569-8686 Japan Research Division of Acupuncture and Moxibustion Kansai University of Health Sciences Osaka 590-0482 Japan Takarazuka University of Medical and Health Care Takarazuka 666-0162 Japan

Objective： Hie （cold sensation） is one of the most well-known health complaints in Japan and elsewhere in East Asia. Those who suffer from severe hie are considered to have hiesho （cold disorder）. This study was conducted to determine symptoms associated with hie in young females using a survey consisting of the hie scale and hie diary. Methods： Two hundred and seventy-one participants were included for the analysis. Survey forms were distributed to the participants. Diagnosis of hiesho was determined by using the hie scale. A discriminant score of over -0.38 was considered hiesho. The Short Form-8 Health Survey Standard Version （SF-8） was used to measure health-related quality of life （QOL）. The participants were also asked to respond to the questionnaire evaluating 14 physical and emotional symptoms, utilizing a six-level Likert scale item. Results： The 1st factor （hie factor） was correlated with hie （r= 0.546）, dry mouth （r= 0.332）, lower- extremity edema （r = 0.450）, headrushes （r=0.470）, shoulder stiffness （r = 0.311 ）, headrushes with chills （r = 0.726）, and fatigue （r= 0.359）. Cronbach＇s α of the 1st factor was 0.748, which indicated reliability between the items. When hie factor was the dependent variable, standardized partial regression coefficient was β=-0.387 for physical component score （P 〈 0.001） and β=-0.243 for mental component score （P 〈 0.001 ）. Conclusion： This study indicated that hiesho symptoms among young female adults were associated with bodily pain and general health perceptions of the SF-8 QOL survey.

关键词： Cold l:ypersensitivity Questionnaires Health surveys Quality of life Regression analysis Reproducibility of results

New anti-proliferative agent,MK615,from Japanese apricot “Prunus mume” induces striking autophagy in colon cancer cells in vitro

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World Journal of Gastroenterology 2007年第48期13卷 6512-6517页

作者： Shozo mori Tokihiko Sawada Toshie Okada Tatsushi Ohsawa Masakazu Adachi Kubota Keiichi Second Department of Surgery Dokkyo University School of Medicine Japan Apricot Co. Ltd

AIM: To investigate the anti-neoplastic effects of MK615, an extract from the Japanese apricot (Prunus mume), against colon cancer cells. METHODS: Three colon cancer cell lines, SW480, COLO, and WiDr, were cultured with MK615. Growth inhibition was evaluated by cell proliferation assay and killing activity was determined by lactate dehydrogenase assay. Induction of apoptosis was evaluated by annexin Ⅴ flow cytometry. Morphological changes were studied by light and electron microscopy, and immunofluorescence staining with Atg8. RESULTS: MK615 inhibited growth and lysed SW480, COLO and WiDr cells in a dose-dependent manner. Annexin Ⅴ flow cytometry showed that MK615 induced apoptosis after 6 h incubation, at which point the occurrence of apoptotic cells was 68.0%, 65.7% and 64.7% for SW480, COLO, and WiDr cells, respectively. Light and electron microscopy, and immunofluorescence staining with Atg8 revealed that MK615 induced massive cytoplasmic vacuoles (autophagosomes) in all three cell lines. CONCLUSION: MK615 has an anti-neoplastic effect against colon cancer cells. The effect may be exerted by induction of apoptosis and autophagy.

关键词： Colon cancer Japanese apricot Prunus mume Autophagy Apoptosis MK615

Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells

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World Journal of Gastroenterology 2005年第36期11卷 5638-5643页

作者： Joji Kitayama Hironori Yamaguchi Hiroharu Yamashita Ken mori Toshiaki Watanabe Hirokazu Nagawa Department of Surgical Oncology University of Tokyo Graduate School of Medicine Tokyo 113-8655 Japan

AIM： To examine whether lysophosphatidic acid （LPA） induces phosphorylation of c-Met and epidermal growth factor receptor （EGFR）, both of which have been proposed as prognostic markers of colorectal cancer, and whether LPA induces cyclooxygenase-2 （COX-2） expression in human colon cancer cells. METHODS： Using a human colon cancer cell line, LoVo cells, we performed immunoprecipitation analysis, followed by Western blot analysis. We also examined whether LPA induced COX-2 expression, by Western blot analysis. RESULTS： Immunoprecipitation analysis revealed that 10 μmol/L LPA induced tyrosine phosphorylation of c-Met and EGFR in LoVo cells within a few minutes. We found that c-Met tyrosine phosphorylation induced by LPA was not attenuated by pertussis toxin or a matrix metalloproteinase inhibitor, in marked contrast to the results for EGFR. In addition, 0.2-40 IJmol/L LPA induced COX-2 expression in a dose-dependent manner. CONCLUSION： Our results suggest that LPA acts upstream of various receptor tyrosine kinases （RTKs） and COX-2, and thus may act as a potent stimulator of colorectal cancer. 2005 The WJG Press and Elsevier Inc. All rights reserved.

