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Efficacy of Japanese traditional(Kampo) medicine for treating chemotherapy-induced peripheral neuropathy: A retrospective case series study

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World Journal of Clinical Cases 2016年第10期4卷 310-317页

作者： Yumiko Kimata Keiko Ogawa Hideki Okamoto Atsushi Chino takao namiki Department of Japanese-Oriental(Kampo)Medicine Chiba University School of Medicine Department of Japanese-Traditional(Kampo)Medicine Kanazawa University Hospital Department of Japanese-Oriental(Kampo)Medicine Chiba Central Medical Center

AIM To investigate Japanese traditional(Kampo) medicine's effectiveness on cancer chemotherapy-induced peripheral neuropathy(CIPN), we carried out this retrospective *** By searching our outpatient database of 3154 patients who consulted our outpatient clinic of Japanese-Oriental(Kampo) Medicine at Chiba University Hospital from November 2005 to December 2010, a total of 281 patients diagnosed with cancer were identified. Twentyfour patients out of the 281 patients identified met the following three conditions and were eligible for further investigation of the effectiveness of Kampo treatment: At least one course of cancer chemotherapy had been administered; numbness and pain appeared after the chemotherapy; and CIPN was diagnosed before they were given Kampo *** The 24 patients included 6 males and 18 females and ranged in age from 39 to 86(mean 61.2 ± 11.5) years old. Kampo formulas were individually chosen by Kampo expert doctors based on Kampo-specific diagnostics. Beneficial outcomes were obtained by Kampo treatment in 20 out of the 24 cases(83.3%). Nine out 20 cases had a major response(the numbness and pain showed improvement or reduction by 50% or more), with 7 of 9 cases showing a more than 70% symptom reduction. Eleven out of 20 cases showed a minor response(less than 50% symptom reduction), and 4 out of the 24 cases had no beneficial response. The most frequently used formula was goshajinkigan(GJG), followed by hachimijiogan(HJG) and keishibukuryogan. Thirteen of the 24 cases(54.2%) were prescribed aconite rootcontaining formulas including GJG and HJG. Aconite root has "warming" effects and ameliorates pain and numbness; 21 out of 24 cases(87.5%) in total used warming formulas such as aconite root-containing formulas to reduce *** Our current study suggested that Kampo formulas chosen based on Kampo-specific diagnostics could be for treating CIPN that is refractory to conventional medicine.

关键词： Asian medicine Traditional Chinese medicine Goshajinkigan Keishibukuryogan Hachimijiogan

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Oxalic acid in ginger specifically denatures the acrid raphides in the unprocessed dried tuber of Pinellia ternata

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Acupuncture and Herbal Medicine 2022年第1期2卷 33-40页

作者： Tsukasa Fueki Itsuki Nose Yan Liu Koichiro Tanaka takao namiki Toshiaki Makino Matsuya Pharmacy NiigataJapan Department of Pharmacognosy Graduate School of Pharmaceutical SciencesNagoya City UniversityNagoyaJapan Department of Traditional Medicine Toho University School of MedicineTokyoJapan Department of Japanese-Oriental(Kampo)Medicine Graduate School of MedicineChiba UniversityChibaJapan

Objective:Pinellia Tuber,the dried tuber of Pinellia ternata,is widely used in Japanese Kampo medicines and traditional Chinese *** unprocessed Pinellia Tuber is known to cause very strong acrid irritation at oral and laryngopharynx *** studies have shown that the sharp needle-like crystals called raphides,that are composed of calcium oxalate and proteins,are the main causative substances of the ***,the rhizome of Zingiber officinale,has been used in the processing to reduce the acridity of Pinellia Tuber since before the sixth century,however,the mechanisms of reducing acridity have not been scientifically proved ***:We developed the raphides denaturation assay(RDA)to quantify the degree of denaturation in the raphides to cause *** their lipophilic characters,the raphides could be extracted in petroleum ether(PE)layer from powdered Pinellia Tuber suspended in water,and the contents of the raphides in PE layer were measured by the *** this assay,we conducted the activity-guided fractionation from the boiling water extract of ginger to find the ingredients to denature the *** also conducted the gustatory tests to detect the change of the irritation of the denatured ***:The treatment of powdered Pinellia Tuber suspension with ginger extract reduced the distribution of raphides in PE layer in RDA in a concentration-dependent *** activity-guided fractionation using RDA revealed that oxalic acid was the main active ingredient in ginger extract to denature the raphides of Pinellia *** acid reduced the lipophilicity of the raphides in the thermo-,time-,and concentration-dependent manners,and its activity was affected by *** treatment of powdered Pinellia Tuber suspension with oxalic acid significantly reduced its acrid irritation in gustatory test in ***:We found that oxalic acid is the main active ingredient in ginger to reduce the acrid irritation of Pinell

关键词： Acridity Ginger Pinellia ternata Pinellia Tuber Processing Raphide

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Annual meeting of the Japan Traditional Chinese Medicine Association: Quantifying and objectifying traditional Chinese medicine

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Journal of Traditional Chinese Medical Sciences 2017年第1期4卷 10-13页

作者： Koh Iwasaki takao namiki Mitsuyuki Takamura Tetsuhiro Yoshino Shin Takayama Kaoru Sakatani Long Term Care Facility Aoinosono-East Sendai SendaiJapan Department of Japanese-Oriental(Kampo)Medicine Chiba University HospitalSchool of MedicineChiba UniversityChibaJapan Kampo Medicine Outpatient Clinic Mie University HospitalMieJapan Center for Kampo Medicine Keio University School of MedicineTokyoJapan Department of Education and Support for Regional Medicine Department of Kampo MedicineTohoku University HospitalSendaiJapan College of Engineering NEWCAT Research InstituteSchool of MedicineNihon UniversityTokyoJapan

Five researchers reported on their studies to quantify and objectify traditional medicine at the symposium 'Verification of Traditional Chinese Medicine' during the 2016 annual meeting of the Japan Traditional Chinese Medicine *** namiki reported on a methodology to quantify tongue *** Yoshino presented work on predictive prescribing two Kampo formulas for dysmenorrhea,Tangkuei and Peony Powder (Danggui Shaoyao San) and Cinnamon Twig and Poria Pill (Guizhi Fuling Wan).Koh Iwasaki presented work on validation of a questionnaire for assessing qi stagnation and Mitsuyuki Takamura reported on application of the questionnaire to evaluate the efficacy of Pinellia and Magnolia Bark Decoction (Banxia Houpo Tang).Kaoru Sakatani presented research on near-infrared spectroscopy as a diagnostic tool for wei bing,a concept of pre-symptomatic state in traditional Chinese medicine.

关键词： Validation of traditional Chinese medicine Tongue diagnosis qi stagnation Traditional Japanese medicine Near infrared spectroscopy

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Association of a cytosine-adenine repeat polymorphism in the estrogen receptor β gene with occurrence and severity of rheumatoid arthritis

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Open Journal of Internal Medicine 2013年第1期3卷 3-7页

作者： Kanako Watanabe Hiromi Sato Ayano Ito Tomomi Sato Aránzazu González-Canga Hana Sugai Masahiko Suzuki takao namiki Koichi Ueno Department of Geriatric Pharmacology and Therapeutics Graduate School of Pharmaceutical SciencesChiba UniversityChibaJapan Assessment Area Medicines for Veterinary Use DepartmentAgencia Espanola de Medicamentosy Productos Sanitarios(AEMPS)MadridSpain Research Center for Frontier Medical Engineering Chiba UniversityChibaJapan Department of Frontier Japanese-Oriental(Kampo)Medicine Graduate School of MedicineChiba UniversityChibaJapan

