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Case Reports in Clinical Medicine 2014年第8期3卷 496-499页

作者： Satoko Minakawa Takahide Kaneko Tomohisa Fukui Yusuke Sakuraba Takayuki Aizu Ayumi Korekawa Noriko Takiyoshi Akiko Rokunohe takako moriyama Daisuke Sawamura Department of Dermatology Graduate School of Medicine Hirosaki University Hirosaki Japan Endocrinology and Metabolism Graduate School of Medicine Hirosaki University Hirosaki Japan

We report a 64-year-old female patient with an insulin allergy. She was treated with a combination of oral antihistamines, topical hydrocortisone cream, and moisturizing agents, which resulted in the improvement of eczema and intense pruritus. To evaluate insulin allergy, intradermal skin tests were performed with several insulin agents for clinical use and 0.9% NaCl. Skin testing with semisynthetic human insulin resulted in local, immediate skin reactions such as itchy erythema and wheals. Furthermore, we analyzed our case and 25 Japanese cases of insulin allergy previously reported in the literature as far as we know. Interestingly, the number of male patients was approximately two times higher than that of female, and the insulin-specific IgE antibody test was positive in 21 patients. We should keep the possibility of human insulin allergy in mind and prepare for it when initiating human insulin therapy.

关键词： Immediate-Type Allergy IgE Intradermal Skin Tests Human Insulin Human Insulin Analog

Clues for diagnosing misplaced central venous catheter in the right ascending lumbar vein during right femoral venous access

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World Journal of Clinical Cases 2024年第24期12卷 5473-5475页

作者： Joho Tokumine Kiyoshi moriyama Tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan

The right ascending lumbar vein is difficult to detect on anteroposterior abdominalradiographs because it overlaps with the inferior vena cava on *** observation by medical providers may be a cue ***,knowledge of catheter misplacement of the right ascendinglumbar vein is also necessary,because misplacement cannot be suspected withoutthat awareness.

关键词： Central venous catheter Ascending lumbar vein Femoral vein Catheter misplacement Anteroposterior abdominal X-ray

Lattice Boltzmann Simulations of Water Transport from the Gas Diffusion Layer to the Gas Channel in PEFC

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Communications in Computational Physics 2011年第5期9卷 1206-1218页

作者： Koji moriyama Takaji Inamuro Fundamental Research Center Honda R&D Co.Ltd.Saitama 351-0193Japan Department of Aeronautics and Astronautics Graduate School of EngineeringKyoto UniversityKyoto 606-8501Japan Advanced Research Institute of Fluid Science and Engineering Graduate School of EngineeringKyoto UniversityKyoto 606-8501Japan

Water management is a key to ensuring high performance and durability of polymer electrolyte fuel cell(PEFC),and it is important to understand the behavior of liquid water in *** this study,the two-phase lattice Boltzmann method is applied to the simulations of water discharge from gas diffusion layers(GDL)to gas *** GDL is porous media composed of carbon fibers with hydrophobic treatment,and the gas channels are hydrophilic micro-scale *** the simulations,arbitrarily generated porous materials are used as the structures of the *** investigate the effects of solid surface wettabilities on water distribution in the gas channels and the ***,the results of X-ray computed tomography images in the operating PEFC are compared with the numerical simulations,and the mechanism of the water transport in PEFC is considered.

关键词： Two-phase lattice Boltzmann method polymer electrolyte fuel cell X-ray CT imaging gas diffusion layer

Direct-acting antiviral agents against hepatitis C virus and lipid metabolism

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World Journal of Gastroenterology 2017年第31期23卷 5645-5649页

作者： tatsuo kanda mitsuhiko moriyama division of gastro-enterology and hepatology department of medicine nihon university school of medicine

Hepatitis C virus (HCV) infection induces steatosis and is accompanied by multiple metabolic alterations including hyperuricemia, reversible hypocholesterolemia and insulin resistance. Total cholesterol, low-density lipoprotein-cholesterol and triglyceride levels are increased by peginterferon and ribavirin combination therapy when a sustained virologic response (SVR) is achieved in patients with HCV. Steatosis is significantly more common in patients with HCV genotype 3 but interferon-free regimens are not always effective for treating HCV genotype 3 infections. HCV infection increases fatty acid synthase levels, resulting in the accumulation of fatty acids in hepatocytes. Of note, low-density lipoprotein receptor, scavenger receptor class B type I and Niemann-Pick C1-like 1 proteins are candidate receptors that may be involved in HCV. They are also required for the uptake of cholesterol from the external environment of hepatocytes. Among HCV-infected patients with or without human immunodeficiency virus infection, changes in serum lipid profiles are observed during interferon-free treatment and after the achievement of an SVR. It is evident that HCV affects cholesterol metabolism during interferon-free regimens. Although higher SVR rates were achieved with interferon-free treatment of HCV, special attention must also be paid to unexpected adverse events based on host metabolic changes including hyperlipidemia.

