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Rational arrangement of measuring shear wave speed in the liver

World Journal of Gastroenterology 2019年第20期25卷 2503-2513页

作者： Takeshi Yokoo Tsutomu Kanefuji Takeshi Suda Itsuo Nagayama takahiro hoshi Satoshi Abe Shinichi Morita Hiroteru Kamimura Kenya Kamimura Atsunori Tsuchiya Masaaki Takamura Kazuyoshi Yagi Shuji Terai Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life Niigata University School of MedicineNiigataNiigata 951-8122Japan Division of Gastroenterology and Hepatology Niigata Tokamachi HospitalTokamachiNiigata 948-0065Japan Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami UonumaNiigata 949-7302Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan

BACKGROUND Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM To provide procedural standardization of shear wave speed measurement. METHODS Point shear wave elastography (pSWE) was measured in 781 patients, and twodimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS The CVR showed a significantly broader distribution in the left lobe (P < 0.0001),and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes.

关键词： Liver stiffness Ultrasound Shear wave elastography Acoustic radiation force impulse Heterogeneity

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Gravity assistance enables liver stiffness measurements to detect liver fibrosis under congestive circumstances

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World Journal of Hepatology 2022年第4期14卷 778-790页

作者： Takeshi Suda Ai Sugimoto Tsutomu Kanefuji Atsushi Abe Takeshi Yokoo takahiro hoshi Satoshi Abe Shinichi Morita Kazuyoshi Yagi Masashi Takahashi Shuji Terai Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami Uonuma 949-7302NiigataJapan Division of Thoracic and Cardiovascular Surgery Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan Department of Gastroenterology and Hepatology Tsubame Rosai HospitalTsubame 959-1228NiigataJapan Department of Administration Joetsu-Area General Health Care CenterJoetsu 943-0803NiigataJapan Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life Niigata University School of MedicineNiigata 951-8122Japan Division of Gastroenterology and Hepatology School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan

BACKGROUND As survival has been prolonged owing to surgical and medical improvements,liver failure has become a prognostic determinant in patients with congestive heart *** hepatopathy,an abnormal state of the liver as a result of congestion,insidiously proceed toward end-stage liver disease without effective biomarkers evaluating pathological *** measurements of shear wave elastography cannot qualify liver fibrosis,which is a prognosticator in any type of chronic liver disease,in cases of congestion because congestion makes the liver stiff without *** hypothesized that the effects of congestion and fibrosis on liver stiffness can be dissociated by inducing architectural deformation of the liver to expose structural *** establish a strategy measuring liver stiffness as a reflection of architectural rigidity under *** Two-dimensional shear wave elastography(2dSWE)was measured in the supine(Sp)and left decubitus(Ld)positions in 298 consecutive cases as they were subjected to an ultrasound study for various liver *** of interest were placed at twelve sites,and the median and robust coefficient of variation were *** data were compared using the Mann-Whitney U or Kruskal-Wallis test followed by Dunn's post-hoc multiple *** inferior vena cava(IVC)diameters at different body positions were compared using the Wilcoxon matched pairs signed rank *** number of cases with cardiothoracic ratios greater than or not greater than 50%was compared using Fisher’s exact test.A correlation of 2dSWE between different body positions was evaluated by calculating Spearman correlation *** The IVC diameter was significantly reduced in Ld in subjects with higher 2dSWE values in Ld(LdSWE)than in Sp(SpSWE)(P=0.007,(average±SD)13.9±3.6 vs 13.1±3.4 mm)but not in those with lower LdSWE values(P=0.32,13.3±3.5 vs 13.0±3.5 mm).In 81 subjects,SpSWE was increased or decreased in

关键词： Shear wave elastography Inferior vena cava diameter Congestive hepatopathy Liver fibrosis Body positions Fibrosis-4 index

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World Journal of Clinical Cases 2019年第21期7卷 3553-3561页

作者： Takeshi Mizusawa Kenya Kamimura Hiroki Sato Takeshi Suda Hiroyuki Fukunari Go Hasegawa Osamu Shibata Shinichi Morita Akira Sakamaki Junji Yokoyama Yu Saito Yoshihisa Hori Yuduru Maruyama Fumitoshi Yoshimine takahiro hoshi Shinichi Morita Tsutomu Kanefuji Masaaki Kobayashi Shuji Terai Department of Internal Medicine Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan Department of Gastroenterology and Hepatology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Surgery Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Department of Pathology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Internal Medicine Tokamachi Central ClinicTokamachiNiigata 948-0065Japan

BACKGROUND Immunosuppression is effective in treating a number of diseases,but adverse effects such as bone marrow suppression,infection,and oncogenesis are of *** is a key immunosuppressant used to treat rheumatoid *** it is effective for many patients,various side effects have been reported,one of the most serious being methotrexate-related lymphoproliferative *** this may occur in various organs,liver involvement is *** on these liver lesions,including clinical characteristics,course,and imaging studies,has not been summarized to *** SUMMARY We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal *** had had rheumatoid arthritis for 5 years and was being treated with medication including ***-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3,CD4,CD8,and CD79a but negative for CD20 and *** for Epstein-Barr virus-encoded RNA was *** based on these findings,the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders.A timedependent disappearance of the liver tumors after stopping methotrexate supported the *** The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.