We investigated the influence of the cytosine-adenine (CA) dinucleotide repeat polymorphism in intron 6 of estrogen receptor β (ERβ) gene on rheumatoid arthritis (RA) risk. One hundred and ninety-three RA patients and 77 control subjects with osteoarthritis (OA) were recruited. The CA repeat polymorphism was assayed by a dye-terminator cycle sequencing analysis. No statistically significant difference in the mean number of CA repeats between the RA and OA patients was observed (RA: 21.47, OA: 21.23, P = 0.324). The alleles were categorized according to the number of repeats: short (S, ≦21) and long (L, ≧22), in which the genotypes SS, SL, and LL were observed. No significant differences were observed for the allele and genotype distributions of this polymorphism in both patient groups. The RA patients were classified according to RA severity: mild (least erosive disease) and severe (more erosive and mutilating disease). Again, no significant difference in genotype frequency between these groups was observed, even after stratifying by sex. The present study indicates that additional studies are needed to clarify the roles of this polymorphism, estrogen, and ER in the development of autoimmune diseases.

关键词： Polymorphism Rheumatoid Arthritis Sex Estrogen Receptor β CA Repeat

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Clinical efficacy of anti-Mullerian hormone inspection in supporting diagnosis for climacteric disorders

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Open Journal of Internal Medicine 2011年第3期1卷 93-98页

作者： takao namiki Haruka Kakikura Yukari Matsumoto Ueno Koichi Hiromi Sato Atsushi Chino Akito Hisanaga Akiyo Kaneko Toshiaki Kita Maki Kihara Makio Shozu Katsutoshi Terasawa 不详

The diagnosis of climacteric disorders in gynecology is performed on the basis of symptoms rather than hormonal levels. Generally, the follicle-stimulating hormone (FSH) level increases when the 17β-estradiol (E2) level decreases in menopause. However, the problem of these hormones should be determined by strict timing of sampling, and there are individual specificities of decreases of hormone levels. We considered that anti-Mullerian hormone (AMH) can be measured at any time of the menstrual cycle and that it shows ovary functional decline earlier than FSH/E2, and we examined whether AMH would possibly become a good index for climacteric disorders. The subjects were 163 healthy females and 21 patients with climacteric disorders between 20 and 59 years old. We examined AMH, FSH and E2 at the same time. It is understood that in healthy females, AMH decreases with age and a decline in ovary function occurs at a relatively early age. Patients visiting clinics for climacteric disorders often have normal-range serum FSH/E2 levels, and it is clear that these values could not serve as indices of menopause at these inspections. Upon measurement of AMH in patients with climacteric disorders, most showed less than normal range (< 14 pmol/L), suggesting a decline in ovarian function. In addition, AMH was low in females with climacteric disorders compared with those without them. In conclusion, AMH was suggested as an objective index for climacteric disorders and possibly as a new diagnostic marker.

关键词： Climacteric Syndrome Anti-Mullerian Hormone (AMH) Kupperman Index(KI) Follicle Stimulating Hormone (FSH) 17β-Estradiol (E2)

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α-淀粉和甘草甜素在半夏传统炮制中对刺激性针晶的变性作用

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Acupuncture and Herbal Medicine 2023年第1期3卷 38-45页

作者：笛木司能瀬逸紀刘艳田中耕一郎並木隆雄牧野利明松屋药局新潟日本名古屋市立大学大学院药学研究科愛知日本東邦大学医学部漢方医学東京日本千葉大学医学部漢方医学千葉日本

目的:生半夏,植物半夏的干燥块茎,当以生的形式吞食时,会对口腔和喉咙造成严重的辛辣刺激。根据中医理论,通过加热或使用生姜、甘草、明矾或石灰进行处理后可以减轻这种辛辣感。尽管这些解毒方法自古为人所知,但人们对其解毒半夏块茎的... 详细信息

