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Portal Hypertension & Cirrhosis 2023年第3期2卷 109-114页

作者： Fumimasa Tomooka Kei Moriya takahiro kubo Akihiko Shibamoto Jyunya Suzuki Satoshi Iwai Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Yuki Tsuji Yukihisa Fujinaga Koh Kitagawa Norihisa Nishimura Hiroaki Takaya Kosuke Kaji Hideto Kawaratani Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji Department of Gastroenterology and Hepatology Nara Medical UniversityKashiharaJapan Department of Gastroenterology Nara Prefectural General Medical CenterShichijo-NishimachiJapan

Aims:No solid evidence-based opinion was raised regarding predictors of the degree of ascites reduction with *** retrospective cohort study aimed to examine whether serum copeptin concentration is a useful predictor of ***:The study population consisted of 80 patients with liver cirrhosis treated with tolvaptan for hepatic ascites effusions at Nara Medical University Hospital from May 2014 to December ***-three patients who lost>1.5 kg of body weight in the first week after starting tolvaptan were classified as good responders and the remaining 37 as poor *** laboratory parameters were measured immediately before the start of tolvaptan therapy to examine factors associated with predicting its ***:In the univariate analysis,no significant differences with respect to age(67.6 vs.69.8 years,p>0.05),sex,body mass index(24.8 vs.23.7 kg/m^(2),p>0.05),Child-Pugh score(9.4 vs.9.7,p>0.05),and Model for End-stage Liver Disease score(11 vs.12,p>0.05)were found between the two ***,aspartate transferase and alanine transaminase(ALT)levels were significantly lower in the good response group(52.9±56.3 vs.68.8±50.7 U/L,p<0.05;26.2±30.6 vs.40.5±33.5 U/L,p<0.01),whereas serum copeptin and serum sodium concentrations were significantly higher(57.1±15.0 vs.45.8±16.0 pg/mL,p<0.01;136.3±3.4 vs.133.8±5.8 mEq/L,p<0.05).In the multivariate analysis,serum copeptin concentration and ALT were statistically significant factors(p<0.01,p<0.05).Regression analysis of the association between the tolvaptan efficacy for refractory ascites and pretreatment serum copeptin concentration showed that a copeptin concentration cutoff of 45.9 pg/mL could predict treatment efficacy with a sensitivity,specificity,and area under the curve of 76.7%,59.5%,and 0.71%,***:Serum copeptin concentration may be a predictor of tolvaptan efficacy for refractory ascites effusion in Japanese patients with liver cirrhosis.

关键词： ascites copeptin decompensated liver cirrhosis diuretics tolvaptan

Electrochemical and Thermal Properties of Polymer Electrolytes Based on the Random and Triblock Copolymers of Poly（Ethylene Oxide） with Poly（Propylene Oxide）

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材料科学与工程（中英文A版） 2011年第5X期1卷 607-615页

作者： Masashi Matsumoto takahiro Uno Masataka kubo Takahito Itoh Division of Chemistry for Materials Graduate School of Engineering Mie University 1577 Kurima Maehiya-cho Tsu Mie 514-8507 Japan Graduate School of Regional Innovation Studies Mie University 1577 Kurima Machiya-cho Tsu Mie 514-8507 Japan

Piezo Impact Driven X-Y stage for Accurate Micro Lens Alignment

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Piezo Impact Driven X-Y stage for Accurate Micro Lens Alignm...

Solar power sail mission of OKEANOS

第三届亚洲机械电子学学术会议

作者： Yuuka Irie Hisayuki Aoyama Junichi kubo takahiro Fujioka Takashi Usuda Advanced Technology Development 1st Dept. Applied Micro Systems Inc. University of Electro-Communications SVBL302 UECChofugaoka1-5-1 Chofu TokyoJapan

INTRODUCTIONOne of the latest technical trends in the micro production is the development of the special mechanism to manipulate, handle and transport such the small parts, because many of products are

关键词： Piezoelectric actuator V-shaped groove guide Minute parts Inertia drive.

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Astrodynamics 2020年第3期4卷 233-248页

作者： Osamu Mori Jun Matsumoto Toshihiro Chujo Masanori Matsushita Hideki Kato Takanao Saiki Yuichi Tsuda Jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki Takao Yuki kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki Okada takahiro Iwata Hajime Yano Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan Tokyo Institute of Technology Tokyo 152-8550Japan The University of Tokyo Tokyo 113-8654Japan Patchedconics LLCSagarmihara 252-5210Japan

The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail *** Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in *** demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary *** up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary *** this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to *** paper proposes a system design for OKEANOS and includes analyses of the latest mission.

