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Biological properties of self-assembled nanofibers of elastin-like block polypeptides for tissue-engineered vascular grafts:platelet inhibition,endothelial cell activation and smooth muscle cell maintenance

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Regenerative Biomaterials 2023年第1期10卷 386-395页

作者： Kazuki Natsume Jin Nakamura Kazuhide sato Chikara Ohtsuki Ayae Sugawara-Narutaki Department of Materials Chemistry Graduate School of EngineeringNagoya UniversityNagoya 464-8603Japan Department of Biological Functions Engineering Graduate School of Life Science and Systems EngineeringKyushu Institute of TechnologyFukuoka 808-0196Japan Institute for Advanced Research Nagoya UniversityNagoya 464-8601Japan Department of Respiratory Medicine Graduate School of MedicineNagoya UniversityNagoya 466-8560Japan Department of Energy Engineering Graduate School of EngineeringNagoya UniversityNagoya 464-8603Japan

Strategic materials design is essential for the development of small-diameter,tissue-engineered vascular ***-assembled nanofibers of elastin-like polypeptides represent promising vascular graft components as they replicate the organized elastin structure of native blood ***,the bioactivity of nanofibers can be modified by the addition of functional peptide *** the present study,we describe the development of a novel nanofiber-forming elastin-like polypeptide(ELP)with an arginine-glutamic acid-aspartic acid-valine(REDV)*** biological characteristics of the REDV-modified ELP nanofibers relevant to applications in vascular grafting were compared to ELP without ligands for integrin,ELP with arginine-glycine-aspartic acid(RGD)sequence,collagen and cell culture *** them,REDV-modified ELP nanofibers met the preferred biological properties for vascular graft materials,i.e.(i)inhibition of platelet adhesion and activation,(ii)endothelial cell adhesion and proliferation and(iii)maintenance of smooth muscle cells in a contractile phenotype to prevent cell *** results indicate that REDV-modified ELP nanofibers represent promising candidates for the further development of small-diameter vascular grafts.

关键词： elastin-like polypeptide nanofiber platelet endothelial cell smooth muscle cell

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Nanometer-Order Contouring Control in a Feed Drive System Using Linear Ball Guides by Applying a Combination of Modified Disturbance Observer and Repetitive Control

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Nanomanufacturing and Metrology 2021年第2期4卷 118-129页

作者： Tomofumi Ohashi Hitoshi Shibata Shigeru Futami Ryuta sato THK Co. Ltd.4-9-16 HigashikoujiyaOta-kuTokyoJapan Advanced Manufacturing Systems Laboratory Kobe University2-1 RokkodaiNada-kuKobeHyogoJapan

This paper proposes a quadrant glitch compensation method to achieve nanometer-level accuracy of contouring control for a feed drive system using linear ball *** proposed method is a combination of a modified disturbance observer(“disturbance suppressor”)and an improved repetitive control *** motion tests with 1 mm amplitude and 0.1 Hz driving frequency were conducted using a single-axis feed drive system to verify the quadrant glitch compensation ability of this ***,the repeatability of the quadrant glitches in the experimental system was verified,which is the most important characteristic required for compensation via repetitive ***,by applying the combination of disturbance suppressor and conventional repetitive control,the amplitudes of the quadrant glitches were decreased to less than 1 nm;in other words,the ratio of the magnitude of the quadrant glitch to the amplitude of the position reference was less than 1/1,000,***,for both compensation schemes mentioned before,vibrations were generated when the feed speed ***,the amplitudes increased with the number of *** reason for the vibrations was identified as the repetitive control *** suppress these vibrations,the repetitive control was applied only to narrowed regimes near the quadrant ***,the maximum contouring error was decreased to 2 *** addition,the nonlinear spring behavior of the linear ball guides was confirmed to affect the stability of the control systems.

关键词： Quadrant glitch Feed drive system Contouring control Repetitive control Disturbance observer Nonlinear spring behavior

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Some Remarks on the Restriction Theorems for the Maximal Operators on R^d

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Analysis in Theory and Applications 2015年第2期31卷 123-137页

作者： Enji sato Department of Mathematical Sciences Faculty of Science Yamagata University

The aim of this paper is to give a simple proof of the restriction theorem for the maximal operators on the d-dimensional Euclidean space Ra, whose theorem was proved by Carro-Rodriguez in 2012. Moreover, we shall give some remarks of the restriction theorem for the linear and the multilinear operators by Carro-Rodriguez and Rodriguez, too.

关键词： Weighted L^P spaces Fourier multipliers multilinear operators.

