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Production of β-Carotene by a Newly Isolated Rhodotorula Glutinis UCP1555 Strain and Cytotoxic Effect Evaluation

Journal of Chemistry and Chemical Engineering 2016年第5期10卷 212-220页

作者： Rosileide Fontenele da Silva Andrade Roberto Albuquerque Lima Daylin Rubio Ribeaux Helvia Waleska Casulo Araujo Luciana Oliveira Franco Adalberto Pessoa-Junior Galba M. Campos-takaki National Program Postdoctoral CAPES (PNPD)-Postgraduate in Development of Environmental Processes Catholic Universityof Pernambuco PE Brazil Nucleus of Research in Environmental Sciences and Biotechnology Catholic University of Pernambuco PE Brazil Center of Biological Sciences Federal University of Pernambuco PE Brazil Chemistry Department State University of Paraiba 58429-500 Campina Grande Paralba Brazil Department of Biology Federal Rural University of Pernambuco PE Brazil Department of Pharmacy University of Sao Paulo SP Brazil

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Changes in Health Consciousness of Nursing Students in Japan after Acquiring Medical Care Knowledge from a Nursing School

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Open Journal of Nursing 2021年第9期11卷 794-800页

作者： Yuriko Inoue Hiromitsu Ezure Junji Ito Chika Sawa Masato Yamamoto Mone Hatasa Wakatsuki Harumi Hata Akiko Sasaki Masaaki Takayanagi Takashi takaki Mikako Tanaka Hiroshi Moriyama Naruhito Otsuka Department of Anatomy School of Medicine Showa University Tokyo Japan Department of Nursing School of Nursing and Rehabilitation Sciences Showa University Tokyo Japan Department of Chemistry Faculty of Arts and Sciences at Fujiyoshida Showa University Tokyo Japan Department of Perioperative Medicine Division of Anesthesiology School of Dentistry Showa University Tokyo Japan Center for Research and Development in Pharmacy Education School of Pharmacy Nihon University Chiba Japan Department of Pharmacology School of Medicine Showa University Tokyo Japan Saitama Prefectural University Saitama Japan Division of Electron Microscopy Showa University Tokyo Japan Department of Chemical Engineering Science Yokohama National University Yokohama Japan

Background: Health consciousness in daily life is very important because lifestyle habits, such as dietary and exercise habits, sleep, and smoking, are involved in the development and progression of lifestyle-related diseases, such as cancer, heart diseases, stroke, liver diseases, kidney diseases, and diabetes. Purpose: In this study, we surveyed to see if the health consciousness increased and what behaviors in daily life changed in students of a nursing school (Seiwa Nursing College, Tokyo, Japan) after they learned medical care knowledge required to become a nurse. Results: After learning medical care knowledge for 3 years, the students were found to have a higher level of health consciousness in the third year than they did in the first year. They applied the medical care knowledge they learned in daily life. All data were collected in 2019. Conclusions: The medical care knowledge learned in a nursing school was demonstrated to serve as information to increase the health consciousness.

关键词： Health Consciousness Nursing Students

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可持续设计--城市级别的挑战

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世界建筑导报 2023年第2期38卷 12-14页

作者：田中互朱君慧(整理) 林旭浩(整理) 高木弥佳(整理) 日建设计城市设计部门日建设计

一直以来,日建设计都将城市、建筑及其周围社会的可持续性作为重要的设计目标,并从以下四个视角出发,致力开展各种项目。第一个视角是环境的可持续性。基于碳中和理念,日建设计致力于尽可能减少城市开发和建筑对地球环境影响的同时,亦... 详细信息

一直以来,日建设计都将城市、建筑及其周围社会的可持续性作为重要的设计目标,并从以下四个视角出发,致力开展各种项目。第一个视角是环境的可持续性。基于碳中和理念,日建设计致力于尽可能减少城市开发和建筑对地球环境影响的同时,亦不断思考如何最大限度地提高环境的“质量”。第二个重要视角是社会的可持续性。力求通过以人为本的城市和建筑建设,在科技的助力下打造可持续发展社区。第三个视角是经济的可持续性。

