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远端器官缺血性预处理对心血管功能的影响

心脏杂志 2001年第5期13卷 363-365,368页

作者：夏正远 takahiro nishida Willem FLAMENG 湖北医科大学附属第一医院麻醉科湖北武汉430060 比利时鲁汶大学(K.U.Leuven)实验外科与麻醉学中心

目的 :观察远端器官缺血性预处理 (RPC)对非缺血心脏功能的影响 ,初步探讨 RPC的作用机制。方法 :19只成年绵羊麻醉后随机分为对照组 (n=9)及 RPC组 (n=10 )。测定基础状态 (BS1 )各参数后 ,RPC组动物经历 3次左侧股动脉阻断 5 min及再... 详细信息

目的 :观察远端器官缺血性预处理 (RPC)对非缺血心脏功能的影响 ,初步探讨 RPC的作用机制。方法 :19只成年绵羊麻醉后随机分为对照组 (n=9)及 RPC组 (n=10 )。测定基础状态 (BS1 )各参数后 ,RPC组动物经历 3次左侧股动脉阻断 5 min及再灌注 5 m in,第三次再灌注后 10 min测 RPC后 (BS2 )各参数。对照组动物不阻断股动脉 ,但于相应时间测定 BS1 及 BS2 各参数。结果 :对照组 BS1 及 BS2 各参数无显著变化。 RPC显著降低平均动脉压(MAP)、外周血管阻力 (SVR)及冠脉循环阻力 (CVR) (P0 .0 5 )。但RPC对心率、左房压、每搏输出量、射血分数及每搏作功无显著影响。 BS2 时 RPC组左室收缩末期压 (L VESP)、左室压力上升及下降最大速率 (± dp/ dtmax)、动脉有效弹回性 (Effective arterial elastance,Ea)均显著低于对照组 (P<0 .0 5 ) ,而心脏收缩及舒张期左室容积下降及增加最大速率 (± dv/ dtmax)无显著变化。结论 :远端器官缺血性预处理降低动脉有效弹性及循环阻力、减弱心脏收缩性的同时 ,并不减弱反而轻度增强心脏泵血功能 ,提高了心肌收缩效率。

关键词：远端器官缺血性预处理股动脉心血管功能

Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report

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World Journal of Gastroenterology 2017年第21期23卷 3928-3933页

作者： Hiromi Tamura Hirotsugu Saiki takahiro Amano Masashi Yamamoto Shiro Hayashi Hiroka Ando Reiko Doi Tsutomu nishida Katsumi Yamamoto Shiro Adachi Department of Pathology City Hospital of Toyonaka Department of Gastroenterology JCHO Osaka Hospital Department of Gastroenterology City Hospital of Toyonaka

A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.

关键词： Esophageal adenocarcinoma Bilayered structure Esophageal gland duct

Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report

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World Journal of Gastroenterology 2018年第2期24卷 290-296页

作者： takahiro Amano Tokuhiro Matsubara Tsutomu nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi Kaori Mukai Masashi Yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada Department of Gastroenterology and Hepatology Toyonaka Municipal Hospital

A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests.

关键词： Wilson’s disease Fulminant hepatitis Lateonset Liver cirrhosis Copper

Non-crimp Tubular Preforming with Automation System and High Productivity

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Journal of Mechanics Engineering and Automation 2015年第8期5卷 435-439页

作者： Tadashi Uozumi Akio Ohtani Asami Nakai Motohiro Tanigawa Tatsuhiko nishida takahiro Miura Gifu University Gifu City 501-1193 Japan Murata Machinery Ltd. Kyoto 612-8686 Japan

A new filament winding method developed in this study named MFW （multiple-supply FW） method. It performed a high productivity. In the MFW method, a large number of bobbins are used. Carbon fibers are arranged equiangularly above a mandrel, and they are wound and stacked on the mandrel simultaneously. Furthermore, CFRP pipes with non-crimp structure were made by MFW, and the torsional tests were performed in order to investigate mechanical properties comparing with braided CFRP pipes. These results made clear that the non-crimp structure by MFW was capable to improve torsional properties. The MFW machine produce non-crimp tubular preform with carbon fiber automatically. It is expected to produce non-crimp preforms for automotive parts which required high productivity.

关键词： Non-crimp structure CFRP filament winding high productivity automation.

Isolated proteinuria as an initial sign of severe preeclampsia

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Open Journal of Obstetrics and Gynecology 2011年第2期1卷 13-16页

作者： takahiro Yamada Takashi Yamada Mamoru Morikawa Masamitsu Takeda Ryutaro nishida Rina Akaishi Hisanori Minakami 不详

Two pregnant women who initially developed proteinuria alone followed by serious preeclampsia are presented to emphasize that there is no adequate technical term to express the period of proteinuria alone based on the current criteria of pregnancy-induced hypertension. Case 1 exhibited a urinary protein concentration of 46 mg/dL in the absence of hypertension, and abdominal pain due to placental abruption with hypertension at gestational week (GW) 29–3/7 and 29–4/7, respectively. Case 2 exhibited a urinary protein/creatinine ratio of 2.67, developed hypertension, required cesarean section, and developed posterior reversible encephalopathy syndrome at GW 28–1/7, 29–6/7, and 32–0/7, and on postpartum day 2, respectively. As women with proteinuria alone are not diagnosed as having preeclampsia and as a diagnosis of gestational proteinuria can be made only at 12 weeks postpartum, a prospective technical term applicable to the condition of proteinuria alone is needed to increase physicians’ attention to this condition.

