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Does a combined intervention program of repetitive transcranial magnetic stimulation and intensive occupational therapy affect cognitive function in patients with post-stroke upper limb hemiparesis?

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Neural Regeneration Research 2016年第12期11卷 1932-1939页

作者： Takatoshi Hara Masahiro Abo Kiyohito Kakita Takeshi Masuda Ryunosuke yamazaki Department of Rehabilitation Medicine The Jikei University School of Medicine Department of Rehabilitation Medicine Kyoto Ohara Memorial Hospital

Low-frequency repetitive transcranial magnetic stimulation（LF-r TMS） to the contralesional hemisphere and intensive occupational therapy（i OT） have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-r TMS and i OT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient＇s Trail-Making Test part B（TMT-B） performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions. Twenty-five patients received 11 sessions of LF-r TMS to the contralesional hemisphere and 2 sessions of i OT per day over 15 successive days. Patients with right- and left-sided hemiparesis demonstrated significant improvements in upper limb motor function following the combined intervention program. Only patients with right-sided hemiparesis exhibited improved TMT-B performance following the combined intervention program, and there was a significant negative correlation between Fugl-Meyer Assessment scale total score change and TMT-B performance. The results indicate the possibility that LF-r TMS to the contralesional hemisphere combined with i OT improves the upper limb motor function and cognitive function of patients with right-sided hemiparesis. However, further studies are necessary to elucidate the mechanism of improved cognitive function.

关键词： nerve regeneration stroke repetitive transcranial magnetic stimulation Trail-Making Test cognitive function occupational therapy neural regeneration

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Discrete Differential Evolution for Mixed Discrete Non-Linear Problems

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Journal of Civil Engineering and Architecture 2012年第5期6卷 594-605页

作者： Satoshi Kitayama Masao Arakawa Koetsu yamazaki College of Science and Engineering Kanazawa University Kanazawa 920-1192 Japan Kagawa University Hayashi-cho Takamatsu Kagawa 761-0396 Japan

Differential evolution （DE） is a global optimizer for continuous design variables. To enhance DE, it is necessary to handle discrete design variables. In this paper, a discrete differential evolution （DDE） algorithm is proposed to handle discrete design variables The proposed DDE is based on the DE/l/rand/bin method. In the proposed DDE, the mutation ratio is regarded as the exchange probability, and thus, no modifications of DE/l/rand/bin are required. In addition, in order to maintain diversity through the search process, we initialize all search points. By introducing the initialization of all search points, global or quasi-optimum solution can be found. We validate the proposed DDE by applying it to several benchmark problems.

关键词： Global optimization differential evolution mixed-discrete nonlinear problems.

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A new Speedy/RINGO protein may help regulate male meiosis

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Asian Journal of Andrology 2011年第3期13卷 363-363页

作者： Yukiko yamazaki W Steven Ward Institute for Biogenesis Research University of Hawaii at Manoa Honolulu HI 96822 USA

Reproductive biology, although seen as a specialty study area, has many unique biology models that offer insight into the regulation of cellular processes that are shared by many different cell types. The most celebra... 详细信息

关键词： Chemical sciences Nanotechnology

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Proposal and Verification of Simultaneous Measurement Method for Three Thermoelectric Properties with Film-Type Thermocouple Probe

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Journal of Electronics Cooling and Thermal Control 2017年第2期7卷 23-32页

作者： Takumi yamazaki Ai Ueno Hosei Nagano Department of Aerospace Engineering Nagoya University Nagoya Japan Department of Mechanical Science and Engineering Nagoya University Nagoya Japan

A new simultaneous measurement method for the measurement of the three thermoelectric properties with a film-type thermocouple probe was proposed. Seebeck coefficient was measured using the steady-state condi-tion of the differential method. The electrical resistivity was measured us-ing the four-probe method and the thermal diffusivity is measured using the periodic heating method. The effectiveness of the proposed method was verified using constantan as a reference material. After describing the effectiveness of the method, the measurement of three thermoelectric properties of Bi0.3Sb1.7Te3, which is a thermoelectric material, was per-formed.

