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Field measurements of absolute gravity in East Antarctica

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Advances in Polar Science 2013年第4期24卷 339-343页

作者： Koichiro Doi Hideaki Hayakawa takahito Kazama Toshihiro Higashi Shingo Osono Yoichi Fukuda Jun Nishijima Yuichi Aoyama Junichi Ueda National Institute of Polar Research The Graduate University for Advanced Studies (SOKENDAI) Aso Volcanological Laboratory Kyoto University Graduate School of Science Kyoto University TerraGrav LLC. GNSS Technologies Inc. Graduate School of Engineering Kyushu University Japan Association of Surveyors

This paper reports the results of field-based absolute gravity measurements aimed at detecting gravity change and crustal displacement caused by glacial isostatic adjustment. The project was initiated within the framework of the 53rd Japanese Antarctic Research Expedition （JARE53）. Absolute gravity measurements, together with GPS measurements, were planned at several outcrops along the Prince Olav Coast and S6ya Coast of East Antarctica, including at Syowa Station. Since the icebreaker Shirase （AGB 5003） was unable to moor alongside Syowa Station, operations were somewhat restricted during JARE53. However, despite this setback, we were able to complete measurements at two sites： Syowa Station and Langhovde. The absolute gravity value at the Syowa Station IAGBN （A） site, observed using an FG-5 absolute gravimeter （serial number 210; FG-5 #210）, was 982 524 322.7＋0.1 ktGal, and the gravity change rate at the beginning of 2012 was -0.26 gGal.a-1. An absolute gravity value of 982 535 584.2~0.7 ktGal was obtained using a portable A-10 absolute gravimeter （serial number 017; A-10 #017） at the newly located site AGS01 in Langhovde.

关键词： absolute gravity field measurement Antarctica A-10 and FG-5 absolute gravimeters GPS JARE

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台北Christian Dada旗舰店

现代装饰 2019年第6期 74-79页

作者： Fumiko Takahama takahito Ohno Kie Torii 范嘉苑(编译) 日本Fumiko Takahama Architects 不详

日本服装品牌Christian Dada台北旗舰店是该品牌在海外的第二家专卖店,其第一家海外专卖店位于新加坡,风格聚焦'达达主义'与品牌的起源及概念,特立独行的呈现让Christian Dada与其他奢侈品牌区分开来。此次的台北旗舰店延续了其个性化... 详细信息

日本服装品牌Christian Dada台北旗舰店是该品牌在海外的第二家专卖店,其第一家海外专卖店位于新加坡,风格聚焦'达达主义'与品牌的起源及概念,特立独行的呈现让Christian Dada与其他奢侈品牌区分开来。此次的台北旗舰店延续了其个性化的表达,以'废墟'主题贯穿150平方米的空间设计。提起'废墟',人们不禁会联想到这样的场景:破败的墙面,渗水的地板,光线从屋顶的窟窿里照射进来。

关键词：旗舰店 Christian Dada

The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study

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Advances in Alzheimer's Disease 2018年第4期7卷 141-152页

作者： Ryutaro Arita Tetsuhiro Yoshino Miwako Ohgishi Takuya Hamaguchi Yuko Horiba Kaori Sawai Kei Funaki Hajime Tabuchi Mizuki Oka takahito Yoshizaki Kenji Watanabe Masaru Mimura Center for Kampo Medicine School of Medicine Keio University Tokyo Japan Department of Neuropsychiatry School of Medicine Keio University Tokyo Japan Department of Neurology School of Medicine Keio University Tokyo Japan Faculty of Environmental and Information Study Keio University Fujisawa Japan

Previous clinical trials have demonstrated the efficacy of yokukansan, a traditional Japanese medicine, for the treatment of behavioral and psychological symptoms of dementia (BPSD). However, less evidence is available for the treatment of BPSD with yokukansankachimpihange (YKSCH), which consists of yokukansan and two additional herbal ingredients. The present study was conducted to investigate the efficacy and safety of YKSCH for treating BPSD in patients with Alzheimer’s disease (AD). We enrolled outpatients with mild-to-moderate AD who exhibited BPSD and obtained a Neuropsychiatric Inventory (NPI) score of >3 including subscale scores for “agitation”, “anxiety”, “irritability”, and “sleep and night-time behavior change”. A daily YKSCH dose of 7.5 g was administered for 12 weeks with concomitant administration of anti-dementia medication. BPSD was evaluated using the NPI at baseline and every 4 weeks during the intervention. We also examined apathy using the Japanese translation of the Apathy Scale, the short version of the Japanese version of the Zarit Caregiver Burden Interview, and the Modified Crichton Rating Scale for Predicting Activities of Daily Living. Cognitive dysfunction was evaluated using the Mini Mental State Examination and the AD Assessment Scale-Cognitive (Japanese version). Five participants were enrolled. The NPI total score tended to decrease between the baseline and 8-week evaluations during the YKSCH intervention (Wilcoxon signed rank test, P = 0.063). In terms of the NPI subscale scores, “apathy”, “agitation”, “delusions”, and “sleep and night-time behavior change” decreased after the intervention in those who exhibited each symptom at baseline. There were no significant differences in the other scores examined. No serious adverse events were observed. YKSCH could ameliorate BPSD in patients with mild-to-moderate AD with agitation, anxiety, irritability, and sleep and night-time behavior change, and it was well-tolerated.