关键词： Lysophosphatidic acid c-Met EGFR Transactivation Cyclooxygenase-2 Colon cancer

Current status of function-preserving surgery for gastric cancer

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World Journal of Gastroenterology 2014年第46期20卷 17297-17304页

作者： Takuro Saito Yukinori Kurokawa Shuji Takiguchi Masaki mori Yuichiro Doki Department of Gastroenterological Surgery Osaka University Graduate School of MedicineOsaka 565-0871Japan

Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer(GC)at an early *** to the low incidence of lymph node metastasis and favorable prognosis in early GC,function-preserving surgery which improves postoperative quality of life may be ***-preserving gastrectomy(PPG)is one such function-preserving procedure,which is expected to offer advantages with regards to dumping syndrome,bile reflux gastritis,and the frequency of flatus,although PPG may induce delayed gastric *** gastrectomy(PG)is another functionpreserving procedure,which is thought to be advantageous in terms of decreased duodenogastric reflux and good food reservoir function in the remnant stomach,although the incidence of heartburn or gastric fullness associated with this procedure is ***,these disadvantages may be overcome by the reconstruction method *** other important problem after PG is remnant GC,which was reported to occur in approximately 5%of ***,the reconstruction technique used with PG should facilitate postoperativeendoscopic examinations for early detection and treatment of remnant gastric *** safety seems to be assured in both procedures,if the preoperative diagnosis is *** selection should be carefully *** many retrospective studies have demonstrated the utility of function-preserving surgery,no consensus on whether to adopt functionpreserving surgery as the standard of care has been *** prospective randomized controlled trials are necessary to evaluate survival and postoperative quality of life associated with function-preserving surgery.

关键词： Gastric cancer Function preserving surgery Quality of life Pylorus preserving surgery Proximal gastrectomy

Kawasaki disease without changes in inflammatory biomarkers:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13038-13043页

作者： Kosei Yamashita Takeru Kanazawa Yoshifusa Abe Takuya Naruto Masaaki mori Children’s Medical Center Showa University Koto Toyosu HospitalTokyo 135-8577Japan Lifetime Clinical Immunology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8510Japan Department of Rheumatology Clinical Immunology and AllergologySt.Marianna University School of MedicineKanagawa 216-8511Japan

BACKGROUND Kawasaki disease(KD)is diagnosed based on clinical *** tests and other tests are auxiliary diagnostic *** KD is a disease caused by arterial inflammation,many patients with KD have elevated levels of inflammatory biomarkers,such as C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and serum amyloid A protein(SAA)in blood *** report our experience of a patient with KD who did not have elevated levels of inflammatory *** SUMMARY A 1-year-old boy presented with a 3-day history of *** of the six symptoms of KD were observed,except for changes in the lips and oral *** tests revealed no elevation in CRP,ESR,or SAA *** the blood test results were atypical,the patient was diagnosed with KD based on clinical symptoms and was admitted to the hospital for *** patient was administered intravenous immunoglobulin(IVIG)and *** commencing treatment,the fever persisted;therefore,additional IVIG was administered,the dosage of aspirin was increased,and ulinastatin was *** doses of IVIG were administered and the fever resolved on day 11 of KD symptoms *** tests performed during hospitalization showed normal levels of inflammatory *** examined leucine-rich alpha-2-glycoprotein 1-a protein that is elevated during the acute phase of *** protein levels did not increase during *** This case suggests the need to identify criteria and biomarkers for detecting KD conditions that do not require KD treatment.

关键词： Blood test C-reactive protein Erythrocyte sedimentation rate Intravenous immunoglobulin Kawasaki disease Case report

Solar power sail mission of OKEANOS

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Astrodynamics 2020年第3期4卷 233-248页

作者： Osamu mori Jun Matsumoto Toshihiro Chujo Masanori Matsushita Hideki Kato Takanao Saiki Yuichi Tsuda Jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki takao Yuki Kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki Okada Takahiro Iwata Hajime Yano Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan Tokyo Institute of Technology Tokyo 152-8550Japan The University of Tokyo Tokyo 113-8654Japan Patchedconics LLCSagarmihara 252-5210Japan

The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail *** Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in *** demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary *** up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary *** this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to *** paper proposes a system design for OKEANOS and includes analyses of the latest mission.

关键词： solar power sail Trojan asteroid landing in-situ analysis outer solar system OKEANOS