关键词： Film-Type Thermocouple Sensor Simultaneous Measurement Thermoelectric Properties

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Response evaluation of a compact and highly efficient neutron diffractometer for compact accelerator neutron sources

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辐射防护 2020年第6期40卷 540-544页

作者： Sho Imai Kenichi Watanabe Astushi yamazaki Sachiko Yoshihashi Akira Uritani Seiji Tasaki Setsuo Satoh Nagoya University Furo-choChikusa-kuNagoya464-8603Japan Kyoto University YoshidahonmachiSakyo-kuKyoto606-8501Japan High Energy Accelerator Research Organization Oh-hoTsukuba305-0801Japan

We fabricated the spheroid neutron diffractometer with 79 neutron detector rings using the transparent rubber sheet type Eu:LiCaAlF6 scintillators and wavelength-shifting *** confirmed that the fabricated detector shows a clear neutron peak and can discriminate neutron and gamma-ray events in a signal pulse *** additionally checked that the fabricated diffractometer can detect a neutron diffraction peak of ferrite powder at Kyoto University Accelerator-driven Neutron ***,it can be expected that crystal structural analysis will be possible even by small accelerator neutron sources.

关键词： TRUST Eu:LiCAF scintillator neutron diffractometer neutron detector time-of-flight KUANS LiTA12

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Sofosbuvir/Ribavirin therapy for patients experiencing failure of ombitasvir/paritaprevir/ritonavir + ribavirin therapy: Two cases report and review of literature

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World Journal of Clinical Cases 2019年第9期7卷 1043-1052页

作者： Ken Sato Yuichi yamazaki Takeshi Kobayashi Satoshi Takakusagi Norio Horiguchi Satoru Kakizaki Masayasu Andou Yoshihiro Matsuda Toshio Uraoka Hiroshi Ohnishi Hiroaki Okamoto Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Department of Nephrology and Rheumatology Gunma University Graduate School of Medicine Department of Diagnostic Radiology and Nuclear Medicine Gunma University Graduate School of Medicine Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine

BACKGROUND The effectiveness of sofosbuvir/ribavirin(SOF/RBV) combination therapy,which is one of the 1 st-choice therapeutic options for patients with hepatitis C virus(HCV) genotype 2(HCV-G2) in Japan according to the most recent version of the Japan Society of Hepatology guideline, for patients who experienced failure of the ombitasvir/paritaprevir/ritonavir plus ribavirin(OBV/PTV/r+RBV) combination therapy, which was another option for patients with HCV-G2, is *** SUMMARY We evaluated the effects of SOF/RBV combination therapy in two patients with genotype 2 a who could not achieve a sustained virological response(SVR) by OBV/PTV/r+RBV combination therapy. One patient was complicated with VogtKoyanagi-Harada(VKH) disease. Resistance-associated variations before SOF/RBV combination therapy were not detected in two patients. Both patients had an SVR at 12 wk after the treatment(SVR12). Regarding adverse events(AEs), itching, chill, a dull feeling in the throat and cough as well as increase of alanine transaminase level were shown in one patient, while a headache and deterioration of light aversion probably due to the recurrence of VKH disease were shown in the other patients. In addition, the latter patient developed arthralgia and morning stiffness approximately 7 wk after the therapy and turned out to be diagnosed with rheumatoid *** SOF/RBV therapy might be effective for patients experiencing failure of OBV/PTV/r+RBV therapy, but caution should be taken regarding the AEs.

关键词： Direct-acting antiviral agent failure Hepatitis C Genotype 2 Ribavirin Sofosbuvir Case report

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Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers

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World Journal of Gastroenterology 2020年第4期26卷 424-432页

作者： Akiko Shida Takashi Fukuyama Nobue Futawatari Haruki Ohmiya Yoshinobu Ichiki Tetsuro Yamashita Yatsushi Nishi Noritada Kobayashi Hitoshi yamazaki Masahiko Watanabe Yoshihito Takahashi Division of Pathology Kitasato UniversitySagamiharaKanagawa 252-0374Japan Division of Biomedical Research Kitasato University Medical CenterKitamotoSaitama 364-8501Japan Division of Surgery Toho UniversityOhashi Medical CenterMegurokuTokyo 153-8515Japan Department of Biological Chemistry and Food Sciences Faculty of AgricultureIwate UniversityMoriokaIwate 020-8505Japan Division of Surgery Kitasato University Medical CenterKitamotoSaitama 364-8501Japan Division of Pathology Kitasato University Medical CenterKitamotoSaitama 364-8501Japan Division of Surgery Kitasato UniversitySagamiharaKanagawa 252-0374Japan

BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(***)]is effective for the classification of individuals at risk of developing gastric cancer(GC).The Kita–Kyushu lung cancer antigen-1(KK-LC-1)is a Cancer/Testis antigen frequently expressed in *** To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of *** We analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC *** levels of serum PG I/PG II and IgG against *** were *** to their serological status,the patients were classified into the four groups of the ABCD *** Of the 77 examined patients,63(81.8%)expressed *** IgG titers of *** and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P=0.0289 and P=0.0041,respectively).The expression of KK-LC-1 in group C[PG method(+)/*** infection(+)]was as high as 93.9%***-LC-1 was also detected in group A[-/-].CONCLUSION The KK-LC-1 expression in GC was associated with *** infection and atrophic status,so that,KK-LC-1 may be a useful marker for the diagnosis of GC.

