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Nuclear Science and Techniques 2021年第6期32卷 11-22页

作者： Feng Qiu Shinichiro Michizono Toshihiro Matsumoto takako miura High Energy Accelerator Research Organization 1-1 OhoTsukubaIbaraki 305-0801Japan The Graduate University for Advanced Studies HayamaKanagawa 240-0193Japan Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

The development of iterative learning control combined with disturbance-observer-based(DOB)control for the digital low-level radio frequency(LLRF)system of the International Linear Collider project is *** objective of this study is to compensate for both repetitive(or predictable)and unpredictable disturbances in a radio frequency system(e.g.,beam loading,Lorentz force detuning,and microphonics).The DOB control approach was verified using the LLRF system at the Superconducting Test Facility(STF)at KEK in the absence of a *** method comprising DOB control combined with an iterative learning control algorithm was then demonstrated in a cavity-simulator-based test bench,where a simulated beam was *** results showed that the performance of the LLRF system was improved,as expected by this combined control *** plan to further generalize this approach to LLRF systems at the STF and the future International Linear Collider project.

关键词： Low-level radio frequency Disturbance observer Iterative learning control

Liver biopsy in the post-hepatitis C virus era in Japan

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World Journal of Gastroenterology 2024年第14期30卷 1949-1957页

作者： Yoshihiro Ikura takako Okubo Yasuhiro Sakai Department of Pathology Takatsuki General HospitalTakatsuki 569-1192Osaka PrefectureJapan Department of Pathology Kansai Medical University Medical CenterMoriguchi 570-8507Japan

In Japan,liver biopsies were previously crucial in evaluating the severity of hepatitis caused by the hepatitis C virus(HCV)and diagnosing HCV-related hepatocellular carcinoma(HCC).However,due to the development of effective antiviral treatments and advanced imaging,the necessity for biopsies has significantly *** change has resulted in fewer chances for diagnosing liver disease,causing many general pathologists to feel less confident in making liver biopsy *** article provides a comprehensive overview of the challenges and potential solutions related to liver biopsies in ***,it highlights the importance of considering steatotic liver diseases as independent conditions that can coexist with other liver diseases due to their increasing ***,it emphasizes the need to avoid hasty assumptions of HCC in nodular lesions,because clinically diagnosable HCCs are not targets for ***,the importance of diagnosing hepatic immune-related adverse events caused by immune checkpoint inhibitors is increasing due to the anticipated widespread use of these *** conclusion,pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.

关键词： Liver biopsy Alteration Post-hepatitis C virus era Steatotic liver disease Hepatic tumors Immune checkpoint inhibitors

Development and Evaluation of 3D Delivery Animation Software Designed to Improve the Mother’s and Spouse’s Satisfaction with Delivery

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Health 2024年第5期16卷 439-458页

作者： Ayako Sasaki Sachi Chikazawa Nojima Kumiko Tomita takako Hatakeyama Keiko Imoto Yasufumi Imoto Nobutane Faculty of Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan Imoto Ladies Clinic Echizen Japan

Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands.

关键词： Mother Spouse Satisfaction 3D Delivery Animation Software

Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats

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Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro Yokoyama takako Yamada Tetsuo Iida Susumu Mochizuki Akihide Yoshihara Kazuya Akimitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warran

关键词： Rare Sugar d-Allulose Medium-Chain Triglycerides Body Fat Rat

TIME-RESOLVED X-RAY SPECTRA AND ATOMIC PROCESSES

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原子与分子物理学报 1990年第4期7卷 1640-1648页

作者： takako KATO National Institute for Fusion Science Nagoya 464-01Japan

In this article we will discuss time-resolved He-like X-ray spectra of titanium ions from a TFTR tokamak plasma[1] and of iron ions from solar flares[2] in particular attention to a presence of high energy electrons which affect the spectra and ionization *** consider a model that a hot component interacts with a bulk *** this model,the time evolution of the spectra and ionization balaces derived therefrom can be described consistently.

