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Worsening of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in patients with prostate cancer after androgen deprivation therapy

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Asian Journal of Andrology 2018年第6期20卷 634-636页

作者： Ryo Oka takanobu Utsumi Takumi Endo Masashi Yano Shuichi Kamijima Naoto Kamiya Hiroyoshi Suzuki Department of Urology Toho University Sakura Medical Center Sakura-shi Chiba 285-8741 Japan Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27599-7295 USA

Dear Editor, Prostate cancer （PCa） is the most frequently diagnosed male cancer in Western countries, and the number of PCa patients is also rapidly increasing in ]apan.1,2 Simultaneously, androgen deprivation therapy （ADT） has also been increasingly used in PCa patients in recent years2-5 However, the long-term use of ADT is associated with a variety of pivotal adverse events, including diabetes, anemia, osteoporosis, serum lipid profile changes, and cardiovascular disease （CVD）.1,2 Higher low-density lipoprotein cholesterol （LDL-C） and/or lower high-density lipoprotein cholesterol （HDL-C） are well-established risk factors for CVD, and control of their levels has been an important goal in the treatment and prevention of CVD.6,7 Recently, another alternative parameter, the LDL-C to HDL-C （L/H） ratio, has been reported to be strongly associated with CVD and is thought to be a better predictor of future CVD than LDL-C alone. Closely monitoring serum lipid profile, including the L/H ratio changes affected by ADT, is a key to preventing CVD in PCa patients. Moreover, we previously suggested that a higher L/H ratio might have an impact on the development of arterial stiffness after ADT administration,r Although some cutoff points of the L/H ratio have been reported in clinical use, it has been suggested that thrombosis can occur when the L/H ratio increases to around 2.5 or more in East Asian populations.6 The aim of the present study was to investigate the changes in serum lipid profile and to identify the clinical factors associated with an increased L/H ratio in PCa patients who received ADT.

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Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction

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World Journal of Gastroenterology 2008年第38期14卷 5933-5937页

作者： Tomohide Hori Takashi Wagata Kenji Takemoto takanobu Shigeta Haruko Takuwa Koichiro Hata Shinji Uemoto Naoki Yokoo Department of Surgery Takayama Red Cross Hospital 3-11 Tenman-cho Takayama City Gifu Prefecture 506-8550 Japan Department of Hepato-pancreato-biliary and Transplant Surgery Kyoto University Hospital 54 Shogoinkawara-cho Sakyo-ku Kyoto 606-8507 Japan

A 71-year-old Japanese man with acute cholecystitis and an incarcerated gallbladder （GB） stone was admitted. Plain ultrasonography （US） incidentally detected a mass-like lesion in the fundus. Doppler US revealed that this elevated lesion had no blood flow. Computed tomography showed a relatively low-density mass, measuring 5 cm x 4 cm in diameter, with no positive enhancement. Magnetic resonance imaging showed a mass in the fundus with a slightly low intensity on Tl-weighted images and a slightly high intensity on T2-weighted images. We were agonized in making the qualitative diagnosis of mass-like lesions of the fundus, such as a benign tumor, cancer, or debris. We performed laparoscopic cholecystectomy, because the incarcerated GB stone clearly caused acute cholecystitis. Intra-operative cholangiography clearly revealed pancreaticobiliary maljunction. Amylase levels in the common bile duct and gallbladder were quite high. The elevated lesion in the fundus dearly showed severe necrosis. Although this necrotic nodule included non-viable adenocarcinoma cells, viable cancer cell nests were located in the muscularis propria and subcutaneous layer. Histopathological examination confirmed a solid adenocarcinoma. Thus, we diagnosed it as a gallbladder cancer, based on histopathological analysis of the resected specimen. We therefore undertook radical surgery, including wedge resection of the liver, radical dissection of regional lymph nodes, and resection of the extrahepatic bile duct. Histopathological findings revealed no cancer, hyperplasia or dysplasia in the additionally resected specimens. The patient was finally staged as T2, N0, H0, P0, M（-）, stage Ⅱ. We present the first case of spontaneous necrosis of solid gallbladder adenocarcinoma, with a review of previous studies.

