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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第2期5卷 94-106页

作者： takanori Matsubara Saina Taniguchi Shota Morimoto Asami Yano Aritsugu Hara Isao Wataoka Hiroshi Urakawa Hidekazu Yasunaga Department of Biobased Materials Science Kyoto Institute of Technology Kyoto Japan

Hair colouring was carried out by using catechinone prepared from (+)-catechin by enzymatic or chemical oxidation reaction. The difference of dyeability between the catechinone produced by enzymatic reaction (EC) and that produced by chemical reaction (CC) was studied changing the dyeing condition such as dye concentration, dyeing temperature, pH or the sort and concentration of salts. The colour of the hair dyed by EC or CC at 30°C is yellowish or reddish brown, respectively. The colour of the hair dyed by EC and CC is deeper at a higher dye concentration and at a higher temperature. Hair is dyed deepest by EC or CC at the solution pH = 6.04 or 5.45, respectively. The dyeability is increased by adding NaCl (≤4 M) or CaCl2 (≤1 M), while it is decreased by adding AlCl3. The colour fastness of the dyed hair to washing or ultraviolet light is high enough for practical use. Furthermore, it was found that colourants are obtained from tea extracts which contain catechin derivatives. Hair is dyed reddish brown by the colourants.

关键词： Catechinone Hair Dyestuff Catechin Dyeability Tea Extract

First-line eradication for Helicobacter pylori-positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype

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World Journal of Gastroenterology 2015年第48期21卷 13548-13554页

作者： Yoshimasa Saito Hiroshi Serizawa Yukako Kato Masaru Nakano Masahiko Nakamura Hidetsugu Saito Hidekazu Suzuki takanori Kanai Division of Gastroenterology Kitasato Institute Hospital Division of Pharmacotherapeutics Keio University Faculty of Pharmacy Division of Gastroenterology Department of Internal MedicineKeio University School of Medicine School of Pharmaceutical Sciences Kitasato University

AIM: To evaluate the effect of first line esomeprazole(EPZ)-based triple therapy on Helicobacter pylori(H. pylori) ***: A total of 80 Japanese patients with gastritis who were diagnosed as positive for H. pylori infection by endoscopic biopsy-based or ^(13)C-urea breath tests were included in this study. The average age of the patients was 57.2 years(male/female, 42/38). These patients were treated by first-line eradication therapy with EPZ 40 mg/d, amoxicillin 1500 mg/d, and clarithromycin 400 mg/d for 7 d. All drugs were given twice per day. Correlations between H. pylori eradication, CYP2C19 genotype, and serum pepsinogen(PG) level were analyzed. This study was registered with the UMIN Clinical Trials Registry(UMIN000009642).RESULTS: The H. pylori eradication rates by EPZbased triple therapy evaluated by intention-to-treat and per protocol were 67.5% and 68.4%, respectively, which were similar to triple therapies with other first-generation proton pump inhibitors(PPIs). The eradication rates in three different CYP2C19 genotypes, described as extensive metabolizer(EM), intermediate metabolizer, and poor metabolizer, were 52.2%, 72.1%, and 84.6%, respectively. The H. pylori eradication rate was significantly lower in EM than non-EM(P < 0.05). The serum PG?Ⅰ?level and PG?Ⅰ/Ⅱ ratio were significantly increased after eradication of H. pylori(P < 0.01), suggesting that gastric atrophy was improved by H. pylori eradication. Thus, first-line eradication by EPZbased triple therapy for patients with H. pylori-positive gastritis was influenced by CYP2C19 genotype, and the eradication rate was on the same level with other firstgeneration PPIs in the Japanese ***: The results from this study suggest that there is no advantage to EPZ-based triple therapy on H. pylori eradication compared to other firstgeneration PPIs.

关键词： CYP2C19 esomeprazole Helicobacterpylori pepsinogen proton pump inhibitor

Evapotranspiration Characteristics of a Lowland Dry Evergreen Forest in Central Cambodia Examined Using a Multilayer Model

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Journal of Water Resource and Protection 2009年第5期1卷 325-335页

作者： Tatsuhiko NOBUHIRO Akira SHIMIZU Katsunori TANAKA Koji TAMAI Naoki KABEYA Eriko ITO takanori SHIMIZU Makoto ARAKI Sophal CHANN 不详