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Influence of Setting Condition on Characteristics of Savonius Hydraulic Turbine with a Shield Plate

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Journal of Thermal Science 2011年第3期20卷 224-228页

作者： Shouichiro Iio Yusuke Katayama Fuminori Uchiyama Eiichi sato Toshihiko Ikeda Faculity of Eng. Shinshu University4-17-1 WakasatoNaganoJAPAN380-8553 Student of Shinshu University 4-17-1 WakasatoNaganoJAPAN380-8553 Flowserve Niigata Worthington Co. Ltd.1-32 ShinbashiKashiwazakiNiigataJAPAN945-0056 Faculty of Eng. Niigata Institute of Technology1719 FujihashiKashiwazakiNiigataJAPAN945-1195

The aim of this investigation was to improve power performance of Savonius hydraulic turbine utilizing small stream for electric *** attempt was made to increase the power coefficient of runner by the use of flat shield plate placed upstream of the *** difference of the power coefficient is discussed in relation to clearance between the runner and the bottom wall and the rotation direction of the *** flow field around the runner was also examined visually to clarify influences of setting conditions on the power *** this study it was found that the power coefficient is achieved for 0.47 by only using a flat shield plate,the increase is up to 80% over the runner without the ***,it is the proper condition that clearance ratio is 0.73 in this study.

关键词： Nano-hydraulic turbine Savonius runner Shield plate Performance

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Application of the Solvothermal Process in the Synthesis of High-performance Ag/γ-Al_2O_3 Catalysts

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过程工程学报 2006年第4期6卷 633-638页

作者：唐清李锐星殷澍 Shingo Goto Daisuke Nagai Tsugio sato Institute of Process Engineering Chinese Academy of Sciences Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan

Ag/γ-Al2O3 is a kind of promising catalyst with the relatively lower cost compared with those using noble metals,good resistance against catalytic poisoning and excellent behaviour for NOx *** the present study,Ag/γ-Al2O3 catalysts were synthesized by the solvothermal process and characterized by XRD,TG?DTA,TEM,UV?Vis and FT?*** was found that high-performance Ag/γ-Al2O3 catalysts could be synthesized by properly selecting starting materials,controlling the composition of solvent and other reaction *** microstructure evolution of the catalysts was also discussed.

关键词： Ag/γ-Al2O3 solvothermal process catalyst microstructure

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Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment

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World Journal of Gastroenterology 2019年第12期25卷 1457-1464页

作者： Hiroki sato Manabu Takeuchi satoru Hashimoto Ken-ichi Mizuno Koichi Furukawa Akito sato Junji Yokoyama Shuji Terai Division of Gastroenterology Niigata University Medical and Dental Hospital Division of Gastroenterology Nagaoka Red Cross Hospital Division of Gastroenterology Niigata City General Hospital Division of Gastroenterology Nagaoka Chuo General Hospital

Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant,minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy(POEM). However,the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience.

关键词： Diverticulum Esophagus Epiphrenic diverticulum Zenker's diverticulum Rokitansky diverticulum Iatrogenic disease Esophageal achalasia Peroral endoscopic myotomy Diverticulectomy

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Improvement of solidification model and analysis of 3D channel blockage with MPS method

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Frontiers in Energy 2021年第4期15卷 946-958页

作者： Reo KAWAKAMI Xin LI Guangtao DUAN Akifumi YAMAJI Isamu sato Tohru SUZUKI Cooperative Major in Nuclear Energy Graduate School and Advanced Science and EngineeringFaculty of Science and EngineeringWaseda University3-4-1 OkuboShinjuku-kuTokyo169-8555Japan Department of Nuclear Engineering and Management The University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-8656Japan Department of Nuclear Safety Engineering Faculty of EngineeringTokyo City University1-28-1 TamazutsumiSetagaya-kuTokyo158-0087Japan

In a severe accident of a nuclear power reactor,coolant channel blockage by solidified molten core debris may significantly influence the core degradations that *** moving particle semi-implicit(MPS)method is one of the Lagrangian-based particle methods for analyzing incompressible *** the study described in this paper,a novel solidification model for analyzing melt flowing channel blockage with the MPS method has been developed,which is suitable to attain a sufficient numerical accuracy with a reasonable calculation *** prompt velocity diffusion by viscosity is prioritized over the prompt velocity correction by the pressure term(for assuring incompressibility)within each time step over the“mushy zone”(between the solidus and liquidus temperature)for accurate modeling of solidification before fixing the coordinates of the completely solidified *** sustain the numerical accuracy and stability,the corrective matrix and particle shifting techniques have been applied to correct the discretization errors from irregular particle arrangements and to recover the regular particle arrangements,*** validate the newly developed algorithm,2-D benchmark analyses are conducted for steady-state freezing of the water in a laminar flow between two parallel ***,3-D channel blockage analyses of a boiling water reactor(BWR)fuel support piece have been *** results show that a partial channel blockage develops from the vicinity of the speed limiter,which does not fully develop into a complete channel blockage,but still diverts the incoming melt flow that follows to the orifice region.