关键词： Gallbladder carcinoma Pancreaticobiliary maljunction Spontaneous necrosis

Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2009年第20期15卷 2520-2525页

作者： Eiji Oki Yan Zhao Rintaro Yoshida takanobu Masuda Koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Department of Gastroenterology National Kyushu Cancer Center 3-1-1 Notame Minarni-ku Fukuoka 811-1395 Japan

AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric ***:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c *** microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct ***:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological *** found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation ***:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of ***, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis.

关键词： Checkpoint with forkhead-associated and ring finger Methylation Microsatellite instability Gastric cancer p53

Project Base Learning for IT Personnel Resources Development Using TVML

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通讯和计算机（中英文版） 2012年第10期9卷 1152-1159页

作者： Suriyon Tansuriyavong Endo takanobu Boonmee Choompol Department of Media Information Engineering Okinawa National Collage of Technology Okinawa 9052192 Japan Faculty of Engineering Department of Electrical and Computer Engineering Thammasat University Patumtani 12121 Thailand

SUPPURATIVE KNEE ARTHRITIS FOLLOWING ACUTE OSTEOMYELITIS OF THE FEMUR DETECTED BY MAGNETIC RESONANCE

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中华医学杂志(英文版) 1995年第9期108卷 66-69页

作者： Mansho Itokazu,杨文毅,Yasushi Ooshima,takanobu Matsunaga Department of Orthopaedic Surgery Gifu University School of Medicine 40 Tsukasamahi Gifu 500 Japan Department of Orthopaedic Surgery Gifu University School of Medicine 40 Tsukasamahi Gifu 500 Japan Department of Orthopaedic Surgery Gifu University School of Medicine 40 Tsukasamahi Gifu 500 Japan Department of Orthopaedic Surgery Gifu University School of Medicine 40 Tsukasamahi Gifu 500 Japan

There have been many reports on suppurative arthritis of hip arising from metaphyseal osteomyelitis in pediatric patients. However, only a few articles on this disease in the knee joint appeared. We encountered a pati... 详细信息

关键词：口口 In 回口回圈

Nearest neighbor search algorithm for GBD tree spatial data structure

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重庆邮电大学学报（自然科学版） 2007年第3期19卷 253-259页

作者： Yutaka Ohsawa takanobu Kurihara Ayaka Ohki Saitama University

This paper describes the nearest neighbor (NN) search algorithm on the GBD(generalized BD) tree. The GBD tree is a spatial data structure suitable for two-or three-dimensional data and has good performance characteristics with respect to the dynamic data environment. On GIS and CAD systems, the R-tree and its successors have been used. In addition, the NN search algorithm is also proposed in an attempt to obtain good performance from the R-tree. On the other hand, the GBD tree is superior to the R-tree with respect to exact match retrieval, because the GBD tree has auxiliary data that uniquely determines the position of the object in the structure. The proposed NN search algorithm depends on the property of the GBD tree described above. The NN search algorithm on the GBD tree was studied and the performance thereof was evaluated through experiments.

关键词：邻居搜索算法 GBD树空间数据结构动态数据环境地理信息系统计算机辅助设计

HDPE膜预辐照接枝VBTAC制备阴离子交换膜

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核技术 2008年第4期31卷 280-283页

作者：刘兆民秦莉俎建华 Akio Katatai takanobu Sugo Keizo Makuuchi 上海大学射线应用研究所上海201800 日本原子力研究所高崎辐射化学研究所高崎370-12

在氮气保护下,利用预辐照接枝技术在高密度聚乙烯(HDPE)膜上接枝苯乙烯三甲基氯化铵(VBTAC)单体,以甲基丙烯酸二甲氨基乙酯(DMAEMA)单体作为接枝辅助单体来提高VBTAC的接枝率,制备出阴离子交换膜,解决了在HDPE上难以直接接枝聚合VBTAC... 详细信息