关键词： Alzheimer’s Disease Behavioral and Psychological Symptoms of Dementia Yokukansankachimpihange Kampo Medicine Apathy Neuropsychiatric Inventory

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云南省水稻白叶枯病菌致病力差异的地理分布

西南农业学报 2002年第4期15卷 71-74页

作者：李成云 takahito Noda HIROKAZU Ochiai KAZUO Ise HISATOSHI Kaku 云南省农业科学院生物技术研究所云南昆明650223 Crop Production and Postharvest Division Japan International Research Center for Agricultural Sciences Tsukuba Department of Genetic Resources I National Institute of Agrobiological Resources Tsukuba Department of Genetic Resources I National Institute of Agrobiological Resources TsukubaIbaraki 305-8602JapaniologicalResourcesTsukuba

使用12个分别持有不同抗病基因(Xa1,Xa2,Xa3,Xa4,Xa5,Xa7,Xa8,Xa10,Xa11,Xa13,Xa14和Xa21)的近等基因系水稻白叶枯病鉴别品种及3个对照品种(IR24,Toyonishiki和Sigadagabo),鉴别了从云南省收集的138个菌株。结果根据致病谱可以将这些菌株分成A～J共10组。A组菌株仅对Toyonishiki和Sigadagabo两个对照品种致病,J组菌株则能对9个鉴别品种和3个对照品种致病。对不同海拔采集的菌株进行致病力分析的结果表明,从大理、武定等较高海拔粳稻种植区采集的菌株致病力较弱,在鉴别品种上病斑的平均长度不到50mm;而元江、景洪、潞西等低海拔杂交稻种植区采集的菌株致病力较强,在鉴别品种上的病斑平均长度超过100mm。从高海拔稻区到低海拔稻区,病菌致病力有逐步增强的趋势。

关键词：云南水稻白叶枯病菌致病力地理分布

Usefulness of Fractional Exhaled Nitric Oxide-Guided Treatment in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap

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Open Journal of Respiratory Diseases 2018年第1期8卷 1-12页

作者： Taisuke Akamatsu Toshihiro Shirai Yuko Tanaka Hirofumi Watanabe Yoshinari Endo Yukiko Shimoda takahito Suzuki Rie Noguchi Mika Saigusa Akito Yamamoto Yuichiro Shishido Takefumi Akita Satoru Morita Kazuhiro Asada Department of Respiratory Medicine Shizuoka General Hospital Shizuoka Japan

Background: Some patients present clinical features of both asthma and chronic obstructive pulmonary disease (COPD), which has led to the recent proposal of asthma-COPD overlap (ACO) as a diagnosis. Fractional exhaled nitric oxide (FeNO) is a candidate biomarker to diagnose ACO. We assessed the effect of an add-on treatment with budesonide/formoterol (BUD/FM) combination in patients with ACO, which was diagnosed by FeNO. Methods: This was a prospective, single-arm, open-label, before and after comparison study. Subjects included 83 patients with COPD who attended outpatient clinics for routine checkups at Shizuoka General Hospital between June and November 2016. All patients fulfilled the GOLD definition of COPD and were receiving long-acting muscarinic antagonist (LAMA) or LAMA/long-acting β2 agonist (LABA) combinations. After an 8-week run-in period, BUD/FM was added to the patients with FeNO levels of ≥35 ppb, defined as having ACO. For patients receiving LAMA/LABA, BUD/FM was added after the discontinuation of LABA. The modified British Medical Research Council (mMRC) score, COPD assessment test (CAT) score, spirometric indices, forced oscillation parameters, and FeNO were assessed before and after 8 weeks of BUD/ FM add-on treatment. Results: Twenty-four patients (28.9%) had FeNO levels ≥ 35 ppb, and 17 patients completed the study (mean age: 73 years and GOLD I/II/III/IV, 5/10/1/1). The mean CAT scores significantly improved (9.2 to 5.4, p = 0.015) and 10 patients (58.8%) showed ≥2 points improvement, a minimal clinically important difference. The mean FeNO levels significantly decreased from 63.0 to 34.3 ppb (p Conclusions: FeNO-guided treatment with BUD/FM improves symptoms in patients with ACO.

关键词： Asthma-COPD Overlap Budesonide/Formoterol Combination COPD Assessment Test Fractional Exhaled Nitric Oxide

CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy

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World Journal of Hepatology 2013年第4期5卷 189-195页

作者： Daisuke Satoh takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara Department of Gastroenterological Surgery Transplantand Surgical OncologyOkayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan

AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after *** tomography(CT)images were evaluated every 6 mo after PD for *** steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield *** biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo *** compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver ***-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy ***:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after *** patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin *** biopsy was performed in four patients with NAFLD after *** four patients showed moderate-to-severe steatosis and NASH was diagnosed in *** of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy *** number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with meta

关键词： Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells

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净水方法和设备

水处理信息报导 2003年第1期 42-42页

作者： Sakanishi,takahito