关键词： boiling water reactor(BWR) severe accident channel blockage moving particle semi-implicit(MPS)method solidification*

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A currency basket and future exchange rate arrangements in Asia

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Economic and Political Studies 2018年第1期6卷 53-68页

作者： Junko Shimizu Kiyotaka sato Faculty of Economics Gakushuin UniversitToykoJapan Department of Economics Yokohama National UniversitYokohamaJapan School of Business and Law Edith Cowan UniversitPerthAustralia

Due not only to a dominant role of the US dollar in regional trade and financial transactions but also to de facto US dollar pegged exchange rate policy,Asian countries cannot avoid exchange rate risks between their own currency and the US *** recent years,however,the Chinese government has actively promoted the Renminbi(RMB)internationalisation especially in intermational *** December 2015,China introduced a new exchange rate index against a basket of 13 trade-weighted currencies,which can be considered a major turning point from the US dollar standard toward a more flexible currency basket ***,the estimated implicit basket weights reveal that several Asian economies still tend to stabilise their currencies against the US dollar,while Malaysia and Singapore have stabilised their currencies against RMB in recent *** the internationalisation of local currencies and regional monetary arrangements are typically facilitated with each other,further progress of RMB internationalisation is expected to promote a leading role of China in establishing regional exchange rate policy coordination.

关键词： Currency basket currency internationalisation regional monetary arrangements exchange ratepolicy Asia

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Chronic lung allograft dysfunction post-lung transplantation:The era of bronchiolitis obliterans syndrome and restrictive allograft syndrome

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World Journal of Transplantation 2020年第5期10卷 104-116页

作者： Nobuyuki Yoshiyasu Masaaki sato Department of Thoracic Surgery The University of Tokyo HospitalTokyo 113-8655Japan

Chronic lung allograft dysfunction(CLAD)following lung transplantation limits long-term survival *** main reason for this is a lack of knowledge regarding the pathological condition and the establishment of *** consensus statement from the International Society for Heart and Lung Transplantation on CLAD in 2019 classified CLAD into two main phenotypes:Bronchiolitis obliterans syndrome and restrictive allograft *** with this clear classification,further exploration of the mechanisms and the development of appropriate prevention and treatment strategies for each phenotype are *** this review,we summarize the new definition of CLAD and update and summarize the existing knowledge on the underlying mechanisms of bronchiolitis obliterans syndrome and restrictive allograft syndrome,which have been elucidated from clinicopathological observations and animal experiments worldwide.

关键词： Lung transplantation Chronic lung allograft dysfunction Bronchiolitis obliterans syndrome Restrictive allograft syndrome Interaction of immune cells Anatomical changes in transplanted lungs

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Solid pseudopapillary neoplasm of the pancreas in a young male with main pancreatic duct dilatation: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11382-11391页

作者： Saki Nakashima Yoshiki sato Tsunao Imamura Daisuke Hattori Tetsuo Tamura Rikako Koyama Junichiro sato Yuta Kobayashi Masaji Hashimoto Department of Neurology The University of Tokyo HospitalBunkyo-ku 113-8655TokyoJapan Department of Gastroenterology Toranomon HospitalTokyo 105-0001Japan Department of Pathology Toranomon HospitalTokyo 105-0001Japan Department of Gastrointestinal Surgery Toranomon HospitalTokyo 105-0001Japan

BACKGROUND Solid pseudopapillary neoplasms(SPNs)are rare tumors of the ***,they occur in young females,often have characteristic imaging features,such as cystic components and calcification,and have few effects on the pancreatic *** SUMMARY A 31-year-old man was admitted to our hospital with the chief complaint of epigastric *** was only mild tenderness in his upper abdomen,and blood tests showed only a slight increase in alkaline ***-enhanced computed tomography showed a 40-mm-diameter,hypovascular mass in the head of the pancreas,and the main pancreatic duct upstream of the mass was severely *** resonance imaging showed low intensity on T1-weighted images,with high intensity on T2-weighted image in some *** ductal adenocarcinoma was the primary differential *** vein infiltration could not be ruled out,so this case was a candidate for neoadjuvant ***,endoscopic ultrasound-guided fine needle aspiration was performed,and pathological evaluation and immunostaining suggested a diagnosis of ***,pancreatoduodenectomy was *** year after the operation,the patient is alive with no *** Main pancreatic duct dilatation is usually a finding of suspected pancreatic ***,pancreatic duct dilatation can occur in SPN depending on the location and growth ***,SPN should be considered in the differential diagnosis of tumors with pancreatic duct dilatation,and pathological evaluation by endoscopic ultrasound-guided fine needle aspiration should be actively performed.

关键词： Solid pseudopapillary neoplasm Endoscopic ultrasound-guided fine-needle aspiration Main pancreatic duct dilatation Male Case report

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