在氮气保护下,利用预辐照接枝技术在高密度聚乙烯(HDPE)膜上接枝苯乙烯三甲基氯化铵(VBTAC)单体,以甲基丙烯酸二甲氨基乙酯(DMAEMA)单体作为接枝辅助单体来提高VBTAC的接枝率,制备出阴离子交换膜,解决了在HDPE上难以直接接枝聚合VBTAC的问题。本文研究了接枝条件及接枝液的组分对接枝的影响,并用X射线显微分析方法研究了VBTAC的接枝进程和接枝分布。

关键词：预辐射接枝 VBTAC 接枝单体 DMAEMA HDPE膜阴离子交换 X射线显微分析仪

Classifying genotype F of hepatitis B virus into F1 and F2 subtypes

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World Journal of Gastroenterology 2005年第40期11卷 6295-6304页

作者： Hideaki Kato Kei Fujiwara Robert G. Gish Hiroshi Sakugawa Hiroshi Yoshizawa Fuminaka Sugauchi Etsuro Orito Ryuzo Ueda Yasuhito Tanaka takanobu Kato Yuzo Miyakawa Masashi Mizokami Department of Internal Medicine and Molecular Science Hepatology and Gastroenterology First Department of Medicine Department of Epidemiology and Control of Infectious Diseases Department of Clinical Molecular Informative Medicine Miyakawa Memorial Research Foundation

AIM： To explore the propriety of providing hepatitis B virus （HBV） genotypes F and H with two distinct genotypes. METHODS： Eleven HBV isolates of genotype F （HBV/F） were recovered from patients living in San Francisco, Japan, Panama, and Venezuela, and their full-length sequences were determined. Phylogenetic analysis was carded out among them along with HBV isolates previously reported. RESULTS： Seven of them clustered with reported HBV/F Isolates in the phylogenetic tree constructed on the entire genomic sequence. The remaining four flocked on another branch along with three HBV isolates formerly reported as genotype H. These seven HBV isolates, including the four in this study and the three reported, had a sequence divergence of 7.3-9.5% from the other HBV/F isolates, and differed by 〉13.7% from HBV isolates of the other six genotypes （A-E and G）. Based on a marked genomic divergence, falling just short of 〉8% separating the seven genotypes, these seven HBV/F isolates were classified into F2 subtype and the former seven into F1 subtype provisionally. In a pairwise comparison of the S-gene sequences among the 7 HBV/F2 isolates and against 47 HBV/F1 isolates as well as 136 representing the other six genotypes （A-E and G）, two clusters separated by distinct genetic distances ***： Based on these analyses, dassifying HBV/ F isolates into two subtypes （F1 and F2） would be more appropriate than providing them with two distinct genotypes （F and H）.

关键词： Genotypes Hepatitis B virus Phylogeneticanalysis Subtypes

A durable complete response resulting from treatment with nivolumab plus ipilimumab for metastatic collecting duct carcinoma of the kidney

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Asian Journal of Urology 2023年第3期10卷 376-378页

作者： Keisuke Funajima Sei Naito takanobu Kabasawa Hayato Nishida Tomoyuki Kato Mitsuru Futakuchi Norihiko Tsuchiya Department of Urology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan Department of Pathology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan

Dear Editor,Collecting duct carcinoma(CDC)or Bellini carcinoma originates in the distal collecting *** is a markedly aggressive subtype of renal cell carcinoma and accounts for less than 1%of all renal cell carcinomas[1].We described a patient with CDC and psoriasis,who showed complete response(CR)after being treated with combination therapy of nivolumab and ipilimumab(NI).The study was conducted in accordance with and approved by the Ethics Committee of Yamagata University Faculty of Medicine(approval no.2019-35).The need for patient consent was waived by the same institutional review board;all the patients provided written informed consents.

关键词： markedly nivolumab approval