关键词： Gastric cancer Tumor antigen Cancer/testis antigen Kita–Kyushu lung cancer antigen-1 Helicobacter pylori Early detection of cancer

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Distortion of Space and Time during Saccadic Eye Movements

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Intelligent Information Management 2010年第2期2卷 90-94页

作者： M. Suzuki Y. yamazaki 不详

The space-time distortion perceived subjectively during saccadic eye movements is an associative phenomenon of a transient shift of observer’s visual frame of reference from one position to another. Here we report that the lines of subjective simultaneity defined as two spatially separated flashes perceived during saccades were nearly uniformly tilted along the physical time-course. The causality of the resulting space-time compression may be explained by the Minkowski space-time diagram in physics.

关键词： Saccade Space Time Compression

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Comparative Anatomy of the Vasculature of the Dog (Canis familiaris) and Domestic Cat (Felis catus) Paw Pad

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Open Journal of Veterinary Medicine 2013年第1期3卷 11-15页

作者： Hiroyoshi Ninomiya Kaoru yamazaki Tomo Inomata Department of Laboratory Animal Science Azabu University Kanagawa Japan

The microvasculature of footpads in the dog and domestic cat was investigated using histology and scanning electron microscopy of corrosion casts. Methylmethacrylate resin vascular casts for scanning electron microscopy, Indian ink injected whole mount and histological specimens were each prepared, in a series of 16 limbs of 4 adult dogs and 12 limbs of 3 adult domestic cats. The network of blood vessels in the dog paw pad appears to have an intricate pattern, especially with regard to venous outflow forming a peri-arterial venous network. Numerous arteriovenous anastomoses (AVAs) were found in the canine dermis. While, that of the domestic cat had less complex vascular pattern in the footpad without the peri-arterial venous network. AVAs were observed sporadically in the feline dermis. The peri-arterial venous network in the paw pad formed a countercurrent heat exchanger in dogs. When the foot pad is exposed to a cold environment in dogs, the countercurrent heat exchanger serves to prevent heat loss by re-circulating heat back to the body core, adopting an inhospitable environment. AVAs also play a role in regulating the body temperature. A lack of the peri-arterial venous network and few AVAs appear to make felines more prone to suffer from a cold condition than canines.

关键词： Cat Corrosion Cast Dog Footpad Vasculature

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Retrograde percutaneous coronary intervention via critically degenerated saphenous vein grafts for chronic total occlusion in native coronary arteries

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World Journal of Cardiovascular Diseases 2013年第3期3卷 261-265页

作者： Makoto Sekiguchi Masao yamazaki Masahiko Kurabayashi Department of Cardiology Fukaya Red-Cross Hospital Saitama Japan Department of Medicine and Biological Science Graduate School of Medicine Gunma University Gunma Japan

We report the case of a 78-year-old woman with saphenous vein graft (SVG) disease and chronic total occlusion (CTO) in three native coronary arteries [left anterior descending artery (LAD), left circumflex artery, and the right coronary artery], who was successfully treated by percutaneous coronary intervention (PCI) using the retrograde approach via the critically degenerated SVGs. The patient, a 78-year-old woman, presented with sudden chest pain and dyspnea. She had previously undergone coronary artery bypass surgery using SVGs for the three vessels and percutaneous coronary intervention with sirolimuseluting stent placement in the posterolateral branch 13 and 3 years ago, respectively. Electrocardiography revealed ST-segment elevation in leads V1-4, whereas emergent coronary angiography revealed total occlusion in her native coronary arteries. Primary PCI was scheduled. A channel dilator was advanced very smoothly and safely into the distal site of the CTO lesion in the LAD, which showed complete occlusion in the proximal region, via an SVG that was temporally occluded four days earlier. A reverse controlled antegrade and retrograde tracking technique was used to successfully perform percutaneous recanalization. Subsequently, the other two native CTO lesions protected by critically degenerated SVGs were treated with retrograde intervention via the SVGs. The retrograde approach via critically degenerated SVGs is safe, reliable, and fast. If an SVG bypassing the native CTO lesion is critically degenerated, percutaneous coronary intervention should be performed via the SVG.

关键词： Percutaneous Coronary Intervention Total Occlusion Saphenous Vein Grafts

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