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Reflectance spectra analysis for mucous assessment

World Journal of Gastrointestinal Oncology 2021年第8期13卷 822-834页

作者： Toru Chiba Masaharu Murata takahito kawano Makoto Hashizume Tomohiko Akahoshi Pentax_LifeCare HOYA CorporationAkishima-shi 196-0012TokyoJapan Center for Advanced Medical Innovation Kyushu UniversityFukuoka-shi 812-8582FukuokaJapan Department of Disaster and Emergency Medicine Graduate School of Medical SciencesKyushu UniversityFukuoka_shi 812-8582FukuokaJapan

This review report represents an overview of research and development on medical hyperspectral imaging technology and its *** imaging technology is attracting attention as a new imaging modality for medical applications,especially in disease diagnosis and image-guided *** the recent advances in imaging,this technology provides an opportunity for twodimensional mapping of oxygen saturation(SatO2)of blood with high accuracy,spatial spectral imaging,and its analysis and provides detection and diagnostic information about the tissue physiology and *** imaging also provides information about tissue oxygenation,perfusion,and potential function during *** algorithm has been examined,and indication of accurate map of relative hemoglobin concentration and SatO2 can be indicated with preferable resolution and frame *** technology is expected to provide promising biomedical information in practical *** studies suggested that blood flow and SatO2 are associated with gastrointestinal disorders,particularly malignant tumor *** use and analysis of spectroscopic images are expected to potentially play a role in the detection and diagnosis of these diseases.

关键词： Diffuse reflectance spectroscopy Endoscopy Hemoglobin saturation Hypoxia Gastrointestinal cancer Tumor

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Applications of human hepatitis B virus preS domain in bio-and nanotechnology

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World Journal of Gastroenterology 2015年第24期21卷 7400-7411页

作者： Riki Toita takahito kawano Jeong-Hun Kang Masaharu Murata Department of Biomaterials Faculty of Dental Science Kyushu University Department of Advanced Medical Initiatives Faculty of Medical Sciences Kyushu University Innovation Center for Medical Redox Navigation Kyushu University Division of Biopharmaceutics and Pharmacokinetics Department of Biomedical Engineering National Cerebral and Cardiovascular Center Research Institute

Human hepatitis B virus(HBV) is a member of the family Hepadnaviridae, and causes acute and chronic infections of the liver. The hepatitis B surface antigen(HBs Ag) contains the large(L), middle(M), and small(S) surface proteins. The L protein consists of the S protein, pre S1, and pre S2. In HBs Ag, the pre S domain(pre S1 + pre S2) plays a key role in the infection of hepatocytic cells by HBV and has several immunogenic epitopes. Based on these characteristics of pre S, several pre S-based diagnostic and therapeutic materials and systems have been developed. Pre S1-specific monoclonal antibodies(e.g., MA18/7 and KR127) can be used to inhibit HBV infection. A myristoylated pre S1 peptide(amino acids 2-48) also inhibits the attachment of HBV to Hepa RG cells, primary human hepatocytes, and primary tupaia hepatocytes. Antibodies and antigens related to the components of HBs Ag, pre S(pre S1 + pre S2), or pre S1 can be available as diagnostic markers of acute and chronic HBV infections. Hepatocyte-targeting delivery systems for therapeutic molecules(drugs, genes, or proteins) are very important for increasing the clinical efficacy of these molecules and in reducing their adverse effects on other organs. The selective delivery of diagnosticmolecules to target hepatocytic cells can also improve the efficiency of diagnosis. In addition to the full-length HBV vector, pre S(pre S1 + pre S2), pre S1, and pre S1-derived fragments can be useful in hepatocyte-specific targeting. In this review, we discuss the literature concerning the applications of the HBV pre S domain in bio- and nanotechnology.

关键词： Hepatitis B virus Hepatocyte deliverysystem Vaccine Hepatitis B surface antigen Diagnosis

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