Development pressure has led to serious deforestation on the Indochina Peninsula. Particularly rapid defor-estation has occurred in easily accessible lowland areas, and it is thus important to accumulate knowledge about these forests immediately. We measured evapotranspiration rates for a lowland dry evergreen forest in Kampong Thom Province, central Cambodia, using the energy balance Bowen ratio (EBBR) method based on meteorological data collected from a 60-m-high observation tower. Daily evapotranspiration was higher during the dry season than during the rainy season of the Asian monsoon climate. The seasonal variation in evapotranspiration generally corresponded to the seasonal difference in the vapor pressure deficit. A multi-layer model was used to simulate the seasonal variation in evapotranspiration. The multilayer model also reproduced the larger evapotranspiration rate in the dry season than in the rainy season. However, observed values substantially exceeded model-calculated results during certain periods at the beginning of the dry season and in the late dry season. Moreover, during the rainy season, the model tended to overestimate evapotranspiration. The differences between these observed and simulated values may have been caused by seasonal characteristics of photosynthesis and transpiration in the lowland dry evergreen forest that were not considered in the model simulation.

关键词： Cambodia Energy Balance Bowen Ratio Method Evapotranspiration Lowland Dry Evergreen Forest Multilayered Model

Cardiac Computed Tomography for the Diagnosis of Coronary Artery Atherosclerosis

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International Journal of Clinical Medicine 2013年第3期4卷 183-189页

作者： Ryotaro Wake Hidetaka Iida Hirohito Ogata Hiroaki Takeshita takanori Kusuyama Hiroaki Kohno Shinichi Shimodozono Kenei Shimada Minoru Yoshiyama Department of Cardiology Tsukazaki Hospital Himeji Japan. Department of Cardiology Tsukazaki Memorial Hospital Himeji Japan. Department of Internal Medicine and Cardiology Osaka City University Graduate School of Medicine Osaka Japan.

Coronary artery disease (CAD) is a leading cause of mortality and morbidity in developed countries, although percutaneous coronary intervention and coronary artery bypass grafting have developed recently. Appropriate diagnosis will improve the prevention, treatment, and care of all patients. We could diagnose only calcification in the coronary arteries with the past computed tomography. Recently, multislice computed tomography has been already accepted as an efficient non-invasive tool for the detection of coronary artery stenosis. We get to estimate the coronary artery stenosis with cardiac computed tomography. We discuss the usefulness of cardiac computed tomography for the risk stratification of coronary artery atherosclerosis.

关键词： Cardiac CT Coronary Atherosclerosis

Multi-Schlieren CT Measurements of Supersonic Microjets from Circular and Square Micro Nozzles

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Journal of Flow Control, Measurement & Visualization 2020年第3期8卷 77-101页

作者： Ahmad Zaid Nazari Yojiro Ishino Yuta Ishiko Fumiya Ito Harumi Kondo Ryoya Yamada takanori Motohiro Yoshiaki Miyazato Shinichiro Nakao Electrical and Mechanical Engineering Department Nagoya Institute of Technology Nagoya Japan Department of Mechanical Systems Engineering The University of Kitakyushu Kitakyushu Japan

Instantaneous three-dimensional (3D) density distributions of a shock-cell structure of perfectly and imperfectly expanded supersonic microjets escaping into an ambient space are measured. For the 3D observation of supersonic microjets, non-scanning 3D computerized tomography (CT) technique using a 20-directional quantitative schlieren optical system with flashlight source is employed for simultaneous schlieren photography. The 3D density distributions data of the microjets are obtained by 3D-CT reconstruction of the projection’s images using maximum likelihood-expectation maximization. Axisymmetric convergent-divergent (Laval) circular and square micro nozzles with operating nozzle pressure ratio 5.0, 4.5, 4.0, 3.67, and 3.5 have been studied. This study examines perfectly expanded, overexpanded, and underexpanded supersonic microjets issued from micro nozzles with fully expanded jet Mach numbers Mj ranging from 1.47 - 1.71, where the design Mach number is Md = 1.5. A complex phenomenon for free square microjets called axis switching is clearly observed with two types “upright” and “diagonal” of “cross-shaped”. The initial axis-switching is 45° within the first shock-cell range. In addition, from the symmetry and diagonal views of square microjets for the first shock-cells, two different patterns of shock waves are viewed. The shock-cell spacing and supersonic core length for all nozzle pressure ratios are investigated and reported.