关键词：可持续设计可持续性碳中和环境影响以人为本最大限度可持续发展社区

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普通城市中事业汽油机车排放的多环芳烃的主要因素测定

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环境科学研究 1980年第12期 84-93页

作者： Takash HANDA takaki YAMAMURA Yoshihiro KATO Shoichio SAITO Tadahiro ISHII 陈秋华

本文研究燃料和机油对汽车尾气的多环芳烃(pAH)的贡献。在10—工况(10—mode)操作条件下,燃烧过程残留在汽油中的pAH大约只有原来的1～2%,并从排放中回收。1升普通汽油在发动机中产生的pAH量估计大约如下:苯并(a)芘(Bap)1μg,苯并(a)蒽(... 详细信息

本文研究燃料和机油对汽车尾气的多环芳烃(pAH)的贡献。在10—工况(10—mode)操作条件下,燃烧过程残留在汽油中的pAH大约只有原来的1～2%,并从排放中回收。1升普通汽油在发动机中产生的pAH量估计大约如下:苯并(a)芘(Bap)1μg,苯并(a)蒽(BaA)5μg,(艹屈)5μg,芘24μg。机油中积聚的pAH同燃料的pAH和油公里直接相关,并且影响着尾气的pAH。油消耗增加引起pAH排放增加。在较新的汽车中,燃料和机油对尾气pAH排放的贡献是类似的。随着汽车里程增加,pAH排放水平也增加,而消耗油热解产生的pAH在尾气pAH中占主要成份。通常,在普通城市事业中汽车排放的Bap,BaA和(艹屈)是最主要的,平均来说它们分别占排放的76,68和62%;其它因子的贡献按下面顺序减少:汽油的pAH(Bap BaA和(艹屈)分别为11,16和22%),汽油热解(分别为7、13和11%),油的pAH(分别为6,3和5%)。对汽车排放的芘来说,汽油中存在的原始量是最主要的因子,平均地具有46%的贡献比率,其它因子的贡献:消耗油热解(31%),油中芘(12%)和汽油热解(11%)。

关键词：汽油车多环芳烃汽车排放燃烧过程操作条件苯并线性关系间隙增大消耗率排放水平

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Production and Characterization of New Fibrinolytic Protease from Mucor subtillissimus UCP 1262 in Solid-State Fermentation

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Advances in Enzyme Research 2015年第3期3卷 81-91页

作者： Thiago Pajeu Nascimento Amanda Emmanuelle Sales Camila Souza Porto Romero Marcos Pedrosa Brandao Galba Maria Campos takaki Jose Antonio Couto Teixeira Tatiana Souza Porto Ana Lucia Figueiredo Porto Center for Biological Sciences Federal University of PernambucoRecifeBrazil Department of Morphology and Animal Physiology Federal Rural University of PernambucoRecifeBrazil Center for Research in Environmental Sciences Catholic University of PernambucoRecifeBrazil Institute for Biotechnology and Bioengineering Centre of Biological EngineeringUniversity of MinhoCampus of GualtarBragaPortugal Academic Unit of Garanhuns Federal Rural University of PernambucoGaranhunsBrazil

Fibrinolytic enzymes have received attention regarding their medicinal potential for thrombolytic diseases, a leading cause of morbidity and mortality worldwide. Various natural enzymes purified from animal, plant and microbial sources have been extensively studied. The aim of this work was to produce fibrinolytic protease by solid state fermentation using agro industrial substrates. Rhizopus arrhizus var. arrhizus UCP 1295 and Mucor subtillissimus UCP 1262 filamentous fungi species isolated from soil of Caatinga-PE, Brasil, were used as producer microorganisms. Wheat bran was shown to be the best substrate for the production of the enzyme and by using a 23 full factorial design the main effects and interactions of the quantity of the substrate wheat bran, moisture and temperature on the fibrinolytic enzyme production and protease were evaluated. The best results for fibrinolytic and protease activities, 144.58 U/mL and 48.33 U/mL, respectively, were obtained with Mucor subtillissimus UCP 1262 using as culture medium 3 g wheat bran, 50% moisture at a temperature of 25°C for 72 hours. The optimum temperature for the produced enzyme was 45°C and most of its original activity was retained after being subjected to 80°C for 120 min. The protease activity was enhanced by K+, Ca+ and Mn+;but with Cu+ there was an inhibition. The specificity to chromogenic substrate and the inhibition by PMSF indicates that it is a chymotrypsin-like serine protease. Presented results suggest that this enzyme produced by solid-state fermentation is an interesting alternative as a candidate for thrombolytic therapy.

关键词： Mucor Enzyme Protease Fibrinolytic Wheat

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Simultaneous Determination of Halogen Compounds and Sulfur Oxides in Flue Gas by Ion Chromatography

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Journal of Chemistry and Chemical Engineering 2011年第4期5卷 289-295页

作者： Makoto Nonomura Keiko kurita Evaluation Research Institute for Environmental Technology 2954-1-107 Togasaki Misato-shi Saitama 341-0044 Japan Department of Resource and Environmental Group Tokyo Metropolitan Industrial Technology Research Institute 3-13-10Nishigaoka Kita-ku Tokyo 115-8586 Japan

Ion chromatography (IC) is a suitable analytical method for the determination of anions. As analytical methods for the halogen compounds in flue gas, those of bromine compound, fluorine compound, chlorine (Cl2) and hydrogen chloride (HCl) are listed in JIS. However, IC has not been adopted in JIS except for HCl and Cl2. Because the carbon dioxide in flue gas is absorbed in a 0.1 M sodium hydroxide solution as an absorber, it is interfered with the measurement of F- and Cl- ions. This paper describes the development of the pretreatment equipment for the flue gas analysis by IC, and its applications to real flue gas analysis. The F-, Cl-, Br- and SO4 2- in the absorbing solution can be clearly separated by IC using the pretreatment equipment. The halogen compounds and sulfur oxides in flue gas can be simultaneously determined by IC.

关键词：离子色谱法卤素化合物烟气分析硫氧化物同时测定氢氧化钠溶液溴化合物前处理设备

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Effects of a 24-week course of interferon-αtherapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第40期13卷 5343-5350页

作者： Soo Cheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama Department of Medicine and Molecular Science Division of Frontier Medical SciencePrograms for Biomedical ResearchGraduate School of Biomedical SciencesHiroshima UniversityHiroshima 734-8551Japan

AIM:To assess whether a 24-wk course of interferon (IFN)could prevent hepatocellular carcinoma(HCC) recurrence and worsening of liver function in patients with hepatitis C virus(HCV)-infected patients after receiving curative treatment for primary HCC. METHODS:Outcomes in 42 patients with HCV infection treated with IFN-α,after curative treatment for primary HCC(IFN group),were compared with 42 matched curatively treated historical controls not given IFN(non- IFN group). RESULTS:Although the rate of initial recurrence did not differ significantly between IFN group and non-IFN group (0%,44%,61%,and 67% vs 4.8%,53%,81%,and 87% at 1,3,5,and 7 years,P=0.153,respectively), IFN group showed a lower rate than the non-IFN group for second recurrence(0%,10.4%,28%,and 35% vs 0%,30%,59%,and 66% at 1,3,5 and 7 years, P=0.022,respectively).Among the IFN group,patients with sustained virologic response(SVR)were less likely to have a second HCC recurrence than IFN patients without an SVR,or non-IFN *** analysis identified the lack of SVR as the only independent risk factor for a second recurrence,while SVR and Child-Pugh class A independently favored overall survival. CONCLUSION:Most intrahepatic recurrences of HCV- related HCC occurred during persistent viral infection. Eradication of HCV is essential for the prevention of HCC recurrence and improvement of survival.

关键词：肝细胞癌丙肝药物治疗病毒活性

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迈向碳中和社会--日建设计的动向与举措

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世界建筑导报 2023年第2期38卷 15-16页

作者：三由贤朱君慧(整理) 林旭浩(整理) 高木弥佳(整理) 日建设计工程技术总部设备设计部门日建设计

近年来,世界各地的异常天气已经成为常态。在过去的30年里自然灾害的数量翻了一番,遭受经济损失的同时,人类的正常生活也受到了威胁。在日本政府发布碳中和目标的同时,许多民间企业对TCFD(气候相关财务资讯揭露)和SBT(科学碳目标)等全... 详细信息

近年来,世界各地的异常天气已经成为常态。在过去的30年里自然灾害的数量翻了一番,遭受经济损失的同时,人类的正常生活也受到了威胁。在日本政府发布碳中和目标的同时,许多民间企业对TCFD(气候相关财务资讯揭露)和SBT(科学碳目标)等全球承诺表示赞同与支持。为了向客户和社会分享并推动实现碳中和的各项举措,日建设计于2022年3月发表了《气候紧急状态宣言》,具体举措包括以下六项。

关键词：碳中和异常天气自然灾害具体举措紧急状态气候

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Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第39期13卷 5188-5195页

作者： Soocheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama Department of Medicine and Molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University Hiroshima 734-8551 Japan

AIM: To assess the efficacy of low-dose intermittent interferon (IFN) therapy in patients with hepatitis C virus (HCV)-related compensated cirrhosis who had received curative treatment for primary hepatocellular carcinoma (HCC). METHODS: We performed a prospective case controlled study. Sixteen patients received 3 MIU of natural IFN- alpha intramuscularly 3 times weekly for at least 48 wk (IFN group). They were compared with 16 matched historical controls (non-IFN group). RESULTS: The cumulative rate of first recurrence of HCC was not significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 68.6% vs 80% at 1- and 3-year, P = 0.157, respectively). The cumulative rate of second recurrence was not also significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 35.9% vs 67% at 1- and 3-year, P = 0.056, respectively). Although the difference in the Child-Pugh classification score between the groups at initial treatment of HCC was not signifi cant, the score was signifi cantly worse at the time of data analysis in the non-IFN group than IFN group (7.19 ± 1.42 vs 5.81 ± 0.75, P = 0.0008). The cumulative rate of deviation from objects of any treatment for recurrentHCC was also higher in the non-IFN group than IFN group (6.7% and 27% vs 0 and 0% at 1- and 3-year, P = 0.048, respectively). CONCLUSION: Low-dose intermittent IFN-alpha therapy for patients with HCV-related compensated cirrhosis after curative HCC treatment was effective by making patients tolerant to medical or surgical treatment for recurrent HCC in the later period of observation.

关键词：肝细胞癌肝功能丙肝病毒治疗方法

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Measurements on diproton emission from the break-up channels of ^(23)Al and ^(22)Mg

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 18-23页

作者： TOGANO Y AOI N BABA H HONDA T OKADA K HARA Y IEKI K ISHIBASHI Y ITOU Y IWASA N KANNO S KAWABATA T KIMURA H KONDO Y kurita K KUROKAWA M MORIGUCHI T MURAKAMI H OISHI H OTA S OZAWA A SAKURAI H SHIMOURA S SHIODA R TAKESHITA E TAKEUCHI S YAMADA K YAMADA Y YASUDA Y YONEDA K MOTOBAYASHI T Institute of Physical and Chemical Research (RIKEN) Wako Saitama 351-0198 Japan Department of Physics Rikkyo University Japan Institute of Physics University of Tsukuba Ibaraki Japan Department of Physics Tohoku University Japan Center for Nuclear Study (CNS) University of Tokyo Japan Department of Physics University of Tokyo Japan

Two-proton relative momentum distributions from the break-up channels 23Al→p+p+21Na and 22Mg→p+p+20Ne at an energy of 60-70 A MeV have been measured together with two-proton opening angles at the projectile fragment separator beamline (RIPS) in the RIKEN Ring Cyclotron Facility. The results demonstrate the existence of diproton emission component from single-step 2He for highly excited 23Al and 22Mg.

关键词： diproton emission proton-rich nuclei 23Al and 22Mg

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