关键词： Cholesterol Hepatitis C virus Interferon-free Lipid metabolism

Existence of aromatic sp^2 C-H…O = C intramolecular interaction similar to hydrogen bond

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Science China Chemistry 1996年第3期39卷 285-291页

作者： Zeper Abliz Hiroshi moriyama Junji Aoki Toyotoshi Ueda Department of Chemistry Xin Jiang University Urumchi 830046ChinaDepartment of Chemistry Toho University Funabashi Chiba 274 JapanDepartment of Chemistry Toho University Funabashi Chiba 274 JapanDepartment of ChemistryMeisei UniversityHino Tokyo 191 Japan

A ’H NMR signal shifted drastically to down field (δ - 10.0) at the bay area and in dose proximity to C = O group for H-1 was observed through complete assignments of 1H NMR spectra for pyridino- and benzobenzanthrones. It is concluded that this phenomenon is due not only to the anisotropy effect of C=O plus aromatic ring current effect, but also to the electrostatic attraction of C-H (δ+)…O(δ-)=C interaction. The evidence for the sp2C-H…O = C intramolecular interaction similar to hydrogen bond has also been given by EI-MS and MS/MS (CID) spectroscopy and IR spectroscopy, as well as MNDO-PM3 calculations. This new kind of interaction might be called ’quasi-hydrogen bond’.

关键词： polycyclic aromatic ketone pyridinobenzanthrone intramolecular interaction hydrogen bond quasl-hydrogen bond.

Genome-wide analysis of hepatitis B virus integration in hepatocellular carcinoma: Insights next generation sequencing

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 548-552页

作者： Yutaka Midorikawa Kenji Tatsuno Mitsuhiko moriyama Genome Science and Medicine RCASTUniversity of TokyoTokyoJapan Department of Surgery National Center of Neurology and PsychiatryTokyoJapan Department of Gastroenterology and Hepatology Nihon University School of MedicineTokyoJapan

The development of high-throughput sequencing technologies has provided the opportunity to platform genome-wide *** applications of next generation sequencing(NGS)have revealed that the hepatitis B virus(HBV)genome is randomly integrated throughout the human genome in patients with HBV *** the induction of chronic infection of the liver,HBV integration of the host genome contributes to hepatocarcinogenesis,especially in young patients without cirrhosis(1,2).

关键词： hepatitis patients integration

2019nCoVR—A comprehensive genomic resource for SARS-CoV-2 variant surveillance

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The Innovation 2021年第4期2卷 1-2页

作者： Guoqing Lu Etsuko N.moriyama Department of Biology University of Nebraska at OmahaOmahaNE 68182USA School of Biological Sciences and Center for Plant Science Innovation University of Nebraska-LincolnLincolnNE 68588USA

The coronavirus disease 2019(COVID-19)is a once-in-a-century pandemic,and the virus,the severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2,has infected more than 180 million people and claimed almost 4 million lives worldwide(as of July 5,2021)since the first case was reported in Wuhan,China,on December 31,*** China National Center for Bioinformation(CNCB)responded promptly and launched the 2019 Novel Coronavirus Resource(2019nCoVR;https://***/ncov/)in January 2020 for rapid release and public sharing of SARS-CoV-2 genomic data and analysis tools(Figure 1A).

关键词： Figure prompt VR

Are direct-acting antivirals against hepatitis C virus infection not associated with the recurrence of hepatocellular carcinoma?

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 423-425页

作者： Masahiro Ogawa Tatsuo Kanda Mitsuhiko moriyama Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine Tokyo Japan

Hepatitis C virus (HCV) infection is one of the major causes of end-stage liver disease and hepatocellular carcinoma (HCC). Before the use of direct acting antivirals (DAAs) against HCV, liver transplantation was one of the best ways to achieve long-term survival and a better prognosis in patients with HCV infection and advanced liver fibrosis (1). In the interferon era, it is difficult for HCV infected patients with advanced liver fibrosis to achieve sustained virological response (SVR) because interferon therapy causes severe adverse events and these completely hamper this treatment in these patients.

关键词： interferon infection hepatocellular

Non-prosthetic treatment using segmental osteotomy and bone grafting in a patient with cleft lip and palate

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Plastic and Aesthetic Research 2022年第1期9卷 654-660页

作者： Atsuhiro Inoue Michiko Tsuji Yoshiyuki Baba Keiji moriyama Department of Maxillofacial Orthognathics Graduate School of Medical and Dental SciencesTokyo Medical and Dental University1-5-45 YushimaBunkyo-kuTokyo 113-8549Japan Division of Pedodontics and Orthodontics Department of Surgical SpecialtiesNational Center for Child Health and Development2-10-1 OkuraSetagaya-kuTokyo 157-8535Japan

This case report aimed to present the course of surgically combined comprehensive orthodontic treatment of a male adult with cleft lip and palate,showing a left alveolar cleft,lateral deviation of the major segment of the maxilla,and palatal transposition of the lateral ***,the midline of the upper central incisors was shifted by 7.0 mm to the right,the right lateral incisor showed palatal transposition,and the residual alveolar cleft was 6.5 *** Le Fort I osteotomy of the major segment,and simultaneous bone grafting into the extended alveolar bone and former cleft region were performed at 18 years and 4 months of ***,midline correction,alignment of the right lateral incisor,and cleft closure were achieved;no further prosthetic treatment was required.

关键词： Cleft lip and palate palatal transposition segmental Le Fort I osteotomy bone grafting

Helianthus tuberosus(Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 418-422页

作者： Naoto Okada Shinya Kobayashi Kouta moriyama Kohsuke Miyataka Shinji Abe ChiemiSato Kazuyoshi Kawazoe Department of Clinical Pharmacy Practice Pedagogy Institute of Biomedical SciencesTokushima University Graduate School Department of Pharmacy Tokushima University Hospital Faculty of Pharmaceutical Sciences Tokushima University Faculty of Medicine Tokushima University

Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.

关键词： Helianthus tuberosus Glucose tolerance Hepatic lipid profile