关键词： Supersonic Microjet Multi-Directional Quantitative Schlieren Optical System Three-Dimensional (3D) Measurement Computerized Tomography (CT) Circular and Square Micro Laval Nozzles

Endoscopic submucosal dissection for small submucosal tumors of the rectum compared with endoscopic submucosal resection with a ligation device

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World Journal of Gastrointestinal Endoscopy 2017年第2期9卷 70-76页

作者： Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara takanori Shimizu Yasushi Katsuyama Yasunaga Miyama Kenji Hayasaka Shigetaka Tounou Department of Gastroenterology New Tokyo Hospital Department of Health Service Center Tokyo Medical and Dental University Second Division of Internal Medicine Teikyo University Chiba Medical Center

AIMTo evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) for small rectal submucosal tumors (SMTs). METHODSBetween August 2008 and March 2016, 39 patients were treated with endoscopic submucosal resection with a ligation device (ESMR-L) (n = 21) or ESD (n = 18) for small rectal SMTs in this study. Twenty-five lesions were confirmed by histological evaluation of endoscopic biopsy prior to the procedure, and 14 lesions were not evaluated by endoscopic biopsy. The results for the ESMR-L group and the ESD group were retrospectively compared, including baseline characteristics and therapeutic outcomes. RESULTSThe rate of en bloc resection was 100% in both groups. Although the rate of complete endoscopic resection was higher in the ESD group than in the ESMR-L group (100% vs 95.2%), there were no significant differences between the two groups (P = 0.462). In one patient in the ESMR-L group with a previously biopsied tumor, histological complete resection with a vertical margin involvement of carcinoid tumor could not be achieved, whereas there was no incomplete resection in the ESD group. The mean length of the procedure was significantly greater in the ESD group than in the ESMR-L group (14.7 ± 6.4 min vs 5.4 ± 1.7 min, P vs 2.8 ± 1.5 d, P CONCLUSIONBoth ESMR-L and ESD were effective for treatment of small rectal SMTs. ESMR-L was simpler to perform than ESD and took less time.

关键词： Leiomyoma Lipoma Rectum Submucosal tumor Endoscopic submucosal resection with a ligation device Endoscopic submucosal dissection Carcinoid tumor

Quantitative Schlieren Image-Noise Reduction Using Inverse Process and Multi-Path Integration

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Journal of Flow Control, Measurement & Visualization 2020年第2期8卷 25-44页

作者： Ahmad Zaid Nazari Yojiro Ishino Fumiya Ito Harumi Kondo Ryoya Yamada takanori Motohiro Yu Saiki Yoshiaki Miyazato Shinichiro Nakao Electrical and Mechanical Engineering Department Nagoya Institute of Technology Nagoya Japan Department of Mechanical Systems Engineering The University of Kitakyushu Kitakyushu Japan

This report deals with introducing two new techniques based on a novel concept of complex brightness gradient in quantitative schlieren images, “inverse process” and “multi-path integration” for image-noise reduction. Noise in schlieren images affects the projections (density thickness) images of computerized tomography (CT). One spot noise in the schlieren image appears in a line shape in the density thickness image. Noise effect like an infectious disease spreads from a noisy pixel to the next pixel in the direction of single-path integration. On the one hand, the noise in the schlieren image reduces the quality of the image and quantitative analysis and is undesirable;on the other it is unavoidable. Therefore, the importance of proper noise reduction techniques seems essential and tangible. In the present report, a novel technique “multi-path integration” is proposed for noise reduction in projections images of CT. Multi-path integration is required the schlieren brightness gradient in two orthogonal directions. The 20-directional quantitative schlieren optical system presents only images of schlieren brightness in the horizontal gradient and another 20-directional optical system seems necessary to obtain vertical schlieren brightness gradient, simultaneously. Using the “inverse process”, a new technique enables us to obtain vertical schlieren brightness gradient from horizontal experimental data without the necessity of a new optical system and can be used for obtaining any optional directions of schlieren brightness gradient.