关键词： Arthritis Rheumatoid Methotrexate Malignant lymphoma Case report

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Secretory carcinoma——impact of translocation and gene fusions on salivary gland tumor

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Chinese Journal of Cancer Research 2017年第5期29卷 379-384页

作者： Ryoko Inaki Masanobu Abe Liang Zong takahiro Abe Aya Shinozaki-Ushiku Tetsuo Ushiku Kazuto hoshi Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Division for Health Service Promotion University of Tokyo Graduate School of Medicine University of Tokyo Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Department of Pathology Graduate School of Medicine University of Tokyo

Secretory carcinoma（SC）, previously described as mammary analogue secretory carcinoma（MASC）, is a recently described salivary gland tumor which morphologically resembles mammary secretory carcinoma. The first description of SC/MASC, reported by Skálová et al. in 2010, was as a rare salivary carcinoma imitating secretory carcinoma of the breast. SC/MASC is a unique salivary gland tumor with morphological overlap with acinic cell carcinoma（Aci CC）, mucoepidermoid carcinoma（MEC）, and adenocarcinoma not otherwise specified（ADCNOS）. SC/MASC shares similar clinicopathological features with Aci CC. As a critical difference between SC/MASC and Aci CC, SC/MASC characteristically has the chromosomal translocation t（12;15）（p13;q25） which leads to a fusion gene between the ETV6 gene on chromosome 12 and the NTRK3 gene on chromosome 15. This genetic background is an important differential diagnostic finding for excluding other salivary gland tumors and may be a critical factor determining the prognosis for patients with SC/MASC. Research in recent years has provided a large body of new data on SC/MASC and suggests the possibility that the ETV6-NTRK3 translocation could be a therapeutic target. Here, we review the morphological and clinicopathological features of SC/MASC and discuss new directions for therapy.

关键词： Secretory carcinoma mammary analogue secretory carcinoma MASC ETV6-NTRK3 fusion gene salivary gland tumor

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BRAF inhibitor:a novel therapy for ameloblastoma in mandible

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Chinese Journal of Cancer Research 2018年第6期30卷 677-678页

作者： Masanobu Abe Liang Zong takahiro Abe Hideyuki Takeshima Jiafu Ji Toshikazu Ushijima Kazuto hoshi Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Division for Health Service Promotion University of Tokyo Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal SurgeryPeking University Cancer Hospital & Institute Graduate School of Medicine University of Tokyo Division of Epigenomics National Cancer Center Research Institute

Ameloblastoma is a benign but locally aggressive odontogenic neoplasm that accounts for 10% of all tumors arising in the mandible and maxilla (1). Eighty percent of ameloblastomas arise in the mandible, and they are u... 详细信息

关键词： BRAF inhibitor:a novel therapy for ameloblastoma in mandible

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Whole circumferential endoscopic submucosal dissection of superficial adenocarcinoma in long-segment Barrett's esophagus:A case report

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1285-1292页

作者： Keiichiro Abe Kenichi Goda Akira Kanamori Tsunehiro Suzuki Akira Yamamiya Yoichi Takimoto takahiro Arisaka Koki hoshi Takeshi Sugaya Yuichi Majima Keiichi Tominaga Makoto Iijima Shinichi Hirooka Hidetsugu Yamagishi Atsushi Irisawa Department of Gastroenterology Dokkyo Medical UniversityMibu 321-0293TochigiJapan Department of Pathology The Jikei University School of MedicineNishishimbashi 105-8471TokyoJapan Academic Institutional Research Center Dokkyo Medical UniversityMibu 321-0293TochigiJapan

BACKGROUND Esophageal adenocarcinoma(EAC)derived from long-segment Barrett’s esophagus(LSBE)is extremely rare in ***-related EAC is often difficult to diagnose in the horizontal *** the tumor has spread throughout the LSBE,whole circumferential endoscopic submucosal dissection(ESD)should be performed,which is difficult to complete ***,whole circumferential ESD can bring refractory postoperative *** hereby report a case of EAC involving the whole circumference of the LSBE,achieving complete endoscopic removal without *** SUMMARY An 85-year-old man with the chief complaint of dysphagia underwent *** suspected a flat-type cancerous lesion that extended the whole circumference of the LSBE(C 3.5,M 4.0)using narrow-band imaging magnification endoscopy(NBI-M).We achieved circumferential en bloc resection of the lesion safely with special ESD *** of the ESD specimens demonstrated that the superficial EAC extended the whole circumference of the LSBE,and papillary or well-differentiated tubular adenocarcinoma was confined in the lamina propria mucosa showing a vertical negative *** prevent post-ESD stenosis,we performed endoscopic local injection of steroids,followed by oral administration of *** was no evidence of esophageal refractory stenosis or tumor recurrence 30 mo after *** summary,we experienced a rare case of LSBE-related *** horizontal tumor extent was accurately diagnosed by ***,we achieve whole circumferential ESD safely without postoperative refractory *** NBI-M,ESD,and steroid therapy enabled the curative resection of superficial full circumferential LSBE-related EAC without refractory postoperative stenosis.

关键词： Endoscopic submucosal dissection Long-segment Barrett's esophagus Superficial esophageal adenocarcinoma Steroid Magnification endoscopy Case report

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A Case of Pleomorphic Adenoma of the Parotid Gland with Multiple Local Recurrences through Facial to Cervical Regions

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Open Journal of Stomatology 2014年第9期4卷 441-445页

作者： Masanobu Abe Yoshiyuki Mori Yuki Kanno Kazuto hoshi Hideto Saijo takahiro Abe Kazumi Ohkubo Tsuyoshi Takato Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Tokyo Japan

Pleomorphic adenoma is the most common benign parotid gland tumor. Although its local recurrence rate is known to be high, the recurrence extending to the cervical region is rare. Here we report a case of a young female (25 years old) with pleomorphic adenoma of the parotid gland which showed multiple recurrences through facial to cervical regions over a span of eight years. We also discuss how this benign tumor with a high recurrence rate has been treated in other cases, and how it should be treated.

关键词： Pleomorphic Adenoma Parotid Gland Salivary Neoplasm

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Growth inhibition of a human colon carcinoma cell, COLO 201, by a natural product, Vitex agnus-castusfruits extract, in vivoand in vivo

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Advances in Biological Chemistry 2012年第1期2卷 20-28页

作者： Masahiko Imai Bo Yuan Hidetomo Kikuchi Mai Saito Kunio Ohyama Chieko Hirobe Takashi Oshima takahiro Hosoya Hiroshi Morita Hiroo Toyoda Department of Clinical Molecular Genetics School of Pharmacy Tokyo University of Pharmacy & Life Sciences Tokyo Japan Department of Cultural History Seisen University Tokyo Japan Faculty of Pharmaceutical Sciences Hoshi University Tokyo Japan Gastroenterological Center Yokohama City University Medical Center Yokohama Japan

An extract from ripe fruit of Vitex agnus-castus (Vitex) has been used to treat patients with various obstetric and gynecological disorders in Europe. We have demonstrated that Vitex showed cytocidal effects on various types of cancer cell lines including a human colon carcinoma cell line, COLO 201. In this study, we extended our previous study to investigate the detailed mechanisms underlying cytocidal effects of Vi- tex on COLO 201. Furthermore, a possible clinical application of Vitex was also explored in vivo using nude mice xenografted with the cells. Treatment with Vitex induced apoptosis in COLO 201 in a time-dependent manner, accompanying with activa-tion of caspase-9 and -3, but not caspase-8. An inhibitor for c-Jun NH2-terminal kinase (JNK), but not p38 mitogen-activated protein kinase (MAPK), significantly suppressed the apoptosis induction along with caspase-3 activation. Endoplasmic reticulum (ER) stress-related genes were also upregulated by Vitex treatment. Most importantly, the in vivo efficacy of Vitex evaluated by assessing the tumor growth revealed that the administration of Vitex significantly suppressed tumor growth in COLO 201 xenografted mice. Collectively, current results suggest that apoptosis induction by Vitex in COLO 201 is mediated through the activation of JNK and caspase-9, -3 resulted from ER stress. Based on the current clinical application of Vitex, these results thus provide a new insight into the clinical use of Vitex and leave open a possibility of a new regimen as an alternative medicine approach for such devastating colon cancer treatment.

关键词： Colon Cancer Apoptosis Induction ER Stress JNK Flavonoids Vitex agnus-castus

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Two Novel Triterpenes,Acutaxylines A and B,from Dysoxylum acutangulum

Two Novel Triterpenes,Acutaxylines A and B,from Dysoxylum ac...

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13th Asian Chemical Congress

作者： ISMAIL Intan S. NAGAKURA,Yuta HIRASAWA Yusuke. HOSOYA takahiro MOHD LAZIM M.I. LAJIS Nordin MORITA Hiroshi Faculty of Pharmaceutical Sciences Hoshi University

＜正＞Acutaxylines A（1）and B（2）are a new class of triterpenes consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol（Figure 1）,were isolated from the ethyl acetate leaves fraction of Dysoxylum acutangulum,a species belonging to Meliaceae *** relative stereochemistry of 1 and 2 was determined by NOESY *** though there are many triterpenes,steroids,and

关键词： Acutaxylines triterpene Dysoxylum acutangulum Meliaceae cytotoxicity

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