关键词： X射线谱原子过程等子体

Influence of data analysis when exploiting DFN model representation in the application of rock mass classification systems

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1046-1062页

作者： takako Miyoshi Davide Elmo Steve Rogers NBK Institute of Mining University of British ColumbiaVancouverCanada Golder Associates Ltd. VancouverCanada

Discrete fracture network(DFN) models have been proved to be effective tools for the characterisation of rock masses by using statistical distributions to generate realistic three-dimensional(3 D) representations of a natural fracture network. The quality of DFN modelling relies on the quality of the field data and their interpretation. In this context, advancements in remote data acquisition have now made it possible to acquire high-quality data potentially not accessible by conventional scanline and window mapping. This paper presents a comparison between aggregate and disaggregate approaches to define fracture sets, and their role with respect to the definition of key input parameters required to generate DFN models. The focal point of the discussion is the characterisation of in situ block size distribution(IBSD) using DFN methods. An application of IBSD is the assessment of rock mass quality through rock mass classification systems such as geological strength index(GSI). As DFN models are becoming an almost integral part of many geotechnical and mining engineering problems, the authors present a method whereby realistic representation of 3 D fracture networks and block size analysis are used to estimate GSI ratings, with emphasis on the limitations that exist in rock engineering design when assigning a unique GSI value to spatially variable rock masses.

关键词： Data collection Discrete fracture network(DFN) Classification system Geological strength index(GSI)

Perspectives of Science and Technology in Disaster Risk Reduction of Asia

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International Journal of Disaster Risk Science 2016年第4期7卷 329-342页

作者： Rajib Shaw takako Izumi Peijun Shi Integrated Research on Disaster Risks(IRDR) International Research Institute of Disaster Science(IRIDeS) Tohoku University State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University

Science and technology innovation has always been present in Asia,but its application in disaster risk reduction(DRR) has been *** Asia,globally significant hotspots of disasters and economic development have emerged in which the application of science and technology in DRR has become an essential requirement for informed decision *** has supported establishment and implementation of major international initiatives in DRR,including the Hyogo Framework for Action *** more recent Sendai Framework for DRR 2015-2030 recognizes the importance of science and technology in all of its priority action areas,and subsequent global and regional forums and conferences have reconfirmed science and technology's *** perceive and monitor the progress of science and technology in DRR,a qualitative assessment of different countries is made using three major attributes:(1) science-based decision making;(2) investment in science and technology;and(3) the intensity of science's link to the *** assessment exercise points out several strengths and weaknesses in science and technology application;the method can be employed to develop future multistakeholder and multidisciplinary science and technology plans at the country *** implement regional and national activities,a set of 15 recommendations is put forward,which will strengthen the collective regional "science voice" in DRR.

关键词： DRR policy making Science innovation Science investment Sendai Framework Technology application

Integrated view of plant metabolic defense with particular focus on chewing herbivores

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Journal of Integrative Plant Biology 2022年第2期64卷 449-475页

作者： David Wari takako Aboshi Tomonori Shinya Ivan Galis Institute of Plant Science and Resources Okayama UniversityKurashiki710-0046 Japan Faculty of Agriculture Yamagata UniversityWakaba-machiTsuruoka997-8555 Japan

Success of plants largely depends on their ability to defend against *** emergence of the first voracious consumers,plants maintained adapting their structures and chemistry to escape from *** constant pressure was further accelerated by adaptation of herbivores to plant defenses,which all together sparked the rise of a chemical empire comprised of thousands of specialized metabolites currently found in *** diversity in the plant kingdom is truly amazing,and although many plant metabolites have already been identified,a large number of potentially useful chemicals remain unexplored in plant ***,biosynthetic routes for plant metabolites involve many enzymes,some of which still wait for identification and biochemical ***,regulatory mechanisms that control gene expression and enzyme activities in specialized metabolism of plants are scarcely ***,understanding of how plant defense chemicals exert their toxicity and/or repellency against herbivores remains limited to typical examples,such as proteinase inhibitors,cyanogenic compounds and *** this review,we attempt summarizing the current status quo in metabolic defense of plants that is predominantly based on the survey of ubiquitous examples of plant interactions with chewing herbivores.

