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Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with SLCO2A1 gene:A case report

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World Journal of Gastroenterology 2023年第11期29卷 1757-1764页

作者： Kantaro Kimura Keisuke Jimbo Nobuyasu Arai Masamichi Sato Mitsuyoshi Suzuki takahiro Kudo Tomonori Yano Toshiaki Shimizu Department of Pediatrics Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of Medicine Jichi Medical UniversityTochigi 329-0498Japan

BACKGROUND Eosinophilic gastrointestinal disease(EGID)is a disorder characterized by infiltration of eosinophils causing mucosal damage and dysfunction of the gastrointestinal *** endoscopic findings of eosinophilic enteritis(EoN),an EGID variant,are nonspecific and occasionally difficult to *** contrast,chronic enteropathy associated with SLCO2A1(CEAS)is a chronic persistent small intestinal disorder characterized by endoscopic findings such as multiple oblique and circular *** SUMMARY We report the case of a 10-year-old boy who had suffered abdominal pain and fatigue for the preceding 6 *** was referred to our institute for investigation of suspected gastrointestinal bleeding because of severe anemia with hypoproteinemia and positive fecal human *** upper and lower gastrointestinal endoscopic findings were normal;however,double-balloon small bowel endoscopy showed multiple oblique and circular ulcers with discrete margins and mild constriction of the intestinal lumen in the *** findings were highly consistent with CEAS,but urine prostaglandin metabolites were within normal limits,and no previously reported mutations in the SLCO2A1 gene were *** evaluation demonstrated moderate to severe eosinophilic infiltration localized to the small intestine suggesting a diagnosis of *** remission was maintained with montelukast and a partial elemental diet,but emergent surgery for bowel obstruction due to small intestinal stenosis was performed two years after the initial *** EoN should be considered in the differential diagnosis of CEAS-like small intestinal ulcerative lesions and normal urinary prostaglandin metabolite levels.

关键词： Anemia Chronic enteropathy associated with SLCO2A1 Double-balloon endoscopy Eosinophilic gastrointestinal disease Hypoproteinemia Case report

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POLYMER COLLOIDS FORMED BY POLYELECTROLYTE COMPLEXATION OF VINYL POLYMERS AND POLYSACCHARIDES IN AQUEOUS SOLUTION

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Chinese Journal of Polymer Science 2013年第1期31卷 39-49页

作者： Hui-dan Liu takahiro Sato Department of Macromolecular Science Osaka University

The polyelectrolyte complex formed from the polyanion and polycation was studied by turbidimetry, static and electrophoretic light scattering, and elementary analysis. Sodium salts of polyacrylate （PA） and heparin （Hep） were chosen as the polyanion, and hydrochloric salts of poly（vinyl amine）（PVA） and chitosan （Chts） as the polycation. Although these vinyl polymers and polysaccharides have remarkably different backbone chemical structures and linear charge densities, all the four combinations PA-PVA, PA-Chts, Hep-PVA, and Hep-Chts provide almost stoichiometric polyelectrolyte complexes which are slightly charged owing to the adsorption of the excess polyelectrolyte component onto the neutral complex. The charges stabilize the complex colloids in aqueous solution of a non-stoichiometric mixture, and the aggregation number of the complex colloids increases with approaching to the stoichiometric mixing ratio. The mixing ratio dependence of the aggregation number for the four complexes is explained by the model proposed in the previous study.

关键词： Polyelectrolyte complex Colloidal dispersion Polyacrylate Poly(vinyl amine) Heparin Chitosan Lightscattering.

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Rapid detection of neutralizing antibodies to SARS-CoV-2 variants in post-vaccination sera

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Journal of Molecular Cell Biology 2021年第12期13卷 918-920页

作者： Kei Miyakawa Sundararaj Stanleyraj Jeremiah Hideaki Kato Yutaro Yamaoka Hirofumi Go Satoshi Yajima Tomoko Shimada takahiro Mihara Atsushi goto Takeharu Yamanaka Akihide Ryo Department of Microbiology Yokohama City University School of MedicineYokohamaJapan Infection Prevention and Control Department Yokohama City University HospitalYokohamaJapan Life Science Laboratory Technology and Development DivisionKanto Chemical Co.Inc.IseharaJapan Department of Biostatistics Yokohama City University Graduate School of MedicineYokohamaJapan Clinical Laboratory Department Yokohama City University HospitalYokohamaJapan Nursing Department Yokohama City University HospitalYokohamaJapan Department of Health Data Science Yokohama City University Graduate School of Data ScienceYokohamaJapan

The uncontrolled spread of the coronavirus disease 2019(COVID-19)pandemic has led to the emergence of different severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants across the *** ongoing global vaccination strategy to curtail the COVID-19 juggernaut is threatened by the rapidly spreading variants of concern(VOC)and other regional mutants,which are less responsive to neutralization by infection-or vaccine-derived antibodies(Gomez et al.,2021;Wang et al.,2021).

关键词： vaccination antibodies

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Content Validity of a Self-Management Behavior Assessment Tool for Adult Post-Renal Transplant Recipients Using a Modified Delphi Method

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Health 2022年第1期14卷 70-95页

作者： takahiro Ohashi Chiharu Akazawa Faculty of Nursing School of Nursing Osaka Medical and Pharmaceutical University Osaka Japan Doctoral Program Graduate School of Nursing Osaka Medical and Pharmaceutical University Osaka Japan

Background: Self-management is important for post-renal transplant recipients to resolve renal dysfunction, heart failure, and post-transplant psychosocial issues, and to maintain transplant kidney function, etc. However, because recipients may be unable to adequately self-manage, healthcare providers need to provide self-management support for recipients to improve their skills and confidence in managing their disease. However, it is difficult to comprehensively assess the self-management behaviors in a busy outpatient support setting. Furthermore, since there are no uniform standards for assessment, it is based on the experience and abilities of medical personnel. Therefore, self-management behavior of post-renal transplant recipients is not sufficiently evaluated. Objective: This study aimed to evaluate content validity of a tool that can assess self-management behaviors of adult post-renal transplant recipients, consisting of consensus components from experts familiar with the follow-up of adult post-renal transplant recipients. Methods: A three-round modified Delphi method was used to assess the self-management behaviors of adult post-renal transplant recipients by a panel of experts consisting of certified transplant recipient coordinators, physicians, outpatient nurses, and researchers familiar with the follow-up of post-renal transplant recipients. Regarding management behaviors of adult post-renal transplant recipients, the experts rated the appropriateness and validity of each item using a Likert scale. Consensus ratings from the experts were made by calculating the median, interquartile range, and interquartile range percentage. In the third round, an item-level content validity index was calculated to assess content validity. Conclusions: The 41-item self-management behavior scale for kidney transplant recipients assessed self-management behaviors in five domains: medication, exercise, f

关键词： Post-Renal Transplant Recipient Self-Management Modified Delphi Method

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Study on dynamic response of embedded long span corrugated steel culverts using scaled model shaking table tests and numerical analyses

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第3期7卷 430-435页

作者：车爱兰 IWATATE takahiro 葛修润 School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200030 China Civil and Environmental Engineering Tokyo Metropolitan University Tokyo 192-0397 Japan

A series of scaled-model shaking table tests and its simulation analyses using dynamic finite element method were performed to clarify the dynamic behaviors and the seismic stability of embedded corrugated steel culverts due to strong earth-quakes like the 1995 Hyogoken-nanbu earthquake. The dynamic strains of the embedded culvert models and the seismic soil pressure acting on the models due to sinusoidal and random strong motions were investigated. This study verified that the cor-rugated culvert model was subjected to dynamic horizontal forces (lateral seismic soil pressure) from the surrounding ground, which caused the large bending strains on the structure; and that the structures do not exceed the allowable plastic deformation and do not collapse completely during strong earthquake like Hyogoken-nanbu earthquake. The results obtained are useful for design and construction of embedded long span corrugated steel culverts in seismic regions.

关键词：波纹钢管涵洞振动台试验数值分析动态响应比例模型

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Activity coefficients of NiO and CoO in CaO–Al_2O_3–SiO_2 slag and their application to the recycling of Ni–Co–Fe-based end-of-life superalloys via remelting

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International Journal of Minerals,Metallurgy and Materials 2017年第1期24卷 25-36页

作者： Xin Lu takahiro Miki Tetsuya Nagasaka Graduate School of Engineering Tohoku University

To design optimal pyrometallurgical processes for nickel and cobalt recycling, and more particularly for the end-of-life process of Ni-Co-Fe-based end-of-life（EoL） superalloys, knowledge of their activity coefficients in slags is essential. In this study, the activity coefficients of NiO and CoO in CaO-Al_2O_3-SiO_2 slag, a candidate slag used for the EoL superalloy remelting process, were measured using gas/slag/metal equilibrium experiments. These activity coefficients were then used to consider the recycling efficiency of nickel and cobalt by remelting EoL superalloys using CaO-Al_2O_3-SiO_2 slag. The activity coefficients of NiO and CoO in CaO-Al_2O_3-SiO_2 slag both show a positive deviation from Raoult＇s law, with values that vary from 1 to 5 depending on the change in basicity. The activity coefficients of NiO and CoO peak in the slag with a composition near B =（%CaO）/（%SiO_2） = 1, where B is the basicity. We observed that controlling the slag composition at approximately B = 1 effectively reduces the cobalt and nickel oxidation losses and promotes the oxidation removal of iron during the remelting process of EoL superalloys.

关键词： recycling nickel cobalt end-of-life superalloys activity coefficients remelting slag

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Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation

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Neural Regeneration Research 2023年第11期18卷 2466-2473页

作者： Kanae Murata Kenya Nozawa Mayumi Matsushita Aozora Yamashita Rintaro Fujii Yuji Awaga Aldric Hama takahiro Natsume Go Yoshida Yukihiro Matsuyama Hiroyuki Takamatsu Hamamatsu Pharma Research Inc.HamamatsuShizuokaJapan Department of Orthopedic Surgery Hamamatsu University School of MedicineHamamatsuShizuokaJapan

The lack of truly robust analgesics for chronic pain is owed,in part,to the lack of an animal model that reflects the clinical pain state and of a mechanismbased,objective neurological indicator of *** present study examined stimulus-evo ked brain activation with functional magnetic resonance imaging in male and female cynomolgus macaques following unilateral L7 spinal nerve ligation and the effects of clinical analgesics pregabalin,duloxetine,and morphine on brain activation in these macaques.A modified straight leg raise test was used to assess pain severity in awake animals and to evo ke regional brain activation in anesthetized *** potential effects of clinical analgesics on both awake pain behavior and regional brain activation were *** spinal nerve ligation,both male and female macaques showed significantly decreased ipsilateral straight leg raise thresholds,suggesting the presence of radicula rlike *** treatment increased straight leg raise thresholds in both males and females whereas duloxetine and pregabalin did *** male macaques,the ipsilateral straight leg raise activated contralateral insular and somatosensory cortex(Ins/SII),and *** female macaques,the ipsilateral leg raise activated cingulate cortex and contralateral insular and somatosensory *** leg raises of the contralateral,unligated leg did not evoke brain *** reduced activation in all brain regions in both male and female *** males,neither pregabalin nor duloxetine decreased brain activation compared with vehicle *** females,however,pregabalin and duloxetine decreased the activation of cingulate cortex compared with vehicle *** current findings suggest a diffe rential activation of brain areas depending on sex following a peripheral nerve *** rential brain activation observed in this study could underlie qualitative sexual dimorphism in clinical chronic pain perception and responses to

关键词： biomarkers functional magnetic resonance imaging lumbar radicular pain Macaca fascicularis neuroimaging neuropathic pain sciatica straight leg raise

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Selective excitation of two-wave structure depending on crystal orientation under shock compression

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Science China(Physics,Mechanics & Astronomy) 2020年第11期63卷 59-71页

作者： QiLin Xiong takahiro Shimada Takayuki Kitamura ZhenHuan Li Department of Mechanics Huazhong University of Science&TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment Wuhan 430074China Department of Mechanical Engineering and Science Kyoto UniversityKyoto 615-8540Japan

Single crystals subjected to shock compression exhibit responses with distinct two-wave structures for certain crystal ***,little is known to date regarding how the shock response depends on crystal orientation,and especially why the two-wave structure depends on the crystal *** this work,molecular dynamics simulations of shock compressions in copper single crystals are performed to investigate the orientation dependence of shock responses and the corresponding deformation *** copper single crystals with[001],[011],[012],and[123]crystal orientations along the depth direction are ***[011],[012],and[123]crystal orientations of copper single crystals show distinct two-wave structures in their shock responses,while such a two-wave structure in the shock response is not seen for those orientations having a[001]crystal *** potential causes are analyzed by considering the propagation velocities of both elastic and plastic *** develop a technique for identifying twin structures in face-centered cubic crystals and this technique can effectively identify the twin *** morphology of shock-induced defects(e.g.,dislocations and twins)shows the significant dependence of crystal orientation and the mechanisms behind these are discussed in ***,the Johnson-Cook constitutive model describing dynamic deformations at high temperatures and high strain rates is used to analyze the relationships between the shock responses and microscopic *** predictions of the Johnson-Cook constitutive model are consistent with the results of the molecular dynamics simulations.

关键词： orientation-dependent two-wave structure shock compression copper molecular dynamics

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Evaluation of Dynamic Soil-Structure Interaction and Dynamic Seismic Soil Pressures Acting on It Subjected to Strong Earthquake Motions

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Journal of Shanghai Jiaotong university(Science) 2006年第4期11卷 530-536页

作者：车爱兰 IWATATE takahiro 葛修润 School of Naval Architecture Ocean and Civil Eng. Shanghai Jiaotong Univ. Civil and Environmental Eng. Tokyo Metropolitan Univ.

In order to clarify the damage mechanism of the subway structure, the dynamic soil-structure interaction and the dynamic forces acting on the structure, a series of shaking table tests and simulation analyses were performed. The seismic response of the structure and the dynamic forces acting on the structure due to sinusoidal and random waves were investigated with special attention to the dynamic soil-structure interaction. The result shows that the compression seismic soil pressures and extension seismic soil pressures simultaneously act on the sidewalls, and big shear stress also acts on the ceiling slab due to horizontal excitation. The seismic soil pressure could be approximated to hyperbola curve, and reached a peak value with increase of the shear strain of the model ground. In addition, a slide and exfoliation phenomenon between the structure and the surrounding ground was simulated, using the nonlinear analyses. The foundation is provided for amending the calculation method of seismic soil pressure and improving the anti-earthquake designing level of underground structure.

关键词： subway structure dynamic seismic soil pressure dynamic soil-structure interaction shaking table tests dynamic analyses nonlinear characteristics

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Takeuchi Yoshimi and Civilization

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2021年第1期15卷 32-47页

作者： NAKAJIMA takahiro Institute for Advanced Studies on Asia The University of TokyoTokyo 113-8645Japan

The definition of civilization has been a major issue for Japanese *** European modernity as synonymous with civilization would mean defining the previous stage as barbarism,and considering how to cut out such *** before the war,Takeuchi Yoshimi had consistently tried to consider the problem of the removal of barbarism from *** article argues that Takeuchi's discussion of the problems of civilization and Japanese modernity contributes to our rethinking of a new barbarism in the midst of globalization.

关键词： Takeuchi Yoshimi civilization Japanese modernity

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