目的:生半夏,植物半夏的干燥块茎,当以生的形式吞食时,会对口腔和喉咙造成严重的辛辣刺激。根据中医理论,通过加热或使用生姜、甘草、明矾或石灰进行处理后可以减轻这种辛辣感。尽管这些解毒方法自古为人所知,但人们对其解毒半夏块茎的机制知之甚少。在本研究中,我们旨在揭示α-淀粉和甘草中的甘草甜素对半夏块茎解毒的有效性。方法:之前,我们发现生半夏的完整针晶具有亲脂性,而针晶变性会降低其亲油性和辛辣性。因此,我们开发了一种针晶变性测定方法(RDA),通过测量包含针晶石油醚(PE)层的吸光度来量化针晶的变性程度。然后使用该测定法测定α-淀粉或甘草(植物甘草的根和匍匐茎)煎剂对针晶变性的影响。结果:α-淀粉处理针晶显著增强了针晶的热变性。甘草煎剂、甘草酸和甘草次酸在高pH值下以钙依赖的方式显著变性针晶。甘草酸和甘草次酸也附着在变性针晶上。结论:半夏块茎中的α-淀粉在加热后有助于解毒。在传统的用甘草和石灰炮制半夏块茎的方法中,甘草中的甘草酸和钙离子对针晶的变性起着重要作用。

关键词：半夏针晶炮制 α-淀粉甘草次酸

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Microstructure analysis and thermoelectric properties of iron doped CuGaTe_(2)

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Journal of Materiomics 2018年第3期4卷 221-227页

作者： Fahim Ahmed Naohito Tsujii takao Mori International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Namiki 1-1Tsukuba 305-0044Japan Graduate School of Pure and Applied Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8577Japan

Chalcopyrite related compounds have attracted much attention in recent years due to their promising thermoelectric *** this research we report Fe doping in chalcopyrite-type CuGaTe_(2)and its influence on structural and thermal transport *** synthesized polycrystalline samples with composition CuGa_(1-x)Fe_(x)Te_(2)with x=0.0 to 0.05 by spark plasma sintering *** structural analysis powder X-ray diffraction and electron probe micro analysis were *** of Fe in CuGaTe_(2)was found to be very small,and other phases like FeTe_(2)and CuTe were *** conductivity showed a significant decrease with the addition of Fe up to x=0.02,which started to increase for x≥*** the other hand,the addition of Fe caused slight increase in the power factor from 1.3mW/K^(2)m for x=0.0 to 1.6 mW/K^(2)m for x=0.02 at T=770 *** a result,ZT peak value of 0.92 is recorded for x=0.02 at 870 K,which corresponds to an enhancement of 60%from that of non-doped CuGaTe_(2).This work demonstrates that thermoelectric properties of compositematerials can be greatly improved by controlling its microstructure.

关键词： Thermoelectric CuGaTe_(2) Microstructure Seebeck coefficient Thermal conductivity Composite material

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Distinctive magnetic resonance imaging findings of hepatocellular carcinoma after hepatitis C virus eradication with direct-acting antivirals

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Hepatoma Research 2020年第3期6卷 41-49页

作者： takao Shimizu Kaoru Tsuchiya Masayuki Kurosaki Yutaka Yasui Sakura Kirino Keiya Watakabe Leona Osawa Mao Okada Wan Wang Mayu Higuchi Kenta Takaura Shun Kaneko Nobuharu Tamaki Hiroyuki Nakanishi Jun ltakura Yuka Takahashi Tadakazu Hisamatsu namiki lzumi Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan Department of Gastroenterology and Hepatology Kyorin University HospitalTokyo 180-8610Japan

Aim:The aim of the present study was to evaluate the characteristics of the magnetic resonance imaging features of hepatocellular carcinoma(HCC)that developed early after the eradication of hepatitis C virus(HCV)by direct-acting antiviral(DAA)***:This study included 26 patients who achieved sustained viral response with DAA and developed HCC thereafter within one year(DAA-SVR HCC).The radiologic characteristics of these patients were evaluated by contrast-enhanced magnetic resonance imaging,including diffusion-weighted imaging(DWI)and T2-weighted imaging(T2WI).For comparison,80 HCC patients with positive HCV RNA(HCV-positive HCC)were *** 42 patients where tumor biopsy was available,histological grade and radiologic findings were ***:The rates of high intensity on DWI and T2WI were significantly higher in DAA-SVR HCC compared to HCV-positive HCC(DWI:100%vs.67.5%,P<0.001T2WI:92.6%vs.67.5%,P=0.01).HCC with high intensity on DWI or T2WI was more likely to have moderately or poorly differentiated HCC compared to well-differentiated HCC(DWI:69.7%vs.30.3%,P=0.02;T2WI:66.7%vs.27.3%,P=0.03).Conclusion:High intensity on DWI and hyperintensity on T2WI were distinctive features of HCC that developed within one year after the end of DAA treatment.

关键词： Hepatocellular carcinoma direct-acting antivirals sustained viral response contrast enhanced magnetic resonance imaging

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Review of current ZT>1 thermoelectric sulfides

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Journal of Materiomics 2024年第1期10卷 218-233页

作者： Fu-Hua Sun Hezhang Li Jun Tan Lingmei Zhao Xinyu Wang Haihua Hu Chao Wang takao Mori School of Materials Science and Engineering Hubei Normal UniversityHuangshi435002China International Center for Materials Nanoarchitechtonics(WPI-MANA) National Institute for Materials Science(NIMS)Namiki 1-1Tsukuba305-0047Japan Department of Precision Instrument Tsinghua UniversityBeijing100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Graduate School of Pure and Applied Sciences University of TsukubaTsukuba305-8671Japan Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan528225China

Thermoelectrics has played a fascinating role in the developments of direct energy conversion *** the past decade,sulfur-based thermoelectric materials have been significantly advanced in optimizing electrical and thermal transport due to their similarities in chemical and structural properties with tellurides and *** review provides research progress on metal sulfides,particularly focuses on materials exhibiting high thermoelectric figure of merit(ZT>1.0).It highlights the potential compounds,***-S,Sn-S,Pb-S based,and *** strategies of superionic conducting,band configuration tuning,high-entropy alloying,and anomalous harmonic scattering are try to demonstrate the performance-improved mechanisms for thermoelectric *** addition,some common synthesis recipes are briefly introduced,and thereby making potential candidates as excellent alternatives for producing thermoelectric power generators in the mid *** outcomes along with how to further improve the thermoelectric performance and promote its scale-up applications are also outlined at the end.

关键词： Synthetic technology Figure merit of ZT Sulfides Thermoelectric

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Role of phase separation in nanocomposite indium-tin-oxide films for transparent thermoelectric applications

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Journal of Materiomics 2021年第3期7卷 612-620页

作者： Peter P.Murmu Akhil Shettigar Shen V.Chong Zihang Liu Dana Goodacre Vedran Jovic takao Mori Kevin E.Smith John Kennedy National Isotope Centre GNS SciencePO Box 30368Lower Hutt5010New Zealand The MacDiarmid Institute for Advanced Materials and Nanotechnology New Zealand Robinson Research Institute Victoria University of WellingtonPO Box 33436Lower Hutt5046New Zealand International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki305-0044Japan School of Chemical Sciences University of AucklandAuckland1142New Zealand Department of Physics Boston University BostonMA02215USA

We report that oxygen vacancies have a profound impact on phase separation and thermoelectric properties of ITO films grown at room *** vacancies in non-stoichiometric In1.8Sn0.2O2.5 films aided the formation of In-rich metallic *** yields a high electrical conductivity s=1540 Scm1 and Seebeck coefficient|a|=27.2 mVK1,which resulted in the highest power factor(a2 s=113.8 mW m1 K2)but low optical transmission(Top-25%).An increase in oxygen partial pressure resulted in stochiometric In1.8Sn0.2O3 films which improved the optical transparency by 300%(Top-75.4%),but power factor was reduced by-85%due to a decrease in a and s.A decrease in a was due to the lack of energy filtering of charge carriers in the stoichiometric ITO film which did not have In-rich metallic *** results showed that the valence band energy shifts with a change in oxygen partial pressure due to a decrease in carrier density,which implied a change in Fermi energy due to the reverse Moss-Burstein *** results showed that phase separation can be obtained in nanocomposite ITO films by tuning their stoichiometry simply by varying the oxygen partial pressure during deposition of thermoelectric materials at low temperatures.

关键词： Thermoelectric Indium-tin-oxide(ITO) Seebeck coefficient Power factor X-ray photoelectron spectroscopy(XPS)

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