关键词： defense herbivore mode of action plant specialized metabolism

Two distinct pathways of p16 gene inactivation in gallbladder cancer

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World Journal of Gastroenterology 2007年第47期13卷 6396-6403页

作者： Hiroyuki Tadokoro takako Shigihara Tomomi Ikeda Masaru Takase Masafumi Suyama Department of Gastroenterology Juntendo University School of Medicine2-1-1 HongoBunkyo-kuTokyo 136-0075Japan Biochemical Research Center Division of Molecular and Biochemical ResearchJuntendo University School of MedicineTokyo 136-0075Japan Department of Human Pathology Juntendo University School of MedicineTokyo 136-0075Japan

AIM: To examine the mechanism of inactivation of the p16 gene in gallbladder cancer,and to investigate p16 alterations and their correlation with clinicopathological features. METHODS: Specimens were collected surgically from 51 patients with gallbladder cancer. We evaluated the status of protein expression,loss of heterozygosity (LOH),homozygous deletion and promoter hypermethylation using immunohistochemistry,microsatellite analysis,quantitative real-time polymerase chain reaction (PCR) and methylation-specific PCR,respectively. In addition,mutations were examined by direct DNA sequencing. RESULTS: Homozygous deletions of the p16 gene exon2,LOH at 9p21-22,p16 promoter hypermethylation,and loss of p16 protein expression were detected in 26.0% (13/50),56.9% (29/51),72.5% (37/51) and 62.7% (32/51),respectively. No mutations were found. LOH at 9p21 correlated with the loss of p16 protein expression (P < 0.05). Homozygous deletion of the p16 gene,a combination LOH and promoter hypermethylation,and multiple LOH at 9p21 were significantly correlated with the loss of p16 protein expression (P < 0.05). LOH at 9p21 and promoter hypermethylation of the p16 gene were detected in 15.4% (2/13) and 92.3% (12/13) of the tumors with homozygous deletion of the p16 gene,respectively. P16 alterations were not associated with clinicopathological features. CONCLUSION: Our results suggest that LOH and homozygous deletion may be two distinct pathways in the inactivation of the p16 gene. Homozygous deletion,a combination of LOH and promoter hypermethylation,and multiple LOH are major mechanisms of p16 inactivation in gallbladder cancer.

关键词： Gallbladder cancer Homozygous deletion Loss of heterozygosity p16 Quantitative real time PCR

Excitation and decay dynamics of 1s2s inner-shell double-vacancy states of neon atoms

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Chinese Physics B 2008年第2期17卷 592-598页

作者：丁晓彬董晨钟 Fumihiro Koike takako Kato Stephan Fritzsche College of Physics and Electronic Engineering Northwest Normal University Center of Theoretical Nuclear Physics National laboratory of Heavy-Ion Accelerator of Lanzhou Physics Department School of MedicineKitasato University1-15-1 Kitasato228-8555Japan National Institute for Fusion Science Department of Physics University of KasselHeinrich-Plett-Straβe 40D-34132KasselGermany

The photo-excitation and Auger decay processes of inner-shell double vacancy states 1s2s2p^6（1,3^S）3s3p of neutral neon atoms have been studied theoretically. Multi-configuration Dirac-Fock （MCDF） calculations have been carried out, with electron correlation effects taken into consideration. The relaxation of core and excited orbitals and configuration interaction are found to be crucial to creating the double vacancy states by single photo-absorption. The predominant decay paths for the double vacancy states turn out to be of the LLM Auger decay to 1s 2s^22p^53s（3p）, KLL Auger decay to 1s^22s2p^43s3p, and KLM Auger decay to 1s^22p^63s（3p）. They lead to further Auger decay, creating the neon ions of multiple charge states. For both double and single vacancy states the spectator type of Auger process is dominated in all the Auger decay processes. Theoretical Anger electron spectra are presented for further investigations, experimental and theoretical.

关键词： correlation effects multi-configuration Dirac-Fock (MCDF) method Auger decay