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Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2009年第20期15卷 2520-2525页

作者： Eiji Oki Yan Zhao Rintaro Yoshida takanobu masuda Koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Department of Gastroenterology National Kyushu Cancer Center 3-1-1 Notame Minarni-ku Fukuoka 811-1395 Japan

AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric ***:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c *** microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct ***:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological *** found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation ***:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of ***, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis.

关键词： Checkpoint with forkhead-associated and ring finger Methylation Microsatellite instability Gastric cancer p53

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Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy

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World Journal of Gastroenterology 2017年第11期23卷 2060-2067页

作者： Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma Division of Gastroenterology Department of Internal MedicineKobe University Graduate School of Medicine Department of Pharmacy Kobe University Hospital

AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical *** The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were *** The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms.

关键词： Gastroesophageal reflux disease CYP2C19 FSSG Residual symptoms Proton pump inhibitor

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Prognostic factors in stage IB gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6580-6585页

作者： Toru Aoyama Takaki Yoshikawa Hirohito Fujikawa Tsutomu Hayashi Takashi Ogata Haruhiko Cho takanobu Yamada Shinichi Hasegawa Kazuhito Tsuchida Norio Yukawa Takashi Oshima Mari S Oba Satoshi Morita Yasushi Rino Munetaka masuda Department of Gastrointestinal Surgery Kanagawa Cancer CenterYokohama 241-0815Japan Department of Surgery Yokohama City UniversityYokohama 236-0004Japan Department of Biostatistics and Epidemiology Yokohama City UniversityYokohama 236-0004Japan

AIM:To identify the subset of patients with stage IB gastric cancer with an unfavorable ***:Overall survival(OS)rates were examined in 103 patients with stage IB(T1N1M0 and T2N0M0)gastric cancer between January 2000 and *** and multivariate analyses were performed to identify risk factors using a Cox proportional hazards ***:The OS rates of patients with T1N1 and T2N0 cancer were 89.2%and 94.1%at 5-years,*** univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic *** OS rate was 81.8%at5-years when the tumor was located in the upper third of the stomach and was 95.5%at 5-years when the tumor was located in the middle or lower third of the stomach(P=0.0093).CONCLUSION:These data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer.

关键词： Gastric cancer Stage IB Prognostic factor

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Hayabusa2’s station-keeping operation in the proximity of the asteroid Ryugu

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Astrodynamics 2020年第4期4卷 349-375页

作者： Yuto Takei Takanao Saiki Yukio Yamamoto Yuya Mimasu Hiroshi Takeuchi Hitoshi Ikeda Naoko Ogawa Fuyuto Terui Go Ono Kent Yoshikawa Tadateru Takahashi Hirotaka Sawada Chikako Hirose Shota Kikuchi Atsushi Fuji Takahiro Iwata Satoru Nakazawa Masahiko Hayakawa Ryudo Tsukizaki Satoshi Tanaka Masanori Matsushita Osamu Mori Daiki Koda takanobu Shimada Masanobu Ozaki Masanao Abe Satoshi Hosoda Tatsuaki Okada Hajime Yano Takaaki Kato Seiji Yasuda Kota Matsushima Tetsuya masuda Makoto Yoshikawa Yuichi Tsuda Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan The Graduate University for Advanced Studies Sagarmihara 252-5210Japan NEC Aerospace Systems LtdFruchu 183-8502Japan NEC Corporation Puchu 183-8501Japan

The Japanese interplanetary probe Hayabusa2 was launched on December 3,2014 and the probe arrived at the vicinity of asteroid 162173 Ryugu on June 27,*** its 1.4 years of asteroid proximity phase,the probe successfully accomplished numbers of record-breaking achievements including two touchdowns and one artificial cratering experiment,which are highly expected to have secured surface and subsurface samples from the asteroid inside its sample container for the first time in *** Hayabusa2 spacecraft was designed not to orbit but to hover above the asteroid along the sub Earth *** orbital and geometrical configuration allows the spacecraft to utilize its high-gain antennas for telecommunication with the ground station on Earth while pointing its scientific observation and navigation sensors at the *** paper focuses on the regular station-keeping operation of Hayabusa2,which is called“home position”(HP)-keeping ***,together with the spacecraft design,an operation scheme called HP navigation(HPNAV),which includes a daily trajectory control and scientific observations as regular activities,is *** the description on the guidance,navigation,and control design as well as the framework of optical and radiometric navigation,the results of the HP-keeping operation including trajectory estimation and delta-V planning during the entire asteroid proximity phase are summarized and evaluated as a first ***,this paper states that the *** operation in the framework of HPNAV had succeeded without critical incidents,and the number of trajectory control delta-V was planned fficiently throughout the period.

关键词： small body mission station-keeping guidance,navigation,and control(GNC) optical and radiometric navigation

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2010年上海世博园能源系统规划的研究——能源基础设施的基本规划理念

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暖通空调 2005年第5期35卷 107-111页

作者：尾岛俊雄许雷王健龙惟定范存养束昱吉田公夫生沼哲增田康广吉本哲史米村贵信早稻田大学同济大学电源开发株式会社日本环境技研株式会社

借鉴日本在世博会能源规划方面的经验和技术数据,对2010 年上海世博园能源系统和能源基础设施提出了基本规划理念。根据上海世博会总体规划,对上海世博园区会展期间和后续利用时的最大空调供冷负荷及其分布作了估算,提出了能源中心的3 ... 详细信息

借鉴日本在世博会能源规划方面的经验和技术数据,对2010 年上海世博园能源系统和能源基础设施提出了基本规划理念。根据上海世博会总体规划,对上海世博园区会展期间和后续利用时的最大空调供冷负荷及其分布作了估算,提出了能源中心的3 种方案,并对共同沟等能源基础设施的规划作了介绍。

关键词： 2010年基础设施规划理念世博园系统规划上海世博会技术数据能源规划能源系统总体规划供冷负荷能源中心共同沟

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