关键词： Posterior Reversible Encephalopathy Syndrome Proteinuria Placental Abruption Pregnancy-induced hypertension

Persimmon Leaf Flavonols Enhance the Anti-Cancer Effect of Heavy Ion Radiotherapy on Murine Xenograft Tumors

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Journal of Cancer Therapy 2013年第7期4卷 1150-1157页

作者： Kayoko Kawakami Hiroshi nishida Naoto Tatewaki Kiyomi Eguchi-Kasai Kazunori Anzai takahiro Eitsuka Tetsuya Konishi Masao Hirayama Laboratory of Nutritional Biochemistry Niigata University of Pharmacy & Applied Life Sciences Niigata Japan National Institute of Radiological Sciences Chiba Japan

The cell cycle checkpoint system play a pivotal role in the cellular DNA damage response, and the discovery of checkpoint inhibitors is expected to sensitize current cancer therapies. Checkpoint signaling cascades are critically modulated by ATM (ataxia telangiectasia-mutated) and its related molecules. Generally, ATM primarily responds to ionizing irradiation-induced DNA double-strand breaks. Heavy ions from an accelerated carbon ion beam have been used to cure cancer because they are more effective than ionizing irradiation such as X-ray and γ-radiation in terms of biological damage. In a previous study, we demonstrated that a persimmon leaf flavonol (PLF) promoted the cytotoxic effect of chemotherapeutic agents on cancer cells through inhibition of checkpoint activities, especially in the ATM dependent pathway. The present study investigated whether PLF inhibits checkpoint activity during the DNA damage response induced by heavy ion irradiation. Treatment with PLF significantly increased the cytotoxicity of heavy ion irradiation in A549 adenocarcinoma cells. The phosphorylation of checkpoint proteins such as p53, SMC1, and Chk1 was increased by heavy ions. PLF reduced the phosphorylation of checkpoint proteins. Pre-treatment with PLF significantly prevented the decrease of mitotic cells in heavy ion-exposed cells. We further evaluated tumor volume in SCID mice inoculated with human lung adenocarcinoma A549 cells. The combination treatment of PLF and heavy ion resulted in a decrease of tumor volume compared with controls, although PLF itself did not exhibit any effect. These results indicate that PLF inhibits tumor growth through modulation of the DNA damage response. PLF may be useful for clinical application in combination with heavy ion radiotherapy.

关键词： DNA Damage Checkpoint Persimmon Leaf Flavonols Heavy Ion Irradiation Xenograft

Three-Dimensional Analysis of Melanosomes Isolated from B16 Melanoma Cells by Using Ultra High Voltage Electron Microscopy

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Microscopy Research 2014年第1期2卷 1-8页

作者： Shuuichi Akazaki Toshie Takahashi Yujiro Nakano Tomoki nishida Hirotarou Mori Akio Takaoka Hitomi Aoki Huayua Chen takahiro Kunisada Kenzo Koike Beauty Research Center Kao Corporation Tokyo Japan Department of Anatomy Gifu University Gifu Japan. Department of Tissue and Organ Development Regeneration Gifu University Gifu Japan Research Center for Ultra-High Voltage Electron Microscopy Osaka University Suita Japan

Melanosomes, isolated by centrifugal separation from culture broth of B16 melanoma cells derived from mouse, were observed by scanning electron microscopy (SEM), and by transmission electron microscopy (TEM). Some interesting structural features were found inside and outside of the melanosomes. By SEM observation, the melanosomes were ellipsoid shape, their surface was not smooth and was covered with rough substructure, 10 to 20 nm particles. By TEM, uneven structure and micro particles were observed in the melanosomes. Furthermore, three-dimensional analysis was tried by using the ultra-high voltage electron microscopy(UHVEM). Micrographs of the melanosomes were taken at various tilted angles by UHVEM, after preparing 500 nm thickness specimens stained with lead citrate. From the micrographs collected, the three-dimensional structures were reconstructed by using i-mode software. Melanin stained by lead and non stained parts was clearly observed in the reconstructed structure. Non stained parts were round, regular size, and distributed widely in the melanosomes.

关键词： B16 Melanoma Melanosome Scanning Electron Microscopy Transmission Electron Microscopy Ultra High Voltage Electron Microscopy Three-Dimensional Structure

Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastrointestinal Endoscopy 2016年第20期8卷 777-784页

作者： Shiro Hayashi Tsutomu nishida Hiromi Shimakoshi Akiyoshi Shimoda takahiro Amano Aya Sugimoto Kei Takahashi Kaori Mukai Tokuhiro Matsubara Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada Department of Gastroenterology and Hepatology Toyonaka Municipal Hospital

AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP *** This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December *** amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic *** A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 ***-five of these cases developed *** established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting *** analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for ***-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation *** 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation *** These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP.

关键词： Serum amylase levels Cannulation time Post-endoscopic retrograde cholangiopancreatography pancreatitis Predictor