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Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats

Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro Yokoyama takako yamada Tetsuo Iida Susumu Mochizuki Akihide Yoshihara Kazuya Akimitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warran

关键词： Rare Sugar d-Allulose Medium-Chain Triglycerides Body Fat Rat

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Vitamin D3 Supplementation Improved Physical Performance in Healthy Older Adults in Japan: A Pilot Study

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Health 2018年第9期10卷 1200-1209页

作者： Noboru Hasegawa Miyako Mochizuki Mayumi Kato Nobuko Shimizu takako yamada Department of Health and Medical Sciences Ishikawa Prefectural Nursing University Kahoku Japan Kyoto Bunkyo Junior College Uji Japan Aichi Medical College for Physical and Occupational Therapy Kiyosu Japan Bukkyo University Kyoto Japan

Japan has the highest proportion of older adults and so-called “Super-aged society” in the world. These results suggested that the prevalence of both cognitive and physical functional impairment increases with age. Therefore, the present study was designed to investigate the effect of vitamin D3 supplementation in cognitive and physical functional impairment in healthy older adults in Japan. We enrolled 7 Japanese male (age: 76.0 ± 8.7) and 5 female (age: 78.3 ± 9.3) in this study. The physical function of even a person getting on a wheelchair could be tested in all subjects. Treatment group (n = 7) consisted of a 500 IU/day vitamin D3 corresponding to twice of daily requirement for 6 months. Blood was collected by venipuncture and the serum 25-hydroxy vitamin D (25 OHD), 1,25-hydroxy vitamin D (1,25 OHD), Ca and PTH concentration were measured. The Mini-Mental State Examination and the Montreal Cognitive Assessment-Japanese version were used for the cognitive function test. Physical function was measured objectively using the Timed Up and Go (TUG), 4-mgait speed test (4 MGS), 5-repetition sit-to-stand (5 STS), 30-second chair stand test (CS-30) and measurement of upper grip strength. Our results show that a 6-month intake of vitamin D3 increased serum 25 OHD within the insufficiency and sufficiency levels without changing 1,25 OHD, Ca and PTH concentration. And it significantly decreased 4 MGS without changing TUG, 5 STS, CS-30, upper grip strength and cognitive function. Serum 25 OHD cut-off values for skeletal muscle index, grip strength and 4 MGS in diagnosis of sarcopenia are 18.6 - 23.4 ng/mL. These findings suggest that serum 25 OHD levels (23.4 ng/mL) might improve moving capacity, lower limb muscle strength, and physical balance functional impairment.

关键词： Serum 25-Hydroxyvitamin D Cognitive Function Physical Function Aging Sarcopenia

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Serum 1, 25-Hydroxyvitamin D: A Useful Index of Cognitive and Physical Functional Impairment in Healthy Older Adults in Japan: A Pilot Study

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Health 2016年第15期8卷 1679-1686页

作者： Noboru Hasegawa Miyako Mochizuki Mayumi Kato takako yamada Nobuko Shimizu Akihisa Torii Department of Health and Medical Sciences Ishikawa Prefectural Nursing University Kahoku Japan Kyoto Bunkyo Junior College Uji Japan Aichi Medical College for Physical and Occupational Therapy Kiyosu Japan

We enrolled 23 Japanese men (age: 76.0 ± 8.7) and 17 women (age: 78.3 ± 9.3) in this study. The physical function of even a person getting on a wheelchair could be tested in all subjects. Blood was collected by venipuncture and the serum 1, 25-hydroxy vitamin D (1, 25OHD) concentration was measured. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment-Japanese version (MoCA-J) was used for the cognitive function test. Physical function was measured objectively using the Timed UP and Go (TUG) and 4-m walking test (4MWS). A significant positive correlation was found between serum 1, 25OHD and MMSE or MoCA-J. It is expected that an elderly person can maintain a mean serum 1, 25OHD level of about 100 pg/mL for preventing early cognitive disorder. In the present study, a significant positive correlation was found between urinary 25-hydroxy vitamin D (25OHD)/creatinine and MMSE or MoCA-J. Our results showed that urinary 25OHD might be a useful biomarker for predicting cognitive disorder. There was a significant negative correlation between serum 1, 25OHD and TUG or 4MWS. These findings suggest that serum 1, 25OHD levels might serve as a useful index to improve cognitive and physical functional impairment.

关键词： Serum 1 25-Hydroxyvitamin D Cognitive Function Physical Function Aging Urinary 25-Hydroxyvitamin D

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为淑女们准备的！红酒入门

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国际服装技术 2007年第4期 184-189页

作者： takako Ema Xiyanfeng（翻译） Rena Sonoda（图解） Koji yamada（摄影）

不论在餐厅还是在家中，餐桌上有了葡萄酒就能显出奢华的气氛。但是”实际上不了解昧道的区分“，“点了这类红酒是否适合？”像这类没有自信的人实在不少。在这里向大家介绍红酒的知识让大家更能享受到那份美味与优雅。

关键词：红酒入门知识葡萄酒

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