关键词： solar power sail Trojan asteroid landing in-situ analysis outer solar system OKEANOS

Current status in remnant gastric cancer after distal gastrectomy

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World Journal of Gastroenterology 2016年第8期22卷 2424-2433页

作者： Masaichi Ohira takahiro Toyokawa Katsunobu Sakurai Naoshi kubo Hiroaki Tanaka Kazuya Muguruma Masakazu Yashiro Naoyoshi Onoda Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of Medicine

Remnant gastric cancer(RGC) and gastric stump cancer after distal gastrectomy(DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori(H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis.

关键词： Remnant gastric cancer Helicobacter pylori endoscopic treatment Surveillance laparoscopic surgery

Establishing a Calculation Method for Estimating the Normal Circumference of the Proximal Interphalangeal Finger Joints

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第4期7卷 186-195页

作者： Satoru Nakamura Daisaku Tokunaga Ryo Oda Daigo Taniguchi Shogo Toyama Maki Asada Hiroyoshi Fujiwara Yutaka Kawahito takahiro Seno Toshikazu kubo Department of Orthopaedics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan

Objective: To estimate the normal circumference of the interphalangeal (IP) thumb joint and the proximal IP (PIP) joints from the index finger to the little finger using individual physical parameters such as body height and body weight. Methods: The maximum size on the ring gauge was recorded which caused resistance when the IP joint of the thumb or PIP joints of the index to small fingers were passed through the gauge. RG was defined as the ring gauge number with the same diameter as the circumference of the IP thumb joint and PIP finger joints from the index finger to the little finger. There were 300 healthy subjects and 600 hands. Univariate and multivariate analyses were used to analyze the relationships between RG and the parameters of age, sex, height, weight, and dominant hand, and regression equations were derived. Results: Age, sex and body weight were all statistically significant predictive factors of RG in all fingers. R2, the coefficient of determination in the regression equation, was almost 0.7 for all fingers, indicating that a moderate or strong correlation was observed between RG and the regression equation. Conclusions: The circumference of the IP thumb joint and PIP finger joints from the index finger to the little finger can be estimated in healthy individuals using a calculation formula that takes age, sex, body height and body weight into account.

关键词： PIP Joint Circumference Ring Gauge

Efficacy of MRP8/14 as a Marker of Disease Activity in Rheumatoid Arthritis

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Open Journal of Rheumatology and Autoimmune Diseases 2016年第2期6卷 34-39页

作者： Tetsuro Yamasaki Ryo Oda Kan Imai Daigo Taniguchi Shogo Toyama takahiro Seno Yuji Arai Kazuya Ikoma Hiroyoshi Fujiwara Daisaku Tokunaga Yutaka Kawahito Toshikazu kubo Department of Orthopaedics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan

Objective: Early and accurate evaluation of the presence and activity of synovitis is extremely important in the diagnosis and treatment of rheumatoid arthritis. Myeloid related protein 8/14 (MRP8/14), also known as calprotectin or S100A8/A9 is considered as a sensitive marker for local inflammatory activity in rheumatoid arthritis. The aim of this study is to demonstrate the efficacy of MRP8/14 as a marker of disease activity in RA. Methods: Thirty-one patients with diagnosis of RA who received treatment without biological drugs at our institution were included in this study. Serum MRP8/14, CRP and MMP-3 were tested in all patients. Disease activity was evaluated using DAS28-CRP and SDAI. Ultrasonography was performed on the wrists and MCP joints of both hands using semi-quantitative scale of power Doppler signal. The sum of scales in joints was calculated as the PD score. The correlation of MRP8/14 with serum biomarkers, disease activity and ultrasonography examination was investigated. Result: Serum MRP8/14 was strongly correlated with CRP (r = 0.63) and MMP-3 (r = 0.69). A correlation was observed between serum MRP8/14 and DAS28-CRP (r = 0.53) and SDAI (r = 0.66). No significant correlation was found between PD scores and MRP8/14. Conclusion: This study demonstrated that MRP8/14 is correlated with evaluated disease activity and markers of serum inflammatory response in patients not using biological drugs. MRP8/14 is considered an effective new method for objective evaluation of synovitis in RA.

关键词： Rheumatoid Arthritis Myeloid Related Protein 8/14 (MRP8/14) Calprotectin Disease Activity