关键词： Noise Reduction Technique Inverse Process Quantitative Schlieren Optical System Complex Schlieren Brightness Computerized Tomography (CT)

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跳房子的奇妙乐趣

现代装饰（家居） 2013年第2期 102-107页

作者： Osamu Nishida takanori Ineyama Koichi Torimura 肖俊日本ON design partners

俗话说:对立物互相吸引。如果在同一屋檐下同一个空间的两端各设置一栋房子,会是什么样的场景?现正为一对音乐家和冲浪运动员夫妇设计住宅的日本设计团队ON design partners正面临着这种挑战。住宅位于面朝太平洋的日本群岛的中心——... 详细信息

俗话说:对立物互相吸引。如果在同一屋檐下同一个空间的两端各设置一栋房子,会是什么样的场景?现正为一对音乐家和冲浪运动员夫妇设计住宅的日本设计团队ON design partners正面临着这种挑战。住宅位于面朝太平洋的日本群岛的中心——藤泽市。由于建筑工地是一片位于一个已存在的居住区内的空地,因此对于建筑设计师来说,它就如同一张空白画布一般等待着他们在上面尽情描绘。

关键词：设计住宅建筑设计师日本群岛设计过程空间的公共空间布局方式 partner 土片公共区域

Changes of Intracellular and Extracellular Magnesium Concentration in the Patients With Cardiac Syndrome X

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Changes of Intracellular and Extracellular Magnesium Concent...

More efficient induction of genotoxicity by high-LET Fe-particle radiation than low-LET X-ray radiation at low doses

2006年浙江省心血管病学学术年会

作者：周妍郭航远邢杨波许伟源 Jong-Dae Lee takanori Ueda Department of Cardiology Shaoxing People’s HospitalThe First Affiliated Hospital of Medical CollegeShaoxing UniversityShaoxingZhejiang312000 China Department of Cardiology Shaoxing People’s HospitalThe First Affiliated Hospital of Medical CollegeShaoxing UniversityShaoxingZhejiang312000 China First Department of Internal MedicineFukui Medical University23-3 ShimoaizukiMatsuoka-choFukui 910-1193Japan

Objectives: This study sought to clarify the changes of intracellular and extracellular magnesium levels in the patients with cardiac syndrome X. Methods: We evaluated the intracellular and extracellular magnesium status of 22 patients with cardiac syndrome X (group A) and 22 age and gender matched disorder-free control subjects (group B) . Levels of magnesium were determined in serum, urine, erythrocytes, and the 24-h magnesium retention rate was calculated by magnesium loading test. Results:

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Radiation Medicine and Protection 2023年第1期4卷 11-18页

作者： Bing Wang takanori Katsube Kaoru Tanaka Yasuharu Ninomiya Hirokazu Hirakawa Cuihua Liu Kouichi Maruyama Masahiro Murakami Tetsuo Nakajima Akira Fujimori Mitsuru Nenoi National Institutes for Quantum Science and Technology Chiba263-8555Japan

Objective:To understand differential effects on induction of genotoxicity and genomic instability(GI)by high-LET particle radiation and low-LET photon radiation,based on ground-based experiments using total body irradiation(TBI)of mice with Fe-particle radiation and X-ray ***:TBI was delivered to C57BL/6J Jms strain female mice of 8 weeks old at a dose ranging from 0.1 to 3.0 Gy of Fe-particle radiation or at a dose ranging from 0.1 to 5.0 Gy of X-ray *** of genotoxicity and GI by TBI was determined respectively at 1 and 2 months after exposure using frequency of micronuclei in bone marrow erythrocytes as the *** of bone marrow cell proliferation by TBI was measured as reduced *** conditions were also ***:TBI,regardless of the type of radiation,caused statistically significant increase in genotoxicity at 1 month after exposure,but did not induce GI at 2 months after exposure even at higher doses(>1.0 Gy).The doseresponse curve for the frequency of micronucleated polychromatic erythrocytes induced by Fe-particle radiation and X-ray radiation was y=0.7798 t 1.7889x–0.5978x^(2)(R^(2)=0.8109)and y=0.7421 t 1.3792x–0.2588 x^(2)(R^(2)=0.8081),*** dose-response curve for the frequency of micronucleated normochromatic erythrocytes induced by Fe-particle radiation and X-ray radiation was y=0.7191 t 1.4545x–0.4978x^(2)(R^(2)=0.7047)and y=0.658 t 1.344x–0.2531x^(2)(R^(2)=0.7853),*** general,high-LET Fe-particle radiation was more efficient in inducing genotoxicity than low-LET X-ray radiation at lower doses(<0.5 Gy).Conclusions:These results further confirm that exposure to TBI,even at higher doses and regardless the type of radiation,does not induce GI in C57BL/6J strain mice measured as increased micronuclei in bone marrow *** findings indicate that radiation-induced GI is mouse strain dependent and suggest that more comprehensive studies should be

关键词： Fe-particle radiation Genotoxicity Genomic instability Micronucleated erythrocyte C57BL/6J mice