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Treatment of portosystemic shunt-borne hepatic encephalopathy in a 97-year-old woman using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2023年第4期11卷 945-951页

作者： Akihiro nishi Tsuneaki Kenzaka Misa Sogi Shuichiro Nakaminato takahiro Suzuki General Medicine Awa Regional Medical CenterTateyama 2940014ChibaJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 6500017HyogoJapan Department of Radiology Kameda Medical CenterKamogawa 2968602ChibaJapan

BACKGROUND Hyperammonemia and hepatic encephalopathy are common in patients with portosystemic *** shunt occlusion has been standard treatment,although recently the less invasive balloon-occluded retrograde transvenous obliteration(B-RTO)has gained increasing *** far,there have been no reports on the treatment of portosystemic shunts with B-RTO in patients aged over 90 *** this study,we present a case of hepatic encephalopathy caused by shunting of the left common iliac and inferior mesenteric veins,successfully treated with *** SUMMARY A 97-year-old woman with no history of liver disease was admitted to our hospital because of disturbance of *** had no jaundice,spider angioma,palmar erythema,hepatosplenomegaly,or *** blood tests showed hyperammonemia,and abdominal contrast-enhanced computed tomography revealed a portosystemic shunt running between the left common iliac vein and the inferior mesenteric *** was diagnosed with hepatic encephalopathy secondary to a portosystemic *** patient did not improve with conservative treatment:Lactulose,rifaximin,and a low-protein diet.B-RTO was performed,which resulted in shunt closure and improvement in hyperammonemia and disturbance of ***,there was no abdominal pain or elevated levels of liver enzymes due to *** patient was discharged without further consciousness *** Portosystemic shunt-borne hepatic encephalopathy must be considered in the differential diagnosis for consciousness disturbance,including abnormal behavior and speech.

关键词： Hepatic encephalopathy Hyperammonemia Portosystemic shunt Balloon-occluded retrograde transvenous obliteration Elderly Case report

用于空气中水蒸气吸-脱附的微孔泡沫炭制备研究(英文)

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新型炭材料 2008年第3期23卷 216-220页

作者： Naoto Ohta Yoko nishi takahiro Morishita Yumiko Ieko Akifumi Ito Michio Inagaki Toyo Tanso Co Ltd Faculty of Engineering Aichi Institute of Technology

以蜜胺泡沫体为模板,采用氟化聚酰亚胺制备了微孔泡沫炭。测定了其对环境中水气的吸附/脱附行为,发现:泡沫炭在空气中400℃活化1h,可以提高其对水气的吸附能力。与活化前相比,对水气的吸附量几乎高达3倍,尽管其微孔容积仅增大了1.5倍。... 详细信息

以蜜胺泡沫体为模板,采用氟化聚酰亚胺制备了微孔泡沫炭。测定了其对环境中水气的吸附/脱附行为,发现:泡沫炭在空气中400℃活化1h,可以提高其对水气的吸附能力。与活化前相比,对水气的吸附量几乎高达3倍,尽管其微孔容积仅增大了1.5倍。对环境水气中的可逆吸附率与微孔容积成线性关系,微孔容积为0.75mL/g的泡沫炭,其水气吸附率约为质量分数40%。

关键词：泡沫炭聚酰亚胺模板水蒸气吸/脱附

Combustion synthesis of YAG:Ce phosphors via the thermite reaction of aluminum

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Journal of Rare Earths 2018年第3期36卷 248-256页

作者： Junpei Ohyama Chunyu Zhu Genki Saito Miki Haga takahiro Nomura Norihito Sakaguchi Tomohiro Akiyama Center for Advanced Research of Energy and Materials Hokkaido UniversityKita 13 Nishi 8KitakuSapporo 060-8628Japan Division of Applied Chemistry&Frontier Chemistry Center Faculty of EngineeringHokkaido University5apporoHokkaido 060-8628Japan Graduate School of Chemical Sciences and Engineering Hokkaido University SapporoHokkaido 060-8628Japan

Cerium-doped yttrium aluminum garnet（YAG：Ce） as a yellow phosphor for white light-emitting diodes（LEDs） was synthesized via a facile combustion method using Y2 O3, CeO2, Al2 O3, Al,and NaClO4 as raw materials. The combustion synthesis approach utilizes the strong exothermic oxidation of aluminum to realize a self-sustaining reaction. In this study, we investigated the effects of the ratios of Al2 O3 to AI,fluxes, and coprecipitated materials as raw materials on the luminescence properties of the synthesized YAG：Ce phosphors. When the amount of Al2 O3 x is varied, the combustion reaction proceeds at x ≤ 1.8,with x = 1.725 being the optimum condition for producing a high-performance product. When 5 wt%BaF2 is added, the luminescence intensity is significantly improved owing to a decrease of YAP（YAlO3）formation with improved uniformity. However, the addition of CaF2 and NaF does not improve the luminescence properties. To suppress the segregation of CeO2, we used the coprecipitated material Y2 O3-CeO2 as a raw material. Unlike with separate addition of Y2 O3 and CeO2, Ce ions are uniformly distributed in the coprecipitated material, resulting in improved luminescence properties. The combination of BaF2 and coprecipitated material significantly improves the internal quantum efficiency to83.0%, which is close to that of commercial phosphors.

关键词： Phosphor Yttrium aluminum garnet Combustion synthesis Flux Coprecipitated material Rare earths

Case of arterial hemorrhage after endoscopic papillary large balloon dilation for choledocholithiases using a covered self-expandable metallic stent

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World Journal of Gastroenterology 2015年第16期21卷 5090-5095页

作者： Shuya Shimizu Itaru Naitoh takahiro Nakazawa Kazuki Hayashi Katsuyuki Miyabe Hiromu Kondo Yuji nishi Shuichiro Umemura Yasuki Hori Akihisa Kato Hirotaka Ohara Takashi Joh Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Department of Community-based Medical Education Nagoya City University Graduate School of Medical Sciences

A 78-year-old male was admitted to our hospital because of *** demonstrated choledocholithiases with a maximum diameter of 13 mm, and we performed endoscopic papillary large balloon dilation(EPLBD) with a size of 15 *** following the balloon deflation, spurting hemorrhage occurred from the orifice of the duodenal *** we performed endoscopic hemostasis by compressing the bleeding point with the large balloon catheter, we could not achieve ***, we placed a 10 mm fully covered selfexpandable metallic stent(SEMS) across the duodenal papilla, and the hemorrhage stopped *** 1 wk of SEMS placement, duodenal endoscopy revealed ulcerative lesions in both the orifice of the duodenal papilla and the lower bile duct.A direct peroral cholangioscopy using an ultra-slim upper endoscope revealed a visible vessel with a longitudinal mucosal tear in the ulceration of the lower bile *** believe that the mucosal tear and subsequent ruptured vessel were caused by the EPLBD procedure.

关键词： Endoscopic papillary large balloon dilation Hemorrhage Covered self-expandable metallic stent Direct peroral cholangioscopy Endoscopic hemostasis

Anaplastic Lymphoma Kinase (ALK) and p53 Are Potentially Useful Markers to Distinguish Inflammatory Myofibroblastic Tumor

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Open Journal of Urology 2013年第2期3卷 71-74页

作者： Shinji Kurosaka Kazumasa Matsumoto Akira Irie takahiro Hirayama Morihiro nishi Tetsuo Fujita Takefumi Satoh Yuichi Sato Masatsugu Iwamura Kazunari Yoshida Department of Molecular Diagnostics School of Allied Health Sciences Kitasato University Tokyo Japan Department of Urology School of Medicine Kitasato University Tokyo Japan

Aims: Inflammatory myofibroblastic tumor (IMT) of the urinary bladder is a clinically and histologically uncommon benign tumor that can be easily mistaken for a malignant neoplasm. We sought to determine whether immunohistochemical staining would be evaluated IMT of the urinary bladder. We have also shown the literatures that imminohistochemical staining of IMT was investigated to distinguish malignant lesions using PubMed data base. Methods: Immunohistochemical staining, including anaplastic lymphoma kinase (ALK), p53, cytokeratin, vimentin, desmin, alpha-smooth muscle actin, myoglobin, smooth muscle myosin and S100, was carried out on serial sections from archival specimens of three patients who underwent transurethral resection and partial cystectomy. Results: Immunohistchemical staining in all patients was positive for ALK and weak positive for p53 protein. In the literatures, positive rates of ALK and p53 inthe IMT of the urinary bladder were 60.9% and 53.1%, respectively. Sarcoma and carcinosarcoma were shown in the pathological specimens with negative ALK and strongly positive p53 inthe same data base. Conclusions: Both ALK and p53 were potentially useful protein markers to distinguish between IMT and sarcoma. However, this study was small sample size. Further study was warranted an investigation of the availability of these proteins in IMT.

关键词： Inflammatory Myofibroblastic Tumor Immunohistochemistry Bladder Cancer Anaplastic Lymphoma Kinase p53

The Relationship among Stress Response, Weight Management, and Physical Exercise in Japanese University Students

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Journal of Sports Science 2016年第3期4卷 163-169页

作者： Tomoko Ikeda takahiro Ikeda Osamu Aoyagi Faculty of Children's Studies Nishi-Kyushu University Saga-shi Saga 840-0806 Japan School of Human and Social Sciences Fukuoka Prefectural University Tagawa Fukuoka 825-8585 Japan Faculty of Sports and Health Science Fukuoka University Jonan-ku Fukuoka 814-0180 Japan

The aim of the present study was to investigate the relationship between stress response, gender, weight management, and physical exercise among Japanese university students. The participants were 411 university students （169 males, 242 females）. All participants completed the Stress Response Scale and the European Health and Behavior Survey. T-test results showed that scores of females were consistently higher than those of males （P 〈 0.05）. In the chi-square test, the proportion of females managing their weight （75.3%） was significantly higher than that of males （42.9%）. In multiple regression analysis, the group managing their weight showed a higher stress score, and the group doing physical exercise showed a lower stress score. These results show that weight management through physical exercise reduces mental stress, making it the most beneficial method of weight management for the mental and physical wellbeing of youths.

关键词： Health behavior physical activity Stress Response Scale youth.

Attenuation of nicotine-evoked Ca<sup>2+</sup>influx by antibody to the nicotinic acetylcholine receptor <i>α</i>3 subunits in human embryonic kidney cells

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Advances in Bioscience and Biotechnology 2013年第6期4卷 9-14页

作者： Shota Kobayashi Shigeru Yokoyama takahiro Maruta Akiko Muroyama Hiroaki Yoshikawa Yasuhide Mitsumoto Department of Biophysical Genetics Kanazawa University Graduate School of Medicine Kanazawa Japan Department of Neurology and Neurobiology of Aging Kanazawa University Graduate School of Medical Science Kanazawa Japan Laboratory of Alternative Medicine and Experimental Therapeutics Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University Kanazawa Japan Neurological Center Kanazawa Nishi Hospital Kanazawa Japan

Autoantibody against neuronal nicotinic acetylcholine receptor (nAChR) α3 subunit is implicated in severe autonomic dysfunction in the patients with autoimmune autonomic ganglionopathy (AAG). Although this autoantibody has been revealed to impair fast excitatory synaptic transmission in autonomic ganglia, its precise mechanism remains unknown. Here, we show that antibody-induced reduction of cell-surface α3 subunits result in impairment of nicotine-evoked Ca2+ influx in stably transfected human embryonic kidney cells. These effects of the antibody were remarkably inhibited by interfering with the endocytic machinery at low-temperature. We conclude that reduction of nAChR in autonomic ganglia can be mediated by the endocytosis of α3 subunits, and resulted in autonomic failure in AAG patients.

关键词： Nicotinic Acetylcholine Receptor α3 Subunit Antibody Endocytosis Ca2+ Influx Autoimmune Autonomic Ganglionopathy

Formation of ceramic-metal composite layers on die steels by electron beam irradiation

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材料与冶金学报 2015年第2期14卷 152-158页

作者： takahiro Akao Yuki Sakurai Tetsuhiko Onda Kazutake Uehara Zhongchun Chen Department of Mechanical and Aerospace Engineering Graduate School of EngineeringTottori University Koyama - minami d - 101 Tottori 680 - 8552 Japan Next Generation Advanced Medical Promotion Center Tottori University Hospital Nishi - cho 36 - 1 Yonago Tottori 683 - 8504 Japan

Surface modifications,which result in formation of a hard layer such as CrN,TiN,TiCN etc. on tool surfaces,have been widely utilized in machining tools. How ever,the hard layer has clear interface with the matrix,thereby the delamination between the hard layer and matrix often occurs because of a mismatch of the thermal expansion coefficients. A composite layer with complicated interfaces between hard material and matrix is desired to avoid such a delamination due to a complicated interface existed between workpiece and coating materials. In this study,the formation of ceramic- metal composite layers on the surfaces of die steels by an electron beam( EB) irradiation technique has been investigated. When WC- Co powder was embrocated onto the substrate surfaces,a composite layer of WC- Co and matrix was formed through solidification after the irradiation-induced melting. The composite layer shows a marble- like texture with WC- rich regions. The hardness of the layer reaches up to 1000 HV. For other ceramic pow ders such as TiN and SiC,only small amount of particles has been incorporated into the composite layer,resulting in a relatively low hardness enhancement after the EB irradiation.

关键词： surface modification die steel composite layer electron beam irradiation

Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

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Energy & Environmental Materials 2024年第3期7卷 133-142页

作者： Hiroki Yamada Koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki Hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano Takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara Koji Amezawa Yoshitaka Tateyama Shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Faculty of Materials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Institute of Materials Structure Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Centre for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary International Research Organisation of Advanced Science and Technology(IROAST) Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Faculty of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Faculty of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li_(3)PS_(4)glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li^(+)cation mobility and the PS_(4)^(3-)anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect(i.e.,a cation-cation interaction),which is regarded as the essence of high Li ion ***,the correlation between the Li^(+)ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li_(3)PS_(4)glass,and that the more mobile Li ions(i.e.,the Li3-type ions)exhibit a characteristic correlation